期刊
CANCER INVESTIGATION
卷 30, 期 8, 页码 583-592出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2012.716467
关键词
Oral tongue squamous cell carcinoma; Claudin-7; Trypsin-2; MT1-MMP
类别
资金
- Academy of Finland
- Finnish Dental Society Apollonia
- Finnish Cultural Foundation
- Sigrid Juselius Foundation
- Helsinki
- Oulu University Hospital state support for research (EVO)
- Oulu University Hospital state support for research (KEVO)
- Helsinki Biomedical Graduate School
Enhanced proteolysis and altered tight junction (TJ) proteins associate with carcinoma invasion. We hypothesized that trypsin-2, a tumor-associated serine proteinase, induces tongue carcinoma invasion by activating pro-membrane type-1 matrix metalloproteinase (MT1-MMP) and disturbing the TJs. The effects of invasion were analyzed using trypsin-2 over-expressing human tongue squamous cell carcinoma cells (Try2-HSC-3) in vitro and in vivo. The invasion of Try2-HSC-3 cells was increased in mouse xenografts and human organotypic model. Trypsin-2 activated proMT1-MMP, as well as altered the expression of TJ protein claudin-7. In conclusion, trypsin-2 over-expression enhanced tongue carcinoma cell invasion by various genetic and proteolytic mechanisms.
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