Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform

Assessment of intravenous pbi-shRNA PDX1 nanoparticle (OFHIRNA-PDX1) in yucatan swine

(2013) C M Jay et al.   CANCER GENE THERAPY

Predominance of β-Cell Neogenesis Rather Than Replication in Humans With an Impaired Glucose Tolerance and Newly Diagnosed Diabetes

(2013) S. Yoneda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis

(2013) Teresa Coelho et al.   NEW ENGLAND JOURNAL OF MEDICINE

First-in-Humans Trial of an RNA Interference Therapeutic Targeting VEGF and KSP in Cancer Patients with Liver Involvement

(2013) Josep Tabernero et al.   Cancer Discovery

Phase 1 dose-escalation study of a siRNA targeting the RTP801 gene in age-related macular degeneration patients

(2012) Q D Nguyen et al.   EYE

Evaluation of the siRNA PF-04523655 versus Ranibizumab for the Treatment of Neovascular Age-related Macular Degeneration (MONET Study)

(2012) Quan Dong Nguyen et al.   OPHTHALMOLOGY

PDX-1 Is a Therapeutic Target for Pancreatic Cancer, Insulinoma and Islet Neoplasia Using a Novel RNA Interference Platform

(2012) Shi-He Liu et al.   PLoS One

Adult Pancreas Side Population Cells Expand after β Cell Injury and Are a Source of Insulin-Secreting Cells

(2012) Ilia Banakh et al.   PLoS One

RNA interference and its potential applications to chronic HBV treatment: results of a Phase I safety and tolerability study

(2011) Robert G Gish et al.   ANTIVIRAL THERAPY

Hepatic cell-to-cell transmission of small silencing RNA can extend the therapeutic reach of RNA interference (RNAi)

(2011) Qiuwei Pan et al.   GUT

Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors

(2011) Dirk Strumberg et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Phase I Trial of “bi-shRNAifurin/GMCSF DNA/Autologous Tumor Cell” Vaccine (FANG) in Advanced Cancer

(2011) Neil Senzer et al.   MOLECULAR THERAPY

RNAi-Based Treatment for Neovascular Age-Related Macular Degeneration by Sirna-027

(2010) Peter K. Kaiser et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

RNA Interference Therapy in Lung Transplant Patients Infected with Respiratory Syncytial Virus

(2010) Martin R. Zamora et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PDX-1

(2010) Shi-He Liu et al.   CANCER

Enhanced target gene knockdown by a bifunctional shRNA: a novel approach of RNA interference

(2010) D D Rao et al.   CANCER GENE THERAPY

Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats

(2010) W.-C. Li et al.   JOURNAL OF CELL SCIENCE

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras

(2009) Sharon Y. Gidekel Friedlander et al.   CANCER CELL

Pancreatic Duct Glands Are Distinct Ductal Compartments That React to Chronic Injury and Mediate Shh-Induced Metaplasia

(2009) Oliver Strobel et al.   GASTROENTEROLOGY

PDX-1 Acts as a Potential Molecular Target for Treatment of Human Pancreatic Cancer

(2009) Shihe Liu et al.   PANCREAS

Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)

(2008) J DEVINCENZO et al.   ANTIVIRAL RESEARCH

Maturation of Adult β-Cells Revealed Using aPdx1/InsulinDual-Reporter Lentivirus

(2008) Marta Szabat et al.   ENDOCRINOLOGY

Not miR-ly small RNAs: Big potential for microRNAs in therapy

(2008) Tara M. Love et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic

(2008) Jeffery C Giering et al.   MOLECULAR THERAPY

The Expression Pattern of PDX-1, SHH, Patched and Gli-1 Is Associated with Pathological and Clinical Features in Human Pancreatic Cancer

(2008) Karl Quint et al.   PANCREATOLOGY