Article
Oncology
Keita Kai, Tomokazu Tanaka, Takao Ide, Atsushi Kawaguchi, Hirokazu Noshiro, Shinichi Aishima
Summary: The infiltration level of CD1a-DCs is closely related to the prognosis of patients with gallbladder cancer, with the high CD1a-DC group showing better overall survival and disease-specific survival. This suggests that the presence of CD1a-DCs may help improve patient outcomes.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Angelo Mandarino, Swetha Thiyagarajan, Allana C. F. Martins, Roberto da Silva Gomes, Stefan W. Vetter, Estelle Leclerc
Summary: Pancreatic cancer is difficult to treat, and S100 proteins and HMGB1 protein play important roles in the tumorigenesis process. By analyzing the transcript levels of 13 cancer-related S100 genes and HMGB1 in 19 pancreatic cancer tumor samples and 8 human pancreatic cancer cell lines, statistically significant positive correlations were found in 5.5% (5 out of 91) and 37.4% (34 of 91) of the possible S100/S100 or S100/HMGB1 pairs in cells and tumors, respectively. These findings suggest that S100 proteins may interact with each other and with HMGB1, providing valuable insights for further characterization of pancreatic tumors based on S100 and HMGB1 transcription profiles.
Article
Cell Biology
Yifan He, Yan Qu, Bowen Meng, Weiying Huang, Jianxia Tang, Runci Wang, Zetao Chen, Xiaoxing Kou, Songtao Shi
Summary: This study reveals the presence of immunosupportive MSCs in lymph nodes and the important role of the MCP-1/PD-L1 axis in MSC-based immunoregulation. The study also demonstrates the potential use of LNMSCs for treating immunosuppressive disorders.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Jinpu Yang, Xia Liu, Yiwen Cheng, Jingchen Zhang, Feng Ji, Zongxin Ling
Summary: Gastric cancer is the fifth most common neoplasm and the third most deadly cancer worldwide. Helicobacter pylori infection is the major cause of gastric carcinogenesis and triggers immune responses in the host. Plasmacytoid dendritic cells (pDCs), as important components of the tumor immune microenvironment, have been gaining attention for their potential roles in immunosuppression. Recent studies have shown that pDCs play vital roles in the development of immunosuppression in gastric cancer. Understanding the contribution of pDCs to the development and progression of gastric cancer may lead to improved cancer therapy strategies.
FRONTIERS IN ONCOLOGY
(2022)
Review
Surgery
Zhihan Zhong, Yuhao Xu, Junwei Liu, Chengwu Zhang, Zunqiang Xiao, Yan Xia, Yu Wang, Jianfeng Wang, Qiuran Xu, Yi Lu
Summary: This study investigated the clinical features, diagnosis, treatment, and prognosis of patients with gastric schwannoma. The results showed that the size and imaging characteristics of gastric schwannoma have certain regularities, and immunohistochemistry can assist in diagnosis. The main treatment options include endoscopy and surgery, and long-term follow-up results indicate that gastric schwannoma is mostly benign.
Review
Oncology
Asif Sukri, Alfizah Hanafiah, Nik Ritza Kosai
Summary: Gastric cancer remains a leading cause of cancer-related death in developing countries, while immunotherapy has shown promising results in improving prognosis. Research on the roles of immune cells in gastric cancer pathogenesis is vital for developing effective immunotherapy strategies.
Article
Oncology
Asmaa M. Zahran, Helal F. Hetta, Shimaa Mansour, Ereny S. Saad, Amal Rayan
Summary: This study revealed significantly reduced levels of pDCs and mDCs in NSCLC patients compared to controls, and a significant accumulation of pDCs in non-metastatic patients. There was a significant negative correlation between mDCs levels and OS, while patients with higher levels of pDCs had significantly higher OS rates.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Eunji Jang, Min-Kyue Shin, Hyunki Kim, Joo Yeon Lim, Jae Eun Lee, Jungmin Park, Jungeun Kim, Hyeseon Kim, Youngmin Shin, Hye-Young Son, Yoon Young Choi, Woo Jin Hyung, Sung Hoon Noh, Jin-Suck Suh, Ji-Yong Sung, Yong-Min Huh, Jae-Ho Cheong
Summary: The mesenchymal cancer phenotype in gastric cancer is associated with poor prognosis and treatment resistance. By identifying gene signature-based molecular subtypes and investigating the tumor microenvironment, the study suggests that targeting the tumor-intrinsic mesenchymal reprogramming could be a potential therapeutic strategy.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Tatsuya Aoki, Jun Kinoshita, Seiichi Munesue, Toshihide Hamabe-Horiike, Takahisa Yamaguchi, Yusuke Nakamura, Koichi Okamoto, Hideki Moriyama, Keishi Nakamura, Shinichi Harada, Yasuhiko Yamamoto, Noriyuki Inaki, Sachio Fushida
Summary: CD36 plays a pro-metastatic role in peritoneal metastasis from gastric cancer and is associated with the uptake of fatty acids. The expression of CD36 is significantly associated with the prognosis of peritoneal metastasis from gastric cancer.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lianping Wei, Wenhao Dong, Zhen Han, Chen Chen, Qing Jin, Jinling He, Yongping Cai
Summary: This study used network pharmacology and cytology experiments to explore the potential active components, targets, and cell pathways of Dendrobium officinale extract in inhibiting gastric cancer cell proliferation. The results showed that the extract could significantly inhibit gastric cancer cell proliferation through its effects on multiple components, targets, and pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Ryo Negishi, Hitomi Yamakawa, Takeru Kobayashi, Mayuko Horikawa, Tatsu Shimoyama, Fumiaki Koizumi, Takeshi Sawada, Keisuke Oboki, Yasushi Omuro, Chikako Funasaka, Akihiko Kageyama, Yusuke Kanemasa, Tsuyoshi Tanaka, Tadashi Matsunaga, Tomoko Yoshino
Summary: The study reports the transcriptome analysis of single circulating tumor cells (CTCs) from gastric cancer patients, revealing that the majority of gastric CTCs have undergone EMT and indicating the contribution of platelet adhesion towards EMT progression and chemoresistance acquisition.
COMMUNICATIONS BIOLOGY
(2022)
Article
Immunology
Louis Hinkle, Yongbin Liu, Chaoyang Meng, Zhe Chen, Junhua Mai, Licheng Zhang, Yitian Xu, Ping-Ying Pan, Shu-Hsia Chen, Haifa Shen
Summary: The sympathetic nervous system plays a role in regulating immune cell function, particularly in tumor growth and antitumor immunity. Combining propranolol with a peptide cancer vaccine showed promising results in treating melanoma in mice by enhancing DC maturation and reducing the presence of myeloid-derived suppressor cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Atefeh Talebi, Carlos A. Celis-Morales, Nasrin Borumandnia, Somayeh Abbasi, Mohamad Amin Pourhoseingholi, Abolfazl Akbari, Javad Yousefi
Summary: This study aims to develop predictive models using different machine learning classifiers based on demographic and clinical variables to predict the metastasis status of gastric cancer patients. By training and testing the data of 733 gastric cancer patients, it was found that Support Vector Machine and Neural Network are two better predictive models among the applied machine learning algorithms.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Xiaowu Bai, Chi Chun Wong, Yasi Pan, Huarong Chen, Weixin Liu, Jianning Zhai, Wei Kang, Yu Shi, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Philip Chiu, Jun Yu, Enders Kwok-wai Ng
Summary: YTHDF1 is overexpressed in gastric cancer and promotes cancer growth by inducing cell proliferation and suppressing dendritic cell-mediated anti-tumor immune response. YTHDF1 is a promising therapeutic target for gastric cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Xiaoting Ma, Liming Peng, Junqing Wang, Lizhen Gao, Wen Zhang, Xu Lu, Jingwei Liu, Lin Yang
Summary: This study evaluated the safety and initial efficacy of autologous cytokine-induced killer (CIK) cells combined with S-1+oxaliplatin (SOX) as the first-line treatment for gastric cancer (GC). The results showed that the CIK-SOX treatment was safe and resulted in an absolute improvement in progression-free survival (PFS) and overall survival (OS) of about 8.05 months. Patients receiving more than three injections of specific lymphocyte subsets benefitted the most from this combination therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
