Article
Multidisciplinary Sciences
Faiza Hayat, Najeeb Ullah Khan, Aakif Ullah Khan, Iftikhar Ahmad, Ahmad M. Alamri, Bushra Iftikhar
Summary: This study investigated the association of RANKL and OPG gene polymorphisms with breast to bone metastasis in the Pashtun population of Pakistan. The results showed that OPG (rs3102735) and RANKL (rs9533156) were significantly associated with breast to bone metastasis, while OPG (rs2073618) did not show a significant association. This study opens up more questions for further investigation into the genetic predisposition of breast to bone metastasis.
Article
Endocrinology & Metabolism
Yan Yang, Xiangxin Li
Summary: This study revealed the effects of SIRT1 on the OPG/RANKL signaling pathway and periodontitis progression. The results showed that overexpression of SIRT1 can activate the OPG/RANKL pathway, inhibit osteoclastogenesis, and attenuate periodontitis progression.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Charlotte Le Cornet, Audrey Y. Y. Jung, Theron S. S. Johnson, Sabine Behrens, Nadia Obi, Heiko Becher, Jenny Chang-Claude, Renee T. Fortner
Summary: This study found that higher levels of osteoprotegerin (OPG) in the blood were associated with an increased risk of all-cause mortality in breast cancer patients, especially in those with ER-PR- tumors, while no associations were found for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). These findings suggest that OPG may serve as a biomarker for poor prognosis in ER- breast cancer.
BREAST CANCER RESEARCH
(2023)
Article
Plant Sciences
Xiangmin Ni, Bin Wu, Shuo Li, Wenyi Zhu, Zhe Xu, Guiming Zhang, Hanqiang Cui, Qian Bai, Jian Wang
Summary: Eq, as a metabolite of soy isoflavones, has a therapeutic effect on PMOP by promoting osteoblast proliferation, inhibiting apoptosis, and upregulating the OPG/RANKL pathway.
Article
Multidisciplinary Sciences
Daisuke Nishida, Atsushi Arai, Lijuan Zhao, Mengyu Yang, Yuko Nakamichi, Kanji Horibe, Akihiro Hosoya, Yasuhiro Kobayashi, Nobuyuki Udagawa, Toshihide Mizoguchi
Summary: The relative ratio of RANKL/OPG plays a significant role in pulpal odontoclastogenesis, with OPG expression not required for maintenance of pulp homeostasis but for protecting pulp from odontoclastogenesis caused by damages.
SCIENTIFIC REPORTS
(2021)
Article
Materials Science, Multidisciplinary
Maha Abdelhamid Fathy, Amal Anbaig, Raja Aljafil, Sherein F. El-Sayed, Hanim Magdy Abdelnour, Mona Mostafa Ahmed, Eman M. A. Abdelghany, Sulaiman Mohammed Alnasser, Shaimaa Mohamed Abdelfattah Hassan, Amany Mohamed Shalaby
Summary: Liraglutide can prevent diabetic osteoporosis by increasing bone growth and inhibiting bone resorption. The study also suggests that the vitamin D receptor Bsm1 polymorphism may have an impact on the therapeutic outcomes of liraglutide.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Endocrinology & Metabolism
Hyo Shik Shin, Hyun Jin Sun, Young Mi Whang, Young Joo Park, Do Joon Park, Sun Wook Cho
Summary: Metformin significantly reduced the viabilities of thyroid cancer cells and delayed tumor growth in bone metastasis. In the microenvironment of bone metastasis, metformin inhibited cancer cell growth, blocked cancer cell-induced osteoblastic RANKL production, which further activated osteoclastogenesis, and directly reduced osteoclast differentiation.
Review
Endocrinology & Metabolism
Yan Zhang, Jingqi Liang, Peilong Liu, Qiong Wang, Liang Liu, Hongmou Zhao
Summary: With the increasing incidence of cancer, tumor bone metastasis has become more common among patients. The RANK/RANKL/OPG system and osteoclasts play important roles in bone homeostasis and tumor bone metastasis formation, and inhibiting this system can prevent metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chao Liu, Yining Li, Ren Sheng, Xiaowan Han, Li Bao, Chenyin Wang, Weizhi Wang, Xinhai Jiang, Jiangxue Han, Lijuan Lei, Ni Li, Jing Zhang, Minghua Chen, Yan Li, Yexiang Wu, Shunwang Li, Yu Ren, Yanni Xu, Shuyi Si
Summary: The study demonstrated that the N-methylpyridine-chlorofuranformamide analog 3i1 shows promise in upregulating OPG activity, inhibiting RANKL-induced osteoclastogenesis, and promoting osteoblast differentiation, potentially serving as a new therapeutic agent for osteoporosis.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jiarui Li, Xiang Li, Shengji Zhou, Yuxin Wang, Yang Lu, Quan Wang, Fengchao Zhao
Summary: Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting TRAIL degradation and promotes osteoblast differentiation, suggesting its potential in anti-osteopenia pharmacotherapy.
MOLECULAR MEDICINE
(2022)
Correction
Endocrinology & Metabolism
Hisataka Yasuda
Summary: Reference 12 was published incorrectly in the original article.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Physiology
Mingming Zhang, Ming Chen, Yi Li, Man Rao, Duanyang Wang, Zhongqi Wang, Licheng Zhang, Pengbin Yin, Peifu Tang
Summary: Recent evidence has revealed the important role of OPG/RANKL/RANK signaling axis in both bone and muscle tissue, but its effects on muscle atrophy are not well understood. This study found that denervated Opg knockout mice showed improved functional recovery and delayed muscle atrophy. OPG deficiency also led to milder activation of the ubiquitin-proteasome pathway in denervated muscle. Transcriptome sequencing revealed changes in gene expression in denervated muscle from Opg knockout mice, and in vitro experiments showed enhanced differentiation ability of satellite cells from Opg knockout mice.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Cell Biology
Sofia Passaponti, Leonardo Ermini, Giulia Acconci, Filiberto Maria Severi, Roberta Romagnoli, Santina Cutrupi, Marinella Clerico, Gisella Guerrera, Francesca Ietta
Summary: This study demonstrates the influence of late pregnancy on the balance between RANKL and OPG in women with multiple sclerosis (MS), and identifies the placenta as an important source of homodimeric OPG. Placental OPG suppresses the mRNA expression of CCL20 and affects the recruitment of Th17 cells. Therefore, placental OPG may play a crucial role in the beneficial effects of late pregnancy on MS, and could potentially be used for the development of new and more effective therapeutic approaches.
Article
Dentistry, Oral Surgery & Medicine
Balarama Krishna, Isha Duggal, Jitendra Sharan, Manaswini Mangaraj, Ritu Duggal, Ashok Kumar Jena
Summary: This study evaluated the effect of leukocyte-platelet-rich fibrin (L-PRF) on maxillary canine retraction and its correlation with the levels of RANKL, OPG, and RANKL:OPG in gingival crevicular fluid (GCF). The results showed that L-PRF accelerated the rate of maxillary canine retraction by enhancing RANKL and suppressing OPG concentrations, but there was no significant correlation between the rate of canine retraction and expression of RANKL, OPG, and RANKL:OPG in GCF.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Endocrinology & Metabolism
Sandhya Nair, Sonam Hatkar, Anushree Patil, Suchitra Surve, Beena Joshi, Nafisa Balasinor, Meena Desai
Summary: A study on 374 healthy Indian women established reference intervals for serum RANKL, OPG, RANKL/OPG ratio, CTX, and PINP, providing valuable information for the diagnosis and management of osteoporosis in this population.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Physiology
Andrew C. Noah, Thomas M. Li, Leandro M. Martinez, Susumu Wada, Jacob B. Swanson, Nathaniel P. Disser, Kristoffer B. Sugg, Scott A. Rodeo, Theresa T. Lu, Christopher L. Mendias
JOURNAL OF APPLIED PHYSIOLOGY
(2020)
Article
Cell Biology
Nicholas M. Clark, Leandro M. Martinez, Steven Murdock, James T. deLigio, Amy L. Olex, Comfort Effi, Mikhail G. Dozmorov, Paula D. Bos
Article
Biology
Silvia Diaz-Lora, Tomas Perez-Contreras, Manuel Azcarate-Garcia, Juan Manuel Peralta-Sanchez, Manuel Martinez-Bueno, Juan Jose Soler, Manuel Martin-Vivaldi
Summary: The signaling hypothesis suggests that avian eggshell coloration may act as a post-mating sexual signal of female quality to males, with males adjusting their provisioning rate accordingly. This study provides the first experimental evidence that egg color stained with uropygial secretion could serve as a cue for male investment in hoopoes.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Allergy
Yanyan Luo, Valeria Fernandez Vallone, Jiajun He, Stefan Frischbutter, Pavel Kolkhir, Sherezade Monino-Romero, Harald Stachelscheid, Viktoria Streu-Haddad, Marcus Maurer, Frank Siebenhaar, Joerg Scheffel
Summary: This study developed a novel method for the rapid and efficient differentiation of mast cells (MCs) from human-induced pluripotent stem cells (hiPSCs). The generated hiPSC-MCs showed similar characteristics and functions as human skin MCs and peripheral hematopoietic stem cell-derived MCs. This new method provides a sustainable and homogeneous cell source for the investigation of disease- and patient-specific MC populations.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Neurosciences
Christian Schinke, Valeria Fernandez Vallone, Andranik Ivanov, Yangfan Peng, Peter Koertvelyessy, Luca Nolte, Petra Huehnchen, Dieter Beule, Harald Stachelscheid, Wolfgang Boehmerle, Matthias Endres
Summary: Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect with no predictive biomarkers or preventive treatments available. Using sensory neurons derived from induced pluripotent stem cells as an experimental model for CIPN, researchers found differential responses to neurotoxic drugs between cell lines from different healthy donors, showcasing potential for studying CIPN pathogenesis and neuroprotective treatments.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Cell & Tissue Engineering
Janine Cernoch, Tanja Fisch, Iris Fischer, Kristin Fischer, Anna Iwanska, Norman Krueger, Judit Kuechler, Claudia Schaar, Sandra Schommer, Narasimha Telugu, Duncan Miller, Valeria Fernandez Vallone, Andreas Kurtz, Petra Reinke, Sebastian Diecke, Harald Stachelscheid
Summary: Researchers generated 20 iPSC lines from FSGS patients, covering a wide range of gender and age. These cell lines were fully characterized and quality controlled, serving as valuable tools for disease modeling and drug development for FSGS.
STEM CELL RESEARCH
(2021)
Article
Cell & Tissue Engineering
Iris Fischer, Judit Kuechler, Claudia Schaar, Tanja Fisch, Janine Cernoch, Kristin Fischer, Valeria Fernandez Vallone, Peter Kuehnen, Harald Stachelscheid
Summary: MIRAGE syndrome is a multisystem disorder with high mortality in early life, caused by mutations in SAMD9. Researchers have generated two human induced pluripotent stem cell lines from male children with MIRAGE syndrome, providing a valuable tool for studying the disease mechanism.
STEM CELL RESEARCH
(2021)
Article
Oncology
Maria Belen Giorello, Ayelen Matas, Pablo Marenco, Kevin Mauro Davies, Francisco Raul Borzone, Maria de Lujan Calcagno, Hernan Garcia-Rivello, Alejandra Wernicke, Leandro Marcelo Martinez, Vivian Labovsky, Norma Alejandra Chasseing
Summary: The study suggests that in early breast cancer patients, high levels of CD1a( +) dendritic cells are associated with lower risk of bone metastasis and better prognosis, while high levels of CD83( +) dendritic cells are linked to lower risk of mix metastasis and improved prognosis. Therefore, the numbers of CD1a and CD83 dendritic cells can serve as independent prognostic factors for metastasis in early breast cancer.
Article
Multidisciplinary Sciences
Christian Schinke, Valeria Fernandez Vallone, Andranik Ivanov, Yangfan Peng, Peter Koertvelyessy, Luca Nolte, Petra Huehnchen, Dieter Beule, Harald Stachelscheid, Wolfgang Boehmerle, Matthias Endres
Summary: Chemotherapy-induced peripheral neuropathy is a common adverse event of cytotoxic chemotherapy. Sensory neurons derived from induced pluripotent stem cells were used to study the effects of neurotoxic drugs, showing differential responses to treatment between different cell lines.
Article
Behavioral Sciences
Juan Jose Soler, Ester Martinez-Renau, Manuel Azcarate-Garcia, Cristina Ruiz-Castellano, Jose Martin, Manuel Martin-Vivaldi
Summary: This study explores the cosmetic use of intensely yellow-colored uropygial secretion by spotless starling nestlings and its role in parent-offspring communication. The secretion color is genetically determined and correlates positively with Vitamin E supplementation and plasma carotenoid concentration. The coloration of begging-related traits and nestling secretion predicts parental feeding preferences. These findings suggest the informative value and significance of cosmetic coloration in offspring- parent communication.
BEHAVIORAL ECOLOGY
(2022)
Article
Microbiology
Ester Martinez-Renau, Monica Mazorra-Alonso, Cristina Ruiz-Castellano, Manuel Martin-Vivaldi, Antonio M. Martin-Platero, Maria Dolores Baron, Juan Jose Soler
Summary: Symbiotic bacteria on animal hosts can prevent pathogenic bacterial infections by enhancing host's immune responses or producing antimicrobial substances. The antimicrobial properties of bacterial symbionts vary among different host species, reflecting their risk of microbial infection. This suggests that the risk of infection drives natural selection to enhance animal immunocompetence through selecting for antibiotic-producing symbionts.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Behavioral Sciences
Laura Arco, Juan Manuel Peralta-Sanchez, Manuel Martin-Vivaldi, Manuel Soler
Summary: Brood parasites lay their eggs in nests of other species, tricking hosts into raising their parasitic offspring. Hosts may fight back impeding successful parasitism by developing defenses at any of the stages of their breeding cycle. This study found that hoopoes have evolved the less common host defense: discrimination of parasite fledglings, even in the absence of their own fledgling for comparison. This suggests that discrimination during the later stages of the nesting cycle may be more common than previously assumed.
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2023)
Article
Oncology
Valeria Fernandez Vallone, Francisco Raul Borzone, Leandro Marcelo Martinez, Maria Belen Giorello, Hosoon Choi, Federico Dimase, Leonardo Feldman, Raul Horacio Bordenave, Ana Marisa Chudzinski-Tavassi, Emilio Batagelj, Norma Alejandra Chasseing
Summary: This study describes the bone marrow pre-metastatic niche in advanced breast cancer patients, showing an increase in osteoclast precursors and spontaneous osteoclastogenesis at both bone marrow and peripheral levels. The expression levels of specific microRNAs in primary breast tumors may indicate a pro-osteoclastogenic environment prior to bone metastasis. These findings have important clinical implications for the prevention and management of bone metastasis in advanced breast cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Lara Lechner, Robert Opitz, Matt J. Silver, Philipp M. Krabusch, Andrew M. Prentice, Martha S. Field, Harald Stachelscheid, Elsa Leitao, Christopher Schroeder, Valeria Fernandez Vallone, Bernhard Horsthemke, Karl-Heinz Joeckel, Boerge Schmidt, Markus M. Noethen, Per Hoffmann, Stefan Herms, Patrick W. Kleyn, Matthias Megges, Ulrike Blume-Peytavi, Katja Weiss, Knut Mai, Oliver Blankenstein, Benedikt Obermayer, Susanna Wiegand, Peter Kuehnen
Summary: Increasing evidence suggests that epigenetic variants play a role in the development of obesity. The study identified POMC hypermethylation as a risk factor for obesity and found that it is not genetically determined. The researchers also established an embryonic stem cell model to investigate the early establishment of POMC methylation states.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Zoology
Juan Jose Soler, Manuel Martin-Vivaldi, Sona Nuhlickova, Cristina Ruiz-Castellano, Monica Mazorra-Alonso, Ester Martinez-Renau, Manfred Eckenfellner, Jan Svetlik, Herbert Hoi
Summary: Sibling cannibalism is found to be common in the Eurasian hoopoe, with a higher incidence in the Spanish population compared to the Austrian population. The higher occurrence of sibling cannibalism in the southern population may be due to more nestlings condemned to die. Factors such as hatching failure, food scarcity, and hatching asynchrony influence the likelihood and intensity of sibling cannibalism.
ZOOLOGICAL RESEARCH
(2022)