Article
Microbiology
Keshu Liu, Yangyang Sun, Liu Chen, Tao Yun, Zheng Ni, Weicheng Ye, Cun Zhang
Summary: This study predicted CTL epitope peptides of TMUV antigens and identified that 4 peptides could significantly induce cellular immune responses. Additionally, two H-2d-restricted CTL epitopes in BALB/c mice were identified, providing clues for further investigation of epitope vaccines against TMUV infection.
VETERINARY MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jia-Nan Cheng, Wen Luo, Chengdu Sun, Zheng Jin, Xianghua Zeng, Peter B. Alexander, Zhihua Gong, Xin Xia, Xiaofang Ding, Shouxia Xu, Ping Zou, Yisong Y. Wan, Qingzhu Jia, Qi-Jing Li, Bo Zhu
Summary: Cancer immunotherapy efficacy can be improved by enhancing eosinophil infiltration through radiation, which also boosts the effectiveness of CD8(+) T cells and adoptive T cell therapy. Eosinophil mobilization may serve as a mechanistically relevant biomarker for predicting the effectiveness of pre-immunotherapy radiation and enhancing T cell-mediated immunotherapy against cancers.
Article
Immunology
Fan Jiang, Yong Han, Yinping Liu, Yong Xue, Peng Cheng, Li Xiao, Wenping Gong
Summary: In this study, a promising multi-epitope vaccine candidate, PP13138R, was developed using reverse vaccinology techniques for tuberculosis prevention. PP13138R demonstrated excellent antigenicity, immunogenicity, and solubility, and interacted strongly with Toll-like receptor 2 and 4, stimulating immune cells to produce specific antibodies and cytokines. The vaccine elicited enhanced immune responses across different stages of Mycobacterium tuberculosis infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ana Copaescu, Andrew Gibson, Yueran Li, Jason A. Trubiano, Elizabeth J. Phillips
Summary: Delayed drug hypersensitivity reactions can range from benign skin conditions to severe cutaneous adverse reactions. Diagnostic approaches include patch testing, delayed intradermal testing, and drug challenges, typically performed 4-6 weeks after acute reaction resolution.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Monty B. Mazer, Charles C. Caldwell, Jodi Hanson, Daniel Mannion, Isaiah R. Turnbull, Anne Drewry, Dale Osborne, Andrew Walton, Tessa Blood, Lyle L. Moldawer, Scott Brakenridge, Kenneth E. Remy, Richard S. Hotchkiss
Summary: Sepsis triggers complex immune responses and the inability to rapidly and quantitatively assess the immune status of patients has been a major challenge in therapeutic trials. The use of a novel whole blood ELISpot assay offers significant advancements in immunophenotyping patients with sepsis.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Shima Mollazadeh, Mehran Bakhshesh, Hadi Keyvanfar, Gholamreza Nikbakht Brujeni
Summary: This study identified and characterized potential CTL target epitopes of bovine ephemeral fever virus (BEFV) using immuno-informatics tools. Four potential CTL epitopes were identified for the G protein of BEFV. The 3D structure of a multi-epitope was predicted and validated. This study provides important information for immune response and vaccine development against BEFV.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Immunology
Alexander A. Lehmann, Greg A. Kirchenbaum, Ting Zhang, Pedro A. Reche, Paul V. Lehmann
Summary: SARS-CoV-2 infection may not induce a durable antibody response in all infected individuals, leading researchers to focus on specific T cell memory against the virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Junqi Zhang, Baozeng Sun, Wenyang Shen, Zhenjie Wang, Yang Liu, Yubo Sun, Jiaxing Zhang, Ruibo Liu, Yongkai Wang, Tianyuan Bai, Zilu Ma, Cheng Luo, Xupeng Qiao, Xiyang Zhang, Shuya Yang, Yuanjie Sun, Dongbo Jiang, Kun Yang
Summary: Promising MHC-II-restricted candidate epitopes of EBOV GP were identified in humans and mice, which is of great significance for the development and evaluation of Ebola vaccines.
Article
Agriculture, Dairy & Animal Science
Xin Li, Aihong Xia, Zhengzhong Xu, Jiaying Liu, Shasha Fu, Zhaoli Cao, Yechi Shen, Yuqing Xie, Chuang Meng, Xiang Chen, Xinan Jiao
Summary: This study aimed to develop an efficient assay for the diagnosis of bovine tuberculosis based on the ELISpot technique. The M. bovis IFN-eta ELISpot assay demonstrated a high level of agreement and had the ability to detect infected cattle earlier.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Medicine, General & Internal
Daria M. Potashnikova, Aleena A. Saidova, Anna V. Tvorogova, Alexandra S. Anisimova, Alexandra Yu Botsina, Elena Yu Vasilieva, Leonid B. Margolis
Summary: The study found that the presence of fibronectin can significantly increase CTL adhesiveness in atherosclerosis patients, and the expression levels of integrin-coding mRNAs also increase accordingly.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Tsutomu Nakazawa, Ryosuke Maeoka, Takayuki Morimoto, Ryosuke Matsuda, Mitsutoshi Nakamura, Fumihiko Nishimura, Shuichi Yamada, Ichiro Nakagawa, Young-Soo Park, Hiroyuki Nakase, Takahiro Tsujimura
Summary: This study investigated the capability of human induced pluripotent stem cells (iPSCs) lysate-pulsed dendritic cells (DCs) to induce cancer-responsive cytotoxic T lymphocytes (CTLs) in vitro. The results demonstrated that the iPSCs/DCs induced sufficient CTL numbers that responded to specific cancer cells, suggesting the potential of iPSC/DCs as a promising universal cancer vaccine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Guocheng Zhong, Weiqiang Zhao, Yisheng Li, Guangyi Jin, Wei Zeng, Changhua Yu, Ji Zhou, Li Yu
Summary: This study found that DAC treatment could up-regulate the expression of cancer testis antigens (CTAs) MAGEA1 and hTERT in AML cells. Pulsing DC-CTL with antigen peptides designed based on these sequences enhanced the activity of CTL cells and inhibited AML progression in a mouse model.
Review
Immunology
Sefina Arif, Clara Domingo-Vila, Emily Pollock, Eleni Christakou, Evangelia Williams, Timothy I. M. Tree
Summary: The increasing number of immunotherapeutic clinical trials in type 1 diabetes highlights the need for robust immune-monitoring assays to detect and characterize islet specific immune responses. Islet-specific T cells can serve as biomarkers for drug selection and patient stratification in future clinical trials. This review focuses on commonly used immune-monitoring techniques and discusses the potential of combining these with single cell transcriptional profiling to gain a deeper understanding of the underlying mechanisms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Pia Leete, Noel G. Morgan
Summary: Significant progress has been made in understanding the phenotypes of circulating immune cell sub-populations in human type 1 diabetes, but much less is known about the equivalent populations that infiltrate the islets to cause beta-cell loss. The phenotype and role of B-lymphocytes in the pancreas remain enigmatic, especially in relation to CD8+ T-lymphocytes. Differences in the proportion of islet-associated B-lymphocytes between different age groups suggest two endotypes of the disease, with CD8+ T-lymphocytes forming the predominant population in all groups.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Roxana Khazen, Marine Cazaux, Fabrice Lemaitre, Beatrice Corre, Zacarias Garcia, Philippe Bousso
Summary: The majority of CTL interactions with tumor cells either in vitro or in vivo result in sublethal hits, which are associated with reversible calcium elevation and membrane damage in the target cells. In the therapeutic context of anti-CD19 CAR T cells, most interactions with tumor cells do not lead to lethal hit delivery. Differences in CTL lytic potential and tumor cell resistance to cytotoxic hits are two important barriers for effective anti-tumor responses in vivo.
Article
Surgery
Hironori Hayashi, Hiroyuki Takamura, Yukari Yamaguchi, Yasuhiro Shoji, Hisatoshi Nakagawara, Hidehiro Tajima, Ichiro Onishi, Hirohisa Kitagawa, Takashi Tani, Masato Kayahara, Tetsuo Ohta
ASIAN JOURNAL OF SURGERY
(2012)
Article
Transplantation
Hironori Hayashi, Hiroyuki Takamura, Takashi Tani, Isamu Makino, Hisatoshi Nakagawara, Hidehiro Tajima, Hirohisa Kitagawa, Ichiro Onishi, Koichi Shimizu, Tetsuo Ohtal
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2012)
Article
Surgery
Hironori Hayashi, Hiroyuki Takamura, Takumi Taniguchi, Shin-ichi Nakanuma, Hisatoshi Nakagawara, Hidehiro Tajima, Hirohisa Kitagawa, Ichiro Onishi, Takashi Tani, Tetsuo Ohta
INTERNATIONAL SURGERY
(2013)
Article
Surgery
Hironori Hayashi, Takashi Tani, Hidehiro Tajima, Yasuhiro Shoji, Shiro Terai, Ichiro Onishi, Hiroyuki Takamura, Hirohisa Kitagawa, Masato Kayahara, Tetsuo Ohta
Article
Surgery
Ichiro Onishi, Masato Kayahara, Masayoshi Munemoto, Seisyo Sakai, Isamu Makino, Hironori Hayashi, Hisatoshi Nakagawara, Hidehiro Tajima, Hiroyuki Takamura, Hirohisa Kitagawa, Takashi Tani, Tetsuo Ohta
Article
Oncology
Hidehiro Tajima, Tetsuo Ohta, Koichi Okamoto, Shinichi Nakanuma, Hironori Hayashi, Hisatoshi Nakagawara, Ichiro Onishi, Hiroyuki Takamura, Hirohisa Kitagawa, Sachio Fushida, Takashi Tani, Takashi Fujimura, Masato Kayahara, Kuniaki Arai, Tatsuya Yamashita, Shuichi Kaneko, Yoh Zen
Article
Surgery
Yuri Higashi, Ichiro Onishi, Masato Kayahara, Shunsuke Kano, Naoki Makita, Masayoshi Munemoto, Yasumichi Yagi
Summary: Intestinal malrotation has a low incidence in adults, but surgery may still be necessary even without intestinal necrosis. Chronic cases may present with abdominal pain as the most common symptom, while weight loss is less common. The development of high intestinal adhesion may contribute to an asymptomatic course in some cases.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Surgery
Masato Kayahara, Ichiro Onishi, Naoki Makita, Shunsuke Kano, Masayoshi Munemoto, Yasumichi Yagi, Makiko Minami, Noriaki Orita, Takuya Komura, Nozomu Kurose
Summary: This study reported a rare case of PACC with MPD extension in a 71-year-old man. Preoperative diagnosis was facilitated by laboratory and radiographic investigations, with EUS and MDCT being useful for determining surgical resection. The study also discussed the possible mechanisms of tumor extension.
SURGICAL CASE REPORTS
(2021)
Article
Medicine, General & Internal
Naoki Makita, Masato Kayahara, Shunsuke Kano, Masayoshi Munemoto, Yasumichi Yagi, Ichiro Onishi, Atsuhiro Kawashima
Summary: This case study presents a rare scenario of multiple gastrointestinal stromal tumors associated with NF1, resulting in a fatal outcome due to the extreme fragility of vessel walls. Adequate surgical preparation is essential for patients with NF1 due to their vulnerable vessel walls.
AMERICAN JOURNAL OF CASE REPORTS
(2021)
Article
Cell Biology
Ichiro Onishi, Paulo J. C. Lin, Graham H. Diering, Warren P. Williams, Masayuki Numata
CELLULAR SIGNALLING
(2007)