Article
Multidisciplinary Sciences
Tomohiko Yasuda, Hyun Seok Lee, Su Youn Nam, Hiroto Katoh, Yuko Ishibashi, Somay Yamagata Murayama, Hidenori Matsui, Hiroki Masuda, Emiko Rimbara, Nobuyuki Sakurazawa, Hideyuki Suzuki, Hiroshi Yoshida, Yasuyuki Seto, Shumpei Ishikawa, Seong Woo Jeon, Masahiko Nakamura, Sachiyo Nomura
Summary: Genetic analysis and culturing techniques for gastric non-Helicobacter pylori Helicobacter (NHPH) are advancing, with NHPH reported to accompany certain gastric conditions. A study on Korean gastric cancer patients found a low percentage positive for NHPH, suggesting it may play a role in gastric cancer development, albeit with lower pathogenicity compared to H. pylori.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Rosanna Capparelli, Domenico Iannelli
Summary: Epigenetics plays a role in regulating gene expression, cell differentiation, and response to environmental stimuli. Helicobacter pylori (Hp) uses DNA methylation to silence genes in human gastric mucosa, which is a primary cause of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ruiting Guo, Xixi Cui, Xue Li, Wen Zang, Mingjie Chang, Zenghui Sun, Zhifang Liu, Yundong Sun, Jihui Jia, Wenjuan Li
Summary: This study found that Helicobacter pylori can induce the upregulation of circMAN1A2 in gastric cancer cells, and the downregulation of circMAN1A2 can inhibit the growth and invasion of gastric cancer cells. Furthermore, circMAN1A2 promotes the progression of H. pylori-induced gastric cancer by regulating the expression of MTA2. This study suggests that circMAN1A2 may be a potential diagnostic marker and therapeutic target for gastric cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Fengxia Wu, Cai Chen, Fulai Peng
Summary: The prevalence of Helicobacter pylori infection is high worldwide and is associated with gastric diseases such as gastric cancer and asthma. Coptidis rhizoma has been reported to have anti-inflammatory and anti-bacterial effects and may be effective in suppressing HPI and preventing asthma.
FRONTIERS IN ONCOLOGY
(2021)
Review
Microbiology
Marina A. Senchukova
Summary: H. pylori plays a role in the development of gastric cancer through interactions with pattern-recognition receptors on immune and epithelial cells. In addition to induction, H. pylori may also affect the mechanisms of gastric cancer progression.
CURRENT MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Shamshul Ansari, Yoshio Yamaoka
Summary: H. pylori infection is associated with gastric mucosal diseases and gastric cancer, and animal models are useful for studying the pathophysiology of these complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Microbiology
Agustina Taglialegna
Summary: In this study, Sharafutdinov et al. report the identification of a single nucleotide polymorphism in the gene encoding the HtrA protease of Helicobacter pylori that is linked to gastric cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Nader Alaridah, Raba'a F. Jarrar, Rayan M. Joudeh, Mallak Aljarawen, Mohammad Jum'ah, Hasan Nassr, Raad Riad AlHmoud, Abdullah Allouzi, Eslam M. Wadi, Anas H. A. Abu-Humaidan
Summary: In 2017, gastric cancer was reported as a leading cancer in Jordan, where Helicobacter pylori is one of the main risk factors. However, there is a lack of awareness among the general population about the harmful effects of this pathogen. A recent study in Jordan aimed to assess the knowledge and sources of information about H. pylori among the general population. The findings revealed low knowledge levels and misconceptions, emphasizing the need for increased awareness and reliable information sources.
Review
Oncology
Michelle C. C. Lim, Phatcharida Jantaree, Michael Naumann
Summary: Helicobacter pylori is a pathogenic bacterium that resides in the stomach lining and causes inflammation called type B gastritis. The chronic inflammation induced by H. pylori and other factors may lead to the development of stomach neoplasms and adenocarcinoma. Dysregulation of cellular processes in the stomach lining and microenvironment is a characteristic of H. pylori infection. In this review, we discuss the contradictory role of H. pylori in promoting or suppressing apoptosis in gastric epithelial cells and highlight the key processes in the microenvironment that contribute to apoptosis and gastric carcinogenesis.
Review
Immunology
Wenting Xu, Liming Xu, Chengfu Xu
Summary: The prevalence of H. pylori infection is high worldwide and is associated with various digestive system diseases. H. pylori infection alters the gastrointestinal microflora and contributes to the development of tumors and extragastrointestinal diseases. Probiotics can improve the efficacy of H. pylori eradication therapy by reducing intestinal flora imbalances.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Raluca Ioana Dascalu, Alexandra Bolocan, Dan Nicolae Paduaru, Alexandru Constantinescu, Magda Mihaela Mitache, Anca Daniela Stoica, Octavian Andronic
Summary: Helicobacter pylori (Hp) is a common pathogen causing chronic bacterial infections and gastrointestinal diseases. The prevalence of Hp infection varies worldwide and is related to socio-economic status, especially during childhood. The increasing antibiotic resistance, poor patient compliance, and bacterial-related factors contribute to the challenge in successfully eradicating Hp. New eradication regimens and strain susceptibility testing are important for effective treatment.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chao Wang, Yiyang Hu, Huan Yang, Sumin Wang, Bo Zhou, Yulu Bao, Yu Huang, Qiang Luo, Chuan Yang, Xia Xie, Shiming Yang
Summary: Gastric cancer, a common malignant tumor of the digestive system, is influenced by genetic, environmental, and microbial factors. Infection of Helicobacter pylori is closely related to the occurrence of gastric cancer, while non-coding RNA plays a crucial role in tumor progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Fernanda Gonzalez, Paula Diaz, Alejandra Sandoval-Borquez, Daniela Herrera, Andrew F. G. Quest
Summary: Extracellular vesicles are important in host-pathogen interactions, playing a role in modulating inflammatory responses and promoting disease development. Both EVs from cells infected with H. pylori and H. pylori-OMVs are involved in the development of gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Fangcheng Yuan, Ruth M. Pfeiffer, Sachelly Julian-Serrano, Simran Arjani, Michael J. Barrett, Jill Koshiol, Rachael Z. Stolzenberg-Solomon
Summary: There is an association between autoimmune conditions and pancreatic cancer risk, with certain autoimmune conditions being associated with an increased risk of pancreatic cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Yishay Pinto, Sigal Frishman, Sondra Turjeman, Adi Eshel, Meital Nuriel-Ohayon, Oshrit Shrossel, Oren Ziv, William Walters, Julie Parsonnet, Catherine Ley, Elizabeth L. Johnson, Krithika Kumar, Ron Schweitzer, Soliman Khatib, Faiga Magzal, Efrat Muller, Snait Tamir, Kinneret Tenenbaum-Gavish, Samuli Rautava, Seppo Salminen, Erika Isolauri, Or Yariv, Yoav Peled, Eran Poran, Joseph Pardo, Rony Chen, Moshe Hod, Elhanan Borenstein, Ruth E. Ley, Betty Schwartz, Yoram Louzoun, Eran Hadar, Omry Koren
Summary: This study comprehensively analyzed the gut microbiome, metabolome, inflammatory cytokines, nutrition, and clinical records of 394 women during the first trimester of pregnancy in order to predict the onset of gestational diabetes mellitus (GDM) earlier than currently accepted. The study also demonstrated the role of the gut microbiome in the development of GDM. These findings provide potential targets for early diagnostics and therapeutic intervention in the prevention of GDM.
Article
Emergency Medicine
Christopher L. Bennett, Carson E. Clay, Khairul A. Siddiqi, Bankole A. Olatosi, Julie Parsonnet, Carlos A. Camargo
Summary: This study aimed to identify the most efficient targets for future HIV testing efforts using a geographic focus in California. The results showed that emergency departments (EDs) affiliated with teaching hospitals in California are more likely to serve populations disproportionately impacted by HIV, suggesting that directing testing efforts towards these EDs could reduce the burden of undiagnosed HIV.
JOURNAL OF EMERGENCY MEDICINE
(2023)
Editorial Material
Nutrition & Dietetics
Rachael Stolzenberg-Solomon
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Microbiology
William A. Walters, Andrea C. Granados, Catherine Ley, Scot Federman, Doug Stryke, Yale Santos, Thomas Haggerty, Alicia Sotomayor-Gonzalez, Venice Servellita, Ruth E. Ley, Julie Parsonnet, Charles Y. Chiu
Summary: The human gut virome and its early life development are not well understood. This study used viral metagenomic sequencing to examine the virome composition of infants and their mothers longitudinally. It was found that the infant virome primarily consisted of bacteriophages, nonhuman dietary/environmental viruses, and human-host viruses, while the maternal virome had a larger presence of undetected vertebrate viruses. The development of the infant virome was mainly influenced by dietary, infectious, and environmental factors rather than direct maternal acquisition.
CELL HOST & MICROBE
(2023)
Article
Immunology
Joseph E. Levitt, Haley Hedlin, Sophie Duong, Di Lu, Justin Lee, Bryan Bunning, Nadia Elkarra, Benjamin A. Pinsky, Eileen Heffernan, Eric Springman, Richard B. Moss, Hector F. Bonilla, Julie Parsonnet, Roham T. Zamanian, Jamison J. Langguth, Jenna Bollyky, Chaitan Khosla, Mark R. Nicolls, Manisha Desai, Angela J. Rogers
Summary: The study aimed to evaluate the effectiveness of Acebilustat in treating outpatients with COVID-19, and the results showed that the medication did not shorten symptom duration.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Urology & Nephrology
Shuchi Anand, Maria Montez-Rath, Meri Varkila, Xue Yu, Martha Block, Stephanie Brillhart, Amanda Leppink, Patti Hunsader, Douglas K. Owens, Glenn M. Chertow, Julie Parsonnet, Geoffrey A. Block
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sabine Naudin, Joshua N. Sampson, Steven C. Moore, Demetrius Albanes, Neal D. Freedman, Stephanie J. Weinstein, Rachael Stolzenberg-Solomon
Summary: The study found that abnormal lipid metabolism in prospective studies is associated with pancreatic ductal carcinoma (PDAC). A comprehensive investigation of two prospective studies revealed that 43 lipid species were associated with PDAC.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Engineering, Environmental
Hongna Zhang, Katherine Z. Sanidad, Jianan Zhang, Guangqiang Wang, Rong Zhang, Chengchen Hu, Yongfeng Lin, Thomas D. Haggerty, Julie Parsonnet, Yuxin Zheng, Guodong Zhang, Zongwei Cai
Summary: Triclosan (TCS) is a commonly used antimicrobial agent with adverse health effects. The gut microbiota plays a role in the toxicity of TCS by converting conjugated TCS derivatives back to their bioactive form in the colon. These findings highlight the importance of considering gut microbial metabolism in assessing the health risks of environmental chemicals.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Nutrition & Dietetics
Ting Zhang, Sabine Naudin, Hyokyoung G. Hong, Demetrius Albanes, Satu Mannisto, Stephanie J. Weinstein, Steven C. Moore, Rachael Z. Stolzenberg-Solomon
Summary: This study examined the associations between dietary quality indices and serum lipidomic profiles. The results showed that adherence to the Healthy Eating Index (HEI)-2015, Alternate HEI-2010 (AHEI-2010), and alternate Mediterranean Diet Index (aMED) were associated with serum lipid species, particularly triacylglycerols and docosahexaenoic acid (DHA)-containing species, which were related to components of seafood and plant proteins, eicosapentaenoic acid-DHA, fish, or fat ratio.
JOURNAL OF NUTRITION
(2023)
Article
Health Care Sciences & Services
Catherine Ley, Heying Duan, Julie Parsonnet
Summary: When conducting seroepidemiologic studies, using letters as invitations and reminders is more effective than postcards for recruiting participants, leading to higher household response rates.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Environmental Sciences
Jongeun Rhee, Erikka Loftfield, Demetrius Albanes, Tracy M. Layne, Rachael Stolzenberg-Solomon, Linda M. Liao, Mary C. Playdon, Sonja I. Berndt, Joshua N. Sampson, Neal D. Freedman, Steven C. Moore, Mark P. Purdue
Summary: This study aimed to investigate the biological effects of PFOS and PFOA on the human body. Through metabolomic analysis, several metabolites associated with PFOS and PFOA were identified, with lipids and xenobiotics being the most common types. These findings provide insights into the potential hazards of PFOS and PFOA.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Christopher L. Bennett, Allan S. Detsky, Carson E. Clay, Janice A. Espinola, Julie Parsonnet, Carlos A. Camargo
Summary: This study found that emergency departments (EDs) in HIV priority jurisdictions in the United States serve populations emphasized in HIV-related efforts, such as Black or African American or Hispanic or Latino populations, as well as communities with higher proportions uninsured and living in poverty, and higher rates of chlamydia, gonorrhea, and syphilis. EDs with teaching hospital affiliations had the highest visit volumes and steady growth. The findings suggest that geographically targeted screening in EDs with a teaching hospital affiliation could efficiently reach vulnerable populations and reduce the burden of undiagnosed HIV in the US.
Article
Medicine, General & Internal
Catherine Ley, Frederik Heath, Trevor Hastie, Zijun Gao, Myroslava Protsiv, Julie Parsonnet
Summary: This cross-sectional study determines the normal oral temperature ranges based on age, sex, height, weight, and time of day by analyzing a large number of clinical visit records. The findings have important implications for temperature assessment and disease diagnosis in clinical medicine.
JAMA INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Meri R. J. Varkila, Maria E. Montez-Rath, Joshua A. Salomon, Xue Yu, Geoffrey A. Block, Douglas K. Owens, Glenn M. Chertow, Julie Parsonnet, Shuchi Anand
Summary: The widespread use of at-home COVID-19 tests affects the determination of community COVID-19 incidence. A study found that wastewater metrics were associated with high case and hospitalization rates in the first quarter of 2022, but the association weakened in subsequent quarters, possibly due to underreporting, reduced testing, and the effect of vaccines and treatments. This study suggests using wastewater metrics to improve the assessment of community infection prevalence when conventional surveillance data is unreliable.
