A nervous tumor microenvironment: the impact of adrenergic stress on cancer cells, immunosuppression, and immunotherapeutic response

Stage-specific associations between beta blocker use and prognosis after colorectal cancer

(2014) Lina Jansen et al.   CANCER

Chronic variable stress activates hematopoietic stem cells

(2014) Timo Heidt et al.   NATURE MEDICINE

Plasma IL-12 levels are suppressed in vivo by stress and surgery through endogenous release of glucocorticoids and prostaglandins but not catecholamines or opioids

(2014) Lee Shaashua et al.   PSYCHONEUROENDOCRINOLOGY

Stressful Presentations: Mild Cold Stress in Laboratory Mice Influences Phenotype of Dendritic Cells in Naïve and Tumor-Bearing Mice

(2014) Kathleen M. Kokolus et al.   Frontiers in Immunology

Improved survival outcomes with the incidental use of beta-blockers among patients with non-small-cell lung cancer treated with definitive radiation therapy

(2013) H. M. Wang et al.   ANNALS OF ONCOLOGY

Use of ß-blockers and mortality following ovarian cancer diagnosis: a population-based cohort study

(2013) Sigrun A Johannesdottir et al.   BMC CANCER

60. The influence of cohabitation with a sick cage mate on pulmonary allergic inflammatory response in mice

(2013) E.K. Hamasato et al.   BRAIN BEHAVIOR AND IMMUNITY

In vivo suppression of NK cell cytotoxicity by stress and surgery: Glucocorticoids have a minor role compared to catecholamines and prostaglandins

(2013) Ella Rosenne et al.   BRAIN BEHAVIOR AND IMMUNITY

Therapeutic effect of β-blockers in triple-negative breast cancer postmenopausal women

(2013) Edoardo Botteri et al.   BREAST CANCER RESEARCH AND TREATMENT

The Antidepressant Desipramine and  2-Adrenergic Receptor Activation Promote Breast Tumor Progression in Association with Altered Collagen Structure

(2013) M. J. Szpunar et al.   Cancer Prevention Research

β-Blocker use and all-cause mortality of melanoma patients: Results from a population-based Dutch cohort study

(2013) E. Livingstone et al.   EUROPEAN JOURNAL OF CANCER

Beta2-adrenergic receptor signaling in CD4+Foxp3+regulatory T cells enhances their suppressive function in a PKA-dependent manner

(2013) Marcia G. Guereschi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Catecholamine-Induced  2-Adrenergic Receptor Activation Mediates Desensitization of Gastric Cancer Cells to Trastuzumab by Upregulating MUC4 Expression

(2013) M. Shi et al.   JOURNAL OF IMMUNOLOGY

Autonomic Dysreflexia Causes Chronic Immune Suppression after Spinal Cord Injury

(2013) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6- and glutathione-dependent mechanism

(2013) Soraya L Valles et al.   Journal of Translational Medicine

β-adrenoceptors are upregulated in human melanoma and their activation releases pro-tumorigenic cytokines and metalloproteases in melanoma cell lines

(2013) Silvia Moretti et al.   LABORATORY INVESTIGATION

Chronic Psychological Stress Induces the Accumulation of Myeloid-Derived Suppressor Cells in Mice

(2013) Jianfeng Jin et al.   PLoS One

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature

(2013) K. M. Kokolus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Src activation by β-adrenoreceptors is a key switch for tumour metastasis

(2013) Guillermo N. Armaiz-Pena et al.   Nature Communications

In vivo suppression of plasma IL-12 levels by acute and chronic stress paradigms: Potential mediating mechanisms and sex differences

(2012) L. Shaashua et al.   BRAIN BEHAVIOR AND IMMUNITY

Impact of beta blockers on epithelial ovarian cancer survival

(2012) Elena S. Diaz et al.   GYNECOLOGIC ONCOLOGY

Unstressing intemperate models: how cold stress undermines mouse modeling

(2012) Christopher L. Karp   JOURNAL OF EXPERIMENTAL MEDICINE

Thermal physiology of laboratory mice: Defining thermoneutrality

(2012) C.J. Gordon   JOURNAL OF THERMAL BIOLOGY

Immune Sculpting of Norepinephrine on MHC-I, B7-1, IDO and B7-H1 Expression and Regulation of Proliferation and Invasion in Pancreatic Carcinoma Cells

(2012) Liancai Wang et al.   PLoS One

Cross-talk between myeloid-derived suppressor cells (MDSC), macrophages, and dendritic cells enhances tumor-induced immune suppression

(2012) Suzanne Ostrand-Rosenberg et al.   SEMINARS IN CANCER BIOLOGY

Chronic exposure to stress hormones promotes transformation and tumorigenicity of 3T3 mouse fibroblasts

(2012) Melanie S. Flint et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Stimulation of Host Bone Marrow Stromal Cells by Sympathetic Nerves Promotes Breast Cancer Bone Metastasis in Mice

(2012) J. Preston Campbell et al.   PLOS BIOLOGY

Beta blockers, norepinephrine, and cancer: an epidemiological viewpoint

(2012) P J Fitzgerald   Clinical Epidemiology

Trastuzumab induces antibody-dependent cell-mediated cytotoxicity (ADCC) in HER-2-non-amplified breast cancer cell lines

(2011) D. M. Collins et al.   ANNALS OF ONCOLOGY

Improving Postoperative Immune Status and Resistance to Cancer Metastasis

(2011) Yael Goldfarb et al.   ANNALS OF SURGERY

Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study

(2011) D. G. Powe et al.   BREAST CANCER RESEARCH AND TREATMENT

Does β-adrenoceptor blocker therapy improve cancer survival? Findings from a population-based retrospective cohort study

(2011) Sunil M. Shah et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

 -Blockers and Survival among Danish Patients with Malignant Melanoma: A Population-Based Cohort Study

(2011) S. Lemeshow et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients

(2011) Bethany L. Mundy-Bosse et al.   CELLULAR IMMUNOLOGY

Molecular Pathways: Beta-Adrenergic Signaling in Cancer: Figure 1.

(2011) Steven W. Cole et al.   CLINICAL CANCER RESEARCH

β2-adrenoceptor blocker synergizes with gemcitabine to inhibit the proliferation of pancreatic cancer cells via apoptosis induction

(2011) Tao Shan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Beta Blockers and Breast Cancer Mortality: A Population- Based Study

(2011) Thomas I. Barron et al.   JOURNAL OF CLINICAL ONCOLOGY

Beta-Blocker Use Is Associated With Improved Relapse-Free Survival in Patients With Triple-Negative Breast Cancer

(2011) Amal Melhem-Bertrandt et al.   JOURNAL OF CLINICAL ONCOLOGY

β2-adrenoceptor blockage induces G1/S phase arrest and apoptosis in pancreatic cancer cells via Ras/Akt/NFκB pathway

(2011) Dong Zhang et al.   Molecular Cancer

Pancreatic Cancer Cells and Normal Pancreatic Duct Epithelial Cells Express an Autocrine Catecholamine Loop that Is Activated by Nicotinic Acetylcholine Receptors  3,  5, and  7

(2011) M. H. Al-Wadei et al.   MOLECULAR CANCER RESEARCH

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

(2011) Makoto R. Hara et al.   NATURE

Tumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism

(2011) Jeremy D. Waight et al.   PLoS One

Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients

(2010) Susan K. Lutgendorf et al.   BRAIN BEHAVIOR AND IMMUNITY

β2-adrenergic antagonists suppress pancreatic cancer cell invasion by inhibiting CREB, NF-κB and AP-1

(2010) Dong Zhang et al.   CANCER BIOLOGY & THERAPY

The Sympathetic Nervous System Induces a Metastatic Switch in Primary Breast Cancer

(2010) E. K. Sloan et al.   CANCER RESEARCH

Adrenal Responses to Stress

(2010) David S. Goldstein   CELLULAR AND MOLECULAR NEUROBIOLOGY

Stress Effects on FosB- and Interleukin-8 (IL8)-driven Ovarian Cancer Growth and Metastasis

(2010) Mian M. K. Shahzad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis

(2010) Anil K. Sood et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonshivering thermogenesis and its adequate measurement in metabolic studies

(2010) B. Cannon et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

(2010) Agnes E. Coutinho et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolic adaptation of mice in a cool environment

(2010) Kunitoshi Uchida et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The sympathetic nervous system modulates CD4+ FoxP3+ regulatory T cells via a TGF-β-dependent mechanism

(2009) Sourojit Bhowmick et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Stress and disorders of the stress system

(2009) George P. Chrousos   Nature Reviews Endocrinology

Upregulation of Phagocyte-Derived Catecholamines Augments the Acute Inflammatory Response

(2009) Michael A. Flierl et al.   PLoS One

Perioperative Use of β-blockers and COX-2 Inhibitors May Improve Immune Competence and Reduce the Risk of Tumor Metastasis

(2008) Marganit Benish et al.   ANNALS OF SURGICAL ONCOLOGY

Rapid Activation of Stat3 and ERK1/2 by Nicotine Modulates Cell Proliferation in Human Bladder Cancer Cells

(2008) Rong-Jane Chen et al.   TOXICOLOGICAL SCIENCES