期刊
CANCER EPIDEMIOLOGY
卷 33, 期 3-4, 页码 257-260出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.canep.2009.08.002
关键词
Non-Hodgkin lymphoma; DNA repair; Single nucleotide polymorphisms
资金
- Leukaemia Research Fund of Great Britain
Non-Hodgkin lymphoma (NHL) represents a complex group of B- and T-cell malignancies characterised by chromosomal translocations. Since defects in DNA repair result in an increased frequency of chromosomal aberrations it has been hypothesised that genetic variation in DNA repair may be associated with risk of NHL. To investigate the relationship between DNA repair and NHL we analysed polymorphisms in XPD (R156R, D312N, K751Q) using DNA collected in a UK population-based case-control study of lymphoma. We observed no association between genetic variation in XPD and risk of NHL. However, the XPD 751 Gln allele was associated with a two-fold decreased risk of diffuse large B-cell lymphoma (OR 0.56, 95% Cl 0.34-0.92, p = 0.02), the major subtype of NHL. Overall, our study identifies that XPD polymorphisms may be important in the aetiology of NHL although analysis of additional polymorphisms and extended haplotype studies are required to clarify their role. (C) 2009 Elsevier Ltd. All rights reserved.
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