Article
Immunology
Jiajia Zhou, Ilona Kryczek, Shasha Li, Xiong Li, Angelo Aguilar, Shuang Wei, Sara Grove, Linda Vatan, Jiali Yu, Yijian Yan, Peng Liao, Heng Lin, Jing Li, Gaopeng Li, Wan Du, Weichao Wang, Xueting Lang, Weimin Wang, Shaomeng Wang, Weiping Zou
Summary: The E3 ubiquitin ligase MDM2, known for inhibiting the tumor suppressor p53, also plays a T cell-intrinsic role that supports antitumor responses. Targeting the p53-MDM2 pathway with APG-115 enhances T cell immunity and synergizes with cancer immunotherapy, with effects dependent on p53 and MDM2 in T cells. This highlights a potential therapeutic strategy for treating cancer patients, regardless of tumor p53 status.
Article
Biochemistry & Molecular Biology
Zhongcai Wu, Xuezhi Zuo, Xiuru Wang, Mengxia Shi, Han Zhu, Chujin Cao, Xiaoqin Liu, Wangqun Liang, Ying Yao, Le Wang
Summary: LCZ can prevent peritoneal fibrosis by modulating the gut microbiota, enhancing butyrate production, activating PPAR γ, and suppressing NF-κB-mediated inflammation. Administration of LCZ significantly improved peritoneal fibrosis in experimental mice, reducing macrophage infiltration, inflammatory M1 polarization, and inflammatory cytokines in peritoneal dialysis effluents.
Article
Multidisciplinary Sciences
Wei Yin, Yihong Li, Yan Song, Jiarui Zhang, Chao Wu, Yu Chen, Ying Miao, Changdong Lin, Yuli Lin, Dapeng Yan, Jianfeng Chen, Rui He
Summary: CCRL2 plays a crucial role in activating immunostimulatory macrophages, enhancing antitumor T-cell responses and promoting tumor rejection. Its deficiency leads to impaired macrophage activation and aggravated tumor growth, highlighting CCRL2 as a potential biomarker and therapeutic target for cancer immunotherapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Qingqing Zhang, Qing Zhao, Tao Li, Longya Lu, Fei Wang, Hong Zhang, Zhi Liu, Huihui Ma, Qihui Zhu, Jingjing Wang, Xuemei Zhang, Yang Pei, Qisha Liu, Yuyu Xu, Jinlong Qie, Xiaoting Luan, Zhibin Hu, Xingyin Liu
Summary: Previous studies have shown that probiotics can ameliorate colorectal cancer in a mouse model, but the underlying mechanisms are still unclear. In this study, the researchers found that a specific probiotic strain and its metabolite could improve intestinal inflammation, tumor growth, and gut dysbiosis. Further investigation revealed that the metabolite enhanced the production of IL12a in dendritic cells, priming CD8+ T cell immunity against tumor growth, and also regulated cholesterol metabolism in CD8+ T cells. These findings provide new insights into the epigenetic regulation of probiotics-mediated anti-tumor immunity and suggest potential therapeutic strategies for colorectal cancer patients.
Article
Multidisciplinary Sciences
Alba Rodriguez-Garcia, Rachel C. Lynn, Mathilde Poussin, Monika A. Eiva, Lauren C. Shaw, Roddy S. O'Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, Takami Matsuyama, Daniel J. Powell
Summary: The study demonstrates that targeting FR beta-expressing TAMs with CAR-T cells can enhance antitumor immune responses and improve the efficacy of adoptive T-cell therapy in pre-clinical models.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Jang Hyun Park, Hyun-Jin Kim, Chae Won Kim, Hyeon Cheol Kim, Yujin Jung, Hyun-Soo Lee, Yunah Lee, Young Seok Ju, Ji Eun Oh, Sung-Hong Park, Jeong Ho Lee, Sung Ki Lee, Heung Kyu Lee
Summary: Glioblastoma presents a hypoxic microenvironment that affects gamma delta T cell-mediated antitumor immune responses. The tumor's high demand for oxygen leads to suppression of gamma delta T cell function, which can be alleviated by reducing hypoxia. This study highlights the importance of gamma delta T cells in antitumor immunity against brain tumors.
Article
Endocrinology & Metabolism
Xing Guo, Kai Zhong, LongFei Zou, Hao Xue, ShuLing Zheng, Jiang Guo, Hui Lv, Ke Duan, DengHua Huang, MeiYun Tan
Summary: This study found that antibiotic treatment leads to dysbiosis of the gut microbiota in mice, which in turn affects bone development and bone density. On the other hand, probiotic treatment promotes fracture healing in osteoporotic mice after dysbiosis, potentially through inhibiting the RAS/RANKL/RANK pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Miaoran Xia, Bingbing Wang, Zihan Wang, Xulong Zhang, Xi Wang
Summary: NK cells are a heterogeneous and plastic population that can directly kill target cells without prior immunization, with their activation controlled by the balance of multiple germline-encoded activating and inhibitory receptors. Epigenetic regulation plays an important role in NK cell-mediated antitumor immunity, and NK cell-based immunotherapy is considered a promising strategy for cancer treatment. By targeting intrinsic epigenetic regulators alone or in combination with other strategies, there is potential to enhance NK cell-mediated antitumor cytotoxicity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Allan Victor Souza Bernardino, Nathalia Santos Rocha, Elaine Maria da Silva, Rafael Augusto Batista de Medeiros, Edvaldo Vieira da Silva Junior, Neide Kazue Sakugawa Shinohara, Neila Mello dos Santos Cortez, Patricia Moreira Azoubel
Summary: The use of ultrasound and impregnation improved the moisture content, drying efficiency, and probiotic concentration in dehydrated jackfruit products. Specifically, the combination of ultrasound pretreatment and AI impregnation maintained a high probiotic concentration in the product over 28 days.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Xuan Ju, Xi Wu, Yukun Chen, Shanshan Cui, Zixuan Cai, Liang Zhao, Yanling Hao, Feng Zhou, Fang Chen, Zhengquan Yu, Dong Yang
Summary: This study identified a novel mode of communication between gut bacteria and their host, mediated by the LevH1 protein displayed on the surface of the bacteria. This protein binds to colorectal cancer cells and inhibits their proliferation. The mechanism of this communication is different from bacterial small metabolites and relies on the specific structure of the LevH1 protein.
Article
Oncology
Shannon Lange, Laurens G. L. Sand, Matthew Bell, Sagar L. Patil, Deanna Langfitt, Stephen Gottschalk
Summary: We designed a chimeric cytokine receptor (GM18) that links CAR T-cell activation to MyD88 signaling. GM18 endows CAR T cells with sustained effector function in the setting of chronic antigen exposure, resulting in potent antitumor activity in preclinical solid tumor models.
Review
Biology
Da Qin, Yixuan Ma, Yanhong Wang, Xilin Hou, Liyun Yu
Summary: The intestine barrier relies on its integrity, microbial composition, and immunity. Lactobacilli have been found to play a significant role in maintaining the intestinal balance and barrier function. Both living cells and derivatives of Lactobacilli may have beneficial effects on the gut mucosal barrier.
Article
Multidisciplinary Sciences
Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, Hui-Yu Huang
Summary: This study found that the immunomodulatory effects of Lactobacillus casei Shirota fermented beverage (LcSFB) depend on the mode of antigen presentation, enhancing immune response in mice injected with OVA, but attenuating it in mice treated with injection plus intranasal administration.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Johanna Joensson, Lianqing Wang, Naoko Kajitani, Stefan Schwartz
Summary: High-risk carcinogenic HPV16 expresses the oncoproteins E6 and E7 through splicing, and the splicing between splice sites SD226 and SA409 is controlled by a splicing enhancer consisting of a repeat of an adenosine-rich 11 nucleotide sequence. The splicing enhancer promotes the production of E7 protein, which is critically linked to the carcinogenic properties of HPV16.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Eduardo Luis de Souza Cruz, Felippe Jose Almeida Loureiro, Artur Luiz da Costa da Silva, Rommel Thiago Ramos, Maria Sueli da Silva Kataoka, Joao de Jesus Viana Pinheiro, Sergio de Melo Alves Junior
Summary: The study aimed to evaluate gene expression alterations using different immortalization methods in ameloblastoma cell lines. RNA-seq revealed changes in expression levels of tumor-related genes after immortalization, with the hTERT method showing fewer changes compared to HPV-E6/E7.