☆ 4.2 Article

Correlation of Expression of Human Arrest-Defective-1 (hARD1) Protein With Breast Cancer

CANCER INVESTIGATION (2009)

期刊

CANCER INVESTIGATION

卷 27, 期 10, 页码 978-983

出版社

TAYLOR & FRANCIS INC

DOI: 10.3109/07357900902769723

关键词

hARD1; Breast cancer; MCF-7; Cell proliferation

类别

Oncology

资金

National Natural Science Foundation of China [30360040]
Science & Technological Key Project of Yunnan Province [2006SG09]

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Protocol

Reagent

摘要

Human arrest-defective-1 (hARD1) was reported to be important in regulating cell cycle and promoting lung cancer cell proliferation. Here we have investigated the correlation between hARD1 and breast cancer. Analysis with 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry (FCM) demonstrated that overexpression of hARD1 was associated with increased proliferation of MCF-7 cell, a human breast cancer cell line. Western blotting and immunohistochemical staining assay showed that hARD1 presented higher in breast cancer tissue than the adjacent tissue; accumulation of hARD1 protein was higher in 86% (37/43) of breast cancer, far more than noncancer samples. Our results suggest that hARD1 might play an important role in breast cancer carcinogenesis.

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