Article
Oncology
Quoc Thang Pham, Daiki Taniyama, Yohei Sekino, Shintaro Akabane, Takashi Babasaki, Go Kobayashi, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue, Wataru Yasui
Summary: The research revealed that TDO2 is upregulated in RCC tissues and associated with advanced disease progression and poor survival. TDO2 is also co-expressed with PD-L1 and CD44, while PTEN regulates TDO2 expression. Knockdown of TDO2 suppresses proliferation and invasion of RCC cells.
Review
Oncology
Vanessa Moreno, Karan Saluja, Sergio Pina-Oviedo
Summary: Nuclear protein in testis (NUT) carcinoma is a rare and highly aggressive tumor that mainly occurs in adolescents and young adults. It originates from midline structures of the thorax, head, and neck, showing variable degrees of squamous differentiation. Diagnosis of NUT carcinoma involves detecting nuclear expression of the NUT protein and the presence of NUTM1 gene rearrangement using immunohistochemistry and molecular methods.
FRONTIERS IN ONCOLOGY
(2022)
Article
Physiology
Mathew Bloomfield, Jing Chen, Daniela Cimini
Summary: This study found that differences in mitotic duration can be explained by variations in spindle microtubule densities and sizes of the cell, spindle, and spindle poles. The study suggests that spindle size does not always scale with cell size in mammalian cells, and cell size alone is not sufficient to explain differences in metaphase duration. Only when considering a number of spindle architectural features along with cell size can the kinetics of SAC silencing, and hence mitotic duration, be explained in different clones.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pathology
Anne T. Taylor, Shawn Dason, Debra L. Zynger
Summary: Scrotal leiomyosarcoma is an exceptionally rare disease process with deceptive clinical presentation, a wide age range, and small tumor size. Complete surgical resection leads to excellent prognosis, and rigorous follow-up or adjuvant treatment is unlikely to be necessary.
Review
Oncology
Nduka Ofoeyeno, Emmanuel Ekpenyong, Chiara Braconi
Summary: Non-coding ribonucleic acid (RNA) plays crucial roles in the pathogenesis and clinical implications of biliary tract cancer (BTC), particularly through the regulation of mRNA transcriptomes. MicroRNAs have been shown to have significant roles in BTC progression, offering potential as biomarkers and therapeutics, but further research and technological advancements are needed before they can be implemented in clinical practice.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hassan Aboughalia, Helen H. R. Kim, Andre A. S. Dick, M. Cristina Pacheco, Robert E. Cilley, Ramesh S. Iyer
Summary: This paper discusses the spectrum of pathologies affecting the pediatric biliary tree, imaging modalities used for assessment, and unique features of pediatric biliary pathologies, emphasizing the importance of understanding the imaging features of biliary pathologies for clinical management.
Article
Medicine, General & Internal
Min Ju Kim, Wonju Hong, Tae Jung Kim, Joungho Han, Yoon-La Choi, Joon Young Choi, Sang Min Lee, Sung Ho Hwang
Summary: SPCH is often incidentally detected in young and middle-aged adults, commonly presenting as an ill-defined part-solid nodule that may accompany air bronchogram, perivascular lucency, fluctuation in size or density on CT, and hypometabolism on PET-CT.
Article
Oncology
Eric D. Whitman, Vadim P. Koshenkov, Brian R. Gastman, Deri Lewis, Eddy C. Hsueh, Ho Pak, Thomas P. Trezona, Robert S. Davidson, Michael McPhee, J. Michael Guenther, Paul Toomey, Franz O. Smith, Peter D. Beitsch, James M. Lewis, Andrew Ward, Shawn E. Young, Parth K. Shah, Ann P. Quick, Brian J. Martin, Olga Zolochevska, Kyle R. Covington, Federico A. Monzon, Matthew S. Goldberg, Robert W. Cook, Martin D. Fleming, David M. Hyams, John T. Vetto
Summary: The study developed a neural network algorithm integrating clinicopathologic features and the 31-gene expression profile score to predict sentinel lymph node positivity. The algorithm showed high concordance between predicted and observed rates, and could help identify patients who are less likely to benefit from sentinel lymph node biopsy or who are more likely to have a positive biopsy.
JCO PRECISION ONCOLOGY
(2021)
Article
Oncology
Fei Teng, Jian Xu, Jian Wang, Bo Yang, Yong-Zhong Wu, Yue-Quan Jiang, Zhi-Qiang Wang
Summary: This study analyzed demographic and clinical parameters of 111 patients with early multiple primary lung cancer and compared the clinicopathologic characteristics based on the gene mutation status of pulmonary nodules. The clinicopathological analysis of 265 pulmonary nodules showed significant differences in features among different genetic mutations. Therefore, the use of targeted therapy based on the genetic sequencing of only one nodule is unreliable.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maria Zulfiqar, Deyali Chatterjee, Norihide Yoneda, Mark J. Hoegger, Maxime Ronot, Elizabeth M. Hecht, Nina Bastati, Ahmed Ba-Ssalamah, Mustafa R. Bashir, Kathryn Fowler
Summary: This article discusses the classification of biliary malignancies, the importance of early detection, and the risk factors and predisposing conditions associated with them. Early diagnosis and treatment are crucial for improving the prognosis of malignancies.
Article
Medicine, General & Internal
Binghui Liu, Juhua Pan, Chenglin Fu
Summary: The expression of miR-367 in breast cancer patients was significantly lower than in the control group, and was closely associated with clinicopathologic features such as tumor node metastasis, tumor diameter, and lymph node metastasis. Additionally, breast cancer patients with underexpressed miR-367 had a shorter disease-free survival and overall survival compared to the control group.
Article
Medicine, General & Internal
Hyunsung Kim, Seungyun Jee, Yeseul Kim, Jongmin Sim, Seongsik Bang, Hwang Kyu Son, Hosub Park, Jaekyung Myung, Young Hyeh Ko, Seung Sam Paik
Summary: The study investigated CD47 expression in 328 CRA tissues, finding positive expression in 16.2% of tissues, which was significantly associated with adverse clinicopathologic features and poor patient outcome.
Article
Cell Biology
Martin Cornillet, Helen Zemack, Hannes Jansson, Ernesto Sparrelid, Ewa Ellis, Niklas K. Bjorkstrom
Summary: Alpha-1 antitrypsin deficiency (A1ATD) is present in 10.8% of patients with biliary tract cancer (BTC), with no significant clinical differences compared to non-A1ATD BTC. The abundance of A1AT protein is increased in intrahepatic cholangiocarcinoma (iCCA) and is influenced by genomic alterations. A1ATD may be associated with a less aggressive phenotype, while high A1AT expression may contribute to a more aggressive phenotype.
Article
Oncology
Caterina Vivaldi, Virginia Genovesi, Clara Ugolini, Laura Bernardini, Andrea Casadei-Gardini, Vincenzo Formica, Francesca Salani, Giulia Orsi, Valentina Massa, Andrea Cacciato-Insilla, Miriam Caccese, Silvia Cesario, Kalliopi Andrikou, Jessica Graziani, Daniela Campani, Enrico Vasile, Gabriella Fontanini, Lorenzo Fornaro, Gianluca Masi
Summary: This study retrospectively assessed the MMR status in 163 patients with biliary tract cancers and found that MMR deficiency was strongly associated with mucinous histology. In patients who underwent radical resection, MMR deficiency was associated with shorter disease-free survival and nodal positivity. MMR deficiency was an independent prognostic factor for disease relapse in patients with resected biliary tract cancers.
Article
Biochemistry & Molecular Biology
Rachel A. Berg, James B. Moseley
Summary: The protein kinase Cdr2 promotes mitotic entry by organizing cortical oligomeric nodes and inhibiting Wee1. Increasing Cdr2 expression leads to hyperphosphorylation of Wee1 and reduction in cell size. Cdr2 sequesters Wee1 in cytoplasmic clusters, away from Cdk1 in the nucleus, acting as a dosage-dependent regulator of cell size.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Oncology
Yu-Yun Shao, Pai-Sheng Chen, Liang-In Lin, Bin-Shyun Lee, Andrew Ling, Ann-Lii Cheng, Chiun Hsu, Da-Liang Ou
Summary: This study identified miR-10b-3p as a potential biomarker for predicting sorafenib efficacy in advanced HCC patients and confirmed its mechanism of action.
BRITISH JOURNAL OF CANCER
(2022)
Article
Immunology
Shih-Hung Yang, Jen-Chieh Lee, Bang-Bin Chen, Sung-Hsin Kuo, Chiun Hsu, Li-Yuan Bai
Summary: This study reports a case of maintenance therapy in PDAC, which resulted in a disease-free state for more than 2 years. This suggests the potential importance of maintenance therapy in the treatment of PDAC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Education & Educational Research
Chiao-Ling Tsai, Yen-Lin Chiu, Chia-Ter Chao, Mong-Wei Lin, Chao-Chi Ho, Huey-Ling Chen, Bor-Ching Sheu, Chiun Hsu, Chih-Wei Yang
Summary: This study evaluated the effect of tutor shadowing on the teaching skills of novice problem-based learning (PBL) tutors and developed a tutoring-skill scale (TS-scale). The results showed that tutor shadowing significantly improved the teaching confidence of novice PBL tutors across three key domains of tutoring competencies. The TS-scale developed in this study can be used in future research on faculty development design.
BMC MEDICAL EDUCATION
(2022)
Article
Oncology
Kuo-Hsing Chen, Chia-Lang Hsu, Yu-Li Su, Chang-Tsu Yuan, Liang-In Lin, Jia-Huei Tsai, Yi-Hsin Liang, Ann-Lii Cheng, Kun-Huei Yeh
Summary: This study found that the immune contexture in the tumor microenvironment is closely associated with prognosis in patients with metastatic BRAF V600E mutant colorectal cancer. High expression of immune genes and complement activation are correlated with poor prognosis, and the complement score is strongly correlated with tumor-associated macrophage M2 signatures.
BRITISH JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Masatoshi Kudo, Richard S. Finn, Shukui Qin, Kwang-Hyub Han, Kenji Ikeda, Ann-Lii Cheng, Arndt Vogel, Francesco Tovoli, Kazuomi Ueshima, Hiroshi Aikata, Carlos Lopez Lopez, Marc Pracht, Zhiqiang Meng, Bruno Daniele, Joong-Won Park, Daniel Palmer, Toshiyuki Tamai, Kenichi Saito, Corina E. Dutcus, Riccardo Lencioni
Summary: The study aimed to validate objective response as an independent predictor of overall survival (OS) in individuals with unresectable hepatocellular carcinoma (HCC) receiving systemic anti-angiogenic therapy. The results showed that objective response assessed by investigator-assessed mRECIST could predict the survival of patients. Further studies are needed to confirm this finding.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Chiun Hsu, Michel Ducreux, Andrew X. Zhu, Shukui Qin, Masafumi Ikeda, Tae-You Kim, Peter R. Galle, Richard S. Finn, Ethan Chen, Ning Ma, Youyou Hu, Lindong Li, Ann-Lii Cheng
Summary: The IMbrave150 trial showed that atezolizumab + bevacizumab is safe and effective in treating patients with hepatocellular carcinoma, including those with hepatitis B or hepatitis C infection.
Article
Education & Educational Research
Chia-Ter Chao, Yen-Lin Chiu, Chiao-Ling Tsai, Mong-Wei Lin, Chih-Wei Yang, Chao-Chi Ho, Yen-Yuan Chen, Chiun Hsu, Huey-Ling Chen
Summary: Team dynamics and facilitator support play important roles in teamwork satisfaction in both conventional and digital small group tutorials, with the role of facilitator support becoming less obvious in digital settings.
BMC MEDICAL EDUCATION
(2022)
Article
Medicine, General & Internal
Jan-Mou Lee, Yi-Ping Hung, Kai-Yuan Chou, Cheng-Yun Lee, Shian-Ren Lin, Ya-Han Tsai, Wan-Yu Lai, Yu-Yun Shao, Chiun Hsu, Chih-Hung Hsu, Yee Chao
Summary: This study aimed to evaluate whether analyzing peripheral immune cell subsets using Mann-Whitney U test and artificial intelligence (AI) algorithms can predict the response to nivolumab treatment in advanced hepatocellular carcinoma (aHCC) patients. The results showed that this method could successfully separate disease control group from disease progression group, and PD-L1(+) monocytes and PD-L1(+) CD8 T cells played a significant role in this discrimination.
FRONTIERS IN MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Chiao-Ling Tsai, Po-Sheng Yang, Feng-Ming Hsu, Ann-Lii Cheng, Wan-Ni Yu, Jason Chia-Hsien Cheng
Summary: This study investigated the effect of TOP1 inhibition and DNA-PKcs/RNF144A mechanism on radiosensitization mediated by natural killer (NK) cells in radiation therapy (RT). The results showed that TOP1 inhibitors and RT had a synergistic effect on hepatocellular carcinoma (HCC) cells, enhancing the anti-HCC effect of RT through increased DNA damage and DNA-PKcs signaling. RNF144A mediated DNA-PKcs ubiquitination and provided a reason for the difference in radiosensitization effect between HCC cells.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Oncology
Yu-Chieh Tsai, Tzu-Yin Wang, Chia-Lang Hsu, Wei-Chou Lin, Jyun-Yu Chen, Jia-Hua Li, Yeong-Shiau Pu, Ann-Lii Cheng, Jason Chia-Hsien Cheng, Sheng-Fang Su
Summary: This study found that inhibiting HDAC6 can enhance the radiosensitivity of bladder cancer and reduce the expression of genes related to cell migration, angiogenesis, and metastasis induced by radiotherapy, thereby improving therapeutic efficacy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Zhong-Zhe Lin, Mickey C-T Hu, Chiun Hsu, Yao-Ming Wu, Yen-Shen Lu, Ja-An Annie Ho, Shiou-Hwei Yeh, Pei-Jer Chen, Ann-Lii Cheng
Summary: This study investigated the potential synergism of the telomerase-specific oncolytic adenovirus Telomelysin and the histone deacetylase inhibitor AR42 in treating hepatocellular carcinoma (HCC). Telomelysin and AR42 exhibited synergistic antiproliferative effects in in vitro and in vivo models of HCC. AR42 attenuated the expression of the coxsackievirus and adenovirus receptor and the mRNA levels of human telomerase reverse transcriptase, enhancing the cytotoxicity of Telomelysin.
Article
Oncology
Yu-Ting Chang, Hsuan-Yu Peng, Chun-Mei Hu, Sui-Chih Tien, Yi-Ing Chen, Yung-Ming Jeng, Ming-Chu Chang
Summary: Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor-derived small extracellular vesicles (sEVs), which mediate cell-to-cell communication between cancer cells and fibroblasts, are also critical for cancer progression and metastasis. In this study, we found that ezrin (EZR) in PDAC cell-derived sEVs can activate fibroblasts and promote PDAC cell proliferation, invasion, and liver metastasis through the STAT3 and YAP-1 signaling pathways.
MOLECULAR ONCOLOGY
(2023)
Article
Oncology
Masatoshi Kudo, Richard S. Finn, Ann-Lii Cheng, Andrew X. Zhu, Michel Ducreux, Peter R. Galle, Naoya Sakamoto, Naoya Kato, Michitaka Nakano, Jing Jia, Arndt Vogel
Summary: This exploratory analysis examined the prognostic impact of baseline albumin-bilirubin (ALBI) score in patients with unresectable hepatocellular carcinoma (HCC) treated with atezolizumab + bevacizumab or sorafenib. The study found that atezolizumab + bevacizumab improved overall survival and progression-free survival compared to sorafenib in patients with ALBI score of 1, but not in patients with ALBI score of 2. ALBI grade appeared to be prognostic for outcomes in both treatment groups.
Article
Oncology
Philippe Merle, Masatoshi Kudo, Julien Edeline, Mohamed Bouattour, Ann-Lii Cheng, Stephen Lam Chan, Thomas Yau, Marcelo Garrido, Jennifer Knox, Bruno Daniele, Valeriy Breder, Ho Yeong Lim, Sadahisa Ogasawara, Stephane Cattan, Yee Chao, Abby B. Siegel, Ivan Martinez-Forero, Ziwen Wei, Chih-Chin Liu, Richard S. Finn
Summary: With extended follow-up, pembrolizumab demonstrated continued improvement in overall survival (OS) and progression-free survival (PFS) compared to placebo in advanced hepatocellular carcinoma (HCC) patients previously treated with sorafenib. The adverse event profile of pembrolizumab remained consistent with placebo.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bang-Bin Chen, Po-Chin Liang, Tiffany Ting-Fang Shih, Tsung-Hao Liu, Ying-Chun Shen, Li-Chun Lu, Zhong-Zhe Lin, Chiun Hsu, Chih-Hung Hsu, Ann-Lii Cheng, Yu-Yun Shao
Summary: Sarcopenia and myosteatosis are independent prognostic factors in patients who received immunotherapy for advanced HCC.
EUROPEAN RADIOLOGY
(2023)
