Article
Plant Sciences
Ying Chen, Hisao-Hsien Wang, Hsin-Han Chang, Yun-Hsuan Huang, Jeffrey R. Wang, Chih-Ying Changchien, Sheng-Tang Wu
Summary: The study demonstrated the anticancer effects of E-isomer GS in human bladder cancer cell lines of different grades through cell cycle regulation, apoptosis, autophagy, and other mechanisms. Additionally, GS reduced cell migration ability and inhibited tumor growth.
Article
Environmental Sciences
Chao-Yen Ho, An-Chen Chang, Chung-Hua Hsu, Te-Fu Tsai, Yi-Chia Lin, Kuang-Yu Chou, Hung-En Chen, Ji-Fan Lin, Po-Chun Chen, Thomas I-Sheng Hwang
Summary: Miconazole induces protective autophagy in bladder cancer cells, increasing lysosome formation and promoting protein phosphorylation, thus exerting an anti-tumor effect on cancer cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Applied
Yuanxiao Zhang, Yu Hai, Yuqing Miao, Xiao Qi, Weiming Xue, Yane Luo, Haiming Fan, Tianli Yue
Summary: The toxicity mechanism of superparamagnetic iron oxide nanoparticles (SPIONs) was investigated to reduce risks, with higher dosage and suitable sizes of SPIONs enhancing uptake into cells and leading to increased reactive oxygen species (ROS) formation. Smaller SPIONs tended to produce more ROS in mitochondria, damaging them, while larger SPIONs promoted ROS production in plasma to destroy cytomembrane. Different size SPIONs activated distinct cell death pathways, with ferroptosis playing a significant role in mitochondrial and cytomembrane damage. ROS levels correlated with gene expression, suggesting RNA-seq as a new method to assess oxidative stress and toxicity of nanomaterials.
Article
Cell Biology
Yasmine Messaoud-Nacer, Elodie Culerier, Stephanie Rose, Isabelle Maillet, Nathalie Rouxel, Sylvain Briault, Bernhard Ryffel, Valerie F. J. Quesniaux, Dieudonnee Togbe
Summary: Stimulator of interferon genes (STING) plays an important role in immune responses against tumors and viral infections. However, activation of the STING pathway by airway silica or smoke exposure can lead to cell death and lung inflammation. The inflammatory response induced by a synthetic STING agonist called diABZI, compared to a natural cyclic dinucleotide cGAMP, is not well understood. This study found that diABZI caused acute neutrophilic inflammation, disrupted the respiratory barrier, released DNA with formation of neutrophil extracellular traps (NETs), and triggered cell death and inflammatory cytokines associated with lung inflammation. These results suggest that using STING activators as therapeutic strategies for infections may worsen lung inflammation and lead to severe acute respiratory distress syndrome (ARDS).
CELL DEATH & DISEASE
(2022)
Article
Immunology
Aleksei Parshenkov, Thierry Hennet
Summary: Altered surface glycosylation is a major characteristic of tumor cells and can be recognized by lectins, which can distinguish tumor cells from healthy cells based on the expression of glycosylation-dependent markers. Lectins induce cell death through various pathways, and their broad cytotoxic response makes them potential candidates for therapies targeting tumor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robert Walmsley, Derek S. Steele, Georgina M. Ellison-Hughes, Sotiris Papaspyros, Andrew J. Smith
Summary: This study investigated the effects of imatinib, a receptor tyrosine kinase inhibitor, on human cardiac progenitor cells. It was found that imatinib reduced cell viability, depolarized mitochondria, increased lysosome and autophagosome content, and induced cell death through necroptosis. However, the toxicity could be rescued by RIP1 inhibition and autophagy played a partial role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yan Zhang, Ning He, Xuejian Zhou, Feifan Wang, Hairong Cai, Shih Han Huang, Xianwu Chen, Zhenghui Hu, Xiaodong Jin
Summary: Betulinic acid (BA) exhibits antitumor effects against human bladder cancer cells by triggering autophagy and apoptosis. The effects can be attenuated by inhibiting ROS production, inhibiting autophagy, or silencing ATG7. BA activates autophagy via the AMPK/mTOR/ULK1 pathway, with potential downregulation of Bmi-1 as a mechanism for autophagy-dependent apoptosis.
Article
Biochemistry & Molecular Biology
Hyung-Mun Yun, Yoon-Ju Kwon, Eonmi Kim, Hea-Jong Chung, Kyung-Ran Park
Summary: In this study, Machilin D (Mach), a lignin, was isolated from the roots of Saururus chinensis and its inhibitory effects on oral squamous cell carcinoma (OSCC) were assessed. Mach exhibited significant cytotoxicity against human OSCC cells and inhibited cell adhesion, migration, and invasion by targeting adhesion molecules, including the FAK/Src pathway. Mach also suppressed multiple signaling pathways, including the PI3K/AKT/mTOR/p70S6K pathway and MAPKs, leading to apoptotic cell death. Moreover, Mach induced autophagy and inhibited necroptosis, further enhancing its inhibitory effects on OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Wojciech Trybus, Teodora Krol, Ewa Trybus, Anna Stachurska
Summary: Physcion exerts antitumor effects by inducing oxidative stress, autophagy, and apoptosis in HeLa cells, resulting in decreased cell viability, G0/G1 phase cell cycle arrest, and activation of the lysosomal system.
Article
Pharmacology & Pharmacy
Rong Sheng Zhou, Ji Zhong Zhao, Li Ming Guo, Jia Li Guo, Aida El Makawy, Zong Yun Li, Shao Chin Lee
Summary: The study demonstrates that clinopodiside A inhibits the growth of bladder cancer cells through autophagy mediated by BLK and RasGRP2 signaling. It has a synergistic effect with cisplatin, enhancing autophagy and autophagy-promoted apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyung-Mun Yun, Ji Eun Park, Joon Yeop Lee, Kyung-Ran Park
Summary: Latif demonstrates significant anticancer effects in oral squamous cell carcinoma by inhibiting cell proliferation, migration, and invasion, inducing apoptotic cell death, targeting multiple signaling pathways, and may serve as a new therapeutic approach for patients with OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Chun-Han Chang, Bo-Jyun Lin, Chun-Han Chen, Nham-Linh Nguyen, Tsung-Han Hsieh, Jui-Hsin Su, Mei-Chuan Chen
Summary: Bladder cancer (BC) is a common and urgent medical issue, yet the current treatment approaches have limited effectiveness. This study investigated the anti-BC activity of SP-2, a triterpene isolated from a marine sponge. SP-2 suppressed BC cell viability and induced apoptosis through the inhibition of the FGFR3-TACC3/Akt/mTOR pathway, and it also triggered autophagy and upregulated DAPK2 expression to enhance cytotoxicity and apoptosis.
Article
Biochemistry & Molecular Biology
Zhaofa Yin, Juan Li, Le Kang, Xiangyang Liu, Jianguo Luo, Ling Zhang, Yuting Li, Jiarong Cai
Summary: This study demonstrated that EGCG could inhibit bladder cancer cells by inducing autophagy-related apoptosis, suggesting it as a novel therapy for bladder cancer treatment. Green tea could be considered as a tumor-preventing beverage.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Neurosciences
Carlos Alfredo Silva-Islas, Ricardo Alberto Santana-Martinez, Juan Carlos Leon-Contreras, Diana Barrera-Oviedo, Jose Pedraza-Chaverri, Rogelio Hernandez-Pando, Perla D. Maldonado
Summary: In this study, the authors investigated the activation and status of autophagy, necroptosis, and apoptosis in the striatum of rats administered with Quinolinic acid (QUIN). Their findings suggest that QUIN initially activates autophagy but on day 7, the autophagy pathway becomes blocked. This blockade leads to organelle and cellular damage, neurodegeneration, and behavioral changes that may be caused by the activation of necroptosis and apoptosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Plant Sciences
Kyung-Ran Park, Hanna Lee, Soo Hyun Kim, Hyung-Mun Yun
Summary: Paonia suffruticosa has been used as a medicinal plant in Asian countries. This study investigated the anti-cancer effects of a compound isolated from P. suffruticosa on head and neck squamous cell carcinomas (HNSCCs). The compound inhibited cell proliferation and induced apoptotic cell death in HNSCC cells, and also affected necroptosis and autophagy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)