期刊
CANCER INVESTIGATION
卷 29, 期 7, 页码 456-459出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2011.590569
关键词
Colorectal & Anal cancer; Gene expression; Treatment
类别
Overexpression or HER-2 gene amplification occurs in approximately 25% of invasive breast cancers and predicts response to the targeting therapeutic antibody trastuzumab (1). In this report, trastuzumab was used in the treatment of a patient with metastatic colorectal cancer harboring HER-2 gene amplification and overexpression. There was a marked radiographic response to the trastuzumab. If a larger series confirms the efficacy of trastuzumab use in patients with colorectal cancers with HER-2 gene amplification, trastuzumab could help improve the outlook for patients with this unusual colorectal cancer variant.
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