期刊
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
卷 17, 期 1, 页码 220-223出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-07-0058
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资金
- NATIONAL CANCER INSTITUTE [K07CA092348] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000400] Funding Source: NIH RePORTER
- NCI NIH HHS [K07 CA 92348-01A1] Funding Source: Medline
- NCRR NIH HHS [M01 RR 00400] Funding Source: Medline
Purpose: The effect of exercise training on lipid peroxidation and endogenous estrogens is not well understood in premenopausal women. Exercise effects on these variables could mediate observed associations of exercise with hormonally related cancers, including breast cancer. The purpose of the study is to determine the effect of 15 weeks of aerobic exercise on lipid peroxidation, endogenous estrogens, and body composition in young, healthy eumenorrheic women. Methods: Fifteen sedentary premenopausal women (18-25 years) participated. Pre- and post-exercise training urine collection (three 24-h samples) started 48 h after most recent exercise session for analysis of a marker of lipid peroxidation (F-2-isoprostane) and endogenous estrogens, including 2-hydroxyestrogens, 4-hydroxyestrogens, 16-alpha-hydroxyestrone, and ratios of these metabolites (2:16, 2:4). Body composition was measured by dual-energy X-ray absorptiometry, and F-2-isoprostanes and estrogens were measured by gas chromatography-mass spectrometry. Results: Aerobic exercise resulted in a 34% decrease in F-2-isoprostane (P = 0.02), a 10% increase in fitness (P = 0.004), a 1.2 kg decrease in body mass (P = 0.007), and a 1.8 kg decrease in fat mass (P = 0.04). No significant changes were noted in estrogens. Conclusions: The effect of exercise training on oxidative stress may be relevant to risk for hormonally related cancers.
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