Article
Oncology
Krishnath M. Jayatilleke, Hendrika M. Duivenvoorden, Gemma F. Ryan, Belinda S. Parker, Mark D. Hulett
Summary: Breast cancer ranks as the second most prevalent malignancy globally and poses a significant health burden. The involvement of Heparanase (HPSE) in the development and progression of solid tumors, including breast cancer, has been well established. Using a murine model, this study investigated the role of HPSE in breast cancer establishment, progression, and metastasis. The findings indicate that HPSE may not play a significant role in the development of mammary tumors in the model used, which has implications for breast cancer treatment using HPSE inhibitors.
Article
Health Care Sciences & Services
Navid Mohammad Mirzaei, Zuzana Tatarova, Wenrui Hao, Navid Changizi, Alireza Asadpoure, Ioannis K. Zervantonakis, Yu Hu, Young Hwan Chang, Leili Shahriyari
Summary: This study uses a mathematical model to analyze the interaction between immune cells and cancer cells in breast tumors. The results show that the presence of immune cells affects the activation and distribution of cancer cells in the tumor. Sensitivity analyses indicate that targeting cancer cell and adipocyte diffusion rates can be a potential treatment strategy for breast cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Sarah M. Bernhardt, Pallave Dasari, Danielle J. Glynn, Lucy Woolford, Lachlan M. Moldenhauer, David Walsh, Amanda R. Townsend, Timothy J. Price, Wendy Ingman
Summary: The stage of the ovarian cycle at the time of tissue collection affects the 21-gene signature in Mmtv-Pymt murine mammary tumors, suggesting that hormonal fluctuations may impact gene expression in breast cancer.
Article
Oncology
Lin Yan, Sneha Sundaram, Bret M. Rust, Matthew J. Picklo, Michael R. Bukowski
Summary: The study revealed that adipose-derived MCP-1 plays a role in the development of male breast cancer. Mice with a deficiency in adipose Mcp-1 had lower tumor incidence and weight, impacting pathways of amino acid and carbohydrate metabolism. Further investigation into the potential role of adipose-derived MCP-1 in cancer metabolism and tumorigenesis is warranted.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Guillermo Martinez-Nieto, Ritva Heljasvaara, Anne Heikkinen, Hanne-Kaisa Kaski, Raman Devarajan, Otto Rinne, Charlotta Henriksson, Emmi Thomson, Camilla von Hertzen, Ilkka Miinalainen, Heli Ruotsalainen, Taina Pihlajaniemi, Sanna-Maria Karppinen
Summary: ColXV suppresses tumor cell malignancy and inhibits angiogenesis. Inactivation of ColXV in mice leads to changes in tumor matrix and increased tumor growth. Despite losing the anti-angiogenic restin domain, neovascularization was reduced in ColXV-deficient mammary tumors compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Virology
Francesca Parisi, Giulia Freer, Chiara Maria Mazzanti, Mauro Pistello, Alessandro Poli
Summary: MMTV is a virus that may cause mammary carcinoma and lymphoma by exploiting the immune system and causing tumors through insertional mutations. Evidence suggests a possible association between an MMTV-like virus and human breast cancer, sparking controversy for over 40 years. The hypothesis of zoonotic transmission raises questions about prevention and treatment of breast cancer.
Article
Gastroenterology & Hepatology
Eva Karamitopoulou, Anna Silvia Wenning, Animesh Acharjee, Inti Zlobec, Pauline Aeschbacher, Aurel Perren, Beat Gloor
Summary: The study investigates spatially organised immune determinants of pancreatic ductal adenocarcinoma (PDAC) recurrence and finds distinct inflammatory/stromal responses in each recurrence group. PDACs with no recurrence show high immunogenicity, adaptive immune responses, and pro-inflammatory chemokines. PDACs with liver and/or peritoneal recurrences display low immunogenicity and innate immune responses. PDACs with local and/or lung recurrences display interferon-gamma signaling and mixed adaptive and innate immune responses.
Review
Immunology
Soren R. Paludan, Thomas Pradeu, Seth L. Masters, Trine H. Mogensen
Summary: This review compares and contrasts the inducible and constitutive mechanisms of immunosurveillance, showing the effectiveness and potential risks of immune responses, as well as the importance of maintaining homeostasis through a variety of immune mechanisms.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Virology
Waqar Ahmad, Neena G. Panicker, Shaima Akhlaq, Bushra Gull, Jasmin Baby, Thanumol A. Khader, Tahir A. Rizvi, Farah Mustafa
Summary: This study aimed to identify genes and pathways dysregulated by MMTV expression in mouse mammary epithelial cells. mRNAseq analysis revealed differentially expressed genes and pathway dysregulation upon MMTV expression. Bioinformatics analysis identified hub genes and dysregulated molecular pathways, including the down-regulation of the PI3-AKT-mTOR pathway. Comparison with other mouse models provided insights into the molecular mechanisms and potential of MMTV to cause cell transformation. These findings have important implications for the understanding of MMTV replication and its involvement in breast cancer.
Review
Biochemistry & Molecular Biology
Qiongyu Hao, Yong Wu, Yanyuan Wu, Piwen Wang, Jaydutt V. Vadgama
Summary: Exosomes are small membrane-bound extracellular vesicles that mediate targeted information transfer by carrying molecular cargo. Tumor-derived exosomes (TEX) differ from normal cell-derived exosomes and have the ability to disrupt receptor discharge and intercellular cross-talk. TEX progressively weakens the immune system defenses by activating suppressive pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Nathalia de Sousa Pereira, Glauco Akelinghton Freire Vitiello, Marla Karine Amarante
Summary: The association between mouse mammary tumor virus (MMTV)-like sequences and human breast cancer (BC) needs further research to determine their influence on cancer development. APOBEC3 cytidine deaminases are viral restriction factors implicated in cancer mutagenesis. Germline deletion of APOBEC3A/B has been linked to increased mutagenic potential, enhanced risk of BC development, and poor prognosis. This study investigated the relationship between MMTV infection, APOBEC3-mediated mutagenesis, and BC development. Results showed that APOBEC3 mutagenesis is active against MMTV-like sequences, and APOBEC3A/B deletion might cooperate with MMTV-like presence to predispose people to early-onset BC.
Review
Virology
Generoso Bevilacqua
Summary: This study summarizes the research progress on MMTV/HMTV/HBRV since its discovery in the early 20th century, demonstrating the strong association between HBRV and breast cancer and PBC. The quantity and quality of scientific evidence supporting the existence of HBRV and its pathogenic role are emphasized.
Article
Microbiology
Marie R. Jacobovitz, Sebastian Rupp, Philipp A. Voss, Ira Maegele, Sebastian G. Gornik, Annika Guse
Summary: Aiptasia larvae selectively phagocytose suitable symbionts from various microalgae in the environment, forming a lysosomal-associated membrane protein 1 niche, while non-symbiotic microalgae are expelled. Alveolata comprises diverse single-celled eukaryotes, including notable examples of parasites and symbionts that have evolved to evade host immune responses for survival. This study sheds light on the evolution of cellular immune response and the mechanisms involved in mediating endosymbiotic interactions.
NATURE MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Kristen Fousek, Lucas A. Horn, Claudia Palena
Summary: IL-8 plays a significant role in the tumor microenvironment by affecting tumor cell proliferation, invasiveness, drug resistance, and immune cell killing capacity, thereby impacting the efficacy of immunotherapy.
PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Oncology
Lawrence L. Leung, Timothy Myles, John Morser
Summary: Osteopontin (OPN) is a protein produced by immune cells and tumor cells, which can bind to receptors on various cell types and cause them to change properties. Thrombin cleavage of OPN yields fragments that suppress the host's immune response to cancer, promoting tumor growth and metastasis.
Review
Oncology
Trina J. Stewart, Mark J. Smyth
CANCER AND METASTASIS REVIEWS
(2011)
Article
Oncology
Ming Li, Deborah A. Knight, Mark J. Smyth, Trina J. Stewart
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2012)
Article
Oncology
Liza B. John, Linda J. Howland, Jacqueline K. Flynn, Alison C. West, Christel Devaud, Connie P. Duong, Trina J. Stewart, Jenny A. Westwood, Z. Sheng Guo, David L. Bartlett, Mark J. Smyth, Michael H. Kershaw, Phillip K. Darcy
Review
Immunology
Trina J. Stewart, Mark J. Smyth
Article
Cell Biology
Trina J. Stewart, Kristy M. Greeneltch, Julia E. Reid, David J. Liewehr, Seth M. Steinberg, Kebin Liu, Scott I. Abrams
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2009)
Article
Immunology
Trina J. Stewart, David J. Liewehr, Seth M. Steinberg, Kristy M. Greeneltch, Scott I. Abrams
JOURNAL OF IMMUNOLOGY
(2009)
Review
Biochemistry & Molecular Biology
T. J. Stewart, S. I. Abrams
Article
Oncology
Dafeng Yang, Trina J. Stewart, Kimberly K. Smith, David Georgi, Scott I. Abrams, Kebin Liu
INTERNATIONAL JOURNAL OF CANCER
(2008)
Article
Oncology
Kristy M. Greeneltch, Monika Schneider, Seth M. Steinberg, David J. Liewehr, Trina J. Stewart, Kebin Liu, Scott I. Abrams
Article
Immunology
Trina J. Stewart, Scott I. Abrams
JOURNAL OF IMMUNOLOGY
(2007)
Meeting Abstract
Immunology
Trina J. Stewart, Kristy Greenelteh, Monika Schneider, Kebin Liu, Scott Abrams
JOURNAL OF IMMUNOLOGY
(2006)
Article
Oncology
MV Nesterova, NR Johnson, T Stewart, S Abrams, YS Cho-Chung
CLINICAL CANCER RESEARCH
(2005)
Article
Cell Biology
TJ Stewart, GJ Fernando, IH Frazer, GR Leggatt
IMMUNOLOGY AND CELL BIOLOGY
(2004)
Article
Immunology
J Malliaros, C Quinn, FH Arnold, MJ Pearse, DP Drane, TJ Stewart, RI Macfarlan