Article
Cell Biology
Wenwen Liu, Lei Xu, Xue Wang, Daogong Zhang, Gaoying Sun, Man Wang, Mingming Wang, Yuechen Han, Renjie Chai, Haibo Wang
Summary: Activated autophagic flux in SGNs after cisplatin treatment can alleviate SGN apoptosis and related hearing loss, indicating a neuroprotective role of autophagy. The antioxidant enzyme PRDX1 plays a crucial role in modulating autophagy in SGNs, which in turn activates the PTEN-AKT signaling pathway to trigger autophagy. These findings suggest potential therapeutic targets for drug-induced SNHL through autophagy activation.
Article
Genetics & Heredity
Stetson Thacker, Charis Eng
Summary: PTEN gene is strongly associated with autism spectrum disorder, and animal models with PTEN mutations provide insight into the neurobiology and pathogenesis of autism. The study identified differential protein expression in P40, predominantly related to PTEN function and neurological processes, with ASD risk genes identified as major regulatory hubs in the affected pathways.
NPJ GENOMIC MEDICINE
(2021)
Article
Engineering, Mechanical
Nan Liu, Hongli Yang, Shasha Li, Danni Wang, Liangui Yang
Summary: The team constructed a coupling model involving p53-Mdm2 negative feedback loop and p53-PTEN-Mdm2 positive feedback loop, finding that PTEN is crucial for p53 oscillation or bistable switching dynamic behaviors, and the positive feedback loop may enrich the dynamic behaviors of the p53 system.
ACTA MECHANICA SINICA
(2021)
Article
Cell Biology
Huizhen Wang, Yifan Wang, Xin Wang, Huimi Huang, Jingfu Bao, Wenhui Zhong, Aiqing Li
Summary: PTEN plays a crucial role in renal adaptive repair by upregulating CHMP2A to alleviate cell damage, apoptosis, and renal fibrosis. PTEN overexpression promotes phagosome closure, providing a potential therapeutic target for the transition from AKI to CKD.
CELL DEATH & DISEASE
(2021)
Article
Medicine, General & Internal
Giovanni Innella, Elena Bonora, Iria Neri, Annalucia Virdi, Alba Guglielmo, Laura Maria Pradella, Claudio Ceccarelli, Laura Benedetta Amato, Anna Lanzoni, Sara Miccoli, Giuseppe Gasparre, Roberta Zuntini, Daniela Turchetti
Summary: Germline PTEN pathogenic variants cause PTEN Hamartoma Tumor Syndrome (PHTS), characterized by hamartomas, developmental anomalies, and increased cancer risk. Mucocutaneous features are crucial for diagnosing PHTS patients, with molecular analyses providing insights into the pathogenic processes induced by PTEN alterations.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Colin Carlock, Yunpeng Bai, Allison Paige-Hood, Qinglin Li, Frederick Nguele Meke, Zhong-Yin Zhang
Summary: Overexpression of PRL2 and reduced PTEN protein are frequently observed in patients with acute myeloid leukemia (AML). Inhibiting PRL2 can prolong animal survival and slow the accumulation of leukemia blasts in the bone marrow niche. This study provides evidence for the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and other PTEN-deficient cancers.
Article
Oncology
Yuan Zhang, Li Li, Xiao-Ping Ke, Ping Liu
Summary: This study identified a prognostic immunometabolic signature, SCGB2A1, for endometrial cancer (EC). The results indicate that PTEN mutation and SCGB2A1 expression are associated with immune infiltration, gene expression, and prognosis in EC patients.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Oncology
Jiayi Huang, Chunshuai Wu, Guanhua Xu, Yue Sun, Chao Gui, Jiawei Fu, Zhiming Cui, Haiming Huang
Summary: The study revealed that the decreased expression of miR-429 in SCI rat plasma exosomes promotes neuronal apoptosis, possibly through the interaction of miR-429 with the downstream target gene PTEN, thereby affecting the PI3K/Akt pathway.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Yeqian Zhang, Fengrong Yu, Bo Ni, Qing Li, Seong-Woo Bae, Jong-Ho Choi, Han-Kwang Yang, Seong-Ho Kong, Chunchao Zhu
Summary: The study revealed that DDX18 is overexpressed in gastric cancer tissues and is closely related to tumor characteristics, clinical data, and prognosis. DDX18 promotes cell proliferation, migration, and invasion while inhibiting apoptosis. DDX18 enhances the maturation of microRNA-21 by interacting with Drosha, thereby affecting the PTEN-AKT signaling pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Jiaxu Wang, Meng Li, Jing Zhang, Qing Gao, Zhaoxi Ding, Jinhao Sun
Summary: The aim of this animal study was to investigate the mechanisms underlying the efficacy of paliperidone, an antipsychotic drug approved by the US FDA for the treatment of schizophrenia. The results showed that paliperidone alleviated neuronal damage induced by MK-801 through the PP2A/PTEN pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, Research & Experimental
Jinping Li, Yaobang Liu, Bing Lian, Hong Li, Dahai Chai, Yali Gao, Yanbai Wang
Summary: This study found that histidine triad nucleotide-binding protein 3 (HINT3) is decreased in breast cancer tissues. In vitro experiments showed that HINT3 knockdown promoted the proliferation and migration of breast cancer cells, while overexpression inhibited these processes. Additionally, HINT3 inhibited breast cancer cell signaling pathway activation by upregulating phosphatase and tensin homolog (PTEN). These findings demonstrate the inhibitory role of HINT3 in the proliferation, migration, and tumor development of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Na Fang, Ping Li
Summary: OGT plays a role in DN, regulating HES1/PTEN by stabilizing histone methyltransferase EZH2 to inhibit the progression of DN.
Article
Chemistry, Physical
Iris N. Smith, Jennifer E. Dawson, Charis Eng
Summary: PTEN is a key regulator of the PI3K/AKT/mTOR signaling pathway, and its phosphorylation affects its tumor suppressor function. Mutations in PTEN are associated with PTEN hamartoma tumor syndrome and autism spectrum disorder. This study used a comparative protein structure network approach to investigate the conformational dynamics induced by PTEN phosphorylation and identified differences between PTEN-ASD and PTEN-cancer phenotypes. The findings suggest that CTT phosphorylation affects the flexibility, inter-residue contacts, and allosteric communication patterns of PTEN.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Immunology
Zixuan Wang, Xinyuan Wei, Caili Ji, Wenhua Yu, Chuanwang Song, Caizhi Wang
Summary: Prostaglandin E2 (PGE2) inhibits the phagocytosis of bacteria by neutrophils through unique G protein-coupled receptors (EP receptors) and increased intracellular cyclic adenosine monophosphate (cAMP) production. Specific signaling pathways and enzymes, such as PTEN, contribute to the regulation of neutrophil phagocytic activity by PGE2.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Article
Neurosciences
Alice Giotta Lucifero, Sabino Luzzi
Summary: PTEN gene mutations are frequently found in high-grade gliomas and are strongly associated with poor prognosis and lower survival rates. PTEN wild-type gliomas exhibit lower sensitivity to chemotherapy compared to PTEN-mutated gliomas. In addition, there is a strong positive correlation between PTEN status and the infiltration of T-reg and M2 macrophages. These findings highlight the importance of PTEN gene in high-grade gliomas and provide potential clues for new therapeutic strategies.