Article
Multidisciplinary Sciences
Dai Yuki, Akira Kikuchi, Takuya Suzuki, Chikako Sakaguchi, Danting Huangfu, Yasufumi Nagata, Aoi Kakehi
Summary: The objective of this clinical study was to demonstrate a reduction in exposure to harmful and potentially harmful constituents in Japanese adult smokers who switched to heated tobacco products. The results showed that after using these products, the reduction in exposure to selected harmful constituents was comparable to that observed in smokers who quit.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Nicolas Sambiagio, Aurelie Berthet, Pascal Wild, Jean -Jacques Sauvain, Reto Auer, Anna Schoeni, Nicolas Rodondi, Martin Feller, Jean -Paul Humair, Ivan Berlin, Florian Breider, Dominique Grandjean, Nancy B. Hopf
Summary: Oxidative stress is associated with exposure to toxicants in air pollution and cigarette smoke, especially PAHs and VOCs. This study found associations between these exposures and oxidative stress biomarkers, and assessed their relative importance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Critical Care Medicine
Farzad Moazed, Carolyn Hendrickson, Alejandra Jauregui, Jeffrey Gotts, Amanda Conroy, Kevin Delucchi, Hanjing Zhuo, Mikhaela Arambulo, Kathryn Vessel, Serena Ke, Thomas Deiss, Amy Ni, Aleksandra Leligdowicz, Jason Abbott, Mitchell J. Cohen, Pratik Sinha, Antonio Gomez, Kirsten Kangelaris, Lucy Kornblith, Michael Matthay, Neal Benowitz, Kathleen Liu, Carolyn S. Calfee
Summary: Cigarette smoke exposure is associated with an increased risk of developing ARDS in both pulmonary and nonpulmonary sepsis patients. Among ARDS patients, those with exposure to cigarette smoke have lower systemic inflammation levels, and active smokers also have lower severity of illness compared to non-smokers, indicating that smoking contributes to biological heterogeneity in ARDS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Medicine, General & Internal
Shane Sakamaki-Ching, Suzaynn Schick, Gabriela Grigorean, Jun Li, Prue Talbot
Summary: The study found that acute dermal exposure to THS can alter the human plasma proteome, initiate mechanisms of skin inflammatory disease, and elevate urinary biomarkers of oxidative harm.
Article
Pharmacology & Pharmacy
Siddhi Jain, Sneha Durugkar, Pritam Saha, Sharad B. Gokhale, V. G. M. Naidu, Pawan Sharma
Summary: This study examined the efficacy of azithromycin alone and in combination with dexamethasone in treating cigarette smoke-induced acute lung inflammation. The results showed that azithromycin inhibited airway fibrosis, inflammation, and cell toxicity caused by cigarette smoke, and improved lung function. Further research is needed to validate the therapeutic efficacy of azithromycin as a treatment for COPD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
K. G. Aghila Rani, Nelson C. Soares, Betul Rahman, Hamza M. Al-Hroub, Mohammad H. Semreen, Sausan Al Kawas
Summary: The study investigates the biochemical and pathophysiological changes caused by medwakh smoking and examines the salivary metabolomics profile of medwakh smokers. Analysis of saliva samples reveals 37 uniquely and differentially abundant metabolites and 20 differentially altered metabolic pathways in medwakh smokers. The study highlights the association of altered redox homeostasis, metabolic pathways, antioxidant system, and CRP levels with the distinctive saliva metabolomics profile in medwakh smokers. Further research is needed to explore the diagnostic utility of these altered metabolites in larger cohorts.
SCIENTIFIC REPORTS
(2023)
Review
Physiology
Marta Schiliro, Elizabeth R. Vogel, Lucia Paolini, Christina M. Pabelick
Summary: The detrimental effects of tobacco exposure on children's health are well known, and the prevalence of secondhand or direct cigarette smoke exposure in the pediatric population has not significantly decreased over time. Additionally, the rapid increase in e-cigarette use among adolescents has raised public health concerns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Article
Immunology
Yiming Ma, Lijuan Luo, Xiangming Liu, Herui Li, Zihang Zeng, Xue He, Zijie Zhan, Yan Chen
Summary: The study demonstrates the potential role of PFD in regulating inflammation and oxidative stress induced by cigarette smoke extract, reversing pathological changes and reducing levels of inflammatory factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Deqing Yang, Dan Xu, Tao Wang, Zhicheng Yuan, Lian Liu, Yongchun Shen, Fuqiang Wen
Summary: Pre-treatment with MitoQ significantly attenuated cigarette smoke-induced airway inflammation and mucus hypersecretion in mice, potentially by modulating mitochondrial function and the NF-kappa B signal pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Pereira da Silva Araujo, Natalia Alves de Matos, Michel Oliveira, Ana Beatriz Farias de Souza, Thalles de Freitas Castro, Pedro Alves Machado-Junior, Debora Maria Soares de Souza, Andre Talvani, Silvia Dantas Cangussu, Rodrigo Cunha Alvim de Menezes, Frank Silva Bezerra
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of disability and mortality worldwide, with cigarette smoke playing a key role in its development. Quercetin may have potential as a preventive agent for smoke-induced pulmonary emphysema.
Article
Endocrinology & Metabolism
Stephen T. Decker, Oh-Sung Kwon, Jia Zhao, John R. Hoidal, Thomas Heuckstadt, Russell S. Richardson, Karl A. Sanders, Gwenael Layec
Summary: This study found that sedentary mice exposed to cigarette smoke for 8 months showed preserved mitochondrial respiratory capacity in skeletal muscle, but also increased risk of chronic oxidative stress.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Cell Biology
Beatriz Mangueira Saraiva-Romanholo, Isabella Santos de Genaro, Francine Maria de Almeida, Soraia Nogueira Felix, Marina Ribeiro Cottes Lopes, Thais Santos Amorim, Rodolfo Paula Vieira, Fernanda Magalhaes Arantes-Costa, Milton Arruda Martins, Iolanda de Fatima Lopes Calvo Tiberio, Carla Maximo Prado
Summary: Cigarette smoke and sodium hypochlorite have an impact on lung mechanics and inflammation. Exposure to these irritants alone induces changes in the lungs. Co-exposure to both irritants reduces lung inflammation, but increases the acidity of mucus.
Article
Biochemistry & Molecular Biology
Ana-Maria Vlasceanu, Daniela Gradinaru, Miriana Stan, Viorela G. Nitescu, Daniela Luiza Baconi
Summary: This study examined the relationship between serum cotinine levels and oxidative stress in 76 adult patients. The results showed an inverse association between tobacco smoke exposure and glutathione levels, suggesting that exposure to smoke particulate components can deplete systemic glutathione. Interestingly, active smokers had higher glutathione levels but lower levels of advanced oxidation protein products (AOPPs), while passive smokers showed a decrease in AOPP levels with an increase in glutathione levels. This suggests that inhalation of smoke particulate constituents can disrupt redox homeostasis and impair the antioxidant role of glutathione.
Article
Substance Abuse
Saul Shiffman, Douglas R. Oliveri, Nicholas Goldenson, Qiwei Liang, Ryan A. Black, Snigdha Mishra
Summary: This study suggests that switching from cigarettes to JUUL-brand ENDS can significantly reduce smokers' exposure to harmful constituents, and result in favorable differences in markers of inflammation, endothelial function, oxidative stress, and cardiovascular risk, as well as fewer respiratory symptoms.
NICOTINE & TOBACCO RESEARCH
(2023)
Article
Environmental Sciences
Ali A. Rostami, Yezdi B. Pithawalla, Jianmin Liu, Michael J. Oldham, Karl A. Wagner, Kimberly Frost-Pineda, Mohamadi A. Sarkar
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2016)
Article
Toxicology
Christopher R. E. Coggins, Kimberly Frost-Pineda, Donna C. Smith, Michael J. Oldham
INHALATION TOXICOLOGY
(2011)
Article
Statistics & Probability
Qiwei Liang, Huajiang Li, Paul Mendes, Hans Roethig, Kim Frost-Pineda
JOURNAL OF APPLIED STATISTICS
(2009)
Review
Substance Abuse
Kimberly Frost-Pineda, Scott Appleton, Michael Fisher, Kathleen Fox, Charles L. Gaworski
NICOTINE & TOBACCO RESEARCH
(2010)
Article
Substance Abuse
Kimberly Frost-Pineda, Qiwei Liang, Jianmin Liu, Lonnie Rimmer, Yan Jin, Shixia Feng, Sunil Kapur, Paul Mendes, Hans Roethig, Mohamadi Sarkar
NICOTINE & TOBACCO RESEARCH
(2011)
Article
Substance Abuse
Diana L. McKinney, Kimberly Frost-Pineda, Michael J. Oldham, Michael T. Fisher, Jingzhu Wang, Maria Gogova, Gerd Kobal
NICOTINE & TOBACCO RESEARCH
(2014)
Article
Medicine, Legal
Kimberly Frost-Pineda, Barbara K. Zedler, Qiwei Liang, Hans J. Roethig
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2008)
Article
Medicine, Legal
Paul Mendes, Qiwei Liang, Kimberly Frost-Pineda, Sagar Munjal, Ruediger-A. Walk, Hans J. Roethig
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2009)
Article
Medicine, Legal
Raheema S. Muhammad-Kah, Angela D. Hayden, Qiwei Liang, Kimberly Frost-Pineda, Mohamadi Sarkar
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2011)
Article
Medicine, Legal
Raheema Muhammad-Kah, Qiwei Liang, Kimberly Frost-Pineda, Paul E. Mendes, Hans J. Roethig, Mohamadi Sarkar
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2011)
Article
Substance Abuse
Kimberly Frost-Pineda, Michael Polster
Summary: Based on survey data analysis, this study found that menthol smokers were not more cigarette dependent than non-menthol smokers, and may be less dependent, as demonstrated by daily smoking and the Heaviness of Smoking Index (HSI).
JOURNAL OF ADDICTIVE DISEASES
(2023)
Editorial Material
Substance Abuse
Kimberly Frost-Pineda, Michael Polster
Summary: Based on the research findings, there is no significant difference in smoking frequency and dependence between young adult menthol smokers and non-menthol smokers.
JOURNAL OF ADDICTIVE DISEASES
(2022)
Review
Substance Abuse
Kimberly Frost-Pineda, J. Daniel Heck, Geoffrey M. Curtin
JOURNAL OF ADDICTIVE DISEASES
(2020)
Article
Substance Abuse
Kimberly Frost-Pineda, Raheema Muhammad-Kah, Lonnie Rimmer, Qiwei Liang
JOURNAL OF ADDICTIVE DISEASES
(2014)