Article
Medicine, Research & Experimental
Magdalena Hinterbrandner, Viviana Rubino, Carina Stoll, Stefan Forster, Noah Schnuriger, Ramin Radpour, Gabriela M. Baerlocher, Adrian F. Ochsenbein, Carsten Riether
Summary: The study showed that leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) can be killed by CD8(+) cytotoxic T cells (CTLs) in vitro, but Tregs in CML bone marrow protect LSCs from CTL-mediated elimination in vivo. TNFRSF4 was identified as a potential target to reduce the function of Tregs and enhance antileukemic immunity in CML.
Article
Urology & Nephrology
Christian Morath, Matthias Schaier, Eman Ibrahim, Lei Wang, Christian Kleist, Gerhard Opelz, Caner Suesal, Gerald Ponath, Mostafa Aly, Cristiam M. Alvarez, Florian Kaelble, Claudius Speer, Louise Benning, Christian Nusshag, Luiza Pego da Silva, Claudia Sommerer, Angela Hueckelhoven-Krauss, David Czock, Arianeb Mehrabi, Constantin Schwab, Ruediger Waldherr, Paul Schnitzler, Uta Merle, Thuong Hien Tran, Sabine Scherer, Georg A. Boehmig, Carsten Mueller-Tidow, Jochen Reiser, Martin Zeier, Michael Schmitt, Peter Terness, Anita Schmitt, Volker Daniel
Summary: This study shows that using donor-derived modified immune cells (MICs)-PBMCs for specific immunosuppression treatment before kidney transplantation can result in an increase in CD19(+)CD24(hi)CD38(hi) transitional B lymphocytes by up to 68-fold compared to transplanted controls.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Immunology
M. Malavika, S. Sanju, M. R. Poorna, Veeraraghavan Vishnu Priya, Neeraj Sidharthan, Praveen Varma, Ullas Mony
Summary: This review focuses on the role of myeloid derived suppressor cells (MDSCs) in infection, sepsis, and septic shock, and their contribution to lymphopenia and immune suppression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Ya-Jui Lin, Caren Yu-Ju Wu, Janet Yuling Wu, Michael Lim
Summary: Glioblastoma is a highly aggressive glioma with resistance to immunotherapy, primarily due to the unique immune environment. Myeloid cells play a significant role in the glioma microenvironment and reprogramming them has emerged as a revolutionary immunotherapy for glioma treatment. This article provides a detailed classification and analysis of myeloid cells in glioma TME, aiming to offer new insights and therapeutic approaches for improving treatment efficacy in glioma patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi
Summary: Regulatory T cells (Tregs) in tumor tissues can be selectively targeted to enhance anti-tumor immune responses, while maintaining immune homeostasis in healthy organs. Current strategies such as immune checkpoint blockade (ICB) antibodies and differential targeting of surface and intracellular molecules show promise in this regard. Combining Treg targeting with ICB antibodies may enhance the efficacy of cancer immunotherapy.
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Songlei Zhou, Yukun Huang, Yu Chen, Yipu Liu, Laozhi Xie, Yang You, Shiqiang Tong, Jianpei Xu, Gan Jiang, Qingxiang Song, Ni Mei, Fenfen Ma, Xiaoling Gao, Hongzhuan Chen, Jun Chen
Summary: The authors developed a nanoplatform consisting of cannabidiol and LIGHT to improve the immune response against glioblastoma. The nanoplatform increased the number of systemic T cells and improved T-cell infiltration in GBM models, leading to successful long-term survival. This work highlights the importance of reprogramming both systemic and local immune function for T-cell based immunotherapy and provides a clinically translatable option for treating brain tumors.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Yudan Cui, Jingshan Cai, Wenxin Wang, Shengjun Wang
Summary: HDACIs are antitumor drugs that enhance gene transcription via epigenetic regulation, with cytotoxic properties against tumor cells. The effects of HDACIs on immunocytes in the tumor microenvironment, specifically MDSCs, are still not fully understood.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mehdi Chaib, Ubaid A. Tanveer, Liza Makowski
Summary: With the advancement of high-resolution analytical methods, the importance of myeloid cells in orchestrating or suppressing antitumor immune responses is increasingly recognized. Targeting myeloid cells has shown promising results as monotherapy or in combination with immunotherapy, although the complexity of their cellular crosstalk and molecular networks poses challenges. This review summarizes the heterogeneity of myeloid cell subsets and their contribution to tumor progression, with a focus on mononuclear phagocytes, and addresses the unanswered questions and therapeutic strategies in the field of myeloid cells and cancer.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Immunology
Kumar Abhishek, Malavika Nidhi, Srinandhini Chandran, Sergey S. Shevkoplyas, Chandra Mohan
Summary: Regulatory T cells (Tregs) are a type of lymphocyte that regulate the immune system by suppressing unwanted immune responses, preventing autoimmune diseases and inappropriate inflammatory reactions. They have shown promise in preventing graft vs. host disease, alleviating autoimmune symptoms, and promoting transplant tolerance. This review provides an overview of Treg cells, including important markers and subsets, as well as the methodology used for manufacturing adoptive regulatory T cell therapies (TRACT). The approaches and outcomes of several clinical trials involving adoptive transfer of Tregs to patients are also discussed.
CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Celine Blaye, Thomas Boyer, Florent Peyraud, Charlotte Domblides, Nicolas Larmonier
Summary: Breast cancers are often associated with an immunosuppressive microenvironment, and myeloid cells play a major role in this tumor-promoting environment. Besides their immunosuppressive properties, breast cancer-induced myeloid cells also have a broad range of non-immunological tumor-promoting functions. However, there are difficulties and challenges in distinguishing specific subsets of these cells, hindering their selective targeting and use as potential biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maaike Suuring, Aurelie Moreau
Summary: Myeloid regulatory cell-based therapy, focusing on generating tolerogenic dendritic cells (tolDCs) and regulatory macrophages (Mregs), has shown great potential in organ transplantation and autoimmune diseases. These cells are produced ex vivo using various differentiation signals and stimuli, with studies in animals and humans leading to clinical trials for therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Xinyu Cheng, Huilan Wang, Zhongyu Wang, Bo Zhu, Haixia Long
Summary: Tumor-associated myeloid cells (TAMCs) are crucial immune cell populations in the tumor microenvironment and have a significant impact on immune checkpoint blockade efficacy. Understanding the origin of TAMCs is essential for determining their functional diversity and developing cancer immunotherapy strategies. This review article provides an overview of recent research progress on evaluating the heterogeneity of TAMC origins. It also summarizes major therapeutic strategies targeting TAMCs with diverse sources, shedding light on their implications for cancer immunotherapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Immunology
Shuyao Qiu, Xiangqian Luo, Lihua Mo, Shuang Zhang, Yun Liao, Li Guan, Liteng Yang, Qinmiao Huang, Dabo Liu, Pingchang Yang
Summary: This study aims to enhance the therapeutic efficacy of allergen-specific immunotherapy (AIT) in experimental allergic rhinitis (AR) by using TAFA4 as an adjuvant. The results show that TAFA4 activates dendritic cells (DCs) in the airway tissues and induces the expression of IL-10, which attenuates the allergic response in mice.
Review
Oncology
Xavier Roussel, Francine Garnache Ottou, Florian Renosi
Summary: Plasmacytoid dendritic cells (pDC) are the main type I interferon-producing cells in humans and are capable of regulating innate and adaptive immune responses. Tumor infiltration by pDC is well-documented in various cancers and is associated with unfavorable clinical outcomes. While Blastic Plasmacytoid Dendritic Cells Neoplasm (BPDCN) is a well-described aggressive leukemia derived from pDCs, the understanding of tumor infiltration by mature pDCs in Myeloid Neoplasms (MN) is limited. This review aims to provide a comprehensive overview of pDC biology in MN, emphasizing the need for further research into pDC oncogenesis and immune responses for better therapeutic strategies.
Review
Oncology
Yuri L. Bunimovich, Anton A. Keskinov, Galina V. Shurin, Michael R. Shurin
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2017)
Editorial Material
Medicine, Research & Experimental
Michael R. Shurin
JOURNAL OF CLINICAL INVESTIGATION
(2018)
Article
Oncology
Galina V. Shurin, Oleg Kruglov, Fei Ding, Yan Lin, Xingxing Hao, Anton A. Keskinov, Zhaoyang You, Anna E. Lokshin, William A. LaFramboise, Louis D. Falo, Michael R. Shurin, Yuri L. Bunimovich
Article
Biochemistry & Molecular Biology
Gulnur K. Zakiryanova, Elena Kustova, Nataliya T. Urazalieva, Emile T. Baimuchametov, Narymzhan N. Nakisbekov, Michael R. Shurin
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Immunology
Michael R. Shurin, Galina V. Shurin, Samuel B. Zlotnikov, Yuri L. Bunimovich
JOURNAL OF IMMUNOLOGY
(2020)
Article
Oncology
Deena M. Maurer, Juraj Adamik, Patricia M. Santos, Jian Shi, Michael R. Shurin, John M. Kirkwood, Walter J. Storkus, Lisa H. Butterfield
CANCER IMMUNOLOGY RESEARCH
(2020)
Review
Cell Biology
Michael R. Shurin, James H. Baraldi, Galina V. Shurin
Summary: Surgery can promote cancer metastasis through mechanisms such as the release of neuroendocrine hormones, immunosuppression, neovascularization, and tissue remodeling. The role of neuroimmune regulation in surgery-associated metastasis is not well understood, highlighting the need for further research in this area.
Article
Medical Laboratory Technology
Nathan Cook, Lingqing Xu, Shaymaa Hegazy, Bradley J. Wheeler, Adam R. Anderson, Nancy Critelli, Mary Yost, Anita K. McElroy, Michael R. Shurin, Sarah E. Wheeler
Summary: The study aimed to detect antibodies to different SARS-CoV-2 antigens, analyzing the performance of the BioRad SARS-CoV-2 IgG multiplex assay in terms of diagnostic accuracy, differentiation of vaccination and natural disease, and retrospective exposure determination. Results showed that the assay is comparable to existing methods, achieving 100% sensitivity when all markers are included, with practical implications for research and infection prevention strategies.
CLINICAL BIOCHEMISTRY
(2021)
Article
Microbiology
Sarah E. Wheeler, Galina Shurin, Mary Yost, Adam Anderson, Lisa Pinto, Alan Wells, Michael R. Shurin
Summary: Understanding the development and duration of virus-specific antibodies after COVID-19 vaccination is important for controlling the pandemic. Postvaccination antibody testing can help in monitoring individuals after vaccination and selecting those who may require additional doses or not need vaccination.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Lingqing Xu, Joshua Doyle, Dominique J. Barbeau, Valerie Le Sage, Alan Wells, W. Paul Duprex, Michael R. Shurin, Sarah E. Wheeler, Anita K. McElroy
Summary: This study found a 4.5-fold increase in SARS-CoV-2 seroprevalence from Fall 2020 to February 2021 in Allegheny County, Pennsylvania, due to increased incidence of both natural disease and vaccination. The neutralization titer was significantly correlated with RBD titer but not with N titer. In the February cohort, higher median income and white race were associated with serological findings consistent with vaccination.
Review
Oncology
James H. Baraldi, German Martyn, Galina Shurin, Michael R. Shurin
Summary: This comprehensive review summarizes the literature on tumor innervation, addressing the evidence, historical developments, and important mechanisms related to tumor development. It concludes that solid tumors are innervated and that nerves, neurons, and glia play a functional role in tumor development.
Review
Oncology
Nuray Erin, Galina V. Shurin, James H. Baraldi, Michael R. Shurin
Summary: Sensory nerve fibers and the vagus nerve play crucial roles in tumor growth and spread. Current findings are contradictory, likely due to the stage and aggressiveness of the tumor model. Sensory neurons and Schwann cells are important players in tumor development, growth, and progression.
Article
Oncology
Shuhui Cao, Yue Wang, Yan Zhou, Yao Zhang, Xuxinyi Ling, Lincheng Zhang, Jingwen Li, Yu Yang, Weimin Wang, Michael R. Shurin, Hua Zhong
Summary: This study demonstrates the role of tumor-associated Schwann cells in the progression of small-cell lung cancer by constructing a mRNA-miRNA-lncRNA network. The findings improve our understanding of the interaction between tumor cells and Schwann cells, and provide insights into cancer progression.
Article
Cell Biology
Galina Shurin, Kavita Vats, Oleg Kruglov, Yuri L. Bunimovich, Michael R. Shurin
Summary: Nerve-cancer crosstalk is controlled by Schwann cells, which can be stimulated by tumor cells to produce prostaglandin E. This inhibits the proliferation of activated T cells and leads to T cell exhaustion. Understanding this pathway is important for the development of cancer therapies.
Editorial Material
Immunology
Michael R. Shurin
IMMUNOTARGETS AND THERAPY
(2018)