Article
Oncology
Shadi Azam, Mikael Eriksson, Arvid Sjolander, Marike Gabrielson, Roxanna Hellgren, Kamila Czene, Per Hall
Summary: The study revealed that mammographic microcalcification clusters are an independent risk factor for breast cancer, with a higher estimated risk in premenopausal women. For postmenopausal women, microcalcification clusters and mammographic density have a similar influence on breast cancer risk, and there is no interaction between the two factors.
BRITISH JOURNAL OF CANCER
(2021)
Article
Environmental Sciences
Tamara Jimenez, Marina Pollan, Alejandro Dominguez-Castillo, Pilar Lucas, Maria Angeles Sierra, Adela Castello, Nerea Fernandez de Larrea-Baz, David Lora-Pablos, Dolores Salas-Trejo, Rafael Llobet, Inmaculada Martinez, Marina Nieves Pino, Mercedes Martinez-Cortes, Beatriz Perez-Gomez, Virgina Lope, Javier Garcia-Perez
Summary: This study examined the association between mammographic density (MD) and proximity to industrial sources in 1225 premenopausal women. The results showed a positive linear trend between MD and proximity to industrial sources, especially with certain types of industrial clusters related to surface treatment, organic solvents, metal manufacturing, animal waste recycling, hazardous waste, and the food sector.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Felix Grassmann, Haomin Yang, Mikael Eriksson, Shadi Azam, Per Hall, Kamila Czene
Summary: This study discovered an association between microcalcifications and increased risk for multiple cardiometabolic diseases, especially in women with pre-existing conditions, while dense breasts were linked to lower incidence of these diseases. Additionally, the presence of microcalcifications was found to be associated with increased cardiometabolic mortality in women with pre-existing conditions.
EUROPEAN HEART JOURNAL
(2021)
Article
Oncology
Sarah Ward, Anya Burton, Rulla M. Tamimi, Ana Pereira, Maria Luisa Garmendia, Marina Pollan, Norman Boyd, Isabel dos-Santos-Silva, Gertraud Maskarinec, Beatriz Perez-Gomez, Celine Vachon, Hui Miao, Martin Lajous, Ruy Lopez-Ridaura, Kimberly Bertrand, Ava Kwong, Giske Ursin, Eunjung Lee, Huiyan Ma, Sarah Vinnicombe, Sue Moss, Steve Allen, Rose Ndumia, Sudhir Vinayak, Soo-Hwang Teo, Shivaani Mariapun, Beata Peplonska, Agnieszka Bukowska-Damska, Chisato Nagata, John Hopper, Graham Giles, Vahit Ozmen, Mustafa Erkin Aribal, Joachim Schuez, Carla H. Van Gils, Johanna O. P. Wanders, Reza Sirous, Mehri Sirous, John Hipwell, Jisun Kim, Jong Won Lee, Caroline Dickens, Mikael Hartman, Kee-Seng Chia, Christopher Scott, Anna M. Chiarelli, Linda Linton, Anath Arzee Flugelman, Dorria Salem, Rasha Kamal, Valerie McCormack, Jennifer Stone
Summary: Late age at menarche is positively associated with higher mammographic density, while taller stature is also related to higher mammographic density. The study reveals a complex relationship between growth and development, mammographic density, and breast cancer risk.
BREAST CANCER RESEARCH
(2022)
Article
Environmental Sciences
Tamara Jimenez, Marina Pollan, Alejandro Dominguez-Castillo, Pilar Lucas, Maria angeles Sierra, Nerea Fernandez de Larrea-Baz, Mario Gonzalez-Sanchez, Dolores Salas-Trejo, Rafael Llobet, Inmaculada Martinez, Marina Nieves Pino, Mercedes Martinez-Cortes, Beatriz Perez-Gomez, Virginia Lope, Javier Garcia-Perez
Summary: This study investigated the relationship between mammographic density (MD) and residential proximity to pollutant industries in premenopausal Spanish women. The results suggest that while there is no statistically significant association between MD and distance to industries as a whole, there are associations with specific industrial sectors and pollutants, indicating a potential mediating role of MD in breast carcinogenesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Maddison Archer, Pallave Dasari, David Walsh, Kara L. Britt, Andreas Evdokiou, Wendy Ingman
Summary: Mammographic density is associated with increased breast cancer risk. This study found that fibroblasts from high mammographic density breast tissue do not show inherent differences compared to those from low mammographic density, suggesting that the function of fibroblasts in breast cancer risk may be regulated by immune signals from surrounding cells in the microenvironment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Marthe Larsen, Elsebeth Lynge, Christoph I. Lee, Kristina Lang, Solveig Hofvind
Summary: The European Society on Breast Imaging recommends supplemental MRI every two to four years for women with dense breasts, but this may not be possible in many screening programs. We propose alternative screening strategies for women with dense breasts based on analyzing interval cancers and time from screening to diagnosis.
Article
Oncology
Li Sturesdotter, Anna-Maria Larsson, Sophia Zackrisson, Hanna Sartor
Summary: This study investigated the relationship between breast cancer-specific survival and mammographic breast density and mammographic tumor appearances. The results showed that high breast density did not significantly impact breast cancer-specific survival. Furthermore, tumor appearance also did not affect breast cancer-specific survival in the long term follow-up.
Article
Astronomy & Astrophysics
Sebastian Heinz
Summary: Recent research suggests that winds and outflows from active galactic nuclei (AGNs) can negatively impact the habitability of exoplanets. However, compared to stellar winds, the planet's magnetosphere, and stellar irradiation, AGN winds are unlikely to play a significant role in the evolution of atmospheric conditions under otherwise favorable conditions for habitability.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Nutrition & Dietetics
Adashi Margaret Odama, Valerie Otti, Shuai Xu, Olamide Adebayo, Adetunji T. Toriola
Summary: This study found no associations of coffee and caffeinated tea intake with mammographic breast density in premenopausal women. However, decaffeinated tea may be positively associated with VPD in non-Hispanic white women and was not associated with African American women. Coffee intake was positively associated with dense volume in African American women, but not in non-Hispanic white women.
Article
Oncology
Felix Heindl, Peter A. Fasching, Alexander Hein, Carolin C. Hack, Katharina Heusinger, Paul Gass, Patrik Poeschke, Frederik A. Stuebs, Rudiger Schulz-Wendtland, Arndt Hartmann, Ramona Erber, Matthias W. Beckmann, Julia Meyer, Lothar Haeberle, Sebastian M. Jud, Julius Emons
Summary: The study investigated the association between percentage mammographic density (PMD) and disease-free or overall survival in primary breast cancer patients. After adjusting for various factors including age, no significant impact of PMD on survival was found in the patients.
Article
Oncology
Gordon P. Watt, Julia A. Knight, Christine Lin, Charles F. Lynch, Kathleen E. Malone, Esther M. John, Leslie Bernstein, Jennifer D. Brooks, Anne S. Reiner, Xiaolin Liang, Meghan Woods, Tuong L. Nguyen, John L. Hopper, Malcolm C. Pike, Jonine L. Bernstein
Summary: The study found that mammographic texture features are associated with the risk of contralateral breast cancer, supporting the potential use of texture features for assessing CBC risk in breast cancer survivors. Adjusting for mammographic density and confounders, the texture risk score was positively correlated with the risk of CBC.
Article
Chemistry, Multidisciplinary
Mary Anne White, Samer Kahwaji, Vera L. S. Freitas, Riko Siewert, Joseph A. Weatherby, Maria D. M. C. Ribeiro da Silva, Sergey P. Verevkin, Erin R. Johnson, Josef W. Zwanziger
Summary: Recent studies using density-functional theory calculations and high-accuracy calorimetric experiments have revealed that graphite is more thermodynamically stable than diamond at ambient pressure, with stability being driven by enthalpy at low temperatures and entropy at higher temperatures. DFT calculations showed good agreement with experimental results, providing revised values for the standard thermodynamic functions of diamond.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nutrition & Dietetics
Nadia Rajaram, Beverley Yap, Mikael Eriksson, Shivaani Mariapun, Lee Mei Tan, Hamizah Sa'at, Evelyn Lai Ming Ho, Nur Aishah Mohd Taib, Geok Lin Khor, Cheng Har Yip, Weang Kee Ho, Per Hall, Soo Hwang Teo
Summary: Observational studies have shown that consuming soy is associated with lower risk of breast cancer in Asian women, but no randomized controlled trials (RCTs) have been conducted among Asian women in Asia. This RCT assessed the effects of one-year soy isoflavone intervention on mammographic density change in Malaysian women. The findings suggest a possible causal association between soy isoflavone intake and breast cancer risk among Asian women, especially those within 5 years of menopause.
Article
Environmental Sciences
Aojie Li, Yongchui Zhang, Mei Hong, Jian Shi, Jing Wang
Summary: The Indonesian Throughflow (ITF) is a crucial connection between the Pacific Ocean and the Indian Ocean, playing a significant role in global ocean circulation. The variability of ITF transport is influenced by climate modes like Central-Pacific and Eastern-Pacific El Nino, and the Indian Ocean Dipole. However, the relative importance of these climate modes on the ITF has not been well understood.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Till F. M. Andlauer, Jose Guzman-Parra, Fabian Streit, Jana Strohmaier, Maria Jose Gonzalez, Susana Gil Flores, Francisco J. Cabaleiro Fabeiro, Francisco del Rio Noriega, Fermin Perez Perez, Jesus Haro Gonzalez, Guillermo Orozco Diaz, Yolanda de Diego-Otero, Berta Moreno-Kustner, Georg Auburger, Franziska Degenhardt, Stefanie Heilmann-Heimbach, Stefan Herms, Per Hoffmann, Josef Frank, Jerome C. Foo, Jens Treutlein, Stephanie H. Witt, Sven Cichon, Manolis Kogevinas, Fabio Rivas, Fermin Mayoral, Bertram Mueller-Myhsok, Andreas J. Forstner, Markus M. Nothen, Marcella Rietschel
Summary: This study analyzed whether the risk for bipolar disorder in BD multiplex families is influenced by common genetic variants. The results showed that familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders, indicating a high baseline risk in the families; familial BD cases had significantly higher BD PRS than unaffected family members and unrelated BD cases, suggesting that development of BD in these families is attributable to common variants with specific risk for BD.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Melissa A. Munn-Chernoff, Emma C. Johnson, Yi-Ling Chou, Jonathan R. I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yilmaz, Jessica H. Baker, Christopher Hubel, Scott Gordon, Sarah E. Medland, Hunna J. Watson, Helena A. Gaspar, Julien Bryois, Anke Hinney, Virpi M. Leppa, Manuel Mattheisen, Stephan Ripke, Shuyang Yao, Paola Giusti-Rodriguez, Ken B. Hanscombe, Roger A. H. Adan, Lars Alfredsson, Tetsuya Ando, Ole A. Andreassen, Wade H. Berrettini, Ilka Boehm, Claudette Boni, Vesna Boraska Perica, Katharina Buehren, Roland Burghardt, Matteo Cassina, Sven Cichon, Maurizio Clementi, Roger D. Cone, Philippe Courtet, Scott Crow, James J. Crowley, Unna N. Danner, Oliver S. P. Davis, Martina de Zwaan, George Dedoussis, Daniela Degortes, Janiece E. DeSocio, Danielle M. Dick, Dimitris Dikeos, Christian Dina, Monika Dmitrzak-Weglarz, Elisa Docampo, Laramie E. Duncan, Karin Egberts, Stefan Ehrlich, Georgia Escaramis, Tonu Esko, Xavier Estivill, Anne Farmer, Angela Favaro, Fernando Fernandez-Aranda, Manfred M. Fichter, Krista Fischer, Manuel Foecker, Lenka Foretova, Andreas J. Forstner, Monica Forzan, Christopher S. Franklin, Steven Gallinger, Ina Giegling, Johanna Giuranna, Fragiskos Gonidakis, Philip Gorwood, Monica Gratacos Mayora, Sebastien Guillaume, Yiran Guo, Hakon Hakonarson, Konstantinos Hatzikotoulas, Joanna Hauser, Johannes Hebebrand, Sietske G. Helder, Stefan Herms, Beate Herpertz-Dahlmann, Wolfgang Herzog, Laura M. Huckins, James I. Hudson, Hartmut Imgart, Hidetoshi Inoko, Vladimir Janout, Susana Jimenez-Murcia, Antonio Julia, Gursharan Kalsi, Deborah Kaminska, Leila Karhunen, Andreas Karwautz, Martien J. H. Kas, James L. Kennedy, Anna Keski-Rahkonen, Kirsty Kiezebrink, Youl-Ri Kim, Kelly L. Klump, Gun Peggy S. Knudsen, Maria C. La Via, Stephanie Le Hellard, Robert D. Levitan, Dong Li, Lisa Lilenfeld, Bochao Danae Lin, Jolanta Lissowska, Jurjen Luykx, Pierre J. Magistretti, Mario Maj, Katrin Mannik, Sara Marsal, Christian R. Marshall, Morten Mattingsdal, Sara McDevitt, Peter McGuffin, Andres Metspalu, Ingrid Meulenbelt, Nadia Micali, Karen Mitchell, Alessio Maria Monteleone, Palmiero Monteleone, Benedetta Nacmias, Marie Navratilova, Ioanna Ntalla, Julie K. O'Toole, Roel A. Ophoff, Leonid Padyukov, Aarno Palotie, Jacques Pantel, Hana Papezova, Dalila Pinto, Raquel Rabionet, Anu Raevuori, Nicolas Ramoz, Ted Reichborn-Kjennerud, Valdo Ricca, Samuli Ripatti, Franziska Ritschel, Marion Roberts, Alessandro Rotondo, Dan Rujescu, Filip Rybakowski, Paolo Santonastaso, Andre Scherag, Stephen W. Scherer, Ulrike Schmidt, Nicholas J. Schork, Alexandra Schosser, Jochen Seitz, Lenka Slachtova, P. Eline Slagboom, Margarita C. T. Slof-Op't Landt, Agnieszka Slopien, Sandro Sorbi, Beata Swiatkowska, Jin P. Szatkiewicz, Ioanna Tachmazidou, Elena Tenconi, Alfonso Tortorella, Federica Tozzi, Janet Treasure, Artemis Tsitsika, Marta Tyszkiewicz-Nwafor, Konstantinos Tziouvas, Annemarie A. van Elburg, Eric F. van Furth, Gudrun Wagner, Esther Walton, Elisabeth Widen, Eleftheria Zeggini, Stephanie Zerwas, Stephan Zipfel, Andrew W. Bergen, Joseph M. Boden, Harry Brandt, Steven Crawford, Katherine A. Halmi, L. John Horwood, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, James Mitchell, Catherine M. Olsen, John F. Pearson, Nancy L. Pedersen, Michael Strober, Thomas Werge, David C. Whiteman, D. Blake Woodside, Jakob Grove, Anjali K. Henders, Janne T. Larsen, Richard Parker, Liselotte V. Petersen, Jennifer Jordan, Martin A. Kennedy, Andreas Birgegard, Paul Lichtenstein, Claes Norring, Mikael Landen, Preben Bo Mortensen, Renato Polimanti, Jeanette N. McClintick, Amy E. Adkins, Fazil Aliev, Silviu-Alin Bacanu, Anthony Batzler, Sarah Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li-Shiun Chen, Toni-Kim Clarke, Franziska Degenhardt, Anna R. Docherty, Alexis C. Edwards, Jerome C. Foo, Louis Fox, Josef Frank, Laura M. Hack, Annette M. Hartmann, Sarah M. Hartz, Stefanie Heilmann-Heimbach, Colin Hodgkinson, Per Hoffmann, Jouke-Jan Hottenga, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Dongbing Lai, Lannie Ligthart, Anu Loukola, Brion S. Maher, Hamdi Mbarek, Andrew M. McIntosh, Matthew B. McQueen, Jacquelyn L. Meyers, Yuri Milaneschi, Teemu Palviainen, Roseann E. Peterson, Euijung Ryu, Nancy L. Saccone, Jessica E. Salvatore, Sandra Sanchez-Roige, Melanie Schwandt, Richard Sherva, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley T. Webb, Robbee Wedow, Leah Wetherill, Amanda G. Wills, Hang Zhou, Jason D. Boardman, Danfeng Chen, Doo-Sup Choi, William E. Copeland, Robert C. Culverhouse, Norbert Dahmen, Louisa Degenhardt, Benjamin W. Domingue, Mark A. Frye, Wolfgang Gabel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, Gabriele Koller, John Kramer, Samuel Kuperman, Susanne Lucae, Michael T. Lynskey, Wolfgang Maier, Karl Mann, Satu Maennistoe, Bertram Mueller-Myhsok, Alison D. Murray, John I. Nurnberger, Ulrich Preuss, Katri Raikkonen, Maureen D. Reynolds, Monika Ridinger, Norbert Scherbaum, Marc A. Schuckit, Michael Soyka, Jens Treutlein, Stephanie H. Witt, Norbert Wodarz, Peter Zill, Daniel E. Adkins, Dorret I. Boomsma, Laura J. Bierut, Sandra A. Brown, Kathleen K. Bucholz, E. Jane Costello, Harriet De Wit, Nancy Diazgranados, Johan G. Eriksson, Lindsay A. Farrer, Tatiana M. Foroud, Nathan A. Gillespie, Alison M. Goate, David Goldman, Richard A. Grucza, Dana B. Hancock, Kathleen Mullan Harris, Victor Hesselbrock, John K. Hewitt, Christian J. Hopfer, William G. Iacono, Eric O. Johnson, Victor M. Karpyak, Kenneth S. Kendler, Henry R. Kranzler, Kenneth Krauter, Penelope A. Lind, Matt McGue, James MacKillop, Pamela A. F. Madden, Hermine H. Maes, Patrik K. E. Magnusson, Elliot C. Nelson, Markus M. Noethen, Abraham A. Palmer, Brenda W. J. H. Penninx, Bernice Porjesz, John P. Rice, Marcella Rietschel, Brien P. Riley, Richard J. Rose, Pei-Hong Shen, Judy Silberg, Michael C. Stallings, Ralph E. Tarter, Michael M. Vanyukov, Scott Vrieze, Tamara L. Wall, John B. Whitfield, Hongyu Zhao, Benjamin M. Neale, Tracey D. Wade, Andrew C. Heath, Grant W. Montgomery, Nicholas G. Martin, Patrick F. Sullivan, Jaakko Kaprio, Gerome Breen, Joel Gelernter, Howard J. Edenberg, Cynthia M. Bulik, Arpana Agrawal
Summary: Twin studies suggest shared genetic factors between eating disorders and substance use disorders, with strongest associations between bulimia nervosa and problem alcohol use. Genome-wide association studies reveal significant positive genetic correlations between alcohol use disorder and anorexia nervosa, cannabis initiation and anorexia nervosa, and cannabis initiation and anorexia nervosa with binge eating. Conversely, significant negative genetic correlations were observed between smoking behaviors and anorexia nervosa without binge eating.
Article
Oncology
Pooja Middha Kapoor, Nasim Mavaddat, Parichoy Pal Choudhury, Amber N. Wilcox, Sara Lindstrom, Sabine Behrens, Kyriaki Michailidou, Joe Dennis, Manjeet K. Bolla, Qin Wang, Audrey Jung, Zomoroda Abu-Ful, Thomas Ahearn, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Laura E. Beane Freeman, Heiko Becher, Matthias W. Beckmann, Alicia Beeghly-Fadiel, Javier Benitez, Leslie Bernstein, Stig E. Bojesen, Hiltrud Brauch, Hermann Brenner, Thomas Bruening, Qiuyin Cai, Daniele Campa, Federico Canzian, Angel Carracedo, Brian D. Carter, Jose E. Castelao, Stephen J. Chanock, Nilanjan Chatterjee, Georgia Chenevix-Trench, Christine L. Clarke, Fergus J. Couch, Angela Cox, Simon S. Cross, Kamila Czene, James Y. Dai, H. Shelton Earp, Arif B. Ekici, A. Heather Eliassen, Mikael Eriksson, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Lin Fritschi, Marike Gabrielson, Manuela Gago-Dominguez, Chi Gao, Susan M. Gapstur, Mia M. Gaudet, Graham G. Giles, Anna Gonzalez-Neira, Pascal Guenel, Lothar Haeberle, Christopher A. Haiman, Niclas Hakansson, Per Hall, Ute Hamann, Sigrid Hatse, Jane Heyworth, Bernd Holleczek, Robert N. Hoover, John L. Hopper, Anthony Howell, David J. Hunter, Esther M. John, Michael E. Jones, Rudolf Kaaks, Renske Keeman, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Allison W. Kurian, Diether Lambrechts, Loic Le Marchand, Eunjung Lee, Flavio Lejbkowicz, Martha Linet, Jolanta Lissowska, Ana Llaneza, Robert J. MacInnis, Maria Elena Martinez, Tabea Maurer, Catriona McLean, Susan L. Neuhausen, William G. Newman, Aaron Norman, Katie M. O'Brien, Andrew F. Olshan, Janet E. Olson, Hakan Olsson, Nick Orr, Charles M. Perou, Guillermo Pita, Eric C. Polley, Ross L. Prentice, Gad Rennert, Hedy S. Rennert, Kathryn J. Ruddy, Dale P. Sandler, Christobel Saunders, Minouk J. Schoemaker, Ben Schoettker, Fredrick Schumacher, Christopher Scott, Rodney J. Scott, Xiao-Ou Shu, Ann Smeets, Melissa C. Southey, John J. Spinelli, Jennifer Stone, Anthony J. Swerdlow, Rulla M. Tamimi, Jack A. Taylor, Melissa A. Troester, Celine M. Vachon, Elke M. van Veen, Xiaoliang Wang, Clarice R. Weinberg, Caroline Weltens, Walter Willett, Stacey J. Winham, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Argyrios Ziogas, Alison M. Dunning, Paul D. P. Pharoah, Marjanka K. Schmidt, Peter Kraft, Douglas F. Easton, Roger L. Milne, Montserrat Garcia-Closas, Jenny Chang-Claude
Summary: The study evaluated the joint associations between a new PRS313 and questionnaire-based breast cancer risk factors, revealing that the PRS313 odds ratio did not differ significantly across strata defined by individual risk factors. A multiplicative model assumption was adopted for breast cancer risk, and the variation in absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Psychiatry
Argus Athanas, Jamison McCorrison, Julie Campistron, Nick Bender, Jamie Price, Susan Smalley, Nicholas J. Schork
Summary: This study aims to characterize individual transitions between emotional states during the prolonged use of a digital app designed to provide guided meditations, impacting the transitions are factors like initial emotional state, type of guided meditations, as well as gender and age. The results suggest that personalized recommendations based on an individual's initial emotional state can have a favorable effect on transitioning between emotional states, with implications for the design and use of guided mental health recommendations in digital device apps.
JMIR MENTAL HEALTH
(2021)
Correction
Psychiatry
Argus J. Athanas, Jamison M. McCorrison, Susan Smalley, Jamie Price, Jim Grady, Paul Wehner, Julie Campistron, Nicholas J. Schork
JMIR MENTAL HEALTH
(2021)
Article
Geriatrics & Gerontology
Xiaoqing Xu, Beate Ritz, Anne L. Coleman, Zeyan Liew, Dennis Deapen, Eunjung Lee, Leslie Bernstein, Rich Pinder, Sarah F. Marshall, Julia E. Heck
Summary: The study found that women who reported regular use of low-dose aspirin or specific COX-2 inhibitors may have a protective effect on the risk of intermediate- or late-stage AMD.
Review
Gastroenterology & Hepatology
Robert J. Huang, Meira Epplein, Chisato Hamashima, Il Ju Choi, Eunjung Lee, Dennis Deapen, Yanghee Woo, Thuy Tran, Shailja C. Shah, John M. Inadomi, David A. Greenwald, Joo Ha Hwang
Summary: This study shows that the burden of GC is unequally distributed in the US, predominantly affecting Asian, African American, Hispanic, and American Indian/Alaskan Native populations. International studies have provided substantial evidence supporting the effectiveness of strategies such as H. pylori testing and treatment, as well as endoscopic screening in reducing GC-specific mortality. However, there is a lack of data from US sources. Therefore, there is an urgent need for cancer prevention trials targeting high-risk immigrant and minority populations in the US, and for the development of national strategies for GC prevention.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Surgery
Eunjung Lee, Eric S. Kawaguchi, Juanjuan Zhang, Sue E. Kim, Dennis Deapen, Lihua Liu, Nasim Sheidaee, Amie E. Hwang, Irene Kang, Kulmeet Sandhu, Giske Ursin, Anna H. Wu, Agustin A. Garcia
Summary: The study investigated the prevalence of weight loss surgery in women with breast or endometrial cancer, finding that postdiagnosis weight loss surgery was associated with a decreased hazard for death. Approximately 2000 patients in California underwent weight loss surgery after being diagnosed with breast or endometrial cancer.
SURGERY FOR OBESITY AND RELATED DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Lukas Lofling, Nathalie C. Stoer, Sara Nafisi, Giske Ursin, Solveig Hofvind, Edoardo Botteri
Summary: This study evaluates the association between aspirin use and breast cancer risk, finding inconsistent results. The use of low-dose aspirin is associated with a reduced risk of ER-positive breast cancer, especially in women aged 65 years and above, as well as overweight women.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Cell Biology
Eric Frankel, Avijit Podder, Megan Sharifi, Roshan Pillai, Newell Belnap, Keri Ramsey, Julius Dodson, Pooja Venugopal, Molly Brzezinski, Lorida Llaci, Brittany Gerald, Gabrielle Mills, Meredith Sanchez-Castillo, Chris D. Balak, Szabolcs Szelinger, Wayne M. Jepsen, Ashley L. Siniard, Ryan Richholt, Marcus Naymik, Isabelle Schrauwen, David W. Craig, Ignazio S. Piras, Matthew J. Huentelman, Nicholas J. Schork, Vinodh Narayanan, Sampathkumar Rangasamy
Summary: Through studying RTT-L patients, we discovered that their gene mutations are unrelated to RTT but cause a similar clinical phenotype. We analyzed the protein-protein interaction network of these genes and found that HDAC1 and CHD4 play important regulatory roles between RTT and RTT-L genes.
Article
Health Care Sciences & Services
Elin Borosund, Anders Meland, Hege R. Eriksen, Christine M. Rygg, Giske Ursin, Lise Solberg Nes
Summary: This study aimed to develop two digital psychosocial stress-management interventions, namely cognitive behavioral therapy-based intervention (CBI) and mindfulness-based intervention (MBI), for survivors of breast cancer. Through extensive collaboration, researchers successfully developed these two interventions for survivors of breast cancer and made improvements through iterative user testing.
JMIR FORMATIVE RESEARCH
(2023)
Article
Oncology
L. Lukas Lofling, Nathalie C. Stoer, Bettina Kulle Andreassen, Giske Ursin, Edoardo Botteri
Summary: This study assessed the prognostic effect of aspirin, statins, and metformin in breast cancer patients, with inconclusive results. It found evidence supporting an association between post-diagnostic use of statins and metformin and survival in patients with breast cancer, with potential differences according to estrogen receptor status.
BREAST CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Juan Pablo Hinestrosa, Razelle Kurzrock, Jean M. Lewis, Nicholas J. Schork, Gregor Schroeder, Ashish M. Kamat, Andrew M. Lowy, Ramez N. Eskander, Orlando Perrera, David Searson, Kiarash Rastegar, Jake R. Hughes, Victor Ortiz, Iryna Clark, Heath I. Balcer, Larry Arakelyan, Robert Turner, Paul R. Billings, Mark J. Adler, Scott M. Lippman, Rajaram Krishnan
Summary: This study developed an EV-based blood biomarker classifier utilizing machine learning algorithm to detect early-stage pancreatic, ovarian, and bladder cancer. The results showed high sensitivity and specificity of this classifier in early cancer detection, indicating its potential clinical value for further studies.
COMMUNICATIONS MEDICINE
(2022)
Article
Oncology
Kirsti Hjerkind, Anna L. Johansson, Cassia B. Trewin, Hege G. Russnes, Giske Ursin
Summary: Breast cancer incidence differs between non-immigrants and immigrants from low- and middle-income countries, and there are also differences in subtype-specific incidences among immigrant groups from different regions.
BREAST CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Caryn Kseniya Rubanovich, Riley Taitingfong, Cynthia Triplett, Ondrej Libiger, Nicholas J. Schork, Jennifer K. Wagner, Cinnamon S. Bloss
Summary: Consumer uptake of direct-to-consumer DNA ancestry testing is increasing, with a study showing impacts on personal identity, sharing genetic information with family and healthcare providers, and likelihood to undergo other genetic tests. While most individuals planned to share results with family, a smaller percentage intended to share with healthcare providers. Surprising ancestry results and reshaping personal identity were noted, highlighting the implications of DNA ancestry testing on individuals.
JOURNAL OF COMMUNITY GENETICS
(2021)