Review
Oncology
Sascha Hoppe, Christoph Jonas, Marten Christian Wenzel, Oscar Velazquez Camacho, Christoph Arolt, Yue Zhao, Reinhard Buttner, Alexander Quaas, Patrick Sven Plum, Axel Maximilian Hillmer
Summary: Esophageal adenocarcinoma (EAC) is a deadly disease with limited options for targeted therapy. Next-generation sequencing studies have provided insights into the genomic complexity of EAC, revealing high burden of point mutations and genomic rearrangements, which hamper targeted therapies. The development of personalized treatment may benefit from dividing EAC patients into different subgroups based on their gene mutations and gene activity changes.
Article
Oncology
Felipe Alvarez-Mancenido, Paula Jimenez-Fonseca, Alberto Carmona-Bayonas, Virginia Arrazubi, Raquel Hernandez, Juana M. Cano, Ana Custodio, Carles Pericay Pijaume, Gema Aguado, Nieves Martinez Lago, Manuel Sanchez Canovas, Diego Cacho Lavin, Laura Visa, Alba Martinez-Torron, Aranzazu Arias-Martinez, Flora Lopez, M. Luisa Limon, Rosario Vidal Tocino, Ana Fernandez Montes, Maria Alsina, Paola Pimentel, Pablo Reguera, Alfonso Martin Carnicero, Avinash Ramchandani, Monica Granja, Aitor Azkarate, Marta Martin Richard, Olbia Serra, Carolina Hernandez Perez, Alicia Hurtado, Aitziber Gil-Negrete, Tamara Sauri, Patricia Morales del Burgo, Javier Gallego
Summary: The study found that advanced esophageal adenocarcinoma (EAC) exhibits clinicopathological characteristics, prognostic factors, and treatment outcomes comparable to intestinal gastroesophageal junction (GEJ-AC) and gastric adenocarcinoma (GAC). HER2-positive tumors treated with trastuzumab show a favorable prognosis across all three subgroups.
Article
Surgery
Carlos S. Cabalag, Michael Yates, Mariana Benitez Corrales, Paul Yeh, Stephen Q. Wong, Bonnie Z. Zhang, Kenji M. Fujihara, Lynn Chong, Michael W. Hii, Sarah-Jane Dawson, Wayne A. Phillips, Cuong P. Duong, Nicholas J. Clemons
Summary: The study demonstrates the clinical utility of ctDNA in predicting disease status and treatment response in esophageal adenocarcinoma patients. It shows that ctDNA can provide additional prognostication over conventional staging investigations and may be a useful biomarker for surveillance of recurrent disease.
Review
Oncology
Jessie A. Elliott, John V. Reynolds
Summary: Visceral obesity is closely associated with esophageal adenocarcinoma, and it may promote cancer development through various pathways, impacting the tumor microenvironment and cancer outcomes. Current research focuses on exploring the role of dietary, lifestyle, pharmacologic, and surgical interventions in modulating the risk of EAC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ruijie Zeng, Shujie Huang, Xinqi Qiu, Zewei Zhuo, Huihuan Wu, Lei Jiang, Weihong Sha, Hao Chen
Summary: A pyroptosis-related five-gene signature correlated with the survival of esophageal adenocarcinoma patients has been identified and a prognostic nomogram based on the signature has been constructed. Downregulation of GSDMB within the signature may be associated with enhanced DNA methylation, and the signature is potentially related to immune response and regulation of the tumor microenvironment. Several inhibitors show promise in reversing the altered differentially expressed genes in high-risk patients, providing insights into the involvement of pyroptosis in EAC progression and potential implications for risk assessment and prognosis in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Kiran H. Lagisetty, Dyke P. McEwen, Derek J. Nancarrow, Johnathon G. Schiebel, Daysha Ferrer-Torres, Dipankar Ray, Timothy L. Frankel, Jules Lin, Andrew C. Chang, Laura A. Kresty, David G. Beer
Summary: The study identified immune microenvironment changes during Barrett's esophagus progression to esophageal adenocarcinoma, characterized by increased chemokines and cytokines expression and alterations in immune cell populations. Esophageal adenocarcinoma microenvironment was found to have poor cytotoxic effector cell infiltration and increased immune inhibitory signaling, suggesting a potential immunosuppressive environment requiring further exploration for immune modulatory therapy.
Article
Oncology
Le Zhang, Yueyuan Zheng, Wenwen Chien, Benjamin Ziman, Sandrine Billet, H. Phillip Koeffler, De-Chen Lin, Neil A. Bhowmick
Summary: ARID1A deficiency enhances tumor immune response and promotes CD8(+) T cell recruitment and cytolytic activity in esophageal adenocarcinoma (EAC). Additionally, ARID1A regulates fatty acid metabolism genes, influencing CD8(+) T cell recruitment and cytolytic activity.
Article
Multidisciplinary Sciences
Alexander Damanakis, Isabell Wahler, Hans Fuchs, Heike Loeser, Wolfgang Schroeder, Thomas Zander, Seung-Hun Chon, Christiane Bruns, Alexander Quaas, Florian Gebauer
Summary: This study demonstrates for the first time the prognostic significance of ITGB1 expression in a large population of patients with esophageal adenocarcinoma (EAC). High expression of ITGB1 is associated with tumor aggressiveness and poor survival.
SCIENTIFIC REPORTS
(2022)
Article
Health Care Sciences & Services
Riad Haddad, Oran Zlotnik, Tal Goshen-Lago, Mattan Levi, Elena Brook, Baruch Brenner, Yulia Kundel, Irit Ben-Aharon, Hanoch Kashtan
Summary: This study investigated the association between neoadjuvant treatment, tumor-infiltrating immune lymphocyte (TIL), and tumor-associated macrophage (TAM) in patients with esophageal adenocarcinoma. The results showed that high enrichment of lymphocyte subpopulations in the tumor microenvironment was associated with a favorable response to neoadjuvant treatment and improved patient outcome. The overexpression of TAM and colony-stimulating factor 1 receptor (CSF-1R) was also identified in the analysis of The Cancer Genomic Atlas (TCGA) dataset.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Leila Shahbaznejad, Ali Hosseininasab, Leila Mahboobi, Hamid Mohammadi, Hassan Esmaeili, Seyed Majid Farrokhi Far, Mohammad Reza Alipour, Iraj Sedighi, Roxana Mansour Ghanaei, Behnam Sobouti, Alireza Taremiha, Abdol Reza Malek, Keyghobad Ghadiri, Gholamreza Soleimani, Hamed Tabasizadeh, Abdolkarim Ghadimi Moghadam, Manouchehr Barak, Forood Salehi Abarghouei, Houman Hashemian, Hossein Daryani Nezhad, Hamid Reza Sherkatolabbasieh, Masoumeh Abedini-Varamini, Mohammad Bagher Rahmati, Faezeh Sadat Movahedi, Mohammad Sadegh Rezai
Summary: This study conducted a national registry of Kawasaki disease (KD) in Iran for 13 years, and found that most KD cases present with atypical clinical manifestations. Therefore, it is crucial to increase awareness and educate primary healthcare workers to ensure timely diagnosis and management of the disease.
FRONTIERS IN PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Lieven Depypere, Gert De Hertogh, Johnny Moons, An-Lies Provoost, Toni Lerut, Xavier Sagaert, Willy Coosemans, Hans Van Veer, Philippe Nafteux
Summary: In cN+ esophageal adenocarcinoma patients treated with nCRT, those with ypN0 and no signs of lymph node response (LNR) have a tripled median overall survival compared to those with LNR, and their survival is comparable to cN+/pN0 upfront esophagectomy patients.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
R. S. A. Goedegebuure, M. Harrasser, L. K. de Klerk, T. S. van Schooten, N. C. T. van Grieken, M. Eken, M. S. Grifhorst, N. Pocorni, E. S. Jordanova, M. I. van Berge Henegouwen, R. E. Pouw, H. M. W. Verheul, J. J. van der Vliet, H. W. M. van Laarhoven, V. L. J. L. Thijssen, A. J. Bass, T. D. De Gruijl, S. Derks
Summary: In-depth analysis revealed a close relationship between the levels and distribution of T cells and the response to neoadjuvant CRT in esophageal adenocarcinoma patients. The presence of memory T cells in peripheral blood T cells contributes to a complete pathological response to CRT.
Article
Oncology
Andromachi Kotsafti, Matteo Fassan, Francesco Cavallin, Valentina Angerilli, Luca Saadeh, Matteo Cagol, Rita Alfieri, Pierluigi Pilati, Carlo Castoro, Ignazio Castagliuolo, Melania Scarpa, Marco Scarpa
Summary: This study found that immune marker expression, oncogene status, and intra- and peritumoral immune infiltrating cells are associated with lymph node metastasis in patients with esophageal adenocarcinoma. These results suggest that immune surveillance failure is the key driver of lymph node metastasis.
Article
Medicine, Research & Experimental
Jun Cheng, Yize Mao, Wenhui Hong, Wanming Hu, Peng Shu, Kun Huang, Jingjing Yu, Maofen Jiang, Liqin Li, Wei Wang, Dong Ni, Shengping Li
Summary: Through systematic analysis of whole-slide images, survival data, and genome sequencing data from multiple centers, this study provides evidence that pancreatobiliary-type AAC resembles PAC rather than cholangiocarcinoma, which has important implications for treatment selection.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Samuel Han, Jennifer M. Kolb, Patrick Hosokawa, Chloe Friedman, Charlie Fox, Frank Scott, Christopher H. Lieu, Ravy K. Vajravelu, Martin McCarter, Caitlin C. Murphy, Michael B. Cook, Ana Gleisner, Gary W. Falk, David A. Katzka, Sachin Wani
Summary: Using the National Cancer Database, this study found that facilities with higher annual esophageal adenocarcinoma (EAC) case volume had better survival rates compared to lower volume facilities. The results suggest centralization of care for EAC patients at facilities with high annual case volume for improved outcomes.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)