Article
Environmental Sciences
Arpan Dey Bhowmik, Tanmoy Das, Ansuman Chattopadhyay
Summary: Globally, 200 million people suffer from toxic manifestations of fluoride, including dental and skeletal fluorosis, with no currently available treatment. A study on mice exposed to environmentally relevant concentrations of fluoride revealed that fluoride may adversely affect collagen, leading to skeletal fluorosis. The study also found epigenetic regulation and changes in gene expression associated with impaired collagen synthesis and mineralization.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Beatriz Alvarez-Gonzalez, Patricia Porras-Quesada, Veronica Arenas-Rodriguez, Alba Tamayo-Gomez, Fernando Vazquez-Alonso, Luis Javier Martinez-Gonzalez, Antonio F. Hernandez, Maria Jesus Alvarez-Cubero
Summary: The development and progression of prostate cancer are influenced by the interaction between genetic, environmental, and dietary factors. Chemical exposures and genetic polymorphisms in genes encoding xenobiotic metabolizing enzymes, antioxidant enzymes, and DNA repair enzymes play a major role in cancer development. Understanding the causal risk factors for prostate cancer can help identify high-risk individuals and develop effective detection and prevention methods.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Richard Heery, Martin H. Schaefer
Summary: While large-scale studies have identified hundreds of mutated driver genes in various cancer types, the contribution of epigenetic changes to cancer remains unclear. A novel method correcting for epigenetic covariates reveals a concise set of potential epigenetic driver events, indicating higher convergence on common tumor suppressor pathways and higher tolerance of other aberrations in prostate cancer.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Olga Lobanova, Nataliia Medvedieva, Liliia Fishchuk, Olha Dubitska, Valeriy Cheshuk, Roman Vereshchako, Liubov Zakhartseva, Zoia Rossokha, Natalia Gorovenko
Summary: This study compared the contribution of pathogenic variants of the BRCA1/2 genes and hypermethylation of the BRCA1 gene promoter to the risk of breast cancer and clinical features. The results showed that hypermethylation of the BRCA1 gene promoter is a risk factor for breast cancer and possibly an early biological marker of clinical onset.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Genetics & Heredity
Meng Lu, Qin Xueying, Peng Hexiang, Gao Wenjing, Sara Hagg, Cao Weihua, Li Chunxiao, Yu Canqing, Lv Jun, Pang Zengchang, Cong Liming, Wang Hua, Wu Xianping, Wang Yunzhang, Li Liming
Summary: This study found a significant correlation between the hypermethylation of cg07326074 and alcohol consumption in monozygotic twins from China and Sweden.
Article
Biology
Ariel Ogran, Tal Havkin-Solomon, Shirly Becker-Herman, Keren David, Idit Shachar, Rivka Dikstein
Summary: The transformation from normal to malignant cells involves significant changes in gene expression programs, including alterations in transcription start sites and alternative promoter usage, as well as changes in mRNA translation. The oncogenic function of Tcl1 in leukemogenesis is characterized by the activation of intra-genic promoters and the downregulation of mRNA translation.
Article
Biochemistry & Molecular Biology
A. M. Raizis, H. M. Racher, A. Foucal, H. Dimaras, B. L. Gallie, P. M. George
Summary: DNA hypermethylation events are common in human cancers, but the mechanisms leading to their initiation are not fully understood. In retinoblastoma, hypermethylation of the RB1 gene core promoter is specific to sporadic cases, while heritable RB1 promoter variants are not associated with known epigenetic phenomena. Loss of boundary control may be a critical step leading to epigenetic inactivation of the RB1 gene, with novel DNA methylation boundaries identified in Pr-/- retinoblastomas potentially resulting from epigenetic phenomena associated with epimutation.
Article
Multidisciplinary Sciences
Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anais F. Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N. Robinson, Christian Hagemeier, Michael Weber
Summary: During mouse development, the transcription factor E2F6 is crucial in targeting CpG island DNA methylation and epigenetic silencing to germline genes, especially in early embryonic cells. The cooperation between E2F6 and MGA is essential for silencing a subgroup of germline genes, dependent on the E2F6 marked box domain. E2F6 is required for initiating epigenetic silencing in early embryonic cells but becomes dispensable for maintenance in differentiated cells.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Radoslava Saraeva, Zornitsa Kamenarska, Lyubomir Dourmishev, Anton Vinkov, Gyulnas Dzhebir, Darina Kachakova, Neviana Ivanova, Joana Pozharashka, Radka Kaneva, Maria Hristova
Summary: This study found that polymorphisms in the CD247 gene may be associated with photosensitivity and cutaneous diseases, while the rs840015 genotype is related to the development of dermatomyositis and methylation.
IMMUNOLOGICAL INVESTIGATIONS
(2022)
Review
Virology
Rui Guo, Benjamin E. Gewurz
Summary: This review highlights recent advances in understanding the epigenetic mechanisms that control EBV latency and lytic gene expression in transformed B and epithelial cells. The study focuses on the roles of DNA methylation, host histone chaperones, the Hippo pathway, m6A RNA modification, and nonsense mediated decay in regulating the EBV lifecycle.
CURRENT OPINION IN VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeffry C. Granados, Jeramie D. Watrous, Tao Long, Sara Brin Rosenthal, Susan Cheng, Mohit Jain, Sanjay K. Nigam
Summary: Drug transporters and drug-metabolizing enzymes play a crucial role in the ADME of drugs and handling endogenous metabolites. Recent analyses have revealed a network of transporters and enzymes involved in endogenous metabolism, which interacts with signaling metabolites and affects drug metabolism. By associating SNPs in these genes with circulating levels of metabolites, including signaling molecules, the study identified genomic loci associated with specific metabolites and highlighted the coordinated regulation between multiple genes. The results highlight the potential interactions between drug transporters and drug-metabolizing enzymes with signaling networks, GPCRs, and nuclear receptors.
Article
Multidisciplinary Sciences
Cheng-Huang Shen, Pei-Yu Li, Chih-Yu Hsieh, Yuan-Chang Dai, Yi-Wen Liu
Summary: WIF1 gene expression can be regulated by epigenetic modifications, with 5-aza-dC and TSA enhancing its expression. High expression of WIF1 suppresses tumor growth and migration, but its promoter region -184 to +29 is not suitable for methylation analysis in urine. In contrast, the promoter region -258 to -89 of GSTM5 is a useful region for DNA methylation analysis.
Article
Obstetrics & Gynecology
Sanchita Chandra, Subham Sarkar, Paramita Mandal
Summary: This study identified differential gene mutations, DNA methylation, and expression profiles among different categories of cervical cancer samples. The findings provide valuable insights into the molecular markers that can help classify and target therapy for cervical cancer.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Oncology
Maryam Zarkesh, Noman Arab, Raziyeh Abooshahab, Shabnam Heydarzadeh, Sara Sheikholeslami, Zahra Nozhat, Marziyeh Salehi Jahromi, Seyed Ahmad Fanaei, Mehdi Hedayati
Summary: This study investigated the DNA methylation pattern of the NIS gene promoter in thyroid tumor samples. The results showed that the methylation levels of the NIS promoter were higher in FTC tissues compared to MNG tissues, while the methylation levels were low in PTC tissues. Additionally, the mRNA levels of NIS were decreased in tumor tissues of PTC and FTC patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Neurosciences
Camilla Christina Pedersen, Johannes Lange, Marthe Gurine Gunnarsdatter Forland, Angus D. Macleod, Guido Alves, Jodi Maple-Grodem
Summary: There is significant heterogeneity in the clinical presentation and disease progression of patients with Parkinson's disease (PD). Although genetic variants in the SNCA gene region may have some impact on clinical outcomes in PD, they may not be a major factor contributing to the clinical heterogeneity observed in PD.
NPJ PARKINSONS DISEASE
(2021)
Article
Nutrition & Dietetics
Iris W. A. Boot, Anke Wesselius, Evan Y. W. Yu, Maree Brinkman, Piet van den Brandt, Eric J. Grant, Emily White, Elisabete Weiderpass, Pietro Ferrari, Matthias B. Schulze, Bas Bueno-de-Mesquita, Maria Jose-Sanchez, Bjorn Gylling, Maurice P. Zeegers
Summary: This study found that B group vitamins may play a role in preventing bladder cancer, and different genders have different associations between the intake of various vitamins and bladder cancer risk.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Oncology
Josien C. A. Jenniskens, Kelly Offermans, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: Early-life energy balance-related factors are associated with adult colorectal cancer risk, possibly through the activation of the Warburg effect. Height, BMI, and energy restriction proxies during early life are associated with different subtypes of Warburg effect in colorectal cancer.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Mostafa Dianatinasab, Anke Wesselius, Amin Salehi-Abargouei, Evan Y. W. Yu, Mohammad Fararouei, Maree Brinkman, Piet van den Brandt, Emily White, Elisabete Weiderpass, Florence Le Calvez-Kelm, Marc J. Gunter, Inge Huybrechts, Maurice P. Zeegers
Summary: This study investigated the association between fat intake and bladder cancer risk using data from 11 cohort studies. It found an inverse association between mono-unsaturated fatty acids (MUFAs) intake and bladder cancer risk among women, and a positive association between higher dietary cholesterol intake and bladder cancer risk among men.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Public, Environmental & Occupational Health
Mary K. Townsend, Britton Trabert, Renee T. Fortner, Alan A. Arslan, Julie E. Buring, Brian D. Carter, Graham G. Giles, Sarah R. Irvin, Michael E. Jones, Rudolf Kaaks, Victoria A. Kirsh, Synnove F. Knutsen, Woon-Puay Koh, James Lacey, Hilde Langseth, Susanna C. Larsson, I-Min Lee, Maria Elena Martinez, Melissa A. Merritt, Roger L. Milne, Katie M. O'Brien, Michael J. Orlich, Julie R. Palmer, Alpa Patel, Ulrike Peters, Jenny N. Poynter, Kim Robien, Thomas E. Rohan, Lynn Rosenberg, Sven Sandin, Dale P. Sandler, Leo J. Schouten, V. Wendy Setiawan, Anthony J. Swerdlow, Giske Ursin, Piet A. van den Brandt, Kala Visvanathan, Elisabete Weiderpass, Alicja Wolk, Jian-Min Yuan, Anne Zeleniuch-Jacquotte, Shelley S. Tworoger, Nicolas Wentzensen
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Multidisciplinary Sciences
Silvano Gallus, Chiara Stival, Giulia Carreras, Giuseppe Gorini, Andrea Amerio, Martin McKee, Anna Odone, Piet A. van den Brandt, Lorenzo Spizzichino, Roberta Pacifici, Alessandra Lugo
Summary: A study conducted in Italy found that there were minimal changes in the use of electronic cigarettes and heated tobacco products during the lockdown period. A small percentage of non-users started using these products during the lockdown, while the number of users of heated tobacco products slightly increased. The new users were younger, had anxiety symptoms, were male, and were cannabis users.
SCIENTIFIC REPORTS
(2022)
Article
Mathematical & Computational Biology
Colinda C. J. M. Simons, Leo J. Schouten, Roger W. L. Godschalk, Frederik-Jan Van Schooten, Monika Stoll, Kristel Van Steen, Piet A. van den Brandt, Matty P. Weijenberg
Summary: This study investigates the relationship between polygenic risk scores, energy balance-related factors, and colorectal cancer risk. The results suggest that the mTOR-PI3K-Akt pathway may play a role in the development of colon cancer.
Article
Pathology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study found that CRC patients with Warburg-high subtype had the poorest survival rates, especially for those with TNM stage III CRC and cancers located in the rectum. Further research is needed to confirm the findings and explore the potential clinical utility of Warburg subtypes in CRC.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Chiara Stival, Alessandra Lugo, Anna Odone, Piet A. van den Brandt, Esteve Fernandez, Olena Tigova, Joan B. Soriano, Maria Jose Lopez, Silvia Scaglioni, Silvano Gallus
Summary: Based on the data from the TackSHS survey, this study provides updated estimates of the prevalence and determinants of overweight and obesity in Europe. The results show that overweight and obesity are highly prevalent in Europe, particularly in Eastern and Northern European countries. Moreover, there has been an increasing trend in obesity prevalence in these regions compared to 2010.
Review
Clinical Neurology
Carlotta M. Jarach, Alessandra Lugo, Marco Scala, Piet A. van den Brandt, Christopher R. Cederroth, Anna Odone, Werner Garavello, Winfried Schlee, Berthold Langguth, Silvano Gallus
Summary: This systematic review and meta-analysis provides frequency estimates of tinnitus worldwide. The study shows that tinnitus affects more than 740 million adults globally, with over 120 million people considering it a major problem, mostly among those aged 65 years or older. The prevalence of tinnitus does not differ by sex, but increases with age.
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van der Meer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study investigated the prognostic value of mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, MET, and mismatch repair (MMR) status in colorectal cancer (CRC) patients. The results showed that mutational subgroups were associated with survival differences in CRC patients, while Warburg-subtypes did not provide additional prognostic information within these mutational subgroups.
Article
Nutrition & Dietetics
Marta Crous-Bou, Mengmeng Du, Marc J. Gunter, Veronica W. Setiawan, Leo J. Schouten, Xiao-ou Shu, Nicolas Wentzensen, Kimberly A. Bertrand, Linda S. Cook, Christine M. Friedenreich, Susan M. Gapstur, Marc T. Goodman, Torukiri I. Ibiebele, Carlo La Vecchia, Fabio Levi, Linda M. Liao, Eva Negri, Susan E. McCann, Kelly O'Connell, Julie R. Palmer, Alpa Patel, Jeanette Ponte, Peggy Reynolds, Carlotta Sacerdote, Rashmi Sinha, Amanda B. Spurdle, Britton Trabert, Piet A. van den Brandt, Penelope M. Webb, Stacey Petruzella, Sara H. Olson, Immaculata De Vivo
Summary: Epidemiologic studies suggest that coffee consumption may be inversely associated with risk of endometrial cancer. Antioxidants and other chemopreventive compounds in coffee may have anticarcinogenic effects. The largest pooled analysis to date further supports the potentially beneficial health effects of coffee consumption in relation to EC.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Piet A. van den Brandt
Summary: This study investigated the relationship between a combined healthy lifestyle score and the risk of esophageal and gastric cancer. The findings suggest that adhering to a healthy lifestyle can significantly reduce the risk of these types of cancers.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Josien C. A. Jenniskens, Kelly Offermans, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Jaleesa R. M. van der Meer, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike Grabsch, Piet A. van den Brandt
Summary: This study investigated the associations between early-life energy balance-related factors and the risk of CRC subgroups based on mutation and MMR status. The results showed that height was positively associated with any-mutation/dMMR CRC, but not with all-wild-type+pMMR CRC, except for rectal cancer in men. No clear patterns were observed for early-life energy restriction proxies in relation to the risk of CRC subgroups. Early adult BMI was positively, but not significantly, associated with certain CRC subgroups in men and women.
MOLECULAR CARCINOGENESIS
(2022)
Article
Substance Abuse
Silvano Gallus, Chiara Stival, Martin McKee, Giulia Carreras, Giuseppe Gorini, Anna Odone, Piet A. van den Brandt, Roberta Pacifici, Alessandra Lugo
Summary: This study found that the use of e-cigarettes and heated tobacco products increases the risk of starting smoking and relapse, and appears to reduce smoking cessation.
Article
Public, Environmental & Occupational Health
Silvano Gallus, Alessandra Lugo, Chiara Stival, Sonia Cerrai, Luke Clancy, Filippos T. Filippidis, Giuseppe Gorini, Maria Jose Lopez, Angel Lopez-Nicolas, Sabrina Molinaro, Anna Odone, Joan B. Soriano, Olena Tigova, Piet A. van den Brandt, Constantine I. Vardavas, Esteve Fernandez
Summary: According to the survey conducted by the TackSHS project, over 8.3 million adults in 12 European countries use electronic cigarettes. The majority of users are dual users, using both electronic and conventional cigarettes, using electronic cigarettes with nicotine, and using them in smoke-free indoor areas.
JOURNAL OF EPIDEMIOLOGY
(2023)