期刊
CANCER CHEMOTHERAPY AND PHARMACOLOGY
卷 64, 期 6, 页码 1165-1172出版社
SPRINGER
DOI: 10.1007/s00280-009-0979-8
关键词
AZD2171; Cediranib; Phase I study; Tolerability; Vascular endothelial growth factor receptor
To evaluate safety and tolerability of cediranib, a highly potent and selective vascular endothelial growth factor signaling inhibitor, in Japanese patients with advanced solid tumors refractory to standard therapies. In part A (n = 16), patients received once-daily oral cediranib (10-45 mg) to identify the maximum tolerated dose (MTD). In part B (n = 24), patients with non-small-cell lung cancer or colorectal cancer received multiple daily doses at the MTD. Cediranib 30 mg/day was considered the MTD since 50% of evaluable patients receiving 45 mg/day experienced dose-limiting toxicities in part A (proteinuria and diarrhea n = 1, proteinuria n = 1, thrombocytopenia n = 1). The most common adverse events were diarrhea (n = 34) and hypertension (n = 32). Pharmacokinetic analysis confirmed cediranib as suitable for once-daily oral dosing. Of 32 evaluable patients, two had partial RECIST responses and 24 had stable disease a parts per thousand yen8 weeks. Cediranib was generally well tolerated at a parts per thousand currency sign30 mg/day in these Japanese patients and showed encouraging antitumor activity.
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