TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts

Therapeutic targets for neuroblastomas

(2014) Garrett M Brodeur et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer

(2013) Aria Vaishnavi et al.   NATURE MEDICINE

Brain-derived neurotrophic factor/tropomyosin-related kinase B pathway in gastric cancer

(2012) Y Okugawa et al.   BRITISH JOURNAL OF CANCER

AZ64 inhibits TrkB and enhances the efficacy of chemotherapy and local radiation in neuroblastoma xenografts

(2012) Radhika Iyer et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma

(2011) Wook Jin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phase I trial of lestaurtinib for children with refractory neuroblastoma: a new approaches to neuroblastoma therapy consortium study

(2011) Jane E. Minturn et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Role and Relevance of TrkB Mutations and Expression in Non-Small Cell Lung Cancer

(2011) T. Harada et al.   CLINICAL CANCER RESEARCH

More expressions of BDNF and TrkB in multiple hepatocellular carcinoma and anti-BDNF or K252a induced apoptosis, supressed invasion of HepG2 and HCCLM3 cells

(2011) Dawei Guo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Overexpression of TrkB promotes the progression of colon cancer

(2010) YINGJIAO YU et al.   APMIS

The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan

(2010) Peter E. Zage et al.   CANCER

TrkC plays an essential role in breast tumor growth and metastasis

(2010) Wook Jin et al.   CARCINOGENESIS

Lestaurtinib Enhances the Antitumor Efficacy of Chemotherapy in Murine Xenograft Models of Neuroblastoma

(2010) R. Iyer et al.   CLINICAL CANCER RESEARCH

K252a induces anoikis-sensitization with suppression of cellular migration in Epstein-Barr Virus (EBV)—associated nasopharyngeal carcinoma cells

(2010) Yuen-Keng Ng et al.   INVESTIGATIONAL NEW DRUGS

On Trk--The TrkB Signal Transduction Pathway Is an Increasingly Important Target in Cancer Biology

(2009) C. J. Thiele et al.   CLINICAL CANCER RESEARCH

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway

(2009) K. Thress et al.   MOLECULAR CANCER THERAPEUTICS

TrkA overexpression enhances growth and metastasis of breast cancer cells

(2009) C Lagadec et al.   ONCOGENE

Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer

(2008) Xiaohui Yu et al.   CANCER SCIENCE