Article
Oncology
Azadeh Nasrazadani, Yujia Li, Yusi Fang, Osama Shah, Jennifer M. Atkinson, Joanna S. S. Lee, Priscilla F. McAuliffe, Rohit Bhargava, George Tseng, Adrian V. V. Lee, Peter C. Lucas, Steffi Oesterreich, Norman Wolmark
Summary: This study describes the clinicopathologic characteristics of mixed invasive ductal lobular carcinoma (mDLC) and finds that mDLC is clinically more similar to invasive lobular carcinoma (ILC) than invasive ductal carcinoma (IDC). Successful breast-conserving surgery rates after neoadjuvant chemotherapy are higher in mDLC patients compared to ILC patients. The metastatic patterns of mDLC show characteristics of both IDC and ILC.
BRITISH JOURNAL OF CANCER
(2023)
Article
Physiology
Evgeniya Gerasimova-Chechkina, Brian C. Toner, Kendra A. Batchelder, Basel White, Genrietta Freynd, Igor Antipev, Alain Arneodo, Andre Khalil
Summary: The study compares spatial fluctuations of mammographic breast tissue using the WTMM method. Results show significant differences between cancerous and benign breast tissue, as well as statistically significant asymmetry between cancerous breasts and their contralateral counterparts. Lobular and ductal cancerous breasts exhibit similar levels of disruption and asymmetry. This study has the potential to assist in detecting and characterizing tumor-associated breast tissue and could improve screening techniques for lobular lesions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pathology
Belen Perez-Mies, Tamara Caniego-Casas, Irene Carretero-Barrio, Michele Biscuola, Maria A. Lopez-Garcia, David Hardisson, Marta Rosas, Maria J. Lopez Rodriguez, Eva Cristobal, David Pizarro, Juan M. Rosa-Rosa, Jose Palacios
Summary: In this study, the researchers analyzed the molecular alterations of both components of invasive ductolobular carcinomas (IDLC). They found that 80% of tumors had alterations in driver genes in both components, with PIK3CA being the most common alteration. CDH1 mutations were present in the lobular component of 45% of IDLC, but absent in the ductal component. The study also suggested the need for molecular characterization of both components to guide targeted therapies.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Elahe Foroozani, Ali Akbari, Sasan Amanat, Nastaran Rashidi, Dariush Bastam, Shima Ataee, Golnaz Sharifnia, Mohammad Faraouei, Mostafa Dianatinasab, Hassan Safdari
Summary: Little is known about the role of diet in the risk of invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) of the breast, but this study found that adhering to a Western diet (WD) significantly raises the risk of IDC, while having no significant impact on the risk of ILC. This suggests different etiological mechanisms for IDC and ILC.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sanghoon Lee, Hatice Ulku Osmanbeyoglu
Summary: This study characterizes the differences in genome-wide chromatin accessibility between invasive lobular breast carcinoma (ILC) and invasive ductal carcinoma (IDC), revealing distinct epigenomic features and the active transcription factors (TFs) driving cancer progression in these two subtypes.
BREAST CANCER RESEARCH
(2022)
Article
Oncology
Fangyuan Chen, Kai Ding, Nolan Priedigkeit, Ashuvinee Elangovan, Kevin M. Levine, Neil Carleton, Laura Savariau, Jennifer M. Atkinson, Steffi Oesterreich, Adrian V. Lee
Summary: This study revealed transcriptional heterogeneity in breast cancer cell lines and the significant role of E-cadherin depletion in contributing to the molecular features of invasive lobular breast carcinoma.
Article
Multidisciplinary Sciences
Ruwaa Mohamed, Salma A. Bargal, Asmaa S. Mekawy, Iman El-Shiekh, Nurcan Tuncbag, Alaa S. Ahmed, Eman Badr, Menattallah Elserafy
Summary: This study analyzed the transcriptional differences between two invasive breast cancer subtypes and identified overexpressed DNA repair genes in both types. Despite high expression in some samples, noticeable variations were observed within patients of the same cancer subtype.
Article
Oncology
Jasmine Timbres, Charlotte Moss, Anca Mera, Anna Haire, Cheryl Gillett, Mieke Van Hemelrijck, Elinor Sawyer
Summary: Invasive lobular breast cancer (ILC) accounts for 10-15% of breast cancers and may have a poorer response to chemotherapy compared to invasive ductal carcinoma (IDC). A study found worse survival in ER+HER2- ILC patients after chemotherapy compared to ER+HER2- IDC, even after adjusting for various factors. Further research in a larger population is needed to confirm these findings.
Article
Oncology
Jason A. Mouabbi, Akshara Singareeka Raghavendra, Roland L. Bassett Jr, Matthias Christgen, Lavinia Middleton, Mediget Teshome, Azadeh Nasrazadani, Gabriel Hortobagyi, Amy Hassan, Debasish Tripathy, Rachel M. Layman
Summary: The aim of this study was to determine if the outcomes of patients with the co-occurrence of ipsilateral lobular carcinoma in situ (LCIS) and invasive lobular carcinoma (ILC) are similar to pure ILC, and if the presence of LCIS is a prognostic factor for ILC. The results showed that patients in the ILC+LCIS group had better distant recurrence-free and overall survival rates compared to the ILC alone group, suggesting that the absence of LCIS is an independent poor prognostic factor for ILC.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Hengqiang Zhao
Summary: The study of female patients with IDC, ILC, or IDLC revealed that the prognosis was associated with molecular subtypes of breast carcinoma. Management decisions should take into account pathological types and molecular subtypes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Laszlo Tabar, Peter B. Dean, F. Lee Tucker, Amy Ming-Fang Yen, Jean Ching-Yuan Fann, Abbie Ting-Yu Lin, Robert A. Smith, Stephen W. Duffy, Tony Hsiu-Hsi Chen
Summary: The study aims to use mammographic tumor features (imaging biomarkers) to identify and investigate breast cancers originating from the terminal ductal lobular units (TDLUs). The correlation between imaging biomarkers and histopathologic images of breast cancers indicate that imaging biomarkers can reliably determine the site of origin of breast cancers arising from the TDLUs. These findings emphasize the importance of incorporating imaging biomarkers in diagnosis, treatment planning, and prediction of long-term patient outcomes.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Rusen Cosar, Necdet Sut, Sernaz Topaloglu, Ebru Tastekin, Dilek Nurlu, Talar Ozler, Eylul Senodeyici, Melisa Dedeli, Mert Chousein, Irfan Cicin
Summary: This study compared the clinical features and prognosis of invasive lobular carcinoma patients and found that the invasive lobular special type had the worst prognosis, suggesting a need for reclassification and reconsideration of treatment methods.
Article
Oncology
Peeter Karihtala, Katja Porvari, Nelli Roininen, Sari Voutilainen, Johanna Mattson, Paivi Heikkila, Kirsi-Maria Haapasaari, Katri Selander
Summary: The pathophysiology and optimal treatment of breast neuroendocrine tumors (NETs) are still unknown. This study compared the mutational profiles of breast NETs with those of invasive ductal carcinoma (IDC) and pancreatic NET (PNET) cases. The results showed that breast NETs have similar mutational profiles to IDCs and have distinct differences from PNETs. Breast NETs have clock-like mutational signatures and signatures associated with defective DNA mismatch repair. This study suggests that breast NETs are a unique subtype of breast cancer, but more research is needed to determine the optimal treatment.
Review
Medicine, General & Internal
Nektarios Koufopoulos, Ioannis S. Pateras, Alina Roxana Gouloumis, Argyro Ioanna Ieronimaki, Andriani Zacharatou, Aris Spathis, Danai Leventakou, Panagiota Economopoulou, Amanda Psyrri, Nikolaos Arkadopoulos, Ioannis G. Panayiotides
Summary: Invasive lobular carcinoma is the most common special subtype of breast carcinoma, characterized by unique morphological and immunohistochemical features and poor response to neoadjuvant therapy. In addition to classic variant, there are several other recognized variants, and three novel variants have been described in the past decade.
Article
Oncology
Anita Mamtani, Anne Grabenstetter, Varadan Sevilimedu, Monica Morrow, Mary L. Gemignani
Summary: Among patients with invasive lobular breast cancers, non-classic variants respond better to neoadjuvant chemotherapy, but there is only a significant difference in the rates of complete response in the breast and lymph nodes.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Jonathan M. Samet, Weihsueh A. Chiu, Vincent Cogliano, Jennifer Jinot, David Kriebel, Ruth M. Lunn, Frederick A. Beland, Lisa Bero, Patience Browne, Lin Fritschi, Jun Kanno, Dirk W. Lachenmeier, Qing Lan, Gerard Lasfargues, Frank Le Curieux, Susan Peters, Pamela Shubat, Hideko Sone, Mary C. White, Jon Williamson, Marianna Yakubovskaya, Jack Siemiatycki, Paul A. White, Kathryn Z. Guyton, Mary K. Schubauer-Berigan, Amy L. Hall, Yann Grosse, Veronique Bouvard, Lamia Benbrahim-Tallaa, Fatiha El Ghissassi, Beatrice Lauby-Secretan, Bruce Armstrong, Rodolfo Saracci, Jiri Zavadil, Kurt Straif, Christopher P. Wild
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Letter
Health Care Sciences & Services
Thomas B. Richards, Sabitha Dasari, Susan A. Sabatino, Jin Qin, Jacqueline W. Miller, Mary C. White
JOURNAL OF GENERAL INTERNAL MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Stephanie C. Melkonian, Dornell Pete, Melissa A. Jim, Donald Haverkamp, Charles L. Wiggins, Michael G. Bruce, Mary C. White
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Public, Environmental & Occupational Health
Stephanie C. Melkonian, Hannah K. Weir, Melissa A. Jim, Bailey Preikschat, Donald Haverkamp, Mary C. White
Summary: Cancer incidence rates vary among American Indian and Alaska Native populations, with higher rates for certain cancers such as liver, stomach, kidney, lung, colorectal, and female breast cancers. Between 2012 and 2016, nearly 5,200 excess cancer cases were diagnosed among AI/AN populations, with the Southern Plains region having the highest number of excess cases. Efforts informed by culture could help reduce cancer disparities among AI/AN populations.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Sara D. Turbow, Mary C. White, Erica S. Breslau, Susan A. Sabatino
Summary: The study found that the incidence rate of breast cancer is highest among women aged 70-74 years and lowest among women aged 85 years and above. As age increases, the proportion of cancer diagnosed at distant stage or with unknown stage also increases. Over half of women aged 80-84 years and 26.0% of women aged 85 years and above reported having a screening mammogram within the last 2 years. Self-reported health status and independence in daily activities were associated with recent mammography screening.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Environmental Sciences
Deborah J. Bowen, Senaida Fernandez Poole, Mary White, Rodney Lyn, Debra A. Flores, Helen G. Haile, David R. Williams
Summary: This review examines the relationship between stress and breast cancer incidence, discussing the potential of stress as a risk factor, possible intervention strategies, and future research directions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Correction
Oncology
Sara D. Turbow, Mary C. White, Erica S. Breslau, Susan A. Sabatino
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Emily E. Adam, Mary C. White, Mona Saraiya
Summary: The study compared hysterectomy prevalence estimates from BRFSS and NHIS, finding similar increasing trends by age but directional differences by race and ethnicity. Women aged 70-79 had the highest reported rates of hysterectomy.
CANCER CAUSES & CONTROL
(2022)
Article
Health Care Sciences & Services
Emily E. Adam, Mary C. White, Mona Saraiya
Summary: The study reveals that hysterectomy prevalence is higher among rural women compared to urban women, which could distort comparisons of rural-urban cervical and uterine cancer incidence rates. Additionally, differences in hysterectomy prevalence between rural and urban areas vary among different race and ethnic groups, highlighting potential confounding biases in the relationship between rurality and cancer rates.
JOURNAL OF RURAL HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Hannah K. Weir, Trevor D. Thompson, Sherri L. Stewart, Mary C. White
Summary: The number of adults entering the age groups at greatest risk for cancer diagnosis is increasing. By 2050, cancer incidence rates are projected to stabilize in women and decrease in men, while the annual number of cancer cases is expected to increase by 49%, with the largest percentage increase among adults aged 75 years and older. Efforts to reduce cancer risk are needed to address these trends.
PREVENTING CHRONIC DISEASE
(2021)
Letter
Geriatrics & Gerontology
Emily E. Adam, Mary C. White, Jean A. Shapiro
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2022)
Article
Public, Environmental & Occupational Health
Mona Saraiya, Jean Colbert, Geeta L. Bhat, Rose Almonte, David W. Winters, Sharon Sebastian, Michael O'Hanlon, Ginny Meadows, Michael R. Nosal, Thomas B. Richards, Maria Michaels, Julie S. Townsend, Jacqueline W. Miller, Rebecca B. Perkins, George F. Sawaya, Nicolas Wentzensen, Mary C. White, Lisa C. Richardson
Summary: This article discusses CDC's leading initiative to develop computer-interpretable guidelines for cervical cancer screening and management, aiming to improve patient outcomes and reduce disparities among medically underserved populations.
JOURNAL OF WOMENS HEALTH
(2022)
Article
Oncology
Mary C. White, Hannah K. Weir, Ashwini V. Soman, Lucy A. Peipins, Trevor D. Thompson
Summary: The study found that women exposed to DES in utero have an elevated risk of developing CCA in midlife and at older ages. These results underscore the importance of understanding the cancer risk among DES daughters and providing appropriate screening guidance.
CANCER CAUSES & CONTROL
(2022)
Article
Public, Environmental & Occupational Health
Susan A. Sabatino, Trevor D. Thompson, Mary C. White, Jean A. Shapiro, Janet de Moor, V. Paul Doria-Rose, Tainya Clarke, Lisa C. Richardson
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT
(2021)
Article
Rehabilitation
Lucy A. Peipins, Sabitha Dasari, Juan L. Rodriguez, Mary C. White, M. Elizabeth Hodgson, Dale P. Sandler
Summary: Women undergoing diagnosis and treatment for breast cancer may face challenges in employment, and factors such as older age, peripheral neuropathy, lack of sick leave, late-stage diagnosis, recurrence or new cancer, memory or attention problems, and poor general health can significantly impact employment status. Long-term effects of breast cancer treatment and workplace provisions may affect women's ability to sustain employment, highlighting the need for clinical and occupational interventions to support survivors' return to work.
JOURNAL OF OCCUPATIONAL REHABILITATION
(2021)