Article
Biochemistry & Molecular Biology
Miriam J. Kavec, Marketa Urbanova, Pavol Makovicky, Alena Opattova, Kristyna Tomasova, Michal Kroupa, Klara Kostovcikova, Anna Siskova, Nazila Navvabi, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka
Summary: Oxidative stress, oxidative DNA damage, and its repair are closely related to the development of colorectal cancer, but cannot solely explain the onset of sporadic colorectal cancer. Other factors, especially the microenvironment, need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Hanen Chelbi, Refka Jelassi, Sarra Belfkih, Amor Ben Amor, Nasreddine Saidi, Hamza Ben Salah, Nabiha Mzoughi, Imen Ben Dhifallah, Nadia Boujelben, Radhia Ammi, Aida Bouratbine, Ines Zidi, Karim Aoun
Summary: The study found a significant association between HCMV infection and CRC development, but a lack of association between CCR5 Delta 32 mutation and colorectal cancer. Further studies are needed to evaluate the role of CCR5 as a potential candidate gene for CRC susceptibility.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Kaleb Pretto Gatto, Lucas H. B. Souza, Juliana Nascimento, Pablo Suarez, Luciana Bolsoni Lourenco
Summary: A study on Amazonian frogs identified genetic lineage closely related to Physalaemus ephippifer, yet the taxonomic status remains unclear as Lineage 1 of P. cuvieri. The study revealed complex rearrangements involving chromosomes related to the sex chromosomes of P. ephippifer during the divergence of this group of frogs.
Article
Multidisciplinary Sciences
Yuyan Qian, Jianhu Wang, Wenbin wANG, Peng li, Zhenhao Zhao, Yuan Jiang, Dandan Huang, He Ren, Yang Yang, Zhongfan Zhao, Lei Zhang, Jiandan Shi, Mulin Jun, Wangee Li
Summary: Using fine-mapping analysis and functional annotation, we identified likely causal variants and their target genes in prostate cancer. We found 3,395 potential disease-causing variants and linked them to 487 target genes through functional annotation. The top-ranked SNP, rs10486567, was predicted to regulate the HOTTIP gene. Deletion of the enhancer associated with rs10486567 reduced invasive migration in prostate cancer cells, which was rescued by HOTTIP overexpression in enhancer-deficient cells. Furthermore, rs10486567 was found to regulate HOTTIP through allele-specific long-range chromatin interaction.
Article
Biochemistry & Molecular Biology
Han Ling, Chen-Hui Cao, Kai Han, Yong-Rui Lv, Xiao-Dan Ma, Jing-Hua Cao, Jie-Wei Chen, Si Li, Jin-Long Lin, Yu-Jing Fang, Zhi-Zhong Pan, Dan Xie, Feng-Wei Wang
Summary: CEP63 overexpression in colorectal cancer plays a crucial role in promoting cell proliferation and tumor growth through the regulation of RBPs/RNA axis.
Review
Oncology
Andrada Ciuca, Ramona Moldovan, Adriana Baban
Summary: This review examined the impact of psychosocial interventions for individuals with a family history of CRC and described the current state of research in this area. The findings suggest that psychosocial interventions have a positive impact across various outcomes, with genetic counseling appearing to be the most beneficial.
Article
Oncology
Beatriz Gonzalez, Maria Navarro-Jimenez, Maria Jose Alonso-De Gennaro, Sanne Marcia Jansen, Isabel Granada, Manuel Perucho, Sergio Alonso
Summary: This report explores the association between loss of methylation in pericentromeric DNA sequences and genome-doubling in colorectal cancer cells, shedding light on the link between genome demethylation and aneuploidy in cancer. The findings provide further support for an oncogenic pathway linking somatic hypomethylation and genetic copy number alterations in human colorectal cancer.
Article
Pharmacology & Pharmacy
Yonglong Chang, Qinling Ou, Xuhui Zhou, Kechao Nie, Haixia Yan, Jinhui Liu, Jing Li, Sifang Zhang
Summary: Our study comprehensively explores the current research status and development trend of nanodrug delivery systems (NDDS) in colorectal cancer (CRC) research through bibliometric analysis. A total of 1866 publications authored by 9870 individuals affiliated with 6126 institutions across 293 countries/regions were included. The analysis revealed the highest number of publications by Abnous Khalil, with the International Journal of Nanomedicine, International Journal of Pharmaceutics, and Biomaterials being the most published journals. Thematic analysis identified inflammatory bowel disease, oral drug delivery, and ulcerative colitis as areas requiring further development. Keyword analysis revealed emerging keywords such as ulcerative colitis, exosomes, and as1411, which may become the focal points of future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Francesco Ravasini, Eugenia D'Atanasio, Maria Bonito, Biancamaria Bonucci, Chiara Della Rocca, Andrea Berti, Beniamino Trombetta, Fulvio Cruciani
Summary: Chromosome rearrangements involving the AZFc region of the Y chromosome are a major cause of male infertility, and are also relevant in forensic genetics. A study identified an unusual Y-STR pattern in samples, potentially resulting from a large genomic rearrangement event.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Hussain Almasmoum
Summary: Colorectal cancer is a common type of cancer with unclear roles of mucins in its progression. Some mucins act as oncogenes, while others act as tumor suppressors. The mucin family shows potential as a sensitive and specific histopathological marker for early CRC diagnosis.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Immunology
Nicolas Lundahl Ciano-Petersen, Omar Hamad-Cueto, Hania Drissi-Reyes, Alvaro Dona-Diaz, Guillermina Garcia-Martin
Summary: 22q11.2 deletion syndrome is characterized by specific clinical features such as heart abnormalities, thymus issues, palatal abnormalities, and hypocalcemia, as well as autoimmune and psychiatric disorders. Patients may experience psychotic disorders, developmental regression, and long-term cognitive disturbances. The syndrome may be linked to immune dysregulation and an increased prevalence of autoimmune disorders, potentially due to thymic abnormalities playing a role in self-tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Matheus Jacometo Coelho de Castilho, Miyoko Massago, Carlos Eduardo Arruda, Matheus Henrique Arruda Beltrame, Eleanor Strand, Carlos Edmundo Rodrigues Fontes, Oscar Kenji Nihei, Rogerio do Lago Franco, Catherine Ann Staton, Raissa Bocchi Pedroso, Luciano de Andrade
Summary: This study aimed to analyze the spatial heterogeneity of colorectal cancer (CRC) deaths in municipalities in South Brazil and identify associated variables. The results indicate that some areas in South Brazil have high rates of CRC, surrounded by areas with similarly high rates. The study suggests that improved access to specialized health centers, the presence of family health strategy teams, and higher rates of colonoscopies are protective factors against CRC mortality in this region.
Article
Multidisciplinary Sciences
Jiawei Zhou, Amber Cipriani, Yutong Liu, Gang Fang, Quefeng Li, Yanguang Cao
Summary: This study investigates the heterogeneity of lesion-specific response and progression in metastatic colorectal cancer (mCRC) patients. The authors find that the sequence of progression at the organ level is associated with long-term survival.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Wenchao Zhao, Qian Pei, Yongwei Zhu, Dongdong Zhan, Guo Mao, Meng Wang, Yanfang Qiu, Ke Zuo, Haiping Pei, Lun-Quan Sun, Ming Wen, Rong Tan
Summary: By integrated proteogenomic analysis, two subtypes of RLBPs were identified in colorectal cancer, showing distinct prognostic and therapeutic differences. Cluster-I (CI), characterized by high expression of RLBPs, was associated with chromosomal instability and better prognosis, and showed sensitivity to drugs targeting genome integrity and EGFR. Cluster-II (CII), characterized by low expression of RLBPs, was associated with mucinous adenocarcinoma, right-sided colon cancer, and poor prognosis. CII exhibited enrichment of inflammatory signaling pathway and lymphocyte infiltration, suggesting potential application of drugs targeting inflammatory and immune response.
Article
Oncology
Omid Cheraghi, Bahareh Dabirmanesh, Farideh Ghazi, Massoud Amanlou, Mona Atabakhshi-kashi, Yaghoub Fathollahi, Khosro Khajeh
Summary: This study reveals the changes in signaling pathways and survival mechanisms in colorectal cancer cell lines after knocking down the Nrf(2) gene. The results show that the ROS scavenging and detoxification potential of cells significantly decrease after Nrf(2) gene knockout, making the cells more sensitive to chemotherapy drugs. However, there is no significant decrease in cell viability. Further analysis indicates that the expression levels of proteins involved in detoxification processes, respiratory electron transport chain, and mitochondrial-related processes are downregulated after Nrf(2) gene knockout, while proteins related to MAPKs, JNK, and FOXO pathways are upregulated, possibly helping to overcome the detrimental effects of excessive ROS production.
Article
Biochemistry & Molecular Biology
Muhammad Safdar, Sana Zaheer, Rozhgar A. Khailany, Sadaf Parvez, Muhammad Naveed, Piplu Bhuiyan, Mehmet Ozaslan, Rebaz Moatasam, Mustafa S. Al-Attar, Musarrat Abbas Khan, Yasmeen Junejo
CELL BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Clinical Neurology
Naser Gilani, Ehsan Razmara, Mehmet Ozaslan, Ihsan Kareem Abdulzahra, Saeid Arzhang, Ali Reza Tavasoli, Masoud Garshasbi
Summary: This study revealed a novel homozygous frameshift variant in the CLN3 gene as the most likely disease-causing variant in a large Iraqi consanguineous family with juvenile neuronal ceroid lipofuscinosis. It expanded our understanding of the clinical and genetic spectrum of JNCL.
ACTA NEUROLOGICA BELGICA
(2021)
Article
Biochemistry & Molecular Biology
Rozhgar A. Khailany, Mehmet Ozaslan
Summary: Breast cancer is the most common cancer in women worldwide, and detection of susceptibility genes like MLH3 is crucial. This study used exome sequencing to uncover previously undetected breast cancer-predisposing variants and found that the expression of MLH3 was significantly down-regulated in tumor samples compared to normal tissues, especially in grades II and III breast cancer patients.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Belan O. Kanabe, Mehmet Ozaslan, Sherwan Ahmed Aziz, Mustafa S. Al-Attar, Ibrahim Halil Kilic, Rozhgar A. Khailany
Summary: The study revealed down-regulation of APOBEC3C and lncRNA-GAS5 and up-regulation of miRNA 103 in breast cancer patients, suggesting that GAS5 expression could be a potential new treatment target for breast cancer. Further research is needed to clarify the roles of these molecules in cellular signaling pathways.
CELLULAR AND MOLECULAR BIOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Muhammad Safdar, Mehmet Ozaslan, Yasmeen Junejo
Summary: The study synthesized doxycycline capped gold nanoparticles and characterized them through various analytical techniques, demonstrating their potential application in breast cancer and breast epithelial cells, including their impact on TRP channel gene expression levels and antimicrobial activities.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Polymer Science
Muhammad Safdar, Mehmet Ozaslan
Summary: This study successfully fabricated nanosized spherical erythromycin capped gold nanoparticles for the first time, which exhibited remarkable catalysis, antibacterial, and anticancer activities.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2022)
Article
Toxicology
Zoya Hashmat, Iffat Saeed Channa, Muhammad Safdar, Mehmet Ozaslan, Muhammad Saeed, Faisal Siddique, Yasmeen Junejo
Summary: This study investigated the potential use of terazosin in treating APAP-induced acute liver injury in an animal model. The results showed that terazosin, when combined with APAP, improved liver functioning, lipid profile, and renal functionality. This study provides a new approach for alternative treatment of drug-induced liver injury.
TOXICOLOGICAL RESEARCH
(2022)
Article
Environmental Sciences
Muhammad Safdar, Mehmet Ozaslan, Yasmeen Junejo, Iffat Saeed Channa
Summary: This study successfully synthesized novel gold nanoparticles with potential anti-breast cancer effects and demonstrated their therapeutic efficacy on SKBR3 breast cancer cells. Au(0)NPs activated p53 and inhibited NF-kappa B signaling at the cellular level, resulting in apoptosis and proliferation suppression of breast cancer cells.
TOXICOLOGY AND ENVIRONMENTAL HEALTH SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Isik Didem Kara, Ahmet Cakir, Mehmet Ozaslan, Ibrahim Halil Kili, Bektas Tepe, Ebru Akdogan, Cavit Kazaz
Summary: The study investigated the anti-tumoural effects of Xanthium strumarium extracts and its pure constituents on C6 glioma cells, and found that xanthanolides isolated from X. strumarium could be potential chemotherapeutic agents for glioma.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Genetics & Heredity
Sina Salajegheh Tazerji, Fatemeh Shahabinejad, Mahya Tokasi, Mohammad Ali Rad, Muhammad Sajjad Khan, Muhammad Safdar, Krzysztof J. Filipiak, Lukasz Szarpak, Tomasz Dzieciatkowski, Jan Jurgiel, Phelipe Magalhaes Duarte, Md Tanvir Rahman, Md Abdus Sobur, Md Saiful Islam, Adnan Ahmed, Mohamed N. F. Shaheen, Awad A. Shehata, Rasha Gharieb, Mohamed Fawzy, Yashpal Singh Malik, Nagaraj Jaganathasamy, Vinodhkumar Obli Rajendran, Kannan Subbaram, P. Shaik Syed Ali, Sheeza Ali, Saif Ur Rehman, Mehmet Ozaslan, Gulfaraz Khan, Muhammad Saeed, Umair Younas, Safdar Imran, Yasmeen Junejo, Parmida Arabkarami, Unarose Hogan, Alfonso J. Rodriguez-Morales
Summary: This review focused on global data analysis and risk factors associated with morbidity and mortality of coronavirus disease 2019 (COVID-19) from different countries. The findings suggest that males have higher confirmed and death cases compared to females, possibly due to cultural activities and variations in the immune system. Understanding the characteristics of the COVID-19 epidemic is important for mitigating its impact in the future and preparedness for future epidemics.
Article
Medicine, General & Internal
Muhammad Safdar, Mehmet Ozaslan, Rebaz M. Mustafa, Shukur W. Smail, Samiha S. Khan, Muhammad Sajjad Khan, Muhammad Asad Akhtar, Hafiz Khawar Ali, Umair Younas, Muhammad Saeed, Faisal Siddique, Muhammad Naveed, SaifUr Rehman
Summary: This study explores the association between increased susceptibility and severity in hypertensive COVID-19 patients. The findings suggest that certain SNPs in the ACE2 gene may contribute to the severity of COVID-19 in individuals with hypertension.
JOURNAL OF TAIBAH UNIVERSITY MEDICAL SCIENCES
(2023)
Article
Genetics & Heredity
Yasmeen Junejo, Mehmet Ozaslan, Muhamad Safdar, Rozhgar A. Khailany, SaifUr Rehman, Wasim Yousaf, Musarrat Abbas Khan
Article
Medicine, Research & Experimental
Rozhgar A. Khailany, Naser Gilani, Mehmet Ozaslan, Muhamad Safdar, Ihsan Al-Shamari, Belan O. Kanabe, Khandakar A. S. M. Saadat, Javad Homayounvash, Amir Monfaredan, Mustafa S. Al-Attar, Ahmet Arslan
BIOMEDICAL RESEARCH AND THERAPY
(2020)
Article
Genetics & Heredity
Rozhgar A. Khailany, Muhamad Safdar, Mehmet Ozaslan
Review
Biochemistry & Molecular Biology
Rozhgar A. Khailany, Sherwan Ahmed Aziz, Suhel Mawlood Najjar, Muhammad Safdar, Mehmet Ozaslan
CELLULAR AND MOLECULAR BIOLOGY
(2020)