Role of pregnane X receptor in chemotherapeutic treatment

Tissue-specific regulation of pregnane X receptor in cancer development and therapy

(2014) Delira Robbins et al.   Cell and Bioscience

Pregnane X Receptor (PXR) at the Crossroads of Human Metabolism and Disease

(2013) Ioannis Koutsounas et al.   CURRENT DRUG METABOLISM

Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond

(2013) Xiaojuan Chai et al.   Expert Opinion on Drug Metabolism & Toxicology

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters

(2012) Yakun Chen et al.   BIOCHEMICAL PHARMACOLOGY

Pregnane xenobiotic receptor in cancer pathogenesis and therapeutic response

(2012) Satyanarayana R. Pondugula et al.   CANCER LETTERS

Theranostics meets traditional Chinese medicine: rational prediction of drug–herb interactions

(2012) Miao Hu et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

(2012) Jie Cheng et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

(2011) Hongwei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells

(2011) Agnes Basseville et al.   Molecular Cancer

Overcoming drug resistance by regulating nuclear receptors

(2010) Taosheng Chen   ADVANCED DRUG DELIVERY REVIEWS

Induction of CYP3A4 by Vinblastine: Role of the Nuclear Receptor NR1I2

(2010) Nicola F Smith et al.   ANNALS OF PHARMACOTHERAPY

Pregnane X receptor suppresses proliferation and tumourigenicity of colon cancer cells

(2010) N Ouyang et al.   BRITISH JOURNAL OF CANCER

Regulation of drug resistance by human pregnane X receptor in breast cancer

(2010) Yakun Chen et al.   CANCER BIOLOGY & THERAPY

Pharmacogenetics of Target Genes Across Doxorubicin Disposition Pathway: A Review

(2010) Suman Lal et al.   CURRENT DRUG METABOLISM

Endoxifen, the Active Metabolite of Tamoxifen, Is a Substrate of the Efflux Transporter P-Glycoprotein (Multidrug Resistance 1)

(2010) W. A. Teft et al.   DRUG METABOLISM AND DISPOSITION

Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

(2010) Caroline Raynal et al.   Molecular Cancer

Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells

(2009) Suman Verma et al.   BMC CANCER

PXR-mediated induction of P-glycoprotein by anticancer drugs in a human colon adenocarcinoma-derived cell line

(2009) Stefan Harmsen et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The Major Human Pregnane X Receptor (PXR) Splice Variant, PXR.2, Exhibits Significantly Diminished Ligand-Activated Transcriptional Regulation

(2009) Y. S. Lin et al.   DRUG METABOLISM AND DISPOSITION

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

(2009) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Elucidating the ‘Jekyll and Hyde’ Nature of PXR: The Case for Discovering Antagonists or Allosteric Antagonists

(2009) Arunima Biswas et al.   PHARMACEUTICAL RESEARCH

Pregnane X Receptor and its Potential Role in Drug Resistance in Cancer Treatment

(2009) Yakun Chen et al.   Recent Patents on Anti-Cancer Drug Discovery

Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer

(2008) H. E. Meyer zu Schwabedissen et al.   CANCER RESEARCH

PXR Pharmacogenetics: Association of Haplotypes with Hepatic CYP3A4 and ABCB1 Messenger RNA Expression and Doxorubicin Clearance in Asian Breast Cancer Patients

(2008) E. Sandanaraj et al.   CLINICAL CANCER RESEARCH

Expanding the Roles for Pregnane X Receptor in Cancer: Proliferation and Drug Resistance in Ovarian Cancer

(2008) D. Gupta et al.   CLINICAL CANCER RESEARCH

Novel Orphan Nuclear Receptors-Coregulator Interactions Controlling Anti-Cancer Drug Metabolism

(2008) Radharani Gollamudi et al.   CURRENT DRUG METABOLISM

Unique Transcription Start Sites and Distinct Promoter Regions Differentiate the Pregnane X Receptor (PXR) Isoforms PXR 1 and PXR 2

(2008) L. M. Tompkins et al.   DRUG METABOLISM AND DISPOSITION

Role of Human Pregnane X Receptor in Tamoxifen- and 4-Hydroxytamoxifen-Mediated CYP3A4 Induction in Primary Human Hepatocytes and LS174T Cells

(2008) R. S. Sane et al.   DRUG METABOLISM AND DISPOSITION

The pregnane X receptor: from bench to bedside

(2008) Xiaochao Ma et al.   Expert Opinion on Drug Metabolism & Toxicology

PXR: a xenobiotic receptor of diverse function implicated in pharmacogenetics

(2008) Bin Zhang et al.   PHARMACOGENOMICS

Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

(2007) Jie Zhou et al.   GASTROENTEROLOGY

The Antiapoptotic Role of Pregnane X Receptor in Human Colon Cancer Cells

(2007) Jie Zhou et al.   MOLECULAR ENDOCRINOLOGY