期刊
CANCER IMMUNOLOGY IMMUNOTHERAPY
卷 58, 期 9, 页码 1449-1457出版社
SPRINGER
DOI: 10.1007/s00262-009-0703-x
关键词
CML; BCR/ABL; HLA/tetramers; Antigen-specific T cells
资金
- Medical Research Council [G0700711B] Funding Source: researchfish
The BCR/ABL p210 fusion protein has long been considered an ideal target antigen for the development of immunotherapeutic strategies in chronic myeloid leukaemia (CML) due to its central role in malignant transformation and to its unique novel amino acid sequence solely expressed in leukaemia cells. However, the feasibility to expand BCR-ABL-specific T cells remains still controversial. Using BCR/ABL peptide/MHC tetramers, significantly higher frequencies of tetramer positive cells were detected in the peripheral blood of HLA-A*0301 (mean 0.38%) and HLA-B*0801 (mean 0.28%) CML patients than in healthy donors (P = 0.0025 and 0.0026, respectively). However, following stimulation with autologous peptide-pulsed DCs, BCR/ABL-specific T cells were only expanded from some healthy donors, suggesting that CML patients may have a specific immune deficit with respect to the BCR/ABL antigen.
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