Article
Virology
Emily A. Bates, John R. Counsell, Sophie Alizert, Alexander T. Baker, Natalie Suff, Ashley Boyle, Angela C. Bradshaw, Simon N. Waddington, Stuart A. Nicklin, Andrew H. Baker, Alan L. Parker
Summary: Species D adenoviruses, such as human adenovirus type 49 (HAdV-D49), show promise for gene therapy applications due to their low pre-existing immunity rates. HAdV-D49 exhibits a broad range of cell transduction capabilities and interacts with various surface molecules for cell entry. Additionally, compared to adenovirus type 5, HAdV-D49 vectors demonstrate reduced liver targeting but maintain transduction of lung and spleen tissues.
Article
Oncology
Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Samara Singh, Siddharth Mehra, Vanessa T. Garrido, Xinyu Guo, Luis A. Nivelo, Despina S. Kolonias, Shannon J. Saigh, Eric Wieder, Christine I. Rafie, Austin R. Dosch, Zhiqun Zhou, Oliver Umland, Haleh Amirian, Ifeanyichukwu C. Ogobuiro, Jian Zhang, Yuguang Ban, Carina Shiau, Nagaraj S. Nagathihalli, Elizabeth A. Montgomery, William L. Hwang, Roberta Brambilla, Krishna Komanduri, Alejandro V. Villarino, Eneda Toska, Ben Z. Stanger, Dmitry I. Gabrilovich, Nipun B. Merchant, Jashodeep Datta
Summary: We have found that the KRAS-TP53 genomic coalteration in PDAC patients is associated with immune-excluded microenvironments, chemoresistance, and poor survival. By studying the cell-autonomous Cxcl1 in PDAC, we have discovered its role in spatial T-cell restriction via interactions with neutrophilic myeloid-derived suppressor cells. Our findings reveal the cross-talk between cancer cells and neutrophils, and the involvement of TNF signaling in promoting immunosuppression and stromal inflammation in pancreatic tumor microenvironments.
Article
Multidisciplinary Sciences
Koki Yanazawa, Takehito Sugasawa, Kai Aoki, Takuro Nakano, Yasushi Kawakami, Kazuhiro Takekoshi
Summary: This study developed a method for detecting gene doping using rAdV, which was validated through cell line experiments and mouse injections. The results suggest the potential application of this method in detecting gene doping in blood samples.
Article
Multidisciplinary Sciences
Yuanhuan Yu, Xin Wu, Meiyan Wang, Wenjing Liu, Li Zhang, Ying Zhang, Zhilin Hu, Xuantong Zhou, Wenzheng Jiang, Qiang Zou, Fengfeng Cai, Haifeng Ye
Summary: The authors of this study developed an optogenetic-controlled cell therapy approach using engineered cells loaded into a hydrogel scaffold to prevent tumor recurrence after surgery. The engineered cells were able to release specific cytokines upon illumination, leading to sustained immune activation and the prevention of tumor recurrence. This approach offers a safe and precise treatment option for solid tumors.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Wendong Lan, Lulu Quan, Yiqiang Li, Junxian Ou, Biyan Duan, Ting Mei, Xiao Tan, Weiwei Chen, Liqiang Feng, Chengsong Wan, Wei Zhao, James Chodosh, Donald Seto, Qiwei Zhang
Summary: A novel simian adenovirus (SAdV) was isolated and used to construct gene therapy and vaccine vectors. The virus had low pre-existing neutralizing antibody levels and showed potential applications. The study also revealed the critical role of the E3 region in the virus replication in human cells.
JOURNAL OF VIROLOGY
(2023)
Review
Oncology
Xiaoxi Wang, Liping Zhong, Yongxiang Zhao
Summary: Immunogene therapy and oncolytic viruses play important roles in antitumor treatment by enhancing immune effects through genetic engineering and targeting tumor cells specifically for replication and killing, respectively. Modifying the tumor microenvironment is crucial for maximizing the efficacy of oncolytic viruses in combating malignant tumors.
Article
Multidisciplinary Sciences
Marisa K. Kilgour, Sarah MacPherson, Lauren G. Zacharias, Abigail E. Ellis, Ryan D. Sheldon, Elaine Y. Liu, Sarah Keyes, Brenna Pauly, Gillian Carleton, Bertrand Allard, Julian Smazynski, Kelsey S. Williams, Peter H. Watson, John Stagg, Brad H. Nelson, Ralph J. DeBerardinis, Russell G. Jones, Phineas T. Hamilton, Julian J. Lum
Summary: Immune regulatory metabolites in the tumor microenvironment, such as 1-methylnicotinamide (MNA), play a key role in modulating T cell responses. Despite the elevated levels of MNA in T cells infiltrating tumors, the enzyme catalyzing MNA transfer is restricted to fibroblasts and tumor cells. Functionally, MNA induces T cells to secrete tumor-promoting cytokines, suggesting it as a potential immunotherapy target for human cancer treatment.
Review
Cell Biology
David Mai, Carl H. June, Neil C. Sheppard
Summary: Cancer is not only a disease of pathological cells, but also a disease of immune hypofunction. Personalized cellular therapies are crucial for mitigating the disease, and gene-modulating approaches have made this therapy more feasible and effective. The advancing technologies offer opportunities for direct, in vivo precision medicine against cancer.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Anna Voznesenskaya, Per-Olof Berggren, Erwin Ilegems
Summary: This study characterized the transduction performance of AAV serotype 8 (AAV8) and human adenovirus type 5 (AdV5) during pseudoislet formation. The results provide a reference for future studies using AAVs for gene transfer to islet cell organoids and facilitate the development of high-quality engineered pseudoislets for clinical transplantation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Huifeng Fan, Bingtai Lu, Can Cao, Hui Li, Diyuan Yang, Li Huang, Tao Ding, Minhao Wu, Gen Lu
Summary: In pediatric HAdV pneumonia, TNFSF/TNFRSF members function as key molecules in local and systemic inflammatory network, and the plasma TNFSF13B and TNFSF14 may be the potential local and systemic inflammatory indicators of severe HAdV pneumonia in pediatric patients. The levels of these inflammatory cytokines are positively correlated with the severity of the disease and lung lesions in children with HAdV pneumonia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Mengya Zhong, Zhijian Chen, Yang Yan, Argen Bahet, Xin Cai, Huiyu Chen, Honggang Ran, Kaiyong Qu, Zhaopu Han, Guohong Zhuang, Shifeng Zhang, Yinan Wang
Summary: The mRNA expression levels of the TIPE family members in CRC tissues were significantly downregulated compared with adjacent tissues, with discrepancies between the protein levels and mRNA levels of TNFAIP8 and TIPE3. TIPE2 showed strong linear associations with TNFAIP8 and TIPE1, and its mRNA levels were significantly associated with sex in CRC patients. Moreover, TNFAIP8, TIPE2, and TIPE3 mRNA levels were downregulated in colon adenocarcinoma patients compared to normal controls, indicating potential roles of the TIPE family in CRC carcinogenesis.
Article
Biochemistry & Molecular Biology
Ping Li, Yang Yang, Xinyu Yang, Yifei Wang, Chon-Kit Chou, Mengmeng Jiang, Jingbin Zheng, Fengyang Chen, Xin Chen
Summary: The study found that TNF receptor type II (TNFR2) is expressed in a wide range of tumor cells. Knocking out TNFR2 in mouse colon cancer cells MC38 and CT26 using CRISPR/Cas9 technology inhibited in vitro proliferation and colony formation of cancer cells through inhibition of AKT phosphorylation and promotion of autophagy-induced cell death. In addition, TNFR2 deficiency significantly impaired the in vivo growth of MC38 or CT26 tumors in mice, accompanied by a decrease in soluble TNFR2 levels in the circulation and an increase in the number of tumor-infiltrating IFN gamma+ CD8 cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jing Li, Tereza Brachtlova, Ida H. van der Meulen-muileman, Stijn Kleerebezem, Chang Liu, Peiyu Li, Victor W. van Beusechem
Summary: Non-small cell lung cancer (NSCLC) xenograft tumor assays were established on the chorioallantoic membrane (CAM) of chicken embryos to promote preclinical development of new treatments. The A549 and H460 cell lines showed promising results and were further characterized in terms of tumor growth and susceptibility to chemotherapy and gene delivery using viral vectors. The study demonstrated that systemic treatment with Pemetrexed and Cisplatin inhibited tumor growth, and adenoviral vectors showed higher transduction efficiency compared to lentiviral vectors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Shirley Cohen-Mekelburg, Beth I. Wallace, Tony Van, Wyndy L. Wiitala, Shail M. Govani, Jennifer Burns, Rachel Lipson, Huifeng Yun, Jason Hou, James D. Lewis, Jason A. Dominitz, Akbar K. Waljee
Summary: This study in a national cohort of veterans examined the association between the use of anti-TNF or corticosteroids and all-cause mortality in patients with IBD. Results suggest that anti-TNF therapy may be linked to reduced mortality compared with prolonged corticosteroid use, particularly among patients with Crohn disease.
Article
Immunology
Shotaro Kawano, Hiroki Mitoma, Shoichiro Inokuchi, Yusuke Yamauchi, Kana Yokoyama, Jumpei Nogami, Yuichiro Semba, Masahiro Ayano, Yasutaka Kimoto, Mitsuteru Akahoshi, Nobuyuki Ono, Yojiro Arinobu, Koichi Akashi, Takahiko Horiuchi, Hiroaki Niiro
Summary: The study demonstrates that TNFR2-stimulated Tfr cells have the ability to regulate Tfh and B cells, and can modulate GC reactions. Stimulation of Tfr cells through TNFR2 in vitro may be beneficial for controlling GC reactions in inflammatory and autoimmune diseases.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Raja R. Narayan, John M. Creasy, Debra A. Goldman, Mithat Gonen, Cyriac Kandoth, Ritika Kundra, David B. Solit, Gokce Askan, David S. Klimstra, Olca Basturk, Peter J. Allen, Vinod P. Balachandran, Michael D'Angelica, Ronald P. DeMatteo, Jeffrey A. Drebin, T. Peter Kingham, Amber L. Simpson, Ghassan K. Abou-Alfa, James J. Harding, Eileen M. O'Reilly, Jean M. Butte, Ryusei Matsuyama, Itaru Endo, William R. Jarnagin
Article
Oncology
Marcus Noel, Eileen M. O'Reilly, Brian M. Wolpin, David P. Ryan, Andrea J. Bullock, Carolyn D. Britten, David C. Linehan, Brian A. Belt, Eric C. Gamelin, Bishu Ganguly, Donghua Yin, Tenshang Joh, Ira A. Jacobs, Carrie T. Taylor, Maeve A. Lowery
INVESTIGATIONAL NEW DRUGS
(2020)
Article
Medicine, General & Internal
Talia Golan, Pascal Hammel, Michele Reni, Eric Van Cutsem, Teresa Macarulla, Michael J. Hall, Joon-Oh Park, Daniel Hochhauser, Dirk Arnold, Do-Youn Oh, Anke Reinacher-Schick, Giampaolo Tortora, Hana Alguel, Eileen M. O'Reilly, David McGuinness, Karen Y. Cui, Katia Schlienger, Gershon Y. Locker, Hedy L. Kindler
NEW ENGLAND JOURNAL OF MEDICINE
(2019)
Article
Oncology
Rajiv Agarwal, Elyse Shuk, Danielle Romano, Margaux Genoff, Yuelin Li, Eileen M. O'Reilly, William Breitbart, Angelo E. Volandes, Andrew S. Epstein
SUPPORTIVE CARE IN CANCER
(2020)
Article
Oncology
Zishuo Ian Hu, Johanna C. Bendell, Andrea Bullock, Noelle K. LoConte, Hassan Hatoum, Paul Ritch, Hugo Hool, Joseph W. Leach, James Sanchez, Davendra P. S. Sohal, John Strickler, Ravindranath Patel, Andrea Wang-Gillam, Irfan Firdaus, Kenneth H. Yu, Ann M. Kapoun, Eric Holmgren, Lei Zhou, Jakob Dupont, Vincent Picozzi, Vaibhav Sahai, Eileen M. O'Reilly
Article
Oncology
Eileen M. O'Reilly, Do-Youn Oh, Neesha Dhani, Daniel J. Renouf, Myung Ah Lee, Weijing Sun, George Fisher, Aram Hezel, Shao-Chun Chang, Gordana Vlahovic, Osamu Takahashi, Yin Yang, David Fitts, Philip Agop Philip
Article
Oncology
P. Hammel, H. L. Kindler, M. Reni, E. Van Cutsem, T. Macarulla, M. J. Hall, J. O. Park, D. Hochhauser, D. Arnold, D-Y Oh, A. Reinacher-Schick, G. Tortora, H. Alguel, E. M. O'Reilly, D. McGuinness, K. Y. Cui, S. Joo, H. K. Yoo, N. Patel, T. Golan, Lorraine Chantrill, David Goldstein, Warren Joubert, Nick Pavlakis, Annette Tognela, Eric Van Cutsem, Frank Van Fraeyenhove, Jean-Luc Van Laethem, Marc Peeters, Neesha Dhani, Petr Kavan, Frederic Lemay, Antoine Adenis, Pascal Artru, Nabil Hamed, Christine Belletier, Meher Ben Abdelghani, Jean-Frederic Blanc, Christophe Borg, Romain Coriat, Gael Deplanque, Roger Faroux, Philippe Follana, Rosine Guimbaud, Farid el Hajbi, Pascal Hammel, Vincent Hautefeuille, David Malka, Jean-Philippe Metges, David Tougeron, Thomas Walter, Hana Alguel, Thomas Ettrich, Ulrich Thorsten Hacker, Elke Hennes, Lutz Jacobasch, Stephan Kanzler, Ursula Pession, Anke Reinacher-Schick, Christian Scholz, Marianne Sinn, Alexander Stein, Christian Strassburg, Arndt Vogel, Menachem Ben-Shahar, Ronen Brenner, Ron Epelbaum, Ravit Geva, Alexander Gluzman, Talia Golan, Efraim Idelevich, Maya Kolin, Valeriya Semenisty, Ayelet Shai, Salomon Stemmer, Nirit Yarom, Luigi Celio, Pierfranco Conte, Carlo Garufi, Luca Gianni, Francesco Leonardi, Evaristo Maiello, Mariacristina Di Marco, Michele Milella, Carmine Pinto, Daniele Santini, Mario Scartozzi, Giampaolo Tortora, Vanja Vaccaro, Enrico Vasile, Ji-Won Kim, Jin-Won Kim, Youn Oh, Joon Oh Park, Hanneke Wilmink, Rafael Alvarez Gallego, Gema Duran Ogalla, Adelaida Garcia Velasco, Elena Garralda Cabanas, Carlos Gomez Martin, Carmen Guillen Ponce, Berta Laquente Saez, Rafael Lopez, Teresa Macarulla, Andres Munoz Martin, Roberto Pazo, Carles Pericay Pijaume, Javier Rodriguez, Ricardo Yaya-Tur, Arvind Arora, David Alan Anthoney, T. R. Jeffrey Evans, Mark Harrison, Daniel Hochhauser, Daniel Palmer, Debashis Sarker, Naureen Starling, Juan Valle, Lucy Wall, Richy Agajanian, James Bearden, Tanios Bekaii-Saab, Corey Carter, Deirdre Cohen, Alfred DiStefano, Tomislav Dragovich, Samuel Ejadi, James Ford, Stephen Grabelsky, Michael Hall, Howard Hochster, Peter Hosein, Milind Javle, Hedy Kindler, Jill Lacy, Daniel Laheru, Stephen Leong, Maeve Lowery, Robert Marsh, Anne Noonan, Paul Oberstein, Allyson Ocean, Eileen O'Reilly, David Ryan, Tara Seery, Somasundaram Subramaniam, David Van Echo, Andrea Wang-Gillam, Colin Weekes, Stephen Welch
ANNALS OF ONCOLOGY
(2019)
Article
Oncology
E. M. O'Reilly, J. F. Hechtman
ANNALS OF ONCOLOGY
(2019)
Article
Oncology
Alice C. Wei, Fang-Shu Ou, Qian Shi, Xiomara Carrero, Eileen M. O'Reilly, Jeffrey Meyerhardt, Robert A. Wolff, Hedy L. Kindler, Douglas B. Evans, Vikram Deshpande, Joseph Misdraji, Eric Tamm, Dushyant Sahani, Malcolm Moore, Elliot Newman, Nipun Merchant, Jordan Berlin, Laura W. Goff, Peter Pisters, Mitchell C. Posner
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Nitya Raj, Youyun Zheng, Virginia Kelly, Seth S. Katz, Joanne Chou, Richard K. G. Do, Marinela Capanu, Dmitriy Zamarin, Leonard B. Saltz, Charlotte E. Ariyan, Brian R. Untch, Eileen M. O'Reilly, Anuradha Gopalan, Michael F. Berger, Kelly Olino, Neil H. Segal, Diane L. Reidy-Lagunes
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Hannah Maynard, Zsofia K. Stadler, Michael F. Berger, David B. Solit, Michele Ly, Maeve A. Lowery, Diana Mandelker, Liying Zhang, Emmett Jordan, Mane El Dika, Yelena Kernel, Marc Ladanyi, Mark E. Robson, Eileen M. O'Reilly, Ghassan K. Abou-Alfa
Letter
Oncology
Gordon Taylor Moffat, Andrew S. Epstein, Eileen M. O'Reilly
Correction
Multidisciplinary Sciences
Philip Jonsson, Chaitanya Bandlamudi, Michael L. Cheng, Preethi Srinivasan, Shweta S. Chavan, Noah D. Friedman, Ezra Y. Rosen, Allison L. Richards, Nancy Bouvier, S. Duygu Selcuklu, Craig M. Bielski, Wassim Abida, Diana Mandelker, Ozge Birsoy, Liying Zhang, Ahmet Zehir, Mark T. A. Donoghue, Jose Baselga, Kenneth Offit, Howard I. Scher, Eileen M. O'Reilly, Zsofia K. Stadler, Nikolaus Schultz, Nicholas D. Socci, Agnes Viale, Marc Ladanyi, Mark E. Robson, David M. Hyman, Michael F. Berger, David B. Solit, Barry S. Taylor
Review
Oncology
Quisette P. Janssen, Eileen M. O'Reilly, Casper H. J. Van Eijck, Bas Groot Koerkamp
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Lukas Perkhofer, Talia Golan, Pieter-Jan Cuyle, Tamara Matysiak-Budnik, Jean-Luc Van Laethem, Teresa Macarulla, Estelle Cauchin, Alexander Kleger, Alica K. Beutel, Johann Gout, Albrecht Stenzinger, Eric Van Cutsem, Joaquim Bellmunt, Pascal Hammel, Eileen M. O'Reilly, Thomas Seufferlein
Summary: Pancreatic cancer is a devastating malignant disease with limited treatment options, and around 14% of patients have mutations in genes related to DNA repair, which may benefit from tailored therapeutic interventions. Consensus recommendations from an expert panel aim to provide guidance for treating pancreatic cancer with mutations in DNA damage repair genes.