Review
Dentistry, Oral Surgery & Medicine
Narges Ghazi, Maryam Khorasanchi
Summary: Oral lichen planus (OLP) is an autoimmune disease associated with chronic inflammation, potentially leading to oral squamous cell carcinoma. While the pathogenesis of OLP is not fully understood, it is known that epithelial cells in OLP lesions are influenced by immunological reactions. Predictive markers can aid in forecasting and monitoring cancer progression.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study investigated the association between oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in a retrospective cohort of 3568 patients. The findings suggest that not all cases of OSCC are transformed from OLP, indicating that the previous understanding of OLP transformation may have been overestimated. Strict diagnostic criteria for OLP and close surveillance are important in correctly identifying the origin of OSCC and avoiding overestimation of the risk of OLP transformation.
Article
Dentistry, Oral Surgery & Medicine
John Adeoye, Yu-Xiong Su
Summary: This study assessed the validity of nomograms for predicting malignant transformation among patients with oral leukoplakia and oral lichen planus. The nomograms showed some net benefit for risk stratification, but did not outperform binary dysplasia grading.
Article
Dentistry, Oral Surgery & Medicine
Fumihiko Tsushima, Jinkyo Sakurai, Atsushi Uesugi, Yu Oikawa, Toshimitsu Ohsako, Yumi Mochizuki, Hideaki Hirai, Kou Kayamori, Hiroyuki Harada
Summary: Oral lichen planus (OLP) is a chronic inflammatory oral mucosa disease recognized as a potentially malignant disorder. This study examined demographic and clinical characteristics of OLP patients, with results suggesting a low risk of malignant transformation. Regular follow-up for OLP patients is recommended for early detection of malignant transformation, and further investigation on clinical risk factors is necessary.
Article
Oncology
Paolo G. Arduino, Alessandro Magliano, Alessio Gambino, Alessandra Macciotta, Mario Carbone, Davide Conrotto, Dora Karimi, Marco Carrozzo, Roberto Broccoletti
Summary: Up to 1-4% of OLP patients may develop oral cancer, with older age being a risk factor. Regular follow-up for OLP patients, especially in the Northern Italian population, is crucial due to the risk of malignant transformation.
Article
Dentistry, Oral Surgery & Medicine
Rakefet Czerninski, Zinat Awadieh, Svetlana Feldman, Naama Keshet, Abraham Zlotogorski, Yuval Ramot
Summary: This study describes familial OLP in 20 families, predominantly Jewish. The high prevalence of hypothyroidism and oral squamous cell carcinoma in familial OLP patients suggests a potential predisposition to malignant transformation in this high-risk group.
Article
Dentistry, Oral Surgery & Medicine
Mohammed Bindakhil, Sunday Akintoye, Patricia Corby, Eric T. Stoopler, Martin S. Greenberg, Rabie Shanti, Takako Tanaka, Thomas P. Sollecito
Summary: The study found that the use of topical corticosteroids therapy in oral lichen planus (OLP) patients may delay cancer development, while Candida may play a role in the carcinogenesis of OLP patients. Factors such as gender, smoking, and alcohol use did not significantly impact the time of malignant transformation from OLP to OSCC.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2022)
Article
Multidisciplinary Sciences
Cristovao Antunes de lanna, Beatriz Nascimento Monteiro da Silva, Andreia Cristina de Melo, Martin H. Bonamino, Lisia Daltro Borges Alves, Luis Felipe Ribeiro Pinto, Abel Silveira Cardoso, Heliton Spindola Antunes, Mariana Boroni, Daniel Cohen Goldemberg
Summary: By comparing the gene expression profiles of Oral Lichen Planus and Oral Squamous Cell Carcinoma, similarities were found in processes such as keratinization, cell proliferation, and immune response. Key tumor suppressors and oncogenes were dysregulated in both diseases.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Honglin Liao, Yuxue Luo, Li Long, Jiakuan Peng, Xuemei Qiu, Peiyang Yuan, Hao Xu, Lu Jiang
Summary: The study found that anxiety levels were higher in OLP patients compared to healthy individuals, with female patients showing higher levels of anxiety. Gender had an impact on anxiety levels among OLP patients. The research suggests that OLP patients can be classified into weakly anxiety-related or highly anxiety-related types.
Article
Dermatology
S. Utz, V. G. A. Suter, S. Cazzaniga, L. Borradori, L. Feldmeyer
Summary: Topical tacrolimus is an effective therapy for oral lichen planus, especially for patients who are unresponsive to potent topical corticosteroids. Adjusting the treatment frequency based on signs of clinical activity and subjective impairment is important, with regular follow-up essential for early detection of potential squamous cell carcinoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Fangyi Xie, Casey A. Gleue, Maria Deschaine, Surendra Dasari, Julio C. Sartori-Valinotti, M. Cristine Charlesworth, Alexander Meves, Julia S. Lehman
Summary: Oral lichen planus (OLP) has a 1% risk of transforming into oral squamous cell carcinoma (OSCC). This study aimed to identify tissue-based protein biomarkers in OLP patients who developed OSCC compared to those who did not. The proteomic analysis revealed potential biomarkers, such as CA1 overexpression, for higher-risk OLP. Epithelial-mesenchymal transition may be involved in the carcinogenesis of OLP.
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Article
Dentistry, Oral Surgery & Medicine
Marketa Janovska, Katherine J. Bodiford, Alison J. Bruce, Roy S. Rogers III
Summary: The study found that oral lichen planus and vulvar lichen sclerosus may coexist in patients in their seventies. The most commonly used treatment is topical corticosteroids, and the coexistence of both diseases does not increase the risk of malignancy.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Review
Endocrinology & Metabolism
A. Romano, R. Grassi, F. Fiori, G. M. Nardi, R. Borgia, M. Contaldo, R. Serpico, M. Petruzzi
Summary: Oral Lichen Planus is an immune-mediated disease of unknown etiology, and EBV may play a role in its pathogenesis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Miguel angel Gonzalez-Moles, Saman Warnakulasuriya, Isabel Gonzalez-Ruiz, Lucia Gonzalez-Ruiz, Angela Ayen, Daniel Lenouvel, Isabel Ruiz-Avila, Pablo Ramos-Garcia
Summary: The global prevalence of oral lichen planus varies significantly by region, with an increase in prevalence with age. It is recommended to establish reliable diagnostic criteria and enhance awareness of oral lichen planus among healthcare professionals.
