期刊
CANCER INVESTIGATION
卷 32, 期 7, 页码 330-338出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2014.919306
关键词
PKM2; Prostate cancer; Cancer Metabolism
类别
资金
- Prostate Cancer Canada
- Division of Nephrology, Department of Medicine, McMaster University
- St. Joseph's Healthcare in Hamilton, Ontario, Canada, through Hamilton Centre for Kidney Research (HCKR)
Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specificmodification to PKM2 associate with PC progression.
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