期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 62, 期 10, 页码 1619-1628出版社
SPRINGER
DOI: 10.1007/s00262-013-1467-x
关键词
Tumor immunology; Helper T cells; Cancer stem cells; DDX3X
资金
- Ministry of Education, Science, and Culture of Japan
- Otsuka Pharmaceutical Co. Ltd. (Tokyo, Japan)
- Grants-in-Aid for Scientific Research [25860637, 24591156, 23591141] Funding Source: KAKEN
Accumulating evidence suggests that most solid malignancies consist of heterogeneous tumor cells and that a relatively small subpopulation, which shares biological features with stem cells, survives through potentially lethal stresses such as chemotherapy and radiation treatment. Since the survival of this subpopulation of cancer stem cells (CSC) plays a critical role in recurrence, it must be eradicated in order to cure cancer. We previously reported that vaccination with CD133(+) murine melanoma cells exhibiting biological CSC features induced CSC-specific effector T cells. These were capable of eradicating CD133(+) tumor cells in vivo, thereby curing the parental tumor. In the current study, we indicated that DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked (DDX3X) is an immunogenic protein preferentially expressed in CD133(+) tumor cells. Vaccination with DDX3X primed specific T cells, resulting in protective and therapeutic antitumor immunity. The DDX3X-primed CD4(+) T cells produced CD133(+) tumor-specific IFN gamma and IL-17 and mediated potent antitumor therapeutic efficacy. DDX3X is expressed in various human cancer cells, including lung, colon, and breast cancer cells. These results suggest that anti-DDX3X immunotherapy is a promising treatment option in efforts to eradicate CSC in the clinical setting.
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