Article
Biochemical Research Methods
Lorena Usero, Laia Miralles, Ignasi Esteban, Carmen Pastor-Quinones, Maria Jose Maleno, Lorna Leal, Felipe Garcia, Montserrat Plana
Summary: The study found that cryopreservation of MDDCs does not affect their phenotype, cell viability, maturation marker expression, or cytokine secretion. Therefore, cryopreservation is a good method to preserve cells before immunotherapy.
JOURNAL OF IMMUNOLOGICAL METHODS
(2021)
Review
Biochemistry & Molecular Biology
Katerina Kalkusova, Sindija Smite, Elea Darras, Pavla Taborska, Dmitry Stakheev, Luca Vannucci, Jirina Bartunkova, Daniel Smrz
Summary: The immune checkpoint inhibitors are crucial in cancer immunotherapy, but their efficacy is limited in solid tumors. Mast cells and dendritic cells play important roles in the tumor immune microenvironment and controlling these cells may help overcome the resistance of solid tumors to immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pavla Taborska, Dmitry Stakheev, Jirina Bartunkova, Daniel Smrz
Summary: The use of differentially activated human mast cell line LAD2 as a cellular adjuvant can modulate the maturation of ex vivo-produced monocyte-derived iDCs. This method is effective in modulating polyinosinic:polycytidylic acid (poly I:C)-elicited DC maturation in serum-containing media.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Grzegorz Dyduch, Apolonia Miazek, Lukasz Laskowicz, Joanna Szpor
Summary: Treatment options for endometrial cancer are not satisfactory for advanced cases, leading to interest in novel immunological therapies. This study investigated the role of dendritic cells (DCs) in endometrial cancer and found that the distribution of different DC subtypes was associated with the grade and stage of the cancer. The study highlights the potential of targeting specific DC subsets for future treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Xu-Dong Tang, Kui-Lin Lu, Jin Yu, Han-Jian Du, Chao-Qiang Fan, Lei Chen
Summary: This study establishes a novel immunotherapy model targeting antigens to dendritic cell receptors using a combination of heparanase CD4(+) and CD8(+) T-cell epitope peptides, achieving an efficient cytotoxic T-cell response against tumor cells.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Zining Wang, Feifei Xu, Jie Hu, Hongxia Zhang, Lei Cui, Wenhua Lu, Wenzhuo He, Xiaojuan Wang, Mengyun Li, Huanling Zhang, Wenjing Xiong, Chunyuan Xie, Yongxiang Liu, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaofeng Frank Qin, Xiaojun Xia
Summary: Clotrimazole was identified as a drug that could enhance DC-mediated antigen presentation and T cell response, by acting on hexokinase 2 to regulate metabolic production and enhancing the lysosome pathway and Chop expression in DCs. In vivo administration of clotrimazole induced immune infiltration and inhibited tumor growth, synergizing with anti-PD1 antibody therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Pharmacology & Pharmacy
Jihyun Seong, Kyobum Kim
Summary: This article reviews important engineering methods for preparing antigen-containing tumor cell lysates (TCLs), current therapeutic approaches using TCL-mediated activation of dendritic cells (DCs), and the significant sequential mechanism of DC-based signaling and stimulation in adaptive immunity. Furthermore, recent developments in biomaterial-based exogenous TCL delivery platforms and co-delivery strategies with adjuvants for effective cancer vaccination and antitumor effects are emphasized.
Review
Oncology
Yi Yao, Chunmei Fu, Li Zhou, Qing-Sheng Mi, Aimin Jiang
Summary: Dendritic cells (DCs)-based cancer vaccines have not been very successful due to tumor-mediated immunosuppression, leading to limited clinical efficacy. DC-derived exosomes (DCexos) are considered as a promising alternative to DC-based vaccines, as they are more resistant to tumor-mediated suppression and have shown better anti-tumor efficacy in pre-clinical models.
Article
Oncology
Xiaowu Bai, Chi Chun Wong, Yasi Pan, Huarong Chen, Weixin Liu, Jianning Zhai, Wei Kang, Yu Shi, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Philip Chiu, Jun Yu, Enders Kwok-wai Ng
Summary: YTHDF1 is overexpressed in gastric cancer and promotes cancer growth by inducing cell proliferation and suppressing dendritic cell-mediated anti-tumor immune response. YTHDF1 is a promising therapeutic target for gastric cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
S. P. Lau, L. Klaase, M. Vink, J. Dumas, K. Bezemer, A. van Krimpen, R. van der Breggen, L. V. Wismans, M. Doukas, W. de Koning, A. P. Stubbs, D. A. M. Mustafa, H. Vroman, R. Stadhouders, J. B. Nunes, C. Stingl, N. F. C. C. de Miranda, T. M. Luider, S. H. van der Burg, J. G. Aerts, C. H. J. van Eijck
Summary: This study demonstrates the feasibility and safety of using allogeneic lysated dendritic cell vaccine in patients with resected pancreatic ductal adenocarcinoma. The vaccine induces immune reactivity to PDAC expressed antigens and has the potential to prevent disease recurrence and progression.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Maxwell Y. Lee, Yvette Robbins, Cem Sievers, Jay Friedman, Houssein Abdul Sater, Paul E. Clavijo, Nancy Judd, Edward Tsong, Chris Silvin, Patrick Soon-Shiong, Michelle R. Padget, Jeffrey Schlom, James Hodge, Christian Hinrichs, Clint Allen
Summary: The study demonstrates that resistance to T-cell killing in heterogeneous tumors can be overcome by using PD-L1 CAR-engineered NK cells, preventing clonal selection of T cell-resistant tumor cells and promoting PD-L1-dependent killing by PD-L1 t-haNKs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Qingyu Huang, Fuhao Wang, Di Hao, Xinyu Li, Xiaohui Li, Tianyu Lei, Jinbo Yue, Chao Liu
Summary: Dendritic cells play a pivotal role in connecting innate and adaptive immunity. The application of single-cell sequencing has revealed the heterogeneity and functional diversity of dendritic cells in the tumor microenvironment, providing important insights into tumor immune responses.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Seokhyeong Go, Mungyo Jung, Suyoung Lee, Sangjun Moon, Jihye Hong, Cheesue Kim, Yeonseok Chung, Byung-Soo Kim
Summary: A therapeutic cancer nanovaccine has been developed that enhances T cell responses by interacting with both dendritic cells (DCs) and T cells. This nanovaccine, named CCM-MPLA-aCD28, activates tumor-specific CD8+ T cells and exhibits a higher antitumor efficacy compared to nanovaccines that interact with either DCs or T cells.
ADVANCED MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Shumin Luo, Jing Chen, Fang Xu, Huan Chen, Yiru Li, Weihua Li
Summary: This article summarizes a new approach in cancer immunotherapy, which is based on the exosomes derived from dendritic cells (DEXs). DEXs have the potential to improve therapeutic outcomes and overcome tumor cell-mediated immunosuppression. By capturing tumor antigens and promoting immune cell-dependent tumor rejection, DEXs play an important role in enhancing immune responses and overcoming immune escape by tumors.
Article
Multidisciplinary Sciences
Elisa Turriani, Diana F. Lazaro, Sergey Ryazanov, Andrei Leonov, Armin Giese, Margarete Schoen, Michael P. Schoen, Christian Griesinger, Tiago F. Outeiro, Donna J. Arndt-Jovin, Dorothea Becker
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Endocrinology & Metabolism
Matthias Blueher, Nora Kloeting, Stephan Wueest, Eugen J. Schoenle, Michael R. Schoen, Arne Dietrich, Mathias Fasshauer, Michael Stumvoll, Daniel Konrad
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2014)
Article
Dermatology
Verena N. Lorenz, Michael P. Schoen, Cornelia S. Seitz
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2014)
Article
Multidisciplinary Sciences
Elsa Neubert, Daniel Meyer, Francesco Rocca, Gokhan Guenay, Anja Kwaczala-Tessmann, Julia Grandke, Susanne Senger-Sander, Claudia Geisler, Alexander Egner, Michael P. Schoen, Luise Erpenbeck, Sebastian Kruss
NATURE COMMUNICATIONS
(2018)
Article
Orthopedics
Lutz Kretschmer, Simin Hellriegel, Naciye Cevik, Franziska Hartmann, Kai-Martin Thoms, Michael P. Schoen
JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
(2019)
Article
Dermatology
Jacob P. Thyssen, Ivone Jakasa, Christoph Riethmueller, Michael P. Schoen, Andrea Braun, Marek Haftek, Padraic G. Fallon, Jacek Wroblewski, Hieronim Jakubowski, Leopold Eckhart, Wim Declercq, Sjors Koppes, Kristiane A. Engebretsen, Charlotte Bonefeld, Alan D. Irvine, Sokhna Keita-Alassane, Michel Simon, Hiroshi Kawasaki, Akiharu Kubo, Masayuki Amagai, Takeshi Matsui, Sanja Kezic
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Dermatology
Marco Becker, Julia Bauer, Joanna Pyczek, Simone Koenig, Anna Muellen, Hanna Rabe, Michael P. Schoen, Anja Uhmann, Heidi Hahn
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Review
Chemistry, Multidisciplinary
Katharina Amschler, Michael P. Schoen
Letter
Dermatology
Nadja Olbricht, Christian Kromer, Susann Forkel, Michael P. Schoen, Timo Buhl
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2020)
Letter
Dermatology
Matthias A. Hermasch, Helena Janning, Viktor Schnabel, Wiebke Muschalek, Anette Bennemann, Michael P. Schoen, Regina C. Betz, Roland Dosch, Jorge Frank
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Dermatology
L. Vlahova, W. Kempf, M. P. Schoen, C. Mitteldorf
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Allergy
Caroline Beutner, Susann Forkel, Sidhi Gupta, Thomas Fuchs, Michael P. Schon, Johannes Geier, Timo Buhl
JOURNAL OF ASTHMA AND ALLERGY
(2020)
Article
Medical Ethics
Katharina Beier, Alfred Simon, Michael P. Schon
ETHIK IN DER MEDIZIN
(2022)
Article
Health Care Sciences & Services
Caroline Beutner, Anja Lipschik, Luise Erpenbeck, Jason Holsapple, Michael P. Schoen, Hedwig Stanisz
Summary: The COVID-19 pandemic has severely disrupted the work-family balance of medical doctors, primarily due to insufficient childcare. Doctors feel that the measures taken by local governments are not sufficient, particularly placing the professional development of female doctors at risk. Proper and flexible childcare is essential for the career advancement of doctors.
Article
Health Care Sciences & Services
Christian Kromer, Viktoria P. Nuehnen, Wolfgang Pfuetzner, Sebastian Pfeiffer, Hans-Joachim Laubach, Wolf-Henning Boehncke, Joerg Liebmann, Matthias Born, Michael P. Schoen, Timo Buhl
JMIR RESEARCH PROTOCOLS
(2019)