期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 20, 期 1, 页码 23-32出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-10-0698
关键词
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资金
- National Institutes of Health [CA88164, CA127298, P50CA69568, R01 CA056678, R01 CA092579, R01-ES011126, R03 CA128028, UO1 CA86402]
- PA Department of Health [98-PADMOH-ME-98155]
- Fred Hutchinson Cancer Research Center
- National Human Genome Research Institute
- MD Anderson Cancer Center (MDACC) [RO1CA68578, DAMD W81XWH-07-1-0645-01, P50-CA140388]
- National Cancer Institute (NCI) [R01CA128813, CA63464, CA54281, R01CA84979, R01CA112028]
- California Cancer Research Fund [99-00527V-10182]
- (University of California) with the Department of Health Services
- Cancer Research UK [C5047/A7357]
- Institute of Cancer Research and The Everyman Campaign
- Prostate Cancer Research Foundation
- Prostate Research Campaign UK
- National Cancer Research Network UK
- National Cancer Research Institute (NCRI) UK
- NHS
- James Graham Brown Cancer Center
- Bucks for Brains Our Highest Potential in Cancer Research Endowment
- American Cancer Society [TURSG-03-152-01-CCE]
- St. Louis Men's Group against Cancer and the Par for the Cure Foundation
- [R01-CA08574]
- [P01-CA105641]
- National Institute for Health Research [NF-SI-0510-10096] Funding Source: researchfish
- NATIONAL CANCER INSTITUTE [P30CA076292, R01CA056678, U01CA086402, P50CA069568, R01CA092579, R01CA088164, R01CA112028, P50CA140388, R01CA128813, U01CA127298, P50CA105641, R01CA084979, R01CA063464, R37CA054281, R01CA068578, U01CA063464, ZIACP010180, R03CA128028, R01CA054281] Funding Source: NIH RePORTER
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [ZIAHG200325] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES011126] Funding Source: NIH RePORTER
Background: Genome-wide association studies (GWAS) have identified numerous prostate cancer susceptibility alleles, but these loci have been identified primarily in men of European descent. There is limited information about the role of these loci in men of African descent. Methods: We identified 7,788 prostate cancer cases and controls with genotype data for 47 GWAS-identified loci. Results: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of European descent. Significance was attained at all reported prostate cancer susceptibility regions at chromosome 8q24, including associations reaching genome-wide significance in region 2. Conclusion: We have validated in men of African descent the associations at some, but not all, prostate cancer susceptibility loci originally identified in European descent populations. This may be due to the heterogeneity in genetic etiology or in the pattern of genetic variation across populations. Impact: The genetic etiology of prostate cancer in men of African descent differs from that of men of European descent. Cancer Epidemiol Biomarkers Prev; 20(1); 23-32. (C) 2011 AACR.
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