期刊
CANCER INVESTIGATION
卷 27, 期 4, 页码 453-458出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/07357900802527239
关键词
GRP78; GRP94; Human lung cancer cell line SK-MES-1; VP-16; Resistance
类别
资金
- National Nature Science Foundation of China [30470464, 30670532]
The upregulation of GRP78 and GRP94 under the induction of A23187 and its function in drug resistance to etoposide (VP-16) was investigated in human lung cancer cell line SK-MES-1. The expression of GRP78 and GRP94 induced by A23187 at different concentrations was analyzed by RT-PCR and Western blotting. Cell survival to VP-16 was determined using a colony-formation assay. The expression of GRP78 and GRP94 in the cells was found to correspond well with the cell survival to VP-16. The results showed that upregulation of GRP78 and GRP94 can significantly confer the chemoresistance to VP-16 in human lung cancer cell line SK-MES-1.
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