Article
Oncology
Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Carmen Manolio, Maria Lina Tornesello, Franco M. Buonaguro, Siri Amanda Tvingsholm, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro
Summary: This study aimed to identify HCC-specific overexpressed proteins and potential epitopes recognized by CD8(+) cytotoxic T cells that may share homology to viral epitopes. The results showed that circulating CD8(+) T cells targeted both HCC and viral-related epitopes, suggesting their potential use in HCC-specific immunotherapies.
Review
Biochemistry & Molecular Biology
Andrei Sorop, Diana Constantinescu, Florentina Cojocaru, Anca Dinischiotu, Dana Cucu, Simona Olimpia Dima
Summary: Hepatocellular carcinoma (HCC) is the fifth most common cancer globally and is often detected late due to its high clinical and biological heterogeneity. Small nanoparticles with an endosomal origin are valuable biomarkers or carriers for novel treatments in HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Pietro Guerra, Andrea Martini, Patrizia Pontisso, Paolo Angeli
Summary: Hepatocellular Carcinoma (HCC) is a common and aggressive cancer with limited treatment options. Immunotherapy has shown promising results in the treatment of human cancers, including HCC. However, the effectiveness of immunotherapy in HCC is limited, and the identification of new targets is crucial for improved outcomes.
Review
Pharmacology & Pharmacy
Su Jong Yu
Summary: Immunotherapy is a promising approach for treating cancers, including hepatocellular carcinoma (HCC). Current treatment options have a low success rate, and more effective methods are urgently needed. Novel immunotherapeutic methods, such as immune checkpoint inhibitors and immune cell therapies like CAR-T cells and stem cells, are being tested in clinical trials for the treatment of HCC. Overall, immunotherapy is on the brink of major advancements in fighting against HCC.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Cell Biology
Jian Gao, Zuojing Yin, Zhuanbin Wu, Zhen Sheng, Chao Ma, Rui Chen, Xiongwen Zhang, Kailin Tang, Jian Fei, Zhiwei Cao
Summary: This study explored the synergistic effects of Berberine and Evodiamine in hepatocellular carcinoma by co-inhibiting NF-kappa B and c-JUN, which showed significant anticancer activity. The in vivo experiments in zebrafish and analysis of HCC individuals revealed promising results, suggesting the potential of natural compounds for developing combination therapies in combating malignant cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nouf Juaid, Amr Amin, Ali Abdalla, Kevin Reese, Zaenah Alamri, Mohamed Moulay, Suzan Abdu, Nabil Miled
Summary: This report explores the available curative molecules directed against hepatocellular carcinoma (HCC) and highlights the potential of biomolecules in targeting specific pathways involved in oncogenesis. Natural components, novel biomolecules, and chemical modifications are discussed as promising resources for the development of efficient and safe anti-HCC therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Danyu Du, Chan Liu, Mengyao Qin, Xiao Zhang, Tao Xi, Shengtao Yuan, Haiping Hao, Jing Xiong
Summary: Hepatocellular carcinoma is an aggressive cancer with increasing incidence worldwide. Targeting abnormal metabolism has emerged as a new strategy for HCC treatment. This review highlights metabolic targets and discusses current pharmaceutical agents and studies in this field.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Yinjiang Zhang, Hongyun Wei, Lu Fan, Mingyan Fang, Xu He, Binan Lu, Zongran Pang
Summary: The study found that CLEC4A and CLEC4L mRNA levels were significantly higher in HCC tissues compared to normal liver tissues, while CLEC4G/H1/H2/M expression levels were significantly lower. The expression of CLEC4H1 and CLEC4H2 was significantly associated with clinical stages, and the expression of other CLEC4s decreased with tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yaping Chen, Xiaofei Zhang
Summary: The TRABID-DDB2 axis plays a critical role in hepatocellular carcinoma cell proliferation, and TRABID regulates the proliferation of liver cancer cells by deubiquitinating DDB2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cell Biology
Atsushi Kihara, Yusuke Amano, Noriyoshi Fukushima, Hiroyuki Fujiwara, Toshiro Niki
Summary: Immunostaining for ZEB1 is a sensitive and specific method for detecting undifferentiated components of UC/DCs and distinguishing them from G3ECs, though it is not entirely specific for UC/DCs. Careful examination is needed to exclude other tumors such as less differentiated G3ECs, neuroendocrine carcinomas, and carcinosarcomas.
Article
Oncology
Carolina Reduzzi, Serena Di Cosimo, Lorenzo Gerratana, Rosita Motta, Antonia Martinetti, Andrea Vingiani, Paolo D'Amico, Youbin Zhang, Marta Vismara, Catherine Depretto, Gianfranco Scaperrotta, Secondo Folli, Giancarlo Pruneri, Massimo Cristofanilli, Maria Grazia Daidone, Vera Cappelletti
Summary: The majority of breast cancer-related deaths are caused by metastases, which are believed to originate from circulating tumor cells (CTCs), particularly CTC-clusters. Current conventional technology limits the early-stage analysis of CTCs, but a marker-independent blood filtration method has shown promise in detecting a high number of CTC-clusters in stage II-III breast cancer patients. This suggests that CTC-clusters may be an early event in the natural history of breast cancer, with marker-independent approaches improving their detection rates.
Article
Astronomy & Astrophysics
S. Suphapolthaworn, S. Awiphan, T. Chatchadanoraset, E. Kerins, D. Specht, N. Nakharutai, S. Komonjinda, A. C. Robin
Summary: Microlensing is an effective technique for detecting low-mass planets around common stars. The Earth's microlensing signal can potentially be observed by other civilizations across the Galaxy. By analyzing the photometric microlensing signal of Earth, we identify the regions where it is most observable as the Earth microlensing zone (EMZ). The EMZ is similar to the Earth Transit Zone (ETZ) and could serve as a focal point for targeted SETI searches. However, we find that the Earth is well hidden from observers with technology similar to our own.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Oncology
Abdulkadir Elmas, Amaia Lujambio, Kuan-lin Huang
Summary: In this study, proteogenomic analyses were performed on hepatocellular carcinoma (HCC) tumors, revealing overexpressed protein targets that have therapeutic potential even in the absence of clinically actionable mutations. The study demonstrates the importance of proteomics approaches in advancing precision medicine for cancer types lacking druggable mutations.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chun-Ming Ho, Kuen-Tyng Lin, Roger Shen, De-Leung Gu, Szu-Shuo Lee, Wen-Hui Su, Yuh-Shan Jou
Summary: With the increasing incidence and mortality of hepatocellular carcinoma (HCC), identifying innovative targets for therapy is crucial. In a transcriptome analysis of HCC and mouse liver cancer, concordantly expressed genes associated with patient survival were identified. Among these genes, some were found to be enriched in sorafenib-related functions and could serve as innovative targets for combination therapy with sorafenib.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Genetics & Heredity
Waleed Iqbal, Elena V. Demidova, Samantha Serrao, Taha ValizadehAslani, Gail Rosen, Sanjeevani Arora
Summary: The study found that RRM2B is highly amplified in multiple tumor types, particularly in MYC-amplified tumors, and is associated with increased RRM2B mRNA expression. Investigation revealed that cancers with both RRM2B-amplified and MYC have a distinct pattern of amplification compared to other types of cancers.
FRONTIERS IN GENETICS
(2021)
