Review
Integrative & Complementary Medicine
Ashraf Duzan, Desiree Reinken, Timothy L. McGomery, Nicholas M. Ferencz, Jacob M. Plummer, Mufeed M. Basti
Summary: Glioblastoma multiforme (GBM) is a highly aggressive and incurable cancer with no effective treatment options. However, endocannabinoids offer a promising novel therapeutic approach for GBM.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Oncology
Raphael Wilhelm, Timon Eckes, Gergely Imre, Stefan Kippenberger, Markus Meissner, Dominique Thomas, Sandra Trautmann, Jean-Philippe Merlio, Edith Chevret, Roland Kaufmann, Josef Pfeilschifter, Alexander Koch, Manuel Jager
Summary: There is no curative treatment for mycosis fungoides and Sezary syndrome, which are the most common forms of cutaneous T cell lymphoma. Short-chain ceramides like C6 Ceramide can induce cell death in CTCL cell lines. However, primary human keratinocytes and HaCaT keratinocytes are less affected by C6 Ceramide, suggesting potential protective effects. Further clinical trials are warranted to explore the use of C6 Ceramide in the treatment of CTCL.
Article
Oncology
Tom Zimmermann, Sebastian Staebler, R. Verena Taudte, Sumeyya Uenuevar, Sabine Groesch, Stephanie Arndt, Sigrid Karrer, Martin F. Fromm, Anja-Katrin Bosserhoff
Summary: The exact mechanisms of action of cold atmospheric plasma (CAP) treatment for cancer are still unclear. This study found that CAP treatment caused a reduction in intracellular ceramide levels and a strong activation of the unfolded protein response (UPR) in melanoma cells. Additionally, pharmacological reduction in ceramides enhanced the effects of CAP treatment.
Article
Pharmacology & Pharmacy
Soha Ismail, Doaa Garhy, Howida K. Ibrahim
Summary: The aim of this study was to enhance the permeability of curcumin in the skin through the preparation of spanlastics. Spanlastics were prepared using the ethanol injection technique and characterized for particle size, encapsulation efficiency, and dissolution efficiency. The formulae with the highest desirability were found to be elastic, spherical, nonirritant, and compatible. They showed promising results as a potential delivery system for melanoma treatment.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
E. Andrew Thim, Todd Fox, Tye Deering, Luke R. Vass, Natasha D. Sheybani, Mark Kester, Richard J. Price
Summary: Sparse scan partial thermal ablation combined with nanoliposomes can enhance the anti-tumor effect of systemically administered therapeutics. However, resistance of the tumor to C6 can still be a limiting factor for some solid tumor types.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Perng Yang Puah, Dexter Jiunn Herng Lee, Soo Huan Puah, Nik Amin Sahid Nik Lah, Yee Soon Ling, Siat Yee Fong
Summary: In this study, the anticancer effects of a root fraction of Eleusine indica (R-S5-C1-H1) on three cancer cell lines were investigated. The results showed that R-S5-C1-H1 significantly reduced the cell viability of the cancer cells and induced apoptotic cell death. Metabolomic analysis revealed alterations in hydrophobic metabolites, suggesting that modulation of phospholipid synthesis and sphingolipid metabolism may contribute to the anticancer mechanism of R-S5-C1-H1.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sheila S. Fontes, Mateus L. Nogueira, Rosane B. Dias, Clarissa A. Gurgel Rocha, Milena B. P. Soares, Marcos A. Vannier-Santos, Daniel P. Bezerra
Summary: This study investigated the combination of curcumin and disulfiram in the treatment of melanoma and found synergistic anti-tumor effects. The combination promoted apoptosis and DNA fragmentation in melanoma cells and increased oxidative stress. In animal experiments, the combination therapy inhibited tumor growth.
Article
Biochemistry & Molecular Biology
Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Eun-Young Choi, Su-Ji Jeon, Soo-Hyun Jung, BumSeok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Summary: This study investigated the anticancer effects of Chrysin in human melanoma cells and found that it can inhibit cell viability by inducing apoptosis and autophagy. The response to autophagy varies in different cell types, and Chrysin also affects the mTOR/S6K pathway.
Article
Biochemistry & Molecular Biology
Mehrgan Ghazaeian, Khatereh Khorsandi, Reza Hosseinzadeh, Asieh Naderi, Heidi Abrahamse
Summary: The study explores the use of curcumin-silica nanoparticles as a photosensitizer for the treatment of melanoma cancer. The results indicate that the complex has a greater photodynamic effect on cancer cells, increases solubility, and interacts with DNA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Chemistry, Medicinal
Asal Jalal Abadi, Sepideh Mirzaei, Mahmood Khaksary Mahabady, Farid Hashemi, Amirhossein Zabolian, Fardin Hashemi, Pourya Raee, Shahin Aghamiri, Milad Ashrafizadeh, Amir Reza Aref, Michael R. Hamblin, Kiavash Hushmandi, Ali Zarrabi, Gautam Sethi
Summary: Curcumin, isolated from Curcuma longa, has potent tumor-suppressor activity and can decrease the adverse impacts of cisplatin (CP) while enhancing its antitumor activity. Curcumin reduces ROS levels to prevent apoptosis in normal cells, inhibits inflammation, and reduces various toxicities caused by CP. Additionally, curcumin potentiates CP cytotoxicity and suppresses tumor-promoting pathways to prevent drug resistance.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biology
Matthias Hose, Anne Guenther, Eyad Naser, Fabian Schumacher, Tina Schoenberger, Julia Falkenstein, Athanasios Papadamakis, Burkhard Kleuser, Katrin Anne Becker, Erich Gulbins, Adriana Haimovitz-Friedman, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: Modulation of ceramide levels by interfering with Asm or Ac activity affects T cell differentiation and function, representing a potential novel therapeutic strategy for T cell-dependent diseases such as tumorigenesis.
Article
Biochemistry & Molecular Biology
Daiane Manica, Gilnei Bruno da Silva, Alana Patricia da Silva, Filomena Marafon, Sarah Franco Vieira de Oliveira Maciel, Margarete Dulce Bagatini, Marcelo Moreno
Summary: Curcumin inhibits migration and promotes apoptosis in SK-MEL-28 cells, while increasing oxidative stress levels.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Medicine, Research & Experimental
Mohamed Elbadawy, Kimika Hayashi, Hiromi Ayame, Yusuke Ishihara, Amira Abugomaa, Makoto Shibutani, Shim-Mo Hayashi, Shoichi Hazama, Hiroko Takenouchi, Masao Nakajima, Ryouichi Tsunedomi, Nobuaki Suzuki, Hiroaki Nagano, Yuta Shinohara, Masahiro Kaneda, Hideyuki Yamawaki, Tatsuya Usui, Kazuaki Sasaki
Summary: Despite the adverse effects, chemotherapy is commonly used for colorectal cancer treatment. Developing supplement preparations targeting cancer stem cells is necessary. In this study, amorphous curcumin (AC) showed anti-carcinogenic properties against human CRC organoids by inhibiting cell viability, cell cycle, and CSC marker expressions while synergizing with anti-cancer drugs.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Abdelhabib Semlali, Sarra Beji, Ikram Ajala, Mohammed Al-Zharani, Mahmoud Rouabhia
Summary: Oral cancer has traditionally been treated with surgery, radiotherapy, chemotherapy, or a combination of these therapies. Recent studies have shown that 3,5-Bis (4-hydroxy-3-methoxybenzylidene)-N-methyl-4-piperidine (PAC), a new curcumin analog, possesses anticancer properties and could be considered a complementary or alternative therapy. The combination of PAC and cisplatin enhances oral cancer cell death by inducing apoptosis, autophagy, and oxidative stress, indicating PAC's potential as a powerful complementary agent to cisplatin in the treatment of gingival squamous cell carcinomas.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Oncology
Sotiris Kyriakou, William Cheung, Theodora Mantso, Melina Mitsiogianni, Ioannis Anestopoulos, Stephany Veuger, Dimitris T. Trafalis, Rodrigo Franco, Aglaia Pappa, David Tetard, Mihalis Panayiotidis
Summary: The study shows that L-SK-4 induces heightened levels of ROS, leading to upregulation of sphingolipid biosynthesis and promotion of apoptosis in a model of malignant melanoma. This novel therapy holds significant importance for the treatment of melanoma.
INVESTIGATIONAL NEW DRUGS
(2021)