Article
Clinical Neurology
Fumi Nakano, Hideki Kanamaru, Fumihiro Kawakita, Lei Liu, Yoshinari Nakatsuka, Hirofumi Nishikawa, Takeshi Okada, Hidenori Suzuki
Summary: This study aimed to investigate the involvement of the EGFR/NF kappa B inducing kinase (NIK)/NF kappa B pathway in neuronal apoptosis after SAH in mice. The results showed that in SAH mice, there was an increase in TUNEL- and cleaved caspase-3 positive neurons, brain water content, and expression levels of EGFR/NIK/NF kappa B, which were decreased by AG1478 administration. Therefore, the EGFR/NIK/NF kappa B pathway may be involved in neuronal apoptosis after SAH in mice.
Article
Multidisciplinary Sciences
Yuan Yang, Ruizeng Luo, Shengyu Chao, Jiangtao Xue, Dongjie Jiang, Yun Hao Feng, Xin Dong Guo, Dan Luo, Jiaping Zhang, Zhou Li, Zhong Lin Wang
Summary: This article introduces a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS), which can improve the pharmacodynamics of epidermal growth factor and overcome the pharmacodynamic challenges associated with its conventional administration strategies.
NATURE COMMUNICATIONS
(2022)
Article
Pathology
Shunsuke Iriyama, Saori Nishikawa, Junichi Hosoi, Satoshi Amano
Summary: This study demonstrates the influence of basement membrane (BM) integrity on the level of hyaluronan (HA) in the epidermis, showing that BM structure impairment in sun-exposed skin of older subjects is associated with decreased epidermal HA content. In experimental models, inhibitors of BM-degrading matrix metalloproteinases and heparanase lead to increased epidermal HA levels, highlighting the importance of BM in maintaining epidermal HA levels.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wataru Murase, Atsuhito Kubota, Atsuko Ikeda-Araki, Masaru Terasaki, Koji Nakagawa, Ryota Shizu, Kouichi Yoshinari, Hiroyuki Kojima
Summary: This study investigated the gene expression profiles of human HepaRG cells exposed to PFOA. The results suggest that PFOA affects hepatic transcriptomic responses through direct activation of PPARa and indirect activation of CAR, PXR, FXR, and Nrf2. This finding reveals important molecular mechanisms in PFOA-induced human hepatotoxicity.
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Hussein F. Sakr, Boudaka Ammar, Amira AlKharusi, I Al-Lawati, Mahmoud AlKhateeb, Basim H. Elesawy
Summary: The study found that resveratrol can correct osteoporosis induced by male hypogonadism in rat models. By restoring the balance between bone formation and bone resorption, resveratrol can improve bone loss.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
Kenji Nakahama, Motohiro Izumi, Naoki Yoshimoto, Mitsuru Fukui, Akira Sugimoto, Hiroaki Nagamine, Koichi Ogawa, Kenji Sawa, Yoko Tani, Hiroyasu Kaneda, Shigeki Mitsuoka, Tetsuya Watanabe, Kazuhisa Asai, Tomoya Kawaguchi
Summary: Vimentin expression in NSCLC is associated with immune-checkpoint inhibitor efficacy. Measurement of vimentin expression can help determine appropriate immunotherapy strategies.
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Oncology
Orsolya Juhasz, Noemi Jakob, Hajnalka Rajnai, Marcell Imrei, Miklos Garami
Summary: The study found that lower vitamin D receptor (VDR) expression is associated with worse prognosis in different types of childhood cancer. Identifying the VDR status provides clinicians with a valuable biomarker to guide additional therapy.
Article
Oncology
Elham Kalantari, Tahereh Taheri, Saba Fata, Maryam Abolhasani, Mitra Mehrazma, Zahra Madjd, Mojgan Asgari
Summary: This study evaluated the co-expression pattern and clinical significance of EpCAM and CD166 in colorectal cancer (CRC) patients. The results showed that the expression of EpCAM and CD166 was associated with tumor progression and aggressive behavior, suggesting their potential as promising targets for targeted therapy in cancer treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Toxicology
David Filipovic, Wenjie Qi, Omar Kana, Daniel Marri, Edward L. LeCluyse, Melvin E. Andersen, Suresh Cuddapah, Sudin Bhattacharya
Summary: The aryl hydrocarbon receptor (AhR) is a receptor that binds to environmental contaminants and its binding is tissue-specific and influenced by DNA sequences and chromatin context.
TOXICOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Barbara Schreier, Virginie Dubourg, Stefanie Huebschmann, Sindy Rabe, Sigrid Mildenberger, Michael Gekle
Summary: The study reveals that EGFR and AT1R synergistically regulate gene expression, leading to qualitative, quantitative, and temporal changes, potentially impacting cell stress and vascular biology. Synergistic activation of SRF via distinct pathways and transcription factors AP1 and EGR plays a key role in this process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tingting Yang, Xuan Gu, Lizhou Jia, Jiaojiao Guo, Qi Tang, Jin Zhu, Wei Zhao, Zhenqing Feng
Summary: Immunohistochemical testing revealed lower DSG2 expression in colon cancer tissues compared to pericarcinomatous tissues, and this low expression is associated with poor survival in colon cancer patients. Bioinformatics analysis indicated that low DSG2 expression affects protein activation, regulates the P53-related pathway in colon cancer, and activates the EGFR pathway.
BMC GASTROENTEROLOGY
(2021)
Article
Cell Biology
J. G. Conte, M. L. Tellechea, B. Park, M. G. Ballerini, G. Jaita, M. C. Peluffo
Summary: Our study identifies CCR2 and its ligand MCP1 as novel mediators of the ovulatory cascade. We demonstrate that the CCR2/MCP1 pathway is involved in the stimulation of periovulatory gene expression by GNT, AREG, and PGE2, proposing CCR2 as a new mediator in the ovulatory cascade in a feline model. Furthermore, we show that MCP1 can reverse the inhibitory effects of an EGFR inhibitor on AREG expression, HA synthesis, P4 production, and oocyte nuclear maturation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Medical Laboratory Technology
David L. Rimm, Sanja Dacic, Stuart J. Schnitt
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Pathology
Charles J. Robbins, Aileen I. Fernandez, Gang Han, Serena Wong, Malini Harigopal, Mirna Podoll, Kamaljeet Singh, Amy Ly, M. Gabriela Kuba, Hannah Wen, Mary Ann Sanders, Jane Brock, Shi Wei, Oluwole Fadare, Krisztina Hanley, Julie Jorns, Olivia L. Snir, Esther Yoon, Kim Rabe, T. Rinda Soong, Emily S. Reisenbichler, David L. Rimm
Summary: This study evaluated the concordance and interrater reliability of scoring HER2 IHC in breast cancer biopsies by 18 breast cancer-specialized pathologists. The results showed poor concordance within the intermediate categories and for the IHC 0 cases. The use of a 3-category system partially reduced the discordance. The study also revealed the optimal number of raters for determining HER2 IHC scores of 0 and 3+.
Article
Surgery
Nicholas A. Elmer, Sthefano Araya, Juliet Panichella, Brian Egleston, Mengying Deng, Sameer A. Patel
Summary: This study aimed to understand the temporal pattern and risk factors associated with lower extremity free flap failure. It found a reoperation rate of 14.5% within the first 30 postoperative days, with patients with vascular indications having the highest rate. The rate of reoperation was highest during the first 2 days postoperative and significantly decreased afterwards. African American race, malignant tumors, prosthetic/implant complications, and wound/infectious indications were significant predictors for reoperation.
ANNALS OF PLASTIC SURGERY
(2023)
Letter
Oncology
Benjamin G. Carlisle, Donna L. Coffman, Brian L. Egleston, Maia Salholz-Hillel
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Katherine M. Bates, Ioannis Vathiotis, Tyler MacNeil, Fahad Shabbir Ahmed, Thazin Nwe Aung, Yuliya Katlinskaya, Sabyasachi Bhattacharya, Amanda Psyrri, Steven Yea, Amanda Parkes, Nooshin Hashemi Sadraei, Siddhartha Roychoudhury, David L. Rimm, Niki Gavrielatou
Summary: This study used quantitative immunofluorescence to evaluate CD40 expression on solid tumors, including lung, ovarian, and pancreatic cancers. The results showed a high percentage of tumor cells expressing CD40, but no significant impact on overall survival.
Article
Psychology, Clinical
Bradley N. Collins, Stephen J. Lepore, Brian L. Egleston
Summary: This study aimed to examine the effectiveness of the BLiSS multilevel intervention in promoting smoking cessation among low-income maternal smokers and its impact on smoking relapse rates over a 12-month period. The results showed that mothers who received the intervention were more likely to eliminate their children's tobacco smoke exposure within three months, which was significantly associated with long-term smoking abstinence.
JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Oncology
Brian L. Egleston, Richard J. Bleicher, Carolyn Y. Fang, Thomas J. Galloway, Slobodan Vucetic
Summary: Additional evaluations and second opinions before breast cancer surgery may improve care, but could cause detrimental delays. This study investigates the timing of surgical delays associated with survival benefits and potential harm. It found that quick new patient visits have a protective association with breast cancer mortality, but substantial delays may increase mortality in older patients. Similarly, delays in medical oncologist and surgeon visits can also have negative impacts on outcomes.
Article
Surgery
Sthefano Araya, Theresa K. K. Webster, Brian Egleston, Grace M. M. Amadio, Juliet C. C. Panichella, Nicholas A. A. Elmer, Sameer A. A. Patel
Summary: This study reviewed the impact of ERAS implementation on the length of stay (LOS) in patients undergoing DIEP free-flap breast reconstruction. The results showed that the implementation of ERAS protocols led to a significant decrease in LOS and supported safe discharge on postoperative days 2-3.
ANNALS OF PLASTIC SURGERY
(2023)
Article
Oncology
Madison Kilbride, Brian L. Egleston, Wendy K. Chung, Olufunmilayo Olopade, Kara N. Maxwell, Payal Shah, Jane E. Churpek, Linda Fleisher, Mary Beth Terry, Dominique Fetzer, Jill Bennett Gaieski, Jessica Bulafka, Aileen Espinal, Kelsey Karpink, Sarah Walser, Davone Singleton, Monica Palese, Ilona Siljander, Amanda Brandt, Dana Clark, Carrie Koval, Julia Wynn, Jessica M. Long, Danielle Mckenna, Jacquelyn Powers, Sarah Nielsen, Susan M. Domchek, Katherine L. Nathanson, Angela R. Bradbury
Summary: The study showed high interest in web-based predisclosure education for returning genetic research results, but it did not increase the uptake of results. There were no negative patient-reported outcomes with web education, indicating that it is a viable alternative delivery model for reducing burdens and costs of returning genetic research results.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pathology
Aileen I. Fernandez, Patricia Gaule, David L. Rimm
Summary: This study found that the antigenicity of PD-L1 antibody 22C3 may change over time due to the degradation of the glycan part of the epitope. This should be taken into consideration when evaluating archival tissue for diagnostic or research purposes.
Article
Public, Environmental & Occupational Health
Amy H. Auchincloss, Francesca Mucciaccio, Carolyn Y. Fang, Dominic A. Ruggiero, Jana A. Hirsch, Julia Zhong, Minzi Li, Brian L. Egleston, Marilyn Tseng
Summary: This study examined the relationship between neighborhood social composition, gentrification, and acculturation stress among first-generation Chinese immigrants. The findings showed that Chinese immigrants living in neighborhoods with a higher proportion of Chinese immigrants and higher wealth experienced lower acculturation stress, while gentrification had no impact.
SSM-POPULATION HEALTH
(2023)
Article
Health Care Sciences & Services
Margaret L. Longacre, Marcin Chwistek, Cynthia Keleher, Mark Siemon, Brian L. Egleston, Molly Collins, Carolyn Y. Fang
Summary: The study demonstrates the usability and satisfaction of a patient-caregiver portal system in engaging caregivers systematically. The system allows patients to specify their caregiver and communication preferences, connects caregivers to a unique portal page, and provides electronic notifications to the care team. The findings highlight the need for further research on caregivers of patients with different illnesses.
JMIR HUMAN FACTORS
(2023)
Meeting Abstract
Oncology
Mary Daly, Brian Egleston, Kaitlyn Lew, Lisa Bealin, Alexander Husband, Jill Stopfe, Pawel Przybysz, Olga Tchuvatkina, Yu-Ning Wong, Judy Garber, Timothy Rebbeck
Meeting Abstract
Oncology
Marilyn Tseng, Brian Egleston, Julia Zhong, Minzi Li, Carolyn Fang
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Meeting Abstract
Oncology
Ella Batterson, Marilyn Tseng, Emily C. Walton, Brian Egleston, Julia Zhong, Minzi Li, Carolyn Fang
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)