Article
Biochemistry & Molecular Biology
Hatim Boughanem, Patricia Ruiz-Limon, Ana B. Crujeiras, Vanessa de Luque, Francisco J. Tinahones, Manuel Macias-Gonzalez
Summary: Our study showed that dysfunctional visceral adipose tissue may increase the risk of colorectal cancer through epigenetic modifications, with proinflammatory genes being upregulated and hypomethylated in CRC patients. Furthermore, we found associations between serum 25-hydroxyvitamin D levels and gene expression/methylation of key inflammatory genes, suggesting a potential role of vitamin D in mediating the risk of CRC through epigenetic regulation. High IL6 expression was linked to poor survival in CRC, while IL6 methylation was associated with an increased risk of CRC, partially mediated by 25-hydroxyvitamin D.
Article
Oncology
Jeeshan Jiffry, Thongthai Thavornwatanayong, Devika Rao, Elisha J. Fogel, Durvanand Saytoo, Rishika Nahata, Hillary Guzik, Imran Chaudhary, Titto Augustine, Sanjay Goel, Radhashree Maitra
Summary: The study revealed that Pelareorep can enhance its propagation and oncolytic effect in colorectal cancer cells by regulating autophagy-related genes and proteins.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Iris van 't Erve, Nina J. Wesdorp, Jamie E. Medina, Leonardo Ferreira, Alessandro Leal, Joost Huiskens, Karen Bolhuis, Jan-Hein T. M. van Waesberghe, Rutger-Jan Swijnenburg, Daan van den Broek, Victor E. Velculescu, Geert Kazemier, Cornelis J. A. Punt, Gerrit A. Meijer, Remond J. A. Fijneman
Summary: Patients with mCRC carrying a KRAS A146 mutation have higher tumor burden and worse clinical outcomes, and may benefit from more intensive treatments.
JCO PRECISION ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiuna Zhang, Xiaoyu Jiang, Jie Yin, Shiying Dou, Xiaoli Xie, Ting Liu, Yijun Wang, Shuling Wang, Xue Zhou, Dongxuan Zhang, Huiqing Jiang
Summary: RNF141 plays an oncogenic role in colorectal cancer by upregulating KRAS activity, which promotes tumor growth, cell proliferation, migration, and apoptosis by interacting with KRAS to induce its activation and enrichment on the plasma membrane.
Article
Biochemistry & Molecular Biology
Xiao-Shun He, Wen-Long Ye, Yu-Juan Zhang, Xiao-Qin Yang, Feng Liu, Jing-Ru Wang, Xiao-Lu Ding, Yun Yang, Ruo-Nan Zhang, Yuan-Yuan Zhao, Hai-Xia Bi, Ling-Chuan Guo, Wen-Juan Gan, Hua Wu
Summary: In this study, we found that BEST4 promotes cell proliferation and metastasis in colorectal cancer. It activates the Akt signaling pathway by binding to the regulatory subunit p85 alpha of PI3K, leading to the expression of critical regulators such as MYC and CCND1. Additionally, high expression of BEST4 is associated with poor prognosis in patients.
Article
Multidisciplinary Sciences
Chi Chun Wong, Jian-Lin Wu, Fenfen Ji, Wei Kang, Xiqing Bian, Huarong Chen, Lam-Shing Chan, Simson Tsz Yat Luk, Samuel Tong, Jiaying Xu, Qiming Zhou, Dabin Liu, Hao Su, Hongyan Gou, Alvin Ho-Kwan Cheung, Ka Fai To, Zongwei Cai, Jerry W. Shay, Jun Yu
Summary: The cholesterol-uptake regulator PCSK9 drives tumourigenesis and is a therapeutic target in KRAS-mutant colorectal cancer.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Juanzi Zeng, Wenwei Fan, Jiaquan Li, Guowu Wu, Heming Wu
Summary: The study found that KRAS and NRAS gene mutations are associated with distant metastasis in colorectal cancer, while BRAF and PIK3CA gene mutations are associated with poor tumor differentiation. These results contribute to a better understanding of the relationship between clinicopathological characteristics and gene mutations in colorectal cancer patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Sha-Sha Hu, Yue Han, Tian-Yuan Tan, Hui Chen, Jia-Wen Gao, Lan Wang, Min-Hui Yang, Li Zhao, Yi-Qing Wang, Yan-Qing Ding, Shuang Wang
Summary: Emerging evidence shows that targeting glutamine metabolism may be a promising therapeutic strategy for KRAS-mutant colorectal cancer (CRC). In this study, researchers discovered that solute carrier 25 member 21 (SLC25A21) depletion accelerated the growth and metastasis of KRAS-mutant CRC cells by inhibiting Gln-derived alpha-ketoglutarate (alpha-KG) efflux from mitochondria, leading to increased GTP availability for persistent KRAS activation. Restoring SLC25A21 expression impaired cetuximab resistance in KRAS-mutant CRC.
Article
Oncology
Jorge Barriuso, Raghavendar T. Nagaraju, Shreya Belgamwar, Bipasha Chakrabarty, George J. Burghel, Helene Schlecht, Lucy Foster, Elaine Kilgour, Andrew J. Wallace, Michael Braun, Caroline Dive, D. Gareth Evans, Robert G. Bristow, Mark P. Saunders, Sarah T. O'Dwyer, Omer Aziz
Summary: The study identified gene dysregulation in peritoneal metastasis that enhances tumor resistance and inflammatory changes. After adjusting for age, gender, and stage, the gene signature showed significant prognostic value for both overall survival and disease-free survival.
CLINICAL CANCER RESEARCH
(2021)
Article
Nutrition & Dietetics
Tafirenyika Gwenzi, Petra Schrotz-King, Ben Schoettker, Michael Hoffmeister, Hermann Brenner
Summary: According to recent evidence, the prognostic value of Vitamin D (VitD) status for colorectal cancer (CRC) patients might be confined to patients with the GG genotype of Cdx2, a functional polymorphism of the VitD receptor gene. In this study, the researchers aimed to validate these findings in a cohort of CRC patients by measuring serum VitD concentration and performing Cdx2 genotyping. The results showed that VitD deficiency is associated with poorer survival, particularly in patients with the GG genotype of Cdx2.
Article
Oncology
Asimina Koulouridi, Michaela Karagianni, Ippokratis Messaritakis, Maria Sfakianaki, Alexandra Voutsina, Maria Trypaki, Maria Bachlitzanaki, Evangelos Koustas, Michalis Karamouzis, Anastasios Ntavatzikos, Anna Koumarianou, Nikolaos Androulakis, Dimitrios Mavroudis, Maria Tzardi, John Souglakos
Summary: The study reveals that KRAS G12D mutation is associated with better overall survival, while KRAS G12C mutation may indicate worse prognosis in terms of progression-free and overall survival. KRAS exon 3 and exon 4 mutations also have different impacts on progression-free and overall survival.
Article
Nutrition & Dietetics
Sepideh Zununi Vahed, Elham Ahmadian, Peyman Foroughi, Soroush Mostafavi, Henning Madry, Mohammadreza Ardalan, Magali Cucchiarini
Summary: The study revealed a significant association between VDR and VDBP gene polymorphisms with renal allograft rejection and viral infection, showing differences in G allele frequencies among different groups.
Article
Medical Laboratory Technology
Ying Fang, Haojun Song, Jian Huang, Jianbo Zhou, Xiaoyun Ding
Summary: The study revealed that vitamin D receptor expression was significantly different in colorectal adenocarcinoma tissues compared to para-cancerous tissues, and VDR expression levels in normal colorectal tissues were higher than in adenomas and adenocarcinomas. Additionally, plasma 25(OH)D concentrations differed significantly between healthy individuals and patients with colorectal adenomas and adenocarcinomas.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Nutrition & Dietetics
Maria Latacz, Dominika Rozmus, Ewa Fiedorowicz, Jadwiga Snarska, Beata Jarmolowska, Natalia Kordulewska, Huub Savelkoul, Anna Cieslinska
Summary: Colorectal cancer (CRC) is a common type of neoplasia with rising prevalence rates. Genetic factors, including vitamin D receptor gene polymorphisms, may be associated with CRC susceptibility. Some haplotypes were found to increase the likelihood of CRC development. Genotyping is a valuable tool for identifying individuals at high risk of developing CRC.
Article
Biochemistry & Molecular Biology
Jian Ren, Xiao Xiao, Ruofei Li, Cheng Lv, Yu Zhang, Leiming Wang, Tao Hong, Hongqi Zhang, Yibo Wang
Summary: Using single-cell RNA sequencing analysis, researchers identified 11 major cell types in cavernous malformations (CMs) and found a new subpopulation of PLVAP-positive endothelial cells. They also discovered the presence of endothelial-to-mesenchymal transition (EndMT) cells in CMs and identified SPI1 as a key driver of EndMT. These findings provide insights into the pathomechanism and potential therapeutic targets for CMs.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Letter
Gastroenterology & Hepatology
Chun-Han Lo, Sohee Kwon, Liang Wang, Georgios Polychronidis, Markus D. Knudsen, Rong Zhong, Yin Cao, Kana Wu, Shuji Ogino, Edward L. Giovannucci, Andrew T. Chan, Mingyang Song
Article
Oncology
Naohiko Akimoto, Tomotaka Ugai, Rong Zhong, Tsuyoshi Hamada, Kenji Fujiyoshi, Marios Giannakis, Kana Wu, Yin Cao, Kimmie Ng, Shuji Ogino
Summary: The global incidence of early-onset colorectal cancer is on the rise, potentially due to factors such as diet, obesity, lack of exercise, and antibiotic use. Early-onset CRC differs clinically, pathologically, and molecularly from later-onset CRC. Further research spanning childhood and young adulthood is necessary to enhance understanding and management of this disease.
NATURE REVIEWS CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Kai Wang, Wenjie Ma, Kana Wu, Shuji Ogino, Andrew T. Chan, Edward L. Giovannucci, Mingyang Song
Summary: The study found that a healthy lifestyle is associated with lower incidence and mortality of colorectal cancer, regardless of endoscopic screening. Combining a healthy lifestyle with endoscopic screening may significantly enhance colorectal cancer prevention, especially for proximal colon cancer.
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vayrynen, Shuji Ogino, Jonathan A. Nowak, Marjukka Friman, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppala, Jan Bohm, Markus J. Makinen, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vayrynen
Summary: This study evaluated the prognostic significance of tumour cell-T cell co-localisation and T cell densities in colorectal cancer patients. The findings showed that high T cell proximity score was associated with longer cancer-specific survival, indicating the potential of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.
BRITISH JOURNAL OF CANCER
(2022)
Review
Surgery
Richard Hunger, Barbara Seliger, Shuji Ogino, Rene Mantke
Summary: The study found a significant inverse relationship between the extent of risk adjustment and the volume effect, suggesting the presence of unmeasured confounding and overestimation of volume effects. Data from the research showed that patient-specific factors were the most important influencing factors for short-term mortality.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Nutrition & Dietetics
Fenglei Wang, Paulette D. Chandler, Oana A. Zeleznik, Kana Wu, You Wu, Kanhua Yin, Rui Song, Julian Avila-Pacheco, Clary B. Clish, Jeffrey A. Meyerhardt, Xuehong Zhang, Mingyang Song, Shuji Ogino, I-Min Lee, A. Heather Eliassen, Liming Liang, Stephanie A. Smith-Warner, Walter C. Willett, Edward L. Giovannucci
Summary: Red and processed meat consumption is associated with increased risk of colorectal cancer, while the association with fish intake is unclear. This study found that plasma metabolite profiles are differentially associated with red meat and fish groups, and the plasma metabolite profile of fish intake is inversely associated with colorectal cancer risk.
Article
Oncology
Ruitong Li, Tomotaka Ugai, Lantian Xu, David Zucker, Shuji Ogino, Molin Wang
Summary: This paper presents an extended Cox regression model to investigate the effects of risk factors on disease subtypes defined by continuous biomarkers. The method is easily applicable to cancer studies and can be accessed by researchers using user-friendly R scripts. It demonstrates how continuous biomarker data can be utilized to study etiological heterogeneity and improve our understanding of biological and pathogenic mechanisms.
Article
Gastroenterology & Hepatology
Kentaro Inamura, Tsuyoshi Hamada, Susan Bullman, Tomotaka Ugai, Shinichi Yachida, Shuji Ogino
Summary: Cancer should be regarded as a systemic and environmental disease, beyond the localised tumour microenvironment. The exposome, which includes various exposures, can alter the microbiome and immune system, affecting tumour phenotypes. To understand the complex role of the exposome, microbiome, and immunome, it is important to conduct interdisciplinary human population research integrated with advanced methodologies like artificial intelligence and molecular pathological epidemiology.
Article
Oncology
Wan-Jie Gu, Jun-Peng Pei, Jun Lyu, Naohiko Akimoto, Koichiro Haruki, Shuji Ogino, Chun-Dong Zhang
Summary: The global incidence, death, and DALY rates of early-onset colorectal cancer (CRC) have increased from 1990 to 2019, with significant variations at regional and national levels. In 2019, low-milk or low-calcium diets and alcohol use were the main risk factors. The importance of high body mass index and high fasting plasma glucose has increased among both males and females, while the importance of smoking and low-fiber diets has decreased, especially among females. These findings provide policymakers with a quantification of the burden of early-onset CRC and help identify and target high-risk individuals to mitigate the disease burden.
Article
Oncology
Kai Wang, Wenjie Ma, Yang Hu, Markus Dines Knudsen, Long H. Nguyen, Kana Wu, Kimmie Ng, Molin Wang, Shuji Ogino, Qi Sun, Edward L. Giovannucci, Andrew T. Chan, Mingyang Song
Summary: Current recommendations for colorectal cancer screening do not take into account the presence of type 2 diabetes (T2D). This study found that the absolute benefit of endoscopic screening for colorectal cancer prevention may be higher for individuals with T2D compared to those without T2D. Additionally, individuals with T2D reached the threshold risk level for colorectal cancer at a younger age than those without T2D, suggesting the consideration of earlier endoscopic screening in individuals with T2D.
CANCER PREVENTION RESEARCH
(2022)
Article
Oncology
Hanna Elomaa, Maarit Ahtiainen, Sara A. Vaeyrynen, Shuji Ogino, Jonathan A. Nowak, Mai Chan Lau, Olli Helminen, Erkki-Ville Wirta, Toni T. Seppaelae, Jan Boehm, Jukka-Pekka Mecklin, Teijo Kuopio, Juha P. Vaeyrynen
Summary: The expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment are inadequately characterised. This study found that PD-L1(+) macrophages and PD-1(+) T cells were associated with better clinical outcomes in colorectal cancer patients. These findings enhance the understanding of immune checkpoints in the tumor microenvironment and could contribute to the development of improved immunotherapies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Zhangyan Lyu, Dong Hang, Xiaosheng He, Kana Wu, Yin Cao, Bernard Rosner, Andrew T. Chan, Shuji Ogino, Ni Li, Min Dai, Edward L. Giovannucci, Mingyang Song
Summary: A simple prediction model based on five major risk factors for high-risk serrated polyps (SPs) was developed and validated, which may be useful for providing healthy lifestyle recommendations and tailored colorectal cancer screening.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Shanshan Shi, Kai Wang, Tomotaka Ugai, Marios Giannakis, Jules Cazaubiel, Andrew T. Chan, Edward L. Giovannucci, Jonathan A. Nowak, Jeffrey A. Meyerhardt, Shuji Ogino, Mingyang Song
Summary: The association between vitamin C intake and colorectal cancer survival varies depending on the KRAS or BRAF mutation status, suggesting potential benefits for patients with mutated tumors.
BRITISH JOURNAL OF CANCER
(2023)
Review
Gastroenterology & Hepatology
Kosuke Mima, Tsuyoshi Hamada, Kentaro Inamura, Hideo Baba, Tomotaka Ugai, Shuji Ogino
Summary: There has been a significant increase in the incidence of early-onset cancers, particularly in the digestive system. While some of these cancers are associated with genetic variants, the majority are sporadic and multifactorial. Factors such as diets, lifestyle, environment, and the microbiome from early life to adulthood may play a role in the development of these cancers, but their exact contributions are still uncertain. To address this rising trend, interdisciplinary research approaches are needed to improve our understanding of the etiology and develop better prevention and treatment strategies.
Article
Medicine, General & Internal
Markus Dines Knudsen, Kai Wang, Liang Wang, Georgios Polychronidis, Paula Berstad, Kana Wu, Xiaosheng He, Dong Hang, Zhe Fang, Shuji Ogino, Andrew T. Chan, Edward Giovannucci, Molin Wang, Mingyang Song
Summary: This study developed an effective risk stratification tool for predicting post-polypectomy colorectal cancer (PPCRC) based on three population-based cohorts and validated the tool in a clinical cohort. By collecting detailed data on demographics, endoscopic history, polyp features, and lifestyle factors, the researchers developed an 11-predictor risk score for PPCRC, which can guide tailored colonoscopy surveillance strategies.
