Article
Public, Environmental & Occupational Health
Muhammad Waseem Khan, Jukka Juutilainen, Anssi Auvinen, Jonne Naarala, Eero Pukkala, Paivi Roivainen
Summary: Research has shown increased risk of leukemia in children living near power lines, but results on adult hematological malignancies and brain tumors are inconclusive. This study found that exposure to extremely low frequency magnetic fields decreased the risk of most hematological neoplasms, with a positive association only observed for acute lymphocytic leukemia (ALL).
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Health Care Sciences & Services
Huaying Liang, Dianwu Li, Yiqun Zhu, Xin Zhou, Fengyu Lin, Danrong Jing, Xiaoli Su, Pinhua Pan, Yan Zhang
Summary: This study found significant associations between multiple reproductive factors and the risk of adult-onset asthma in females. Age at menarche and age of menopause showed a U-shaped relationship with asthma risk. Factors such as early age at first live birth, multiple miscarriages or stillbirths, more children, and shorter reproductive years were associated with an elevated risk of asthma. Additionally, history of hysterectomy or oophorectomy, as well as hormone replacement therapy, were linked to an increased incidence of adult-onset asthma.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Clinical Neurology
Jillian K. Lee, Ryan D. Frank, Luke R. Christenson, Julie A. Fields, Walter A. Rocca, Michelle M. Mielke
Summary: A study of 2458 women found that the length of reproductive window was not associated with cognition, higher parity was associated with greater cognitive decline, hormonal contraception use was associated with less decline in cognition, and menopausal hormone therapy use was associated with greater decline in cognition except visuospatial.
ALZHEIMERS & DEMENTIA
(2023)
Review
Oncology
Manuela Chiavarini, Giulia Naldini, Irene Giacchetta, Roberto Fabiani
Summary: Many epidemiological studies have investigated the relationship between cutaneous malignant melanoma (CMM) and endogenous and exogenous hormones in women. However, the association between oral contraceptives (OCs) and menopausal hormone therapy (MHT) use and CMM risk remains controversial. This systematic review and meta-analysis aimed to summarize the evidence and provide a more accurate estimation of the association between exogenous hormone factors and CMM risk in women.
Article
Obstetrics & Gynecology
Jim Z. Mai, Rui Zhang, Michael R. Sargen, Mark P. Little, Bruce H. Alexander, Margaret A. Tucker, Cari M. Kitahara, Elizabeth K. Cahoon
Summary: This study found that earlier age at menarche and late age at first birth were associated with an increased incidence rate of melanoma. However, other estrogen-related factors and exogenous hormone use were not significantly associated with melanoma incidence.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Andre Madsen, Emmie N. Upners, Margit Bistrup Fischer, Alexander Siegfried Busch, Hanne Frederiksen, Trine Holm Johannsen, Anders Juul, Casper P. Hagen
Summary: Breast tissue in infancy is common, and it persists for longer in girls than boys. The study supports the early origin of breast tissue (in utero- and early postnatal) and the role of endogenous hormones in later development and maintenance.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Elke Butterbrod, Margriet Sitskoorn, Marjan Bakker, Bernadette Jakobs, Ruth Fleischeuer, Janine Roijers, Geert-Jan Rutten, Karin Gehring
Summary: This study found no significant differences in pretreatment cognitive performance or cognitive decline within 1 year after surgery between APOE epsilon 4 carriers and non-carriers with meningioma and glioma. Larger samples with longer-term follow-up are recommended for further investigation of potential late treatment effects.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Ophthalmology
Sungsoon Hwang, Se Woong Kang, Jisang Han, Kyungdo Han, Dahye Kim, Kyu Na Lee, Keun Hye Jeon, Jung Eun Yoo, Dong-Yun Lee, Dong Wook Shin, Dong Hui Lim
Summary: The study revealed that female reproductive factors were associated with the risk of exudative age-related macular degeneration (AMD). Longer reproductive period, longer duration of hormone replacement therapy, and greater exposure to estrogen were all linked to a higher incidence of exudative AMD.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Jin Ah Song, Heung-Sik Park, Young-Su Park, Kang Hee Kho, Cheol Young Choi
Summary: This study found that cortisol and red light irradiation both increased the expression of gonadotropin-inhibitory hormone (GnIH) and inhibited gonadotropin-releasing hormone (GnRH). Red light irradiation suppressed reproductive responses as much as cortisol treatment at 48 hours, suggesting it could be an alternative method for suppressing reproductive responses in future aquacultures.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Rheumatology
Dala N. Daraghmeh, Ashley M. Hopkins, Catherine King, Ahmad Y. Abuhelwa, Mihir D. Wechalekar, Susanna M. Proudman, Michael J. Sorich, Michael D. Wiese
Summary: This study examined the association between factors influencing female sex hormones and the efficacy of DMARDs in patients with RA. It was found that perimenopausal women were less likely to achieve remission, while the use of exogenous sex hormones was associated with higher remission rates in female RA patients.
Article
Neurosciences
Nienke Wolthuis, Ingeborg Bosma, Roelien Bastiaanse, Perumpillichira J. Cherian, Marion Smits, Wencke Veenstra, Michiel Wagemakers, Arnaud Vincent, Djaina Satoer
Summary: This study investigates the slow-wave brain activity in low-grade glioma and meningioma patients and its relation to pre- and postoperative language functioning. The results show that increased theta activity in glioma patients is associated with language impairments and has prognostic value for language outcome after surgery. Meningioma patients, on the other hand, do not exhibit significant increase in slow-wave brain activity but still experience word retrieval, grammatical, and writing problems preoperatively and writing impairments postoperatively.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Immunology
Stefano Porru, Maria Grazia Lourdes Monaco, Gianluca Spiteri, Angela Carta, Maria Diletta Pezzani, Giuseppe Lippi, Davide Gibellini, Evelina Tacconelli, Ilaria Dalla Vecchia, Emma Sala, Emanuele Sansone, Giuseppe De Palma, Carlo Bonfanti, Massimo Lombardo, Luigina Terlenghi, Enrico Pira, Ihab Mansour, Maurizio Coggiola, Catalina Ciocan, Alessandro Godono, Adonina Tardon, Marta-Maria Rodriguez-Suarez, Guillermo Fernandez-Tardon, Francisco-Jose Jimeno-Demuth, Rafael-Vicente Castro-Delgado, Tania Iglesias Cabo, Maria Luisa Scapellato, Filippo Liviero, Angelo Moretto, Paola Mason, Sofia Pavanello, Anna Volpin, Luigi Vimercati, Silvio Tafuri, Luigi De Maria, Stefania Sponselli, Pasquale Stefanizzi, Antonio Caputi, Fabriziomaria Gobba, Alberto Modenese, Loretta Casolari, Denise Garavini, Cristiana D'Elia, Stefania Mariani, Francesca Larese Filon, Luca Cegolon, Corrado Negro, Federico Ronchese, Francesca Rui, Paola De Michieli, Nicola Murgia, Marco Dell'Omo, Giacomo Muzi, Tiziana Fiordi, Angela Gambelunghe, Ilenia Folletti, Dana Mates, Violeta Claudia Calota, Andra Neamtu, Ovidiu Perseca, Catalin Alexandru Staicu, Angelica Voinoiu, Eleonora Fabianova, Jana Beresova, Zora Kl'ocova Adamcakova, Roman Nedela, Anna Lesnakova, Jana Holcikova, Paolo Boffetta, Mahsa Abedini, Giorgia Ditano, Shuffield Seyram Asafo, Giovanni Visci, Francesco Saverio Violante, Carlotta Zunarelli, Giuseppe Verlato
Summary: This research investigated the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of over 60,000 health workers. The study found that age and previous infection significantly modified breakthrough infection rates, and previous SARS-CoV-2 infection and antibody titer were inversely related to the risk of breakthrough infection.
Article
Biodiversity Conservation
Michal Bogdziewicz, Dave Kelly, Andrew J. Tanentzap, Peter Thomas, Jessie Foest, Jonathan Lageard, Andrew Hacket-Pain
Summary: Climate warming reduces tree reproduction and affects forest dynamics, with consequences for forest regeneration at different levels. A study on European beech trees showed that masting breakdown leads to declining viable seed production over time, contrary to the initial increase in raw seed count. Tree size also plays a role, with seed predation increasing mainly in small trees and pollination efficiency disproportionately decreasing in larger individuals. This study highlights the importance of understanding the relationship between climate change, tree reproduction, and forest resilience.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Oncology
Calistus Wilunda, Norie Sawada, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane
Summary: Reproductive factors such as longer fertility span and late age at menopause were associated with increased risk of lung adenocarcinoma among nonsmoking women. Breastfeeding was found to be associated with reduced risk of nonadenocarcinoma. Other factors like parity, age at first birth, exogenous hormone use, and length of menstrual cycle did not show significant associations with lung cancer risk. Future studies incorporating estrogen and progesterone biomarkers may help clarify the role of endogenous hormones in lung carcinogenesis.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Agriculture, Dairy & Animal Science
J. S. M. van der Laan, P. L. A. M. Vos, B. H. P. van den Borne, H. Aardema, T. van Werven
Summary: The study revealed that prostaglandins were the most commonly used reproductive hormone in Dutch dairy cows, followed by GnRH and progesterone. Participation in veterinary herd health management programs and the use of technologies like pedometers and automatic milking systems were associated with increased reproductive hormone use. Farms with automatic milking systems tended to use more reproductive hormones compared to those with conventional milking systems.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Nutrition & Dietetics
Raul Zamora-Ros, Valerie Cayssials, Ramon Cleries, Maria Torrents, Graham Byrnes, Elisabete Weiderpass, Maria Sandstrom, Martin Almquist, Marie-Christine Boutron-Ruault, Anne Tjonneland, Cecilie Kyro, Verena A. Katzke, Charlotte Le Cornet, Giovanna Masala, Vittorio Krogh, Gabriella Iannuzzo, Rosario Tumino, Lorenzo Milani, Guri Skeie, Esther Ubago-Guisado, Pilar Amiano, Maria-Dolores Chirlaque, Eva Ardanaz, Suzanne Janzi, Linda Eriksson, Heinz Freisling, Alicia K. Heath, Sabina Rinaldi, Antonio Agudo
Summary: This study found that consumption of sweetened beverages was associated with an increased risk of differentiated thyroid cancer, while a dietary pattern characterized by alcohol consumption was associated with a decreased risk of thyroid cancer.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Oncology
Ulla Arthur Hvidtfeldt, Jie Chen, Sophia Rodopoulou, Maciej Strak, Kees de Hoogh, Zorana J. Andersen, Tom Bellander, Jorgen Brandt, Daniela Fecht, Francesco Forastiere, John Gulliver, Ole Hertel, Barbara H. Hoffmann, Klea Katsouyanni, Matthias Ketzel, Boel Brynedal, Karin Leander, Petter L. S. Ljungman, Patrik K. E. Magnusson, Gabriele Nagel, Goran Pershagen, Debora Rizzuto, Marie-Christine Boutron-Ruault, Evangelia Samoli, Rina So, Massimo Stafoggia, Anne Tjonneland, Roel Vermeulen, W. M. Monique Verschuren, Gudrun Weinmayr, Kathrin Wolf, Jiawei Zhang, Emanuel Zitt, Bert Brunekreef, Gerard Hoek, Ole Raaschou-Nielsen
Summary: This study examined the relationship between long-term air pollution exposure and breast cancer incidence. The results showed an association between PM2.5 and breast cancer, suggesting a potential role of exposure to NO2, PM2.5, and BC in the development of breast cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Nutrition & Dietetics
Christian S. Bork, Soren Lundbye-Christensen, Stine K. Veno, Anne N. Lasota, Anne Tjonneland, Erik B. Schmidt, Kim Overvad
Summary: This study aimed to investigate the association between intake of seafood and plant-derived n-3 polyunsaturated fatty acids (PUFA) and the development of total atherosclerotic cardiovascular disease (ASCVD) and acute major ischemic events. The results showed that a high intake of marine n-3 PUFA was associated with a lower risk of total ASCVD and acute major ischemic events, while no association was found for plant-derived ALA.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Oncology
Ziling Mao, Jacqueline Roshelli Baker, Masayoshi Takeuchi, Hideyuki Hyogo, Anne Tjonneland, Anne Kirstine Eriksen, Gianluca Severi, Joseph Rothwell, Nasser Laouali, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Domenico Palli, Sabina Sieri, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Jeroen W. G. Derksen, Inger T. Gram, Guri Skeie, Torkjel M. Sandanger, Jose Ramon Quiros, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Sophia Harlid, Ingegerd Johansson, Aurora Perez-Cornago, Heinz Freisling, Marc Gunter, Elisabete Weiderpass, Alicia K. Heath, Elom Aglago, Mazda Jenab, Veronika Fedirko
Summary: Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) are associated with the development and progression of colorectal cancer due to their oxidative and inflammatory properties. This study found that circulating glycer-AGEs concentrations are positively associated with both colorectal cancer-specific and all-cause mortality. The association between glycer-AGEs and colorectal cancer-specific mortality is stronger in patients with distal colon cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Genetics & Heredity
Eleanor Wong, Nicolas Bertin, Maxime Hebrard, Roberto Tirado-Magallanes, Claire Bellis, Weng Khong Lim, Chee Yong Chua, Philomena Mei Lin Tong, Raymond Chua, Kenneth Mak, Tit Meng Lim, Wei Yang Cheong, Kwee Eng Thien, Khean Teik Goh, Jin-Fang Chai, Jimmy Lee, Joseph Jao-Yiu Sung, Tien Yin Wong, Calvin Woon Loong D. Chin, Peter Gluckman, Liuh Ling Goh, Kenneth Hon Kim Ban, Tin Wee M. Tan, Rob M. Van Dam, Yik Ying Teo, Marie Loh, Paul Eillot, Eng Sing Lee, Joanne Ngeow, Elio Riboli, Rinkoo Dalan, Irfahan Kassam, Lakshmi Narayanan Lakshmanan, Tock Han Lim, Hong Kiat Ng, Theresia Mina, Darwin Tay, Charumathi Sabanayagam, Yih Chung Tham, Tyler Rim, Tin Aung, Miao Ling Chee, Hengtong Li, Miao Li Chee, Khung Keong Yeo, Stuart Alexander Cook, Chee Jian Pua, Chengxi Yang, Yap Seng Chong, Johan Gunnar Eriksson, Kok Hian Tan, Fabian Yap, Chia Wei Lim, Pi Kuang Tsai, Wen Jie Chew, Wey Ching Sim, Li-xian Grace Toh, Clarabelle Bitong Lin, Yee Yen Sia, Tat Hung Koh, Wee Yang Meah, Joanna Hui Juan Tan, Justin Jeyakani, Jack Ow, Shimin Ang, Ashar J. Malik, Dimitar Kenanov, Xueling Sim, Ching-Yu Cheng, Sonia Davila, Neerja Karnani, Khai Pang Leong, Jianjun Liu, Shyam Prabhakar, Sebastian Maurer-Stroh, Chandra Shekhar Verma, Pavitra Krishnaswamy, Rick Siow Mong Goh, Irenaeus Chia, Clarissa Ho, Doreen Low, Suchin Virabhak, Jacklyn Yong, Weiling Zheng, Shih Wee Seow, Yee Kwang Seck, Mingshi Koh, John C. Chambers, E. Shyong Tai, Patrick Tan
Summary: This article discusses Singapore's efforts to establish a National Precision Medicine Strategy by integrating genomic, clinical, and lifestyle data of up to one million individuals. Precision medicine has the potential to revolutionize healthcare by detecting diseases early, refining diagnoses, and tailoring treatments for groups and individuals. The lack of representation of Asian ancestries in existing genomic-phenotypic databases presents a missed opportunity for new discoveries, especially for diseases relevant to these populations. The Singapore National Precision Medicine initiative aims to generate integrated data from various sources over a 10-year period, including genomic, lifestyle, health, social, and environmental data, in order to promote precision medicine adoption and address social, ethical, legal, and regulatory challenges.
Article
Nutrition & Dietetics
Leila Lujan-Barroso, Lucia Iglesias, Raul Zamora-Ros, Cristina Lasheras, Maria-Jose Sanchez, Natalia Cabrera-Castro, Josu Delfrad, Pilar Amiano, Esther Molina-Montes, Sandra Colorado-Yohar, Conchi Moreno-Iribas, Ane Dorronsoro, Miguel Rodriguez-Barranco, Maria Dolores Chirlaque, Amaia Aizpurua, Antonio Agudo, Jose Ramon Quiros, Paula Jakszyn
Summary: Recent evidence suggests that energy distribution during the daytime could be a potential determinant for the development of metabolic syndrome (MetS). This study aimed to assess the association between breakfast size and the prevalence of MetS in Spanish adults. The results showed that a larger breakfast size was associated with a lower prevalence of MetS.
Article
Oncology
S. G. Yammine, I. Huybrechts, C. Biessy, L. Dossus, S. Panico, M. J. Sanchez, V. Benetou, R. Turzanski-Fortner, V. Katzke, A. Idahl, G. Skeie, K. Standahl Olsen, A. Tjonneland, J. Halkjaer, S. Colorado-Yohar, A. K. Heath, E. Sonestedt, H. Sartor, M. B. Schulze, D. Palli, M. Crous-Bou, A. Dorronsoro, K. Overvad, A. Barricarte Gurrea, G. Severi, R. C. H. Vermeulen, T. M. Sandanger, R. C. Travis, T. Key, P. Amiano, B. Van Guelpen, M. Johansson, M. Sund, R. Tumino, N. Wareham, C. Sacerdote, V. Krogh, P. Brennan, E. Riboli, E. Weiderpass, M. J. Gunter, V. Chajes
Summary: Specific dietary fatty acids, such as gamma-linolenic acid and alpha-linolenic acid from plant sources, may be associated with lower risk of endometrial cancer.
Article
Medicine, General & Internal
Joseph A. Rothwell, Jelena Besevic, Niki Dimou, Marie Breeur, Neil Murphy, Mazda Jenab, Roland Wedekind, Vivian Viallon, Pietro Ferrari, David Achaintre, Audrey Gicquiau, Sabina Rinaldi, Augustin Scalbert, Inge Huybrechts, Cornelia Prehn, Jerzy Adamski, Amanda J. Cross, Hector Keun, Marc Chadeau-Hyam, Marie-Christine Boutron-Ruault, Kim Overvad, Christina C. Dahm, Therese Haugdahl Nost, Torkjel M. Sandanger, Guri Skeie, Raul Zamora-Ros, Kostas K. Tsilidis, Fabian Eichelmann, Matthias B. Schulze, Bethany van Guelpen, Linda Vidman, Maria-Jose Sanchez, Pilar Amiano, Eva Ardanaz, Karl Smith-Byrne, Ruth Travis, Verena Katzke, Rudolf Kaaks, Jeroen W. G. Derksen, Sandra Colorado-Yohar, Rosario Tumino, Bas Bueno-de-Mesquita, Paolo Vineis, Domenico Palli, Fabrizio Pasanisi, Anne Kirstine Eriksen, Anne Tjonneland, Gianluca Severi, Marc J. Gunter
Summary: This study investigated the association between pre-diagnostic levels of amino acids and subsequent risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts. The results showed that higher levels of histidine were associated with a lower risk of colorectal cancer, and there was a weak inverse association between glutamine levels and colorectal cancer risk. Further research is needed to understand the role of histidine and glutamine in colorectal cancer development.
Article
Oncology
Sontoria D. King, Swathi Veliginti, Martijn C. G. J. Brouwers, Zhewen Ren, Wei Zheng, Veronica W. Setiawan, Lynne R. Wilkens, Xiao-Ou Shu, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Federico Canzian, Mengmeng Du, Steven J. Gallinger, Graham G. Giles, Phyllis J. Goodman, Christopher A. Haiman, Manolis Kogevinas, Charles Kooperberg, Loic LeMarchand, Rachel E. Neale, Kala Visvanathan, Emily White, Demetrius Albanes, Gabriella Andreotti, Ana Babic, Sonja I. Berndt, Lauren K. Brais, Paul Brennan, Julie E. Buring, Kari G. Rabe, William R. Bamlet, Stephen J. Chanock, Charles S. Fuchs, J. Michael Gaziano, Edward L. Giovannucci, Thilo Hackert, Manal M. Hassan, Verena Katzke, Robert C. Kurtz, I. -Min Lee, Nuria Malats, Neil Murphy, Ann L. Oberg, Irene Orlow, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson Jr, Jean Wactawski-Wende, Xiaoliang Wang, Nicolas Wentzensen, Herbert Yu, Anne Zeleniuch-Jacquotte, Kai Yu, Brian M. Wolpin, Eric J. Duell, Donghui Li, Rayjean J. Hung, Sandra Perdomo, Marjorie L. McCullough, Neal D. Freedman, Alpa Patel, Ulrike Peters, Elio Riboli, Malin Sund, Anne Tjonneland, Jun Zhong, Stephen K. Van den Eeden, Peter Kraft, Harvey A. Risch, Laufey T. Amundadottir, Alison P. Klein, Rachael Z. Stolzenberg-Solomon, Samuel O. Antwi
Summary: This study used Mendelian randomization (MR) to investigate the relationship between genetic predisposition to nonalcoholic fatty liver disease (NAFLD) and risk for pancreatic cancer. The results showed no association between genetically predicted NAFLD and pancreatic cancer risk, suggesting that any association between NAFLD and pancreatic cancer might be due to metabolic disturbances rather than a causal relationship.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Y. Mahamat-Saleh, S. Rinaldi, R. Kaaks, C. Biessy, E. M. Gonzalez-Gil, N. Murphy, C. Le Cornet, J. M. Huerta, S. Sieri, A. Tjonneland, L. Mellemkjaer, M. Guevara, K. Overvad, A. Perez-Cornago, S. Tin Tin, L. Padroni, V. Simeon, G. Masala, A. May, E. Monninkhof, S. Christakoudi, A. K. Heath, K. Tsilidis, A. Agudo, M. B. Schulze, J. Rothwell, C. Cadeau, S. Severi, E. Weiderpass, M. J. Gunter, L. Dossus
Summary: This study investigated the associations between metabolically defined body size and shape phenotypes and the risk of postmenopausal breast cancer. The results suggest that being overweight or obese and metabolically unhealthy raises the risk of breast cancer, while overweight or obese women with normal insulin levels are not at higher risk.
Article
Environmental Sciences
Clara G. Sears, Erin J. Healy, Lissa F. Soares, Dana Palermo, Melissa Eliot, Yaqiang Li, Victoria Fruh, Tesleem Babalola, Katherine A. James, James M. Harrington, Gregory A. Wellenius, Anne Tjonneland, Ole Raaschou-Nielsen, Jaymie R. Meliker
Summary: Limited evidence suggests that environmental antimony exposure is associated with cardiovascular disease risk. This study found that urine antimony concentrations were positively associated with rates of acute myocardial infarction and heart failure in a Danish population who never smoked.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Jesse D. Thacher, Anna Oudin, Erin Flanagan, Kristoffer Mattisson, Maria Albin, Nina Roswall, Andrei Pyko, Gunn Marit Aasvang, Zorana J. Andersen, Signe Borgquist, Jorgen Brandt, Karin Broberg, Thomas Cole-Hunter, Charlotta Eriksson, Kristina Eneroth, Hrafnhildur Gudjonsdottir, Emilie Helte, Matthias Ketzel, Timo Lanki, Youn-Hee Lim, Karin Leander, Petter Ljungman, Jonas Manjer, Satu Mannisto, Ole Raaschou-Nielsen, Goran Pershagen, Debora Rizzuto, Malte Sandsveden, Jenny Selander, Mette K. Simonsen, Lara Stucki, Marten Spanne, Leo Stockfelt, Anne Tjonneland, Tarja Yli-Tuomi, Pekka Tiittanen, Victor H. Valencia, Mikael Ogren, Agneta Akesson, Mette Sorensen
Summary: This study investigated the association between long-term exposure to transportation noise and breast cancer incidence. Weak associations were found between road and railway noise and breast cancer risk. However, more high-quality prospective studies are needed to determine the role of noise as a risk factor for breast cancer.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Lisa Padroni, Laura De Marco, Valentina Fiano, Lorenzo Milani, Giorgia Marmiroli, Maria Teresa Giraudo, Alessandra Macciotta, Fulvio Ricceri, Carlotta Sacerdote
Summary: The analysis of circulating tumor cells and tumor-derived materials, such as circulating tumor DNA, circulating miRNAs (cfmiRNAs), and extracellular vehicles, provides crucial information in cancer research, especially in breast cancer cases. However, the current studies on cfmiRNA levels exhibit high risk of bias and lack standardized protocols, highlighting the need for more robust study designs, standardized procedures, and larger sample sizes for accurate and reliable results. The identified cfmiRNAs show potential as diagnostic and prognostic biomarkers, but further validation studies in different populations are required for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sixten Harborg, Maria Feldt, Deirdre Cronin-Fenton, Marie Klintman, Susanne O. Dalton, Ann H. Rosendahl, Signe Borgquist
Summary: The purpose of this study was to examine the association between obesity and clinical outcomes in early breast cancer and assess if patient, tumor, and treatment characteristics modify such associations. The study found that obesity is associated with a higher risk of breast cancer recurrence and death, especially in patients with low socioeconomic position, larger tumors, estrogen-receptor-negative breast cancer, and those receiving adjuvant chemotherapy. Therefore, weight management is crucial in the treatment of breast cancer patients.
CANCER & METABOLISM
(2023)
