Article
Cell Biology
Xinyuan Liu, Jian Xu, Bingbing Shen, Jichuan Xu, Jianxin Jiang
Summary: Pancreatic cancer (PC) is the fourth leading cause of cancer-related death worldwide, with a survival rate below 5%. Abnormal proliferation and distant metastasis are major challenges for the diagnosis and treatment of PC, making it crucial for researchers to understand the molecular mechanisms underlying PC proliferation and metastasis. This study found that USP33, a member of the deubiquitinating enzyme family, is upregulated in PC samples and cells, and its high expression is associated with poor prognosis. Functional experiments showed that USP33 overexpression promotes PC cell proliferation, migration, and invasion, while inhibition of USP33 has the opposite effect. The study also identified TGFBR2 as a potential binding protein of USP33 and revealed a positive feedback loop between USP33 and the TGF-beta signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Markus A. Brown, Thomas Ried
Summary: The major signaling pathways in colon cancer are WNT, RAS, and TGF-beta. Mutations in these pathways reflect the behavior of intestinal stem cells and play a role in the progression of colon cancer. Understanding the intersection and interaction between these pathways can provide insights into the regulation of cell proliferation and the development of colon cancer.
Article
Multidisciplinary Sciences
Fei Lu, Shuran Chen, Weijun Shi, Xu Su, Huazhang Wu, Mulin Liu
Summary: The study found that CRC patients with high GPC1 expression had poor overall survival, and GPC1 may promote proliferation and migration of CRC cells by influencing the TGF-beta 1 signaling pathway. Additionally, silencing GPC1 inhibited TGF-beta 1 levels and increased SMAD2 expression.
Article
Food Science & Technology
Yi-Shiou Chiou, Yi-Ming Lan, Pei-Sheng Lee, Qianyu Lin, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pan
Summary: This study identified a specific molecular mechanism that can prevent the progression and metastasis of colorectal cancer by regulating the interaction between tumor-associated macrophages and cancer cells. The results showed that piceatannol (PIC) effectively inhibited the aggressive features and stemness of cancer cells by restricting the polarization of M2-like macrophages and blocking the positive feedback loop of transforming growth factor beta 1 (TGF-beta 1) in the tumor microenvironment. In vivo experiments also demonstrated significant repression of tumor growth and lung metastases with the administration of PIC.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Pathology
Hailang Zhou, Junwei Zou, Changjiang Shao, Aijun Zhou, Jiufeng Yu, Song Chen, Chunfang Xu
Summary: The study showed that P4HA3 promotes human colon cancer growth and metastasis by affecting the TGF-beta/Smad signaling pathway. P4HA3 knockdown significantly decreased migration, proliferation, and invasion abilities of colon cancer cells, while overexpression had the opposite effect. Additionally, P4HA3 can serve as a potential new target for early diagnosis, treatment, and prognosis assessment of colon cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Fang Feng, Chunliang Liu, Huahui Bian, Wei Cai, Ying Zhou, Li Zhou, Zhixiang Zhuang
Summary: Pancreatic cancer is a major cause of cancer-related deaths, and understanding the role of TIPE2 in pancreatic cancer is crucial. This study found that decreased expression of TIPE2 in pancreatic cancer tissues was associated with tumor size, and overexpression of TIPE2 inhibited cell proliferation and metastasis while promoting apoptotic events. TIPE2 may suppress pancreatic cancer development by inhibiting PI3K/AKT and Raf/MEK/ERK signaling pathways and activating T cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Maoduo Zhang, Ying Yi Zhang, Yongze Chen, Jia Wang, Qiang Wang, Hezhe Lu
Summary: The TGF-beta pathway in cancer has dual roles and is considered a potential new avenue for cancer therapy, but its functions and mechanisms of action require further investigation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Young Yun Jung, Chakrabhavi Dhananjaya Mohan, Huiyan Eng, Acharan S. Narula, Ojas A. Namjoshi, Bruce E. Blough, Kanchugarakoppal S. Rangappa, Gautam Sethi, Alan Prem Kumar, Kwang Seok Ahn
Summary: This study demonstrates that 2,3,5,6-Tetramethylpyrazine (TMP) can suppress the EMT program in colon cancer cells by regulating MnSOD and related proteins, and inhibit the proliferation, migration, and invasion of tumor cells.
Article
Oncology
Fangting Liu, Zhehao Shi, Wenming Bao, Jiuyi Zheng, Kaiyu Chen, Zhihui Lin, Hao-Nan Song, Xin Luo, Qiantong Dong, Lei Jiang, Yi Wang, Gang Chen, Xiaolei Chen
Summary: ZIC2 promotes the progression and metastasis of colorectal cancer by activating the TGF-beta signaling pathway, and its expression level is associated with poor prognosis in patients, possibly serving as a future therapeutic target.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Oncology
Kiyotaka Hagihara, Naotsugu Haraguchi, Junichi Nishimura, Asuka Yasueda, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizushima, Hirofumi Yamamoto, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi
Summary: This study revealed that PLXND1 induces EMT in colorectal cancer cells through activation of the PI3K/AKT pathway, enhancing cell migration and invasion. The inhibition of Furin can suppress EMT by blocking the binding of p61-SEMA3E to PLXND1. High expression of PLXND1 is significantly associated with poor overall survival in colorectal cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Mathieu Cinato, Laurie Guitou, Amira Saidi, Andrei Timotin, Erwan Sperazza, Thibaut Duparc, Sergey N. Zolov, Sai Srinivas Panapakkam Giridharan, Lois S. Weisman, Laurent O. Martinez, Jerome Roncalli, Oksana Kunduzova, Helene Tronchere, Frederic Boal
Summary: The study highlights the inhibitory effects of Apilimod on cardiac fibrotic remodeling, controlling the TGF beta signaling pathway to prevent adverse remodeling. It also suggests a novel function for PIKfyve in regulating myocardial fibrosis and TGF beta pathway.
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Hongbo Jiang, Pei Ma, Zhiguang Duan, Yannan Liu, Shihong Shen, Yu Mi, Daidi Fan
Summary: This study confirmed the inhibitory effect of Ginsenoside Rh4 on gastric cancer and discovered that it can suppress the migration and invasion of gastric cancer cells by reversing epithelial-mesenchymal transition (EMT) through the inhibition of the SIX1-TGF-beta/Smad2/3 signaling axis.
Article
Cell Biology
Qinglin Li, Wenju Mo, Yuqin Ding, Xiaowen Ding
Summary: The study showed that lncRNA TPA can affect breast cancer EMT through the TGF-beta signaling pathway, thereby promoting invasion and metastasis of breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Qinglin Li, Wenju Mo, Yuqin Ding, Xiaowen Ding
Summary: The study demonstrated that lncRNA TPA affects breast cancer EMT through the TGF-beta signaling pathway, leading to increased invasion and metastasis of breast cancer cells. It is suggested that lncRNA TPA may influence corresponding signaling pathways through interacting proteins, thereby promoting breast cancer invasion and metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Clinical Neurology
Odinachi Moghalu, John T. Stoffel, Sean Elliott, Blayne Welk, Sara Lenherr, Jennifer Herrick, Angela Presson, Jeremy Myers
Summary: This study aimed to examine the relationship between psychosocial aspects of health-related quality of life and patient-reported bladder outcomes in individuals with spinal cord injury. The results indicated that pain interference, independence, and positive affect were associated with bladder-related outcomes, highlighting the importance of clinicians being aware of this relationship to optimize long-term management in this population.
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jordan B. King, Ransmond O. Berchie, Jennifer S. Herrick, Dave L. Dixon, Jordana B. Cohen, Daichi Shimbo, Ian M. Kronish, Joseph J. Saseen, Paul Muntner, Andrew E. Moran, Adam P. Bress
Summary: Combination antihypertensive therapy is underused, especially in certain race/ethnic groups, in the treatment of hypertension in the United States. Factors associated with monotherapy use despite uncontrolled blood pressure include higher systolic blood pressure, younger age, recent healthcare visits, higher body mass index, and the presence of heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Zachary A. Marcum, Jordana B. Cohen, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: The use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors is associated with a lower risk of dementia. This study examines the impact of exclusively stimulating vs inhibiting antihypertensive medication regimens on mild cognitive impairment (MCI) or dementia. The findings suggest that prevalent users of stimulating medications had lower rates of cognitive impairment.
Article
Cardiac & Cardiovascular Systems
Aubrey E. Jones, Madeleine M. McCarty, Juan P. Brito, Peter A. Noseworthy, Kerri L. Cavanaugh, Kenzie A. Cameron, Geoffrey D. Barnes, Benjamin A. Steinberg, Daniel M. Witt, George H. Crossley, Rod Passman, Preeti Kansal, Ian Hargraves, Monika Schmidt, Elizabeth Jackson, Adriana Guzman, Anthony Ariotti, Mandy L. Pershing, Jennifer Herrick, Victor M. Montori, Angela Fagerlin, Elissa M. Ozanne
Summary: This study aims to compare the effectiveness of patient decision aid (PDA) and encounter decision aid (EDA) in shared decision making. The study will recruit atrial fibrillation (AF) patients and their managing clinicians for stroke prevention strategies in a randomized controlled trial. The results will contribute to improving AF outcomes and patient experiences with stroke prevention strategies.
AMERICAN HEART JOURNAL
(2022)
Article
Clinical Neurology
Sudipto Dolui, John A. Detre, Sarah A. Gaussoin, Jennifer S. Herrick, Danny J. J. Wang, Manjula Kurella Tamura, Monique E. Cho, William E. Haley, Lenore J. Launer, Henry A. Punzi, Anjay Rastogi, Carolyn H. Still, Daniel E. Weiner, Jackson T. Wright, Jeff D. Williamson, Clinton B. Wright, R. Nick Bryan, Adam P. Bress, Nicholas M. Pajewski, Ilya M. Nasrallah
Summary: Intensive antihypertensive treatment is associated with increased cerebral perfusion, particularly in patients with a history of cardiovascular disease.
Review
Medicine, General & Internal
Chase Paulson, Samuel C. Thomas, Orlando Gonzalez, Samuel Taylor, Cole Swiston, Jennifer S. Herrick, Lori McCoy, Karen Curtin, Craig J. Chaya, Brian C. Stagg, Barbara M. Wirostko
Summary: This study is the largest epidemiological study of exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in the Baja Verapaz region of Guatemala among individuals seeking eye exams and interventions. The study found a high prevalence of XFS/XFG, particularly among individuals in rural areas and those who speak the Mayan language.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jordana B. Cohen, Zachary A. Marcum, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Daniel Scharfstein, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: This observational cohort study aimed to evaluate the cognitive outcomes of individuals at risk for mild cognitive impairment and probable dementia after initiating an ARB- vs ACEI-based antihypertensive regimen. The study found no significant difference in the rate of amnestic MCI or PD among new users of ARB compared with ACEI.
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jennifer S. Herrick, Robert S. Rosenson, Bharat Poudel, Monika M. Safford, Todd M. Brown, Elizabeth A. Jackson, Mark Woodward, Stephanie Reading, Kate Orroth, Jason Exter, Salim S. Virani, Paul Muntner, Adam P. Bress
Summary: This study investigated lipid-lowering therapy (LLT) among US veterans after myocardial infarction or elective coronary revascularization. The results showed that less than half of the patients received LLT intensification within one year, indicating a missed opportunity to reduce cardiovascular disease risk.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Peripheral Vascular Disease
Jordan B. King, Catherine G. Derington, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Molly B. Conroy, William C. Cushman, Adam P. Bress
Summary: This study aimed to assess the availability of commercially available single-pill combination (SPC) antihypertensive products for achieving an intensive systolic blood pressure goal of <120 mm Hg. The results showed that most participants in the intensive treatment arm were using antihypertensive regimens that are not available as class-equivalent SPC products. Therefore, improvements in the product landscape are needed to achieve the desired results in real-world settings and reduce medication burden.
Article
Peripheral Vascular Disease
Byron C. Jaeger, Ligong Chen, Kathryn Foti, Shakia T. Hardy, Adam P. Bress, Sean P. Kane, Lei Huang, Jennifer S. Herrick, Catherine G. Derington, Bharat Poudel, Ashley Christenson, Lisandro D. Colantonio, Paul Muntner
Summary: A web-based application was developed to provide hypertension statistics for US adults using data from the US National Health and Nutrition Examination Survey. The study found that the mean systolic blood pressure decreased from 123 mm Hg in 1999-2000 to 120 mm Hg in 2009-2010 and then increased to 123 mm Hg in 2017-2020. The age-adjusted prevalence of hypertension was 47.9% in 1999-2000, 43.0% in 2009-2010, and 44.7% in 2017-2020. The study also estimated that 115.3 million US adults had hypertension in 2017-2020.
Article
Cardiac & Cardiovascular Systems
Catherine G. G. Derington, Adam P. P. Bress, Jennifer S. S. Herrick, Joshua A. A. Jacobs, Alexander R. R. Zheutlin, Ransmond O. O. Berchie, Molly B. B. Conroy, William C. C. Cushman, Jordan B. B. King
Summary: It is found that only one-third of hypertensive patients in the US market can be satisfied with the currently available fixed-dose combination antihypertensive products, indicating the need for further improvement in the pharmaceutical product landscape.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Alexander R. Zheutlin, Daniel K. Addo, Joshua A. Jacobs, Catherine G. Derington, Jennifer S. Herrick, Tom Greene, Eric L. Stulberg, Dan R. Berlowitz, Jeff D. Williamson, Nicholas M. Pajewski, Mark A. Supiano, Adam P. Bress
Summary: Despite evidence supporting the benefits of intensive blood pressure management, older adults have the lowest rates of blood pressure control. The association between age and therapeutic inertia was determined in the SPRINT study, with older age found to be associated with greater therapeutic inertia independent of physical or cognitive function. This suggests age bias in hypertension management.
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Catherine G. Derington, Adam P. Bress, Jennifer S. Herrick, Wenjun Fan, Nathan D. Wong, Katherine E. Andrade, Jonathan Johnson, Sephy Philip, David Abrahamson, Lixia Jiao, Deepak L. Bhatt, William S. Weintraub
Summary: Treating all eligible adults with icosapent ethyl as part of the REDUCE-IT trial can prevent a substantial number of ASCVD events, although there are significant medication costs involved. The indirect cost savings from event prevention may outweigh the incurred direct costs.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
