Article
Biochemistry & Molecular Biology
Souvick Roy, Mitsuro Kanda, Sachiyo Nomura, Zhongxu Zhu, Yuji Toiyama, Akinobu Taketomi, James Goldenring, Hideo Baba, Yasuhiro Kodera, Ajay Goel
Summary: This study developed a non-invasive liquid biopsy method for early detection of gastric cancer by using circular RNAs (circRNAs) as biomarkers. The researchers identified a panel of 8 circRNAs that could reliably distinguish gastric cancer patients from non-disease controls, even in early-stage patients. The decreased expression of circRNAs in serum samples suggested their tumor specificity.
Review
Endocrinology & Metabolism
Fang Yang, Jun Tang, Zihao Zhao, Chunling Zhao, Yuancai Xiang
Summary: Ovarian cancer is the fifth leading cause of cancer-related mortality in women worldwide. Despite limitations in traditional treatment methods and biomarkers, circulating tumor DNA (ctDNA) shows promise as a biomarker for ovarian cancer, offering potential for early detection and personalized treatment strategies. However, technical and biological hurdles still need to be addressed before integrating ctDNA assays into clinical practice for cancer screening.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Chemistry, Analytical
Linyang Fan, Xiaoyi Chong, Minzhi Zhao, Fei Jia, Zihua Wang, Ying Zhou, Xiao Lu, Qiongrong Huang, Ping Li, Yanlian Yang, Zhiyuan Hu, Qin Li, Xiaotian Zhang, Lin Shen
Summary: This study optimized a CLDN18.2 molecular beacon with a stem-loop hairpin structure, which can rapidly recognize CLDN18.2 RNA with high resolution and selectivity. The beacon has been successfully applied to circulating tumor cell detection, showing 100% concordance with tissue biopsy results.
ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Olga Bulgakova, Assiya Kussainova, Anuarbek Kakabayev, Akmaral Aripova, Gulim Baikenova, Alberto Izzotti, Rakhmetkazhi Bersimbaev
Summary: This study found that the level of cf mtDNA in radon-induced lung cancer patients was significantly higher than other study participants, and there was a significant difference in cf mtDNA levels in the blood plasma of healthy volunteers exposed and not exposed to high doses of radon. Overall, healthy volunteers living in areas with high radon levels had higher mtDNA copy numbers than lung cancer patients who were not exposed to high doses of radon.
ENVIRONMENTAL RESEARCH
(2022)
Review
Cell Biology
Supriya Borah, Rajeev Mishra, Sananda Dey, Surabhi Suchanti, Neil A. Bhowmick, Biplab Giri, Subhash Haldar
Summary: Circulating DNAs are fragmented DNA in blood plasma, including cell-free mitochondrial and nuclear DNA, and are altered in various pathological conditions. Mitochondrial DNA is associated with inflammation and elevated in cancer patients. It induces pro-inflammatory conditions and activates growth factors. It also triggers a positive feedback loop and activates pro-proliferating signaling in the tumor microenvironment. This review discusses the potential prognostic biomarkers and therapeutic candidates in different cancers, particularly prostate cancer.
Article
Oncology
Qingxiao Fang, Ziming Yuan, Hanqing Hu, Weiyuan Zhang, Guiyu Wang, Xishan Wang
Summary: Through genome-wide analysis and validation, we identified four CpG sites (cg04486886, cg06712559, cg13539460, and cg27541454) as DNA methylation markers in colorectal cancer tissues. The diagnostic prediction model based on these markers can effectively distinguish colorectal cancer from polyp patients, and the md-score can robustly detect colorectal cancer. The cg27541454 may be a promising candidate noninvasive biomarker for early diagnosis of colorectal cancer.
CLINICAL EPIGENETICS
(2023)
Article
Oncology
Mehdi Manoochehri, Nasim Borhani, Clarissa Gerhaeuser, Yassen Assenov, Maximilian Schoenung, Thomas Hielscher, Brock C. Christensen, Min Kyung Lee, Hermann-Josef Grone, Daniel B. Lipka, Thomas Bruening, Hiltrud Brauch, Yon-Dschun Ko, Ute Hamann
Summary: Noninvasive detection of aberrant DNA methylation could provide invaluable biomarkers for earlier detection of triple-negative breast cancer (TNBC), aiding clinicians in easier and more efficient treatment options.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Xin Guo, Yunhua Peng, Qiying Song, Jiangpeng Wei, Xinxin Wang, Yi Ru, Shenhui Xu, Xin Cheng, Xiaohua Li, Di Wu, Lubin Chen, Bo Wei, Xiaohui Lv, Gang Ji
Summary: In this study, a blood-based LR signature was developed to detect gastric cancer (GC) early. EV-derived GClnc1 was identified as a circulating biomarker for the early detection of GC, providing opportunities for curative surgery and improved survival outcomes.
Article
Pathology
Sinan Liu, Ming Cui, Jiayi Zang, Jie Wang, Xin Shi, Fei Qian, Shuizhu Xu, Rongrong Jing
Summary: The study revealed that the expression level of SLC6A3 is significantly elevated in gastric cancer and has potential diagnostic value. Bioinformatic analysis of SLC6A3 showed its involvement in multiple metabolic pathways related to gastric cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Xiao-Han Fan, Yang Zhang, Pei Wang, Qian-Qian Song, Mona Wang, Raquel Mejias-Luque, Zhe-Xuan Li, Tong Zhou, Jing-Ying Zhang, Wei-Dong Liu, Lan-Fu Zhang, Wen-Qing Li, Wei-Cheng You, Markus Gerhard, Yu-Chen Jiao, Xiao-Bing Wang, Kai-Feng Pan
Summary: This study explores noninvasive multianalytical biomarkers and constructs integrative models for risk assessment and gastric cancer (GC) screening. Methylation, mutation, and H. pylori-specific antibody panels were established and validated, and integrated models incorporating these biomarkers outperformed traditional models for risk assessment and GC detection. This study provides new insights for a more precise GC screening strategy in the future.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Yang Song, Suzhu Zhu, Ning Zhang, Lixin Cheng
Summary: A diagnostic signature consisting of four miRNA pairs was developed for early detection of esophageal cancer. The signature was validated in two independent datasets, demonstrating high performance with accuracy in diagnosing early-stage esophageal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yang Liu, Kaixiang Zhou, Shanshan Guo, Yang Wang, Xiaoying Ji, Qing Yuan, Liping Su, Xu Guo, Xiwen Gu, Jinliang Xing
Summary: Mitochondrial DNA mutations play a role in the development of cancer, leading to the use of circulating cell-free mtDNA as a potential tumor biomarker. A new approach for profiling ccf-mtDNA mutations was developed based on systematic optimization of sequencing methodology. The study also highlighted the importance of proper processing of plasma samples for accurate detection of tumor-specific mtDNA mutations in cancer patients.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Sarah Gillen
Summary: The study identifies miR-194 as a potential biomarker for a more favorable prognosis in gastric cancer, due to its downregulation of CCND1, a key protein for cancer development. Early detection and accurate assessment of treatment options play a crucial role in improving survival rates for gastric cancer patients.
Article
Medicine, General & Internal
Luyao Zhao, Muran Li, Shiwu Zhang, Yandi Liu
Summary: This study evaluated the potential performance of plasma SEPT9 methylation as a noninvasive biomarker for the diagnosis of gastric cancer. The results suggest that mSEPT9 may serve as a useful and noninvasive biomarker for the diagnosis of gastric cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Jian-xin Yin, Wen-wei Hu, Hua Gu, Jian-min Fang
Summary: Early diagnosis of non-small cell lung cancer by detecting circulating tumor DNA is crucial in curtailing cancer-related deaths. Combined assay results and post-operative new ctDNA mutation status are promising prognostic indicators in NSCLC patients.
Article
Dermatology
Carmen Maldonado-Bernal, Alberto Ramos-Garibay, Nora Rios-Sarabia, Hector Serrano, Manuel Carrera, Gisela Navarrete-Franco, Fermin Jurado-Santacruz, Armando Isibasi
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2019)
Article
Oncology
Cecilia Martinez-Campos, Kirvis Torres-Poveda, Margarita Camorlinga-Ponce, Lourdes Flores-Luna, Carmen Maldonado-Bernal, Vicente Madrid-Marina, Javier Torres
Review
Biotechnology & Applied Microbiology
D. M. Abarca-Merlin, C. Maldonado-Bernal, L. Alvarez-Arellano
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Chemistry, Medicinal
Sandra Salillas, Miriam Alias, Valerie Michel, Alejandro Mahia, Ainhoa Lucia, Liliana Rodrigues, Jessica Bueno, Juan Jose Galano-Frutos, Hilde De Reuse, Adrian Velazquez-Campoy, Jose Alberto Carrodeguas, Carlos Sostres, Javier Castillo, Jose Antonio Ainsa, Maria Dolores Diaz-de-Villegas, Angel Lanas, Eliette Touati, Javier Sancho
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Gastroenterology & Hepatology
Lionel Costa, Sebastien Corre, Valerie Michel, Krysten Le Luel, Julien Fernandes, Jason Ziveri, Gregory Jouvion, Anne Danckaert, Nicolas Mouchet, David Da Silva Barreira, Javier Torres, Margarita Camorlinga, Mario Milco D'Elios, Laurence Fiette, Hilde De Reuse, Marie-Dominique Galibert, Eliette Touati
Article
Multidisciplinary Sciences
Celine Hoffmann, Nour El Houda Djerir, Anne Danckaert, Julien Fernandes, Pascal Roux, Christine Charrueau, Anne-Marie Lachages, Frederic Charlotte, Isabelle Brocheriou, Karine Clement, Judith Aron-Wisnewsky, Fabienne Foufelle, Vlad Ratziu, Bernard Hainque, Dominique Bonnefont-Rousselot, Pascal Bigey, Virginie Escriou
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Francoise Bussiere, Valerie Michel, Julien Fernandes, Lionel Costa, Vania Camilo, Giulia Nigro, Hilde De Reuse, Laurence Fiette, Eliette Touati
JOURNAL OF ONCOLOGY
(2019)
Article
Cell Biology
Arturo Aguilar-Rojas, Silvia Castellanos-Castro, Mariette Matondo, Quentin Giai Gianetto, Hugo Varet, Odile Sismeiro, Rachel Legendre, Julien Fernandes, David Hardy, Jean-Yves Coppee, Jean-Christophe Olivo-Marin, Nancy Guillen
CELLULAR MICROBIOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Roman Thibeaux, Marie-Estelle Soupe-Gilbert, Malia Kainiu, Dominique Girault, Emilie Bierque, Julien Fernandes, Heike Bahre, Anthony Douyere, Nicolas Eskenazi, Joelle Vinh, Mathieu Picardeau, Cyrille Goarant
NPJ BIOFILMS AND MICROBIOMES
(2020)
Review
Immunology
Erandi Perez-Figueroa, Pablo Alvarez-Carrasco, Enrique Ortega, Carmen Maldonado-Bernal
Summary: Neutrophils play a crucial role in innate immune response by executing various effector functions. When activated, they undergo cell death processes to ensure the proper elimination of pathogens and damaged cells, contributing to timely resolution of inflammation. Neutrophils' cell death mechanisms include apoptosis, pyroptosis, necrosis, and others, ultimately maintaining homeostasis in the organism.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Lourdes Alvarez-Arellano, Pilar Eguia-Aguilar, Patricia Pina-Sanchez, Nadia Gonzalez-Garcia, Alam Palma-Guzman, Mario Perezpena-Diazconti, Carmen Maldonado-Bernal
Summary: The study found that medulloblastomas exhibit cellular infiltration and differential expression of Toll-like receptors depending on the histological subtype. Specifically, TLR7 was identified as an important prognostic factor for patient survival, which is dependent on treatment and age.
CHILDS NERVOUS SYSTEM
(2021)
Article
Oncology
David Sanchez-Herrera, Alejandra Contreras-Ramos, Elva Jimenez-Hernandez, Aurora Medina-Sanson, Silvia Giono-Cerezo, Carmen Maldonado-Bernal
Summary: NK cells are a heterogeneous subpopulation of lymphocytes with potent antitumor activity, exhibiting their function through a complex collection of receptors. Pediatric patients with acute lymphoblastic leukemia showed decreased NK cells and alterations in subpopulations, along with differences in TLR expression.
JOURNAL OF ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Janet Gallardo-Zapata, Carmen Maldonado-Bernal
Summary: This article provides an overview of the response of NK cells to SARS-CoV-2 infection, revealing the significant impact on the number and function of NK cells in patients with COVID-19.
