Article
Immunology
Chuan Wang, Nur Syafinaz Zainal, San Jiun Chai, James Dickie, Chai Phei Gan, Natasha Zulaziz, Bryan Kit Weng Lye, Ruhcha Sutavani, Christian H. Ottensmeier, Emma King, Mannil Thomas Abraham, Siti Mazlipah Binti Ismail, Shin Hin Lau, Thomas George Kallarakkal, Kein Seong Mun, Rosnah Binti Zain, Zainal Ariff Abdul Rahman, Gareth J. Thomas, Sok Ching Cheong, Natalia Savelyeva, Kue Peng Lim
Summary: HPV-independent head and neck squamous cell carcinoma (HNSCC) is a common cancer globally, and a novel DNA vaccine has been shown to promote T cell infiltration and control tumor growth, leading to improved clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Robert L. Ferris, Jessica Moskovitz, Sheryl Kunning, Ayana T. Ruffin, Carly Reeder, James Ohr, William E. Gooding, Seungwon Kim, Brian J. Karlovits, Dario A. A. Vignali, Umamaheswar Duvvuri, Jonas T. Johnson, Daniel Petro, Dwight E. Heron, David A. Clump, Tullia C. Bruno, Julie E. Bauman
Summary: This study investigated the addition of ipilimumab to standard cetuximab-radiotherapy for the treatment of HNSCC. The results showed that the regimen was tolerable and achieved acceptable survival rates. Additionally, high expression of coinhibitory receptors on baseline tumor-infiltrating lymphocytes was associated with poorer disease-free survival.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Nabil F. F. Saba, Saagar Pamulapati, Bhamini Patel, Mayur Mody, Primoz Strojan, Robert Takes, Antti A. A. Maekitie, Oded Cohen, Pia Pace-Asciak, Jan B. B. Vermorken, Carol Bradford, Arlene Forastiere, Yong Teng, Andreas Wieland, Alfio Ferlito
Summary: Head and neck cancer (HNC) is a common malignancy, with oropharyngeal squamous cell carcinoma (OPSCC) being the majority of cases. The incidence of HPV-related OPSCC, caused by human papillomavirus (HPV), is increasing rapidly. Immunotherapy has shown promise in managing recurrent and metastatic HNC, leading to interest in its application for HPV-related OPSCC. This review focuses on the immune characteristics and potential for immunotherapy in this virus-driven cancer.
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Hidekiyo Yamaki, Michihisa Kono, Risa Wakisaka, Hiroki Komatsuda, Takumi Kumai, Ryusuke Hayashi, Ryosuke Sato, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, Kan Kishibe, Miki Takahara, Tatsuya Hayashi, Hiroya Kobayashi, Akihiro Katada
Summary: Brachyury is a transcription factor involved in mesoderm formation and differentiation, and its overexpression is associated with poor prognosis in many cancers. This study identified antigenic peptide segments derived from Brachyury that can induce tumor-reactive T cells. Combination therapy using PD-1/PD-L1 blockade and GEM enhances the tumor-reactivity of Brachyury-reactive T cells. These findings suggest that immunotherapy targeting Brachyury with peptide, GEM, and immune checkpoint blockade holds promise for the treatment of head and neck cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Virology
Qiang Xu, Ye Chen, Yuan Jin, Zhiyu Wang, Haoru Dong, Andreas M. Kaufmann, Andreas E. Albers, Xu Qian
Summary: The incidence of HR-HPV-driven HNSCC is increasing globally, and it has distinct molecular and clinical characteristics compared to HPV-uninvolved cases. Nanotechnology has played a significant role in personalized cancer therapy, including the development of HPV-E6 or -E7 vaccines based on plasmid, messenger RNA or peptide, the design and utilization of nanoparticles for targeting cancer cells and activating certain immunology pathways, as well as chemotherapy and photothermal treatment. However, breakthroughs in nanomedicine are still awaited.
Review
Oncology
Morena Fasano, Carminia Maria Della Corte, Raimondo Di Liello, Giuseppe Viscardi, Francesca Sparano, Maria Lucia Iacovino, Fernando Paragliola, Antonio Piccolo, Stefania Napolitano, Giulia Martini, Floriana Morgillo, Salvatore Cappabianca, Fortunato Ciardiello
Summary: Immunotherapy has revolutionized the treatment of Head and Neck cancer, but there is still limited understanding of its efficacy and resistance mechanisms. Cost-effectiveness analysis and effective patient selection should be encouraged. New biomarker research involving innate immunity, regulatory T lymphocytes, and the microbiome shows promise in improving treatment outcomes.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Immunology
Elin Aamdal, Else Marit Inderberg, Espen Basmo Ellingsen, Wenche Rasch, Paal Fredrik Brunsvig, Steinar Aamdal, Karen-Marie Heintz, Daniel Vodak, Sigve Nakken, Eivind Hovig, Marta Nyakas, Tormod Kyrre Guren, Gustav Gaudernack
Summary: Combining the therapeutic cancer vaccine UV1 with ipilimumab showed good tolerability and efficacy in patients with metastatic melanoma. The rapid expansion of UV1-specific Th1 cells in the majority of patients post-treatment suggests synergy between the UV1 vaccine and CTLA-4 blockade, potentially leading to clinical benefits.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Juliana Runnels, Julie R. Bloom, Kristin Hsieh, Daniel R. Dickstein, Yuhao Shi, Brianna M. Jones, Eric J. Lehrer, Richard L. Bakst
Summary: Head and neck squamous cell carcinoma (HNSCC) is a prevalent and deadly disease worldwide. Immunotherapy has shown promise as a treatment option for HNSCC, and combining it with radiation therapy (RT) may enhance effectiveness. This review highlights the advantages of combining RT and immunotherapy, such as improved tumor response rates, increased survival, and reduced toxicity, while also discussing the challenges in redefining the standard of care and the need for further research.
Editorial Material
Oncology
Shrikant B. Mali
Summary: Liquid biopsy is a valuable tool in personalized medicine, providing real-time monitoring of cancer progression and patient follow-up. This minimally invasive procedure analyzes circulating tumor cells (CTCs) and various circulating tumor-derived materials, such as ctDNA, miRNAs, and EVs. CTC analysis has significant implications for prognosis, minimal residual disease (MRD) detection, treatment selection, and cancer patient monitoring.
Article
Oncology
Avanti Verma, Barbara Burtness
Summary: Advances in treatment deintensification for human papillomavirus-associated oropharyngeal cancer include the use of transoral surgery to reduce the need for postoperative therapy. Trials have shown high progression-free survival rates for intermediate and favorable risk patients treated with radiation or chemoradiation. Immunotherapy shows promise in first-line treatment of recurrent and metastatic head and neck cancer, particularly in patients with nasopharyngeal cancer.
Article
Multidisciplinary Sciences
Christiane S. Eberhardt, Haydn T. Kissick, Mihir R. Patel, Maria A. Cardenas, Nataliya Prokhnevska, Rebecca C. Obeng, Tahseen H. Nasti, Christopher C. Griffith, Se Jin Im, Xu Wang, Dong M. Shin, Mary Carrington, Zhuo G. Chen, John Sidney, Alessandro Sette, Nabil F. Saba, Andreas Wieland, Rafi Ahmed
Summary: The study identified different transcriptional subsets of HPV-specific CD8 T cells in HPV-positive head and neck cancer, highlighting the potential response to PD-1 blockade. Furthermore, the inclusion of E2 and E5 proteins in HPV therapeutic vaccines should be considered to elicit a broader tumor-reactive CD8 T cell response.
Review
Oncology
Simon Beyaert, Jean-Pascal Machiels, Sandra Schmitz
Summary: Therapeutic vaccines are administered to cancer patients to stimulate an immune T cell response against specific antigens, with the challenge of considering tumor heterogeneity. Current research in therapeutic vaccines focuses on viral or non-viral antigens, particularly in head and neck cancers, with advancements seen in clinical trials and FDA approvals for certain treatments.
Article
Biochemistry & Molecular Biology
Xun Yuan, Ming Yi, Wei Zhang, Linping Xu, Qian Chu, Suxia Luo, Kongming Wu
Summary: The development of immune checkpoint inhibitors has revolutionized treatment for head and neck cancer, but patients often exhibit primary resistance to immunotherapy. Ongoing trials are exploring combinations of immunotherapy with other interventions to improve treatment outcomes. As novel strategies are leveraged, the significance of immunotherapy in recurrent/metastatic head and neck cancer is being further revealed.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Review
Oncology
Ricklie Julian, Malvi Savani, Julie E. Bauman
Summary: HPV-positive head and neck squamous cell carcinoma (HNSCC) differs from HPV-negative HNSCC in molecular, pathological, and clinical features, showing a better response to immunotherapy. Numerous clinical trials are underway to further refine the application of immunotherapy specifically for HPV-positive HNSCC.
Correction
Acoustics
Maria Cristina Chammas, Marcelo Straus Takahashi, Raquel Ajub Moyses, Celine Pompeia, Marcos Roberto Tavares, Giovanni Guido Cerri
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Acoustics
Maria Crisitna Chammas, Marcelo Straus Takahashi, Raquel Ajub Moyses, Celine Pompeia, Marcos Roberto Tavares, Giovanni Guido Cerri
Summary: In this study, we introduce a new B-mode ultrasound examination technique for assessing cheek tumors. By imaging with the patient's oral cavity filled with water, the extent and characteristics of the lesions can be clearly evaluated. Compared to the conventional empty mouth technique, this method shows higher accuracy in determining the extent of the lesions.
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Peripheral Vascular Disease
Suellen Ferreira Chagas, Divanei Zaniqueli, Marcelo Perim Baldo, Paulo Andrade Lotufo, Bruce B. Duncan, Rosane Harter Griep, Isabela Martins Bensenor, Rafael de Oliveira Alvim, Jose Geraldo Mill
Summary: Salt intake has direct and body mass index (BMI)-mediated effects on blood pressure (BP) in normotensive individuals, but not in hypertensive individuals.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Urology & Nephrology
Daniella Teixeira Bezerra, Andreia La Selva, Rebeca Boltes Cecatto, Alessandro Melo Deana, Renato Araujo Prates, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Ana Luiza Cabrera Martimbianco, Celine Frochot, Benedito Jorge Pereira, Flavia Rossi, Marcelo Jenne Mimica, Anna Carolina Ratto Tempestini Horliana
Summary: Infections are a significant cause of death in patients on maintenance hemodialysis. This study compares photodynamic therapy and mupirocin treatment for nasal carriers of Staphylococcus aureus, finding that both treatments had similar rates of success in eliminating the bacteria. Photodynamic therapy shows promise as an alternative treatment that does not induce resistance.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Biology
C. Szlejf, A. F. M. Batista, L. Bertola, P. A. Lotufo, I. M. Bensenor, A. D. P. Chiavegatto Filho, C. K. Suemoto
Summary: Machine learning models were developed and tested to predict cognitive impairment based on primary care data, showing good discrimination and high specificity. This can optimize resource allocation and support the detection of patients who would not benefit from cognitive assessment.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Aida de Melo Spilack, Alessandra C. Goulart, Bianca de Almeida-Pititto, Carolina Castro Porto Silva Janovsky, Paulo A. Lotufo, Itamar de Souza Santos, Isabela M. Bensenor
Summary: The association of subclinical hypothyroidism and diabetes with carotid Intima-Media Thickness (cIMT) as a surrogate marker for early cardiovascular disease was analyzed. Diabetes was found to be associated with higher cIMT values. However, no additive effect of subclinical hypothyroidism associated with diabetes over cIMT was detected.
Article
Biochemical Research Methods
Frederico Carlos Jana Neto, Ana Luiza Cabrera Martimbianco, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori, Gustavo Porto Alves, Paulo Victor Dias Almeida, Felipe Guimaraes Delgado, Lucas Resende Fonseca, Maiara Zeni Graiff Gama, Mariana Djrdjrjan Jorge, Michael R. R. Hamblin, Kristianne Porta Santos Fernandes
Summary: This study evaluated the efficacy and safety of multiwavelength photobiomodulation (MPBM) in healing soft tissue injuries associated with tibial and/or ankle fractures. MPBM showed improvement in wound healing, daily pain scores, and reduced infection occurrence at the surgical pin sites. MPBM group also had faster wound resolution time. Subgroup analysis indicated greater improvement in less severe patients.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Biochemical Research Methods
Zenildo Santos Silva, Lucas Andreo Dias dos Santos, Marcela Leticia Leal Goncalves, Juliana Maria Altavista Sagretti Gallo, Tamiris da Silva, Lara Jansiski Motta, Elaine Marcilio Santos, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori
Summary: This study evaluated the potential of photodynamic therapy (PDT) using blue light-emitting diode (LED) 460 nm and three different concentrations of acai extracts (100, 40, and 10 mg/ml) in head and neck tumor cells (SCC9). The results showed that the combination of acai extract and PDT with blue LED significantly decreased cell viability and proliferation.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Pharmacology & Pharmacy
Adriana Nancy Medeiros dos Santos, Daniela Souza Farias-Iao, Isabela M. Bensenor, Alessandra C. Goulart, Andre R. Brunoni, Maria Carmen Viana, Paulo A. Lotufo, Claudia Kimie Suemoto
Summary: This study investigated the association between the use of potentially inappropriate medications (PIM) and medications that may impair cognition (PIM-Cog) with cognitive performance among older adults. The study found that the use of PIM and PIM-Cog was associated with poor cognitive function. Therefore, reviewing the use of PIM and deprescribing these drugs may be an effective way to improve cognitive function.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Correction
Pharmacology & Pharmacy
Adriana Nancy Medeiros dos Santos, Daniela Souza Farias-Itao, Isabela M. Bensenor, Alessandra C. Goulart, Andre R. Brunoni, Maria Carmen Viana, Paulo A. Lotufo, Claudia Kimie Suemoto
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Dermatology
Daysi da C. Tobelem, Lucas Andreo, Tamiris Silva, Taina C. S. Malavazzi, Andreia Martinelli, Anna Carolina R. T. Horliana, Kristianne P. S. Fernandes, Sandra K. Bussadori, Raquel A. Mesquita-Ferrari
Summary: The study aimed to analyze the effects of noninvasive vascular photobiomodulation (VPBM) on recovery following spinal cord injury (SCI). The results showed that early VPBM treatment improved neuromuscular repair and functional recovery after SCI, highlighting the importance of VPBM in treating spinal cord injuries.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Medicine, General & Internal
Erick Frank Bragato, Jefferson Andre Pires, Marcos Momolli, Marina Bertoni Guerra, Adriana Fernandes Paisano, Raquel Agnelli Mesquita Ferrari, Sandra Kalil Bussadori, Lara Jansiski Motta, Kristianne Porta Santos Fernandes
Summary: Skin aging is influenced by age and external factors, and photobiomodulation with red light-emitting diodes has shown benefits for rejuvenation. However, there is variability in treatment parameters and frequency of application.
Article
Medicine, Research & Experimental
Luiz Filipe Barbosa Martins, Leandro Rodrigues de Sena, Diego Martins de Paula, Victor Pinheiro Feitosa, Anna Carolina Ratto Tempestini Horliana, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Lara Jansiski Motta, Marcela Leticia Leal Goncalves, Sandra Kalil Bussadori
Summary: This study aims to evaluate the effectiveness of aPDT with Bixa orellana extract in deep caries lesions. A total of 160 teeth with deep occlusal dental caries will be divided into four groups for different treatments. Clinical and radiographic follow-up will be conducted after treatment, along with microbiological analysis. The efficacy of treatments will be assessed through microbiological, radiographic, and clinical examinations.
Letter
Radiology, Nuclear Medicine & Medical Imaging
Ricardo Miguel Costa de Freitas, Felipe Augusto Brasileiro Vanderlei, Matheus Gerhard Rosenfeld, Alessandra de Pinho Pimenta Borges, Luiz Paulo Kowalski, Maria Cristina Chammas
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Immunology
Jamille Ramos Oliveira, Cesar Manuel Remuzgo Ruiz, Rafael Rahal Guaragna Machado, Jhosiene Yukari Magawa, Isabela Pazotti Daher, Alysson Henrique Urbanski, Gabriela Justamante Haendel Schmitz, Helen Andrade Arcuri, Marcelo Alves Ferreira, Greyce Luri Sasahara, Giuliana Xavier de Medeiros, Roberto Carlos Vieira Silva Jr, Edison Luiz Durigon, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Deborah Schechtman, Helder. I. I. Nakaya, Edecio Cunha-Neto, Gabriele Gadermaier, Jorge Kalil, Veronica Coelho, Keity Souza Santos
Summary: This study used an RBD peptide microarray to identify differences in immunodominant regions between COVID-19 convalescents and vaccinated individuals. They found that a specific peptide, P44, was recognized by 68% of convalescents and correlated with neutralizing antibody titers. This suggests that P44 is a relevant and potential target for neutralizing activity.
FRONTIERS IN IMMUNOLOGY
(2023)
