Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chia-Hsiang Li, Ya-Chen Yang, Te-Chun Hsia, Te-Chun Shen, Yi-Cheng Shen, Wen-Shin Chang, Yun-Chi Wang, Chia-Wen Tsai, Da-Tian Bau
Summary: The interleukin-8 rs4073 genotypes are associated with lung cancer susceptibility, especially for smokers. The study found that the homozygous variant AA genotypes had a lower percentage in lung cancer patients compared to healthy controls, and there was a statistical difference in allele frequencies distribution.
ANTICANCER RESEARCH
(2022)
Review
Medicine, General & Internal
Shiqiao Zhao, Junzuo Gong, Songlin Yin, Xiaofeng Li, Shuangquan Zhao, Tianyi Mou, Shu Luo
Summary: This meta-analysis aims to elucidate the association between IL-8-251 A/T polymorphism and the risk and mortality of sepsis. English studies were analyzed, and the results will be submitted to a peer-reviewed journal.
Review
Medicine, General & Internal
Kexin Wang, Zhen Jiao, Hongxiang Chen, Xiaowan Liu, Jing Lu, Xuli Liu, Jinming Li, Lin Wang
Summary: The meta-analysis reveals a significant negative association between rs1800872 polymorphism in interleukin-10 and risk of cervical cancer, indicating a protective effect of the AC/AA + AC variant in the development of cervical cancer.
Review
Oncology
Ke Zhu, Aiqun Xu, Wanli Xia, Pulin Li, Binbin Zhang, Huihui Jiang, Sijing Zhou, Ran Wang
Summary: The NAT2 slow + intermediate phenotype is significantly associated with an increased risk of lung cancer, while the NAT2 rapid phenotype is associated with a reduced risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Dan Zou, Ailin Song, Wei Yong
Summary: This study investigated whether interleukin 8 (IL-8) can be used as a biomarker to evaluate the efficacy of immune checkpoint inhibitors (ICIs) treatment. The meta-analysis findings showed that the high IL-8 group had a lower objective response rate (ORR), overall survival (OS), and progression-free survival (PFS) compared to the low IL-8 group after ICIs treatment. Therefore, IL-8 can serve as a biomarker to predict the efficacy of ICIs.
FRONTIERS IN ONCOLOGY
(2023)
Review
Medicine, General & Internal
Bei Wang, Fenlai Yuan
Summary: This study suggests a potential association between interleukin-1 beta (IL-1 beta) gene polymorphisms and the risk of breast cancer, although the results are controversial. The three common polymorphisms in IL-1 beta showed no significant associations with breast cancer risk overall. However, in the Asian population, rs16944 was associated with an increased risk of breast cancer, while rs1143627 was associated with a decreased risk, specifically in post-menopausal women.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Review
Genetics & Heredity
Lijun Li, Wei Xiong, Donghua Li, Jiangang Cao
Summary: This meta-analysis suggests that certain IL-10 gene polymorphisms are significantly associated with breast cancer risk in Asian populations, as well as in Caucasian populations. This provides new insights into the prediction and diagnosis of breast cancer susceptibility through the detection of IL-10 gene polymorphisms.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, General & Internal
Farzad Rezaei, Hady Mohammadi, Mina Heydari, Masoud Sadeghi, Hamid Reza Mozaffari, Atefeh Khavid, Mostafa Godiny, Serge Brand, Kenneth M. Dursteler, Annette Beatrix Bruhl, Dominik Cordier, Dena Sadeghi-Bahmani
Summary: The meta-analysis found no significant association between IL-6 (-174G/C) and IL-8 (-251T/A) gene polymorphisms and the susceptibility to oral cancer. However, the source of control and genotyping method may impact the association between IL-6 (-174G/C) polymorphisms and the risk of oral cancer.
MEDICINA-LITHUANIA
(2021)
Review
Immunology
Xin Liu, Hui Li
Summary: This systematic review explores the impact of multiple cytokine gene polymorphisms on the pathogenesis of periodontitis. The results show that some cytokine gene polymorphisms are associated with the risk or prevention of periodontitis. IL-1 beta and Treg cytokines play important roles in periodontitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: The meta-analysis showed no significant association between the ACE I/D polymorphism and lung cancer risk, and subgroup analysis by ethnicity did not yield significant results.
Review
Biotechnology & Applied Microbiology
Xiaoyan Li, Rong Hu, Xinyi Ren, Jie He
Summary: This meta-analysis study found that compared to the control group, adults and children with OSAS have significantly elevated serum IL-8 concentrations. Additionally, researchers observed that the higher the AHI value, the higher the IL-8 concentration.
Article
Biochemistry & Molecular Biology
Etrat Javadirad, Masoud Sadeghi, Pembe Oltulu, Sepehr Sadafi
Summary: This meta-analysis examined the associations between IL-4 and IL-17 polymorphisms and colorectal cancer risk. The results showed that IL-17A rs2275913 and IL-17F rs763780 polymorphisms may be associated with an increased risk of colorectal cancer, while the association between IL-4 and IL-4R polymorphisms and colorectal cancer risk remains unclear. Ethnicity, genotyping method, sample size, control group, and publication year were identified as factors affecting the results.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Article
Immunology
Qianqian Liu, Wenzhang Li, Yunfeng Chen
Summary: The meta-analysis did not find a significant association between IL-4 rs2243250 polymorphism and TB risk overall, but indicated a potential increase in TB risk in the European population with the recessive genetic model. Additional research is needed to clarify the ethnic differences in genetic association studies.
MICROBIAL PATHOGENESIS
(2021)
Article
Cell Biology
Ming-Na Zhao, Ling-Fei Zhang, Zhen Sun, Li-Hua Qiao, Tao Yang, Yi-Zhe Ren, Xian-Zhou Zhang, Lei Wu, Wen-Li Qian, Qiao-Mei Guo, Wan-Xing Xu, Xue-Qing Wang, Fei Wu, Lin Wang, Yutong Gu, Mo-Fang Liu, Jia-Tao Lou
Summary: Bone metastasis is a significant complication in lung cancer patients, leading to poor quality of life and low survival rates. The regulatory mechanisms of lung cancer bone metastasis are not well understood. A study found that miR-182 plays a critical role in promoting osteoclastic metastasis of lung cancer cells. Mechanistically, miR-182 enhances the secretion of Interleukin-8 (IL-8) by NSCLC cells, which in turn activates STAT3 signaling in osteoclast progenitor cells to promote osteoclastogenesis. Inhibition of IL-8 with antibodies effectively suppresses NSCLC bone metastasis in animal models. These findings highlight the importance of the miR-182/IL-8/STAT3 axis as a potential therapeutic target for interrupting lung cancer bone metastasis.
CELL DEATH & DISEASE
(2023)
