Are we ready to start studies of Th17 cell manipulation as a therapy for cancer?

IL-17 is associated with poor prognosis and promotes angiogenesis via stimulating VEGF production of cancer cells in colorectal carcinoma

(2011) Jiankun Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Clinical Impact of Different Classes of Infiltrating T Cytotoxic and Helper Cells (Th1, Th2, Treg, Th17) in Patients with Colorectal Cancer

(2011) Marie Tosolini et al.   CANCER RESEARCH

Human tumor-infiltrating Th17 cells have the capacity to differentiate into IFN-γ+ and FOXP3+ T cells with potent suppressive function

(2011) Jian Ye et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigenetic Changes at Il12rb2 and Tbx21 in Relation to Plasticity Behavior of Th17 Cells

(2011) D. Bending et al.   JOURNAL OF IMMUNOLOGY

Th17 cells: positive or negative role in tumor?

(2010) Yuqiang Ji et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells

(2010) Maria H. Lexberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Generation and Differentiation of IL-17-Producing CD4+ T Cells in Malignant Pleural Effusion

(2010) Z.-J. Ye et al.   JOURNAL OF IMMUNOLOGY

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

Preferential recruitment of interferon-γ-expressing TH17 cells in multiple sclerosis

(2009) Hania Kebir et al.   ANNALS OF NEUROLOGY

Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments

(2009) I. Kryczek et al.   BLOOD

IL-17E, a proinflammatory cytokine, has antitumor efficacy against several tumor types in vivo

(2009) Tania Benatar et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12

(2009) Edda G. Schulz et al.   IMMUNITY

Late Developmental Plasticity in the T Helper 17 Lineage

(2009) Yun Kyung Lee et al.   IMMUNITY

Pretreatment frequency of circulating IL-17+CD4+T-cells, but not Tregs, correlates with clinical response to whole-cell vaccination in prostate cancer patients

(2009) Evelyna Derhovanessian et al.   INTERNATIONAL JOURNAL OF CANCER

Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients

(2009) Jing-Ping Zhang et al.   JOURNAL OF HEPATOLOGY

IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice

(2009) S. von Vietinghoff et al.   JOURNAL OF IMMUNOLOGY

Increased IL-17-producing cells correlate with poor survival and lymphangiogenesis in NSCLC patients

(2009) Xi Chen et al.   LUNG CANCER

Tumor-specific Th17-polarized cells eradicate large established melanoma

(2008) P. Muranski et al.   BLOOD

Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells

(2008) Yongpeng Gu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-21 and TGF-β are required for differentiation of human TH17 cells

(2008) Li Yang et al.   NATURE