Article
Food Science & Technology
Gisela Gerardi, Maria D. Rivero-Perez, Monica Cavia-Saiz, Beatriz Melero, Alicia Salinero-Zorita, Maria L. Gonzalez-SanJose, Pilar Muniz
Summary: Red wine pomace products have antimicrobial activities and may have an anti-Listeria effect. The invasion of Listeria strains in intestinal cell monolayers was found to be inhibited by WPP, with different effects depending on the strain and cell line. WPPs were able to protect the integrity of the intestinal barrier through modification of cell-cell junction protein expression.
Article
Multidisciplinary Sciences
Marie Grosgeorges, Laurence Picque Lasorsa, Brice Pastor, Corinne Prevostel, Evelyne Crapez, Cynthia Sanchez, Florence Frayssinoux, Marta Jarlier, Veronique Pezzella, Laure Monard, Marc Ychou, Alain R. Thierry, Thibault Mazard, Philippe Blache
Summary: Optimizing the biomarker combination in liquid biopsies is important for personalized medicine. A method was developed to purify and quantify circulating cell-free mRNAs in plasma samples using RT-qPCR. Three colorectal cancer biomarkers (B2M, TIMP-1, and CLU) were found to have significantly higher mRNA levels in plasma of metastatic colorectal cancer patients compared to healthy individuals. The analysis of the sum of these mRNA levels showed high discriminatory performance between the two groups.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Andrea Felinto Moura, Mirian Rita Carrilho de Castro, Raquel Ferreira Naves, Ana Jersia Araujo, Maria Claudia Luciano Dos Santos, Jose Delano Barreto Marinho Filho, Caridad Noda-Perez, Felipe Terra Martins, Claudia do O. Pessoa, Manoel Odorico Moraes Filho
Summary: The newly synthesized sulfonamide chalcone, SSC185, exhibited selective cytotoxicity against colorectal cancer cell line SW-620. Its cytotoxic effect was attributed to the induction of cell cycle arrest in the G2/M phase and cell death by apoptosis or necroptosis, depending on the concentration used.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Joao L. Serrano, Ana Maia, Adriana O. Santos, Eurico Lima, Lucinda Reis, Maria J. Nunes, Renato E. F. Boto, Samuel Silvestre, Paulo Almeida
Summary: This study synthesized a series of symmetric cyanine dyes and evaluated their potential as anticancer agents. The dyes demonstrated high antiproliferative effects on several cancer cell lines in the absence of light, with one dye derived from benzoxazole showing the most promise. It had a high selectivity index and could arrest the cell cycle.
Article
Oncology
Imran Khan, Sadaf Mahfooz, Mohd Saeed, Irfan Ahmad, Irfan A. Ansari
Summary: The study demonstrated that andrographolide inhibits the growth of SW-480 cells by suppressing the Notch signaling pathway, inducing apoptosis, and inhibiting migratory and colony forming potential.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Teresa Tellez, Desiree Martin-Garcia, Maximino Redondo, Marilina Garcia-Aranda
Summary: This paper reviews the current genetic knowledge of CLU in tumorigenesis and cancer progression, and discusses its potential use as a therapeutic target in colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Stephanie St-Jean, Ariane Cristina De Castro, Mia Lecours, Christine Jones, Nathalie Rivard, Francis Rodier, Nathalie Perreault, Francois Boudreau
Summary: NCOR1 is essential for colorectal cancer cell growth, and its depletion leads to cellular senescence. Transcriptomic signatures confirm this and predict a potential pro-invasive phenotype. It plays a novel role in preventing cancer-associated senescence and could be a target for controlling colon cancer progression.
Article
Pharmacology & Pharmacy
Andrea del Saz-Lara, Hatim Boughanem, Maria-Carmen Lopez de las Hazas, Carmen Crespo, Alicia Saz-Lara, Francesco Visioli, Manuel Macias-Gonzalez, Alberto Davalos
Summary: The Mediterranean diet is associated with lower incidence of cardio-vascular and cerebrovascular diseases as well as cancer. Extra virgin olive oil, with its phenolic components such as hydroxytyrosol, has been attributed with many healthful effects. Recent studies show that extra virgin olive oil and hydroxytyrosol modulate epigenetic mechanisms, specifically DNA methylation, in human tissues. In this study, colorectal cancer cells treated with hydroxytyrosol demonstrated an increase in global DNA methylation, suggesting a potential gene target for this compound.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Mathematical & Computational Biology
Xuezhi Du, Han Qi, Wenbin Ji, Peiyuan Li, Run Hua, Wenliang Hu, Feng Qi
Summary: This study aimed to construct a prognostic risk model for colorectal cancer using machine-learning algorithms, identifying CLU, PLK1, and IL17RB as potential independent prognostic factors, with the model correctly categorizing CRC patients into high-risk and low-risk groups.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2022)
Article
Pathology
Mahmoud A. Elrebehy, Tamer M. Abdelghany, Mostafa M. Elshafey, Maher H. Gomaa, Ahmed S. Doghish
Summary: This study evaluated the expression of miR-509-5p in colorectal cancer (CRC) cell lines and tissues and found a significant reduction compared to normal tissues. Upregulation of miR-509-5p inhibited cell viability and suppressed the expression of SLC7A11. Overexpression of miR-509-5p also increased levels of MDA and iron, suggesting its role in promoting ferroptosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Murat Sevimli, Dilek Bayram, Meltem Ozgocmen, Ilkay Armagan, Tugba Semerci Sevimli
Summary: The study found that boric acid inhibited cell proliferation and induced apoptosis in the human colon adenocarcinoma cell line SW-480, in both 2D and 3D culture conditions. Additionally, qRT-PCR analysis revealed that the observed apoptotic process was associated with the TNF signaling pathway. Boric acid may be considered a potential anti-cancer agent candidate for colon cancer treatment.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Stefano Russo, Cristina Torrisi, Nunzio Cardullo, Vera Muccilli, Alfonsina La Mantia, Francesco Castelli, Rosaria Acquaviva, Maria Grazia Sarpietro
Summary: Colorectal cancer is a common tumor disease, and the use of naturally derived products for its treatment can be beneficial. The research focused on the encapsulation of ethyl protocatechuate (PCAEE) in solid lipid nanoparticles (SLN) to assess its effectiveness. SLN prepared with Tween 80 showed promising physicochemical properties and encapsulation efficiency, effectively penetrated and released PCAEE, and exhibited greater cytotoxicity on tumor cells. Therefore, further studies on this formulation for colorectal cancer treatment are suggested.
Article
Biochemistry & Molecular Biology
Ahmed A. Abd-Rabou, Ahmed M. Abdelaziz, Olfat G. Shaker, Ghada Ayeldeen
Summary: This study explored the aptitude of MT encapsulated in LC and CS nanoparticles to inhibit CRC proliferation, with NP1 showing the most significant cytotoxic effect on CRC cells. The cytotoxicity of NP1 was achieved through modulation of noncoding RNA expressions.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Microbiology
Junyaluck Rukit, Atsadang Boonmee, Teeratas Kijpornyongpan, Kan Tulsook, Jozsef Baranyi, Soraya Chaturongakul
Summary: This study aimed to investigate the roles of different sigma factors in Listeria monocytogenes invasion and growth inside host cells. The results showed that SigB is the key factor for invasion, while the absence of SigL may enhance host invasion.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ching-Wen Huang, Yen-Cheng Chen, Tzu-Chieh Yin, Po-Jung Chen, Tsung-Kun Chang, Wei-Chih Su, Cheng-Jen Ma, Ching-Chun Li, Hsiang-Lin Tsai, Jaw-Yuan Wang
Summary: In this study, low-molecular-weight fucoidan (LMWF) was found to enhance the anti-cancer effects of fluoropyrimidine-based chemotherapy through different mechanisms in colorectal cancer cells. LMWF enhanced cell viability suppression by inducing cell cycle arrest and late apoptosis in HCT116 cells, and by activating multiple signaling pathways in Caco-2 cells. Moreover, LMWF also inhibited tumor cell migration through specific signaling pathways in both cell types.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Medical Laboratory Technology
Ruben Varela-Calvino, Monica Imbernon, Lorena Vazquez-Iglesias, Maria Paez de la Cadena, Manuel Bande-Rodriguez, Antonio Pineiro, Maria Pardo, Oscar J. Cordero
CLINICA CHIMICA ACTA
(2015)
Article
Multidisciplinary Sciences
Sonia Blanco-Prieto, Lorena Vazquez-Iglesias, Mar Rodriguez-Girondo, Leticia Barcia-Castro, Alberto Fernandez-Villar, Maria Isabel Botana-Rial, Francisco Javier Rodriguez-Berrocal, Maria Paez de la Cadena
Article
Multidisciplinary Sciences
Elena Yaiza Romero-Ventosa, Sonia Blanco-Prieto, Ana Lourdes Gonzalez-Pineiro, Francisco Javier Rodriguez-Berrocal, Guadalupe Pineiro-Corrales, Maria Paez de la Cadena
Article
Multidisciplinary Sciences
Olalla Otero-Estevez, Loretta De Chiara, Leticia Barcia-Castro, Maria Paez de la Cadena, Francisco Javier Rodriguez-Berrocal, Joaquin Cubiella, Vicent Hernandez, Vicenta Soledad Martinez-Zorzano
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Lorena Vazquez-Iglesias, Borja Estefanell-Ucha, Leticia Barcia-Castro, Maria Paez de la Cadena, Paula Alvarez-Chaver, Daniel Ayude-Vazquez, Francisco Javier Rodriguez-Berrocal
Article
Oncology
Maria Gallardo-Gomez, Sebastian Moran, Maria Paez de la Cadena, Vicenta Soledad Martinez-Zorzano, Francisco Javier Rodriguez-Berrocal, Mar Rodriguez-Girondo, Manel Esteller, Joaquin Cubiella, Luis Bujanda, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Loretta De Chiara
CLINICAL EPIGENETICS
(2018)
Article
Oncology
O. Otero-Estevez, L. De Chiara, F. J. Rodriguez-Berrocal, M. Paez de la Cadena, J. Cubiella, I. Castro, C. Gonzalez-Mao, V. Hernandez, V. S. Martinez-Zorzano
BRITISH JOURNAL OF CANCER
(2015)
Article
Multidisciplinary Sciences
Sonia Blanco-Prieto, Loretta De Chiara, Mar Rodriguez-Girondo, Lorena Vazquez-Iglesias, Francisco Javier Rodriguez-Berrocal, Alberto Fernandez-Villar, Maria Isabel Botana-Rial, Maria Paez de la Cadena
SCIENTIFIC REPORTS
(2017)
Article
Biotechnology & Applied Microbiology
Loretta De Chiara, Maria Paez de la Cadena, Javier Rodriguez-Berrocal, M. Carmen Alvarez-Pardinas, M. Carmen Pardinas-Anon, Ruben Varela-Calvino, Oscar J. Cordero
Review
Oncology
Maria Gallardo-Gomez, Loretta De Chiara, Paula Alvarez-Chaver, Joaquin Cubiella
Summary: CRC is a significant health issue in the Western world, with screening and early detection in symptomatic patients being key strategies to reduce its burden. Blood-based biomarkers have been explored recently through omics technologies such as genomics and epigenomics, showing promise for early diagnosis and prevention. Collaboration between researchers, technology experts, and clinicians is crucial for successful translation of these biomarkers into clinical practice.
EXPERT REVIEW OF ANTICANCER THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
A. B. Moldes, P. Alvarez-Chaver, X. Vecino, J. M. Cruz
Summary: Protocols to identify lipopeptide biosurfactant extracts in complex residual streams are crucial for the potential sources and purification of these valuable compounds. In this study, electrophoresis combined with MALDI-TOF-MS was used to purify and identify lipopeptides in corn steep liquor, and it was found to be a useful tool for this purpose.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Luis Freiria-Martinez, Marta Iglesias-Martinez-Almeida, Cynthia Rodriguez-Jamardo, Tania Rivera-Baltanas, Maria Comis-Tuche, Daniela Rodrigues-Amorim, Patricia Fernandez-Palleiro, Maria Blanco-Formoso, Paula Alvarez-Chaver, Yolanda Diz-Chaves, Natalia Gonzalez-Freiria, Montserrat Martin-Forero-Maestre, Cristina Duran Fernandez-Feijoo, Maria Suarez-Albo, Jose Ramon Fernandez-Lorenzo, Ana Concheiro Guisan, Jose Manuel Olivares, Carlos Spuch
Summary: This article discusses the growth and development of the human brain and its impact on the regulation of the nervous system, with a particular focus on the importance of breastfeeding during early life. It proposes a hypothesis that chemical signals in this early period may modulate the complex sequence of events.
ANALYTICAL METHODS
(2023)
Article
Oncology
Sonia Blanco-Prieto, Leticia Barcia-Castro, Maria Paez de la Cadena, Francisco Javier Rodriguez-Berrocal, Lorena Vazquez-Iglesias, Maria Isabel Botana-Rial, Alberto Fernandez-Villar, Loretta De Chiara
Letter
Medical Laboratory Technology
Lorena Vazquez-Iglesias, Pedro Casado-Rey, Maribel Botana-Rial, Maria Amalia Andrade-Olivie, Francisco Javier Rodriguez-Berrocal, Maria Paez de la Cadena, Alberto Fernandez-Villar
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2017)
