Article
Oncology
Dana M. Zaher, Wafaa S. Ramadan, Raafat El-Awady, Hany A. Omar, Fatema Hersi, Vunnam Srinivasulu, Ibrahim Y. Hachim, Farah I. Al-Marzooq, Cijo G. Vazhappilly, Salim Merali, Carmen Merali, Nelson C. Soares, Paul Schilf, Saleh M. Ibrahim, Taleb H. Al-Tel
Summary: SIMR1281 displayed a multi-target anticancer effect by dual inhibition of glutathione and thioredoxin reductases, inhibiting cell proliferation and inducing apoptosis by inducing DNA damage, perturbing the cell cycle, and pathway inactivation.
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
David J. Voce, Giovanna M. Bernal, Kirk E. Cahill, Longtao Wu, Nassir Mansour, Clayton D. Crawley, Paige-Ashley S. Campbell, Ainhoa Arina, Ralph R. Weichselbaum, Bakhtiar Yamini
Summary: The alkylating agent TMZ is commonly used in chemotherapeutic treatment of GBM. TMZ induces CDK1 expression via NF-κB regulation, enhancing its cytotoxic effect. Targeting CDK1, regulated by p50 and BCL-3, may improve TMZ efficacy against GBM.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Alessandra Gentilini, Giulia Lori, Alessandra Caligiuri, Chiara Raggi, Giovanni Di Maira, Mirella Pastore, Benedetta Piombanti, Tiziano Lottini, Annarosa Arcangeli, Stefania Madiai, Nadia Navari, Jesus M. Banales, Sabina Di Matteo, Domenico Alvaro, Lea Duwe, Jesper B. Andersen, Alessandro Tubita, Ignazia Tusa, Luca Di Tommaso, Claudia Campani, Elisabetta Rovida, Fabio Marra
Summary: This study revealed the important role of ERK5 in the growth and migration of CCA cells, as well as its involvement in the protumorigenic crosstalk between the tumor and the microenvironment.
Article
Immunology
Lei Yang, You-Ling Shi, Yan Ma, Wei-Wei Ren, Guang-Ming Pang, Jiao Liu
Summary: The study revealed that the upregulation of KLF16 expression in OSCC cells, interfering with KLF16 resulted in cell cycle arrest, inhibited cell growth, and promoted cell apoptosis.
Article
Biochemistry & Molecular Biology
Anqi Yang, Saina Yan, Yanfei Yin, Chujie Chen, Xiangwei Tang, Maoliang Ran, Bin Chen
Summary: In this study, the regulatory roles of non-CpG methylation in testicular development were explored by analyzing the whole-genome bisulfite sequencing and RNA sequencing data of porcine testicular tissues. It was found that non-CpG methylation regulates the expression of key genes involved in testes development. The importance of FZD7 in the proliferation and apoptosis of Sertoli cells was also demonstrated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Marwa F. Ahmed, Atiah H. Almalki
Summary: New thiosemicarbazone derivatives were synthesized and evaluated for their anticancer activity, with compounds IIIa, IIIe, and IIIh showing promising results. Compound IIIa exhibited potent inhibitory activity against ribonucleotide reductase and induced apoptosis through activating the intrinsic apoptotic pathway.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Min Yu, Xiaoyan Hu, Jingyu Yan, Ying Wang, Fei Lu, Junlei Chang
Summary: The study confirmed that NSC139021 effectively inhibited the proliferation of glioblastoma cells and induced apoptosis by regulating the p53 signaling pathway and cell cycle kinase pathway, suggesting a potential therapeutic role in glioblastoma treatment.
Article
Endocrinology & Metabolism
Yinan Jiang, Apeng Chen, Diana Kline, Qun Liu, Jie Ma, Yan Wang, Ting Zhang, Jieqi Qian, Laura Nelson, Krishna Prasadan, Baoli Hu, George K. Gittes, Xiangwei Xiao
Summary: This study demonstrates a regulatory loop between pancreatic macrophages and gestational beta cells through PlGF/EGF/ERK5 signaling cascades, which plays a crucial role in the growth of beta cells during pregnancy.
DIABETES OBESITY & METABOLISM
(2022)
Article
Pharmacology & Pharmacy
Wei Yang, Jiaqi Su, Mingjing Li, Tiantian Li, Xu Wang, Mingdong Zhao, Xuemei Hu
Summary: Myricetin inhibits the proliferation of HCC cells by downregulating MARCH1 and affecting the p38 MAPK and Stat3 signaling pathways, ultimately suppressing HCC growth. This natural flavonol also induces autophagy and cell cycle arrest in HCC cells, demonstrating its anticancer properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Jun Zhou, Wanpin Nie, Jiajia Yuan, Zeyu Zhang, Liangliang Mi, Changfa Wang, Ranglang Huang
Summary: GSG2 plays a crucial role in the progression of CCA and its overexpression predicts disease deterioration. Experimental results demonstrate that downregulation of GSG2 inhibits proliferation, promotes apoptosis, arrests cell cycle, and weakens migration in CCA cells.
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Hanqing Zhu, Hongliang Zhang, Jiahui Guo, Chao Zhang, Quanwu Zhang, Fenghou Gao
Summary: Mdm2 promotes the degradation of p53, while Mdm2-p60 can bind to p53 and stabilize it. USP2a stabilizes Mdm2, and its role in regulating Mdm2-p60 needs further investigation. We found that oxidative stress up-regulates USP2a and induces its oxidation, which is closely related to cell apoptosis. In apoptotic cells, oxidized USP2a stabilizes Mdm2-p60 and plays a role in cell apoptosis. This provides an experimental basis for targeting USP2a to regulate p53 apoptotic signaling.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Oncology
Richard Brill, Wibke Uller, Veronika Huf, Rene Mueller-Wille, Irene Schmid, Alexandra Pohl, Beate Haeberle, Sybille Perkowski, Katrin Funke, Anne-Marie Till, Melchior Lauten, Jacob Neumann, Christian Guettel, Esther Heid, Franziska Ziermann, Axel Schmid, Dieter Huesemann, Lutz Meyer, Peter B. Sporns, Regina Schinner, Vanessa F. Schmidt, Jens Ricke, Jochen Roessler, Friedrich G. Kapp, Walter A. Wohlgemuth, Moritz Wildgruber
Summary: A study suggests that adjunct transarterial embolization may lead to a quicker resolution of thrombocytopenia in children with KHE and KMP compared to systemic sirolimus alone; however, tumor response and rebound rates were similar between the two treatment groups.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Jochen Rossler, Eulalia Baselga, Victoria Davila, Veronica Celis, Andrea Diociaiuti, Maya El Hachem, Sandrine Mestre, Dario Haeberli, Aram Prokop, Christof Hanke, Wolfgang Loichinger, Isabelle Quere, Iris Baumgartner, Charlotte M. Niemeyer, Friedrich G. Kapp
Summary: In this study, severe adverse events (SAEs) were observed during off-label use of sirolimus for vascular anomalies. Most SAEs occurred within the first year of treatment, especially in infancy, including fatal viral pneumonia. Adequate monitoring is essential to prevent SAEs, especially in patients with complex lymphatic anomalies.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Biochemistry & Molecular Biology
Lorenz M. Bell, Annegret Holm, Uta Matysiak, Wolfgang Driever, Jochen Roessler, Denny Schanze, Ilse Wieland, Charlotte M. Niemeyer, Martin Zenker, Friedrich G. Kapp
Summary: This study investigates the pathogenic factors of vascular malformations, the impact of mutations on the type of malformation, and the use of a zebrafish model for evaluating pathogenicity of mutations and testing candidate drugs in a personalized and mutation-specific approach.
HUMAN MOLECULAR GENETICS
(2022)
Article
Oncology
Vincent Chen, Shigeki Umemura, Yumin Han, Renuka Raman, Robin Tucker, Joeffrey Chahine, In-Kyu Kim, Christoph Schatz, Sabine Zitzmann-Kolbe, Anette Sommer, Masanori Onda, Trevor Lee, Yongfeng He, Giuseppe Giaccone
Summary: This study demonstrates that anetumab ravtansine inhibits the growth of MSLN positive thymic carcinoma cells both in vitro and in vivo. The results show that ARav has potential as a novel therapy for thymic carcinoma, especially in cases where traditional therapies have limited effectiveness.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Anette Sommer, Sandra Berndt, Hans-Georg Lerchen, Sabrina Forveille, Allan Sauvat, Dominik Mumberg, Guido Kroemer, Oliver Kepp
Summary: The study characterizes the mode of action of antibody-drug conjugates (ADCs) and finds that they can activate immune responses and induce immunogenic cell death, contributing to their antineoplastic effects.
Article
Health Policy & Services
Beatrix Cucuruz, Michael Koller, Ronja Pfleiderer, Urban Geisthoff, Lutz Meyer, Friedrich Kapp, Werner Lang, Thomas Schmitz-Rixen, Walter A. Wohlgemuth
Summary: This article discusses the importance of vascular anomalies as orphan diseases and highlights the necessity of multidisciplinary treatment centers for patient care. The authors recommend establishing a set of quality indicators and standards to improve healthcare in Germany.
ZEITSCHRIFT FUR EVIDENZ FORTBILDUNG UND QUALITAET IM GESUNDHEITSWESEN
(2022)
Article
Genetics & Heredity
Andrea Diociaiuti, Eulalia Baselga, Laurence M. Boon, Anne Dompmartin, Veronika Dvorakova, May El Hachem, Paolo Gasparella, Emir Haxhija, Nader Ghaffarpour, Kristiina Kyrklund, Alan D. Irvine, Friedrich G. Kapp, Jochen Roessler, Paivi Salminen, Caroline van den Bosch, Carine van der Vleuten, Leo Schultze Kool, Miikka Vikkula
Summary: The European Reference Network on Rare Multisystemic Vascular Diseases (VASCERN) aims to provide accessible cross-border healthcare to patients with rare vascular diseases. Infantile Hemangiomas (IH) are benign vascular tumors that can cause severe complications in rare cases. Certain publications focus on evidence-based medicine for IH treatment, while consensus statements mainly concentrate on managing rare IH associated with PHACES syndrome.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Genetics & Heredity
Claudia Schuart, Andrea Bassi, Friedrich Kapp, Ilse Wieland, Angelica Pagliazzi, Heike Losch, Carlo Mazzatenta, Giacomo M. Bacci, Teresa Oranges, Denny Schanze, Klaus Mohnike, Arti Nanda, Judith Fischer, Martin Zenker, Rudolf Happle
Summary: This study describes three children with CMTC caused by postzygotic GNA11 mutations. These individuals had widespread and asymmetric CMTC present from birth, becoming fainter during the first years of life. Other associated anomalies including glaucoma, choroidal capillary malformation, and body asymmetry were also observed. The study supports the concept that CMTC can be caused by mosaic GNA11 mutations and belongs to the GNARCAN spectrum.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Biochemical Research Methods
Niels Boehnke, Markus Berger, Nils Griebenow, Antje Rottmann, Michael Erkelenz, Stefanie Hammer, Sandra Berndt, Judith Guenther, Antje M. Wengner, Beatrix Stelte-Ludwig, Christoph Mahlert, Simone Greven, Lisa Dietz, Hannah Jorissen, Naomi Barak, Ulf Boemer, Roman C. Hillig, Uwe Eberspaecher, Jorg Weiske, Anja Giese, Dominik Mumberg, Carl Friedrich Nising, Hilmar Weinmann, Anette Sommer
Summary: A new class of NAMPT inhibitors as ADC payloads was developed, optimizing their structures to create highly potent effector chemistries. The optimized NAMPTi-ADCs demonstrated potent in vivo antitumor efficacy with a very good selectivity profile.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Pediatrics
Hannah Glonnegger, Felicia Andresen, Friedrich Kapp, Stefano Malvestiti, Martin Buechsel, Barbara Zieger
Summary: Emicizumab therapy is safe and efficient in pediatric patients with hemophilia A, leading to a significant reduction in bleeding rates. However, more data is needed, especially for previously untreated and minimally treated patients.
Article
Oncology
Jakob Siebert, Michaela Schneider, Daniela Reuter-Schmitt, Julia Wuertemberger, Annette Neubueser, Wolfgang Driever, Simone Hettmer, Friedrich G. Kapp
Summary: A new zebrafish-based xenotransplant model was established for rapid and accessible drug screening in pediatric soft tissue sarcomas. Chemotherapy drugs with clinical anti-tumor efficacy were shown to significantly reduce tumor size in proof-of-principle experiments. This zebrafish model can be a valuable addition to existing models and offer a cost-effective solution for preclinical drug testing.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Genetics & Heredity
Nader Ghaffarpour, Eulalia Baselga, Laurence M. Boon, Andrea Diociaiuti, Anne Dompmartin, Veronika Dvorakova, May El Hachem, Paolo Gasparella, Emir Haxhija, Kristiina Kyrklund, Alan D. Irvine, Friedrich G. Kapp, Jochen Roessler, Paivi Salminen, Caroline van den Bosch, Carine van der Vleuten, Leo Schultze Kool, Miikka Vikkula
Summary: Lymphatic malformations are developmental defects of lymphatic vessels, which can cause serious complications and psychological strain for patients. There is limited guidance on their management and follow up, so the Vascular Anomalies Working Group of VASCERN developed a diagnostic and management pathway using the Nominal Group Technique to approach these patients practically.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2022)
Article
Medicine, Research & Experimental
Themis-Areti A. Andreoti, Sebastian Berg, Annegret Holm, Marina Angerer, Michael Oberlin, Etelka Foeldi, Iris Baumgartner, Charlotte M. Niemeyer, Jochen Roessler, Friedrich G. Kapp
Summary: This study aimed to elaborate on the phenotypic description of complex lymphatic anomalies (CLA). The results showed that CLA patients have overlapping clinical presentations, which makes clinical diagnosis and differential diagnosis challenging. Further research on the pathogenesis of CLA is necessary for evaluating the effectiveness of targeted therapies and optimizing medical care.
LYMPHATIC RESEARCH AND BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Friedrich G. Kapp, Cedric Schneider, Annegret Holm, Hannah Glonnegger, Charlotte M. Niemeyer, Jochen Roessler, Barbara Zieger
Summary: This study analyzes the coagulation parameters of patients with vascular anomalies and finds impaired platelet aggregometry in patients with Kasabach-Merritt phenomenon and arteriovenous malformation, as well as upregulated von Willebrand factor antigen and activity in patients with complex lymphatic anomalies. These findings contribute to a better understanding of the underlying pathophysiology of these coagulopathies and may lead to new treatment options for life-threatening bleeding risks in these patients in the future.
Article
Immunology
Maria Elena Maccari, Sebastian Fuchs, Patrick Kury, Geoffroy Andrieux, Simon Volkl, Bertram Bengsch, Myriam Ricarda Lorenz, Maximilian Heeg, Jan Rohr, Sabine Jagle, Carla N. Castro, Miriam Gross, Ursula Warthorst, Christoph Koenig, Ilka Fuchs, Carsten Speckmann, Julian Thalhammer, Friedrich G. Kapp, Markus G. Seidel, Gregor Duckers, Stefan Schoenberger, Catharina Schuetz, Marita Fuhrer, Robin Kobbe, Dirk Holzinger, Christian Klemann, Petr Smisek, Stephen Owens, Gerd Horneff, Reinhard Kolb, Nora Naumann-Bartsch, Maurizio Miano, Julian Staniek, Marta Rizzi, Tomas Kalina, Pascal Schneider, Anika Erxleben, Rolf Backofen, Arif Ekici, Charlotte M. Niemeyer, Klaus Warnatz, Bodo Grimbacher, Hermann Eibel, Andreas Mackensen, Andreas Philipp Frei, Klaus Schwarz, Melanie Boerries, Stephan Ehl, Anne Rensing-Ehl
Summary: The identification and characterization of a population of FAS-controlled TCR alpha beta(+) T cells in autoimmune lymphoproliferative syndrome show numerous unique features, including a distinct molecular signature, high proliferation rates, noncytotoxicity, and IL-10 cytokine bias. Mechanistically, the regulation of this population involves FAS and CTLA4 signaling, as well as mTOR and STAT3 signals, and genetic alterations in these pathways can lead to significant lymphoproliferative disease.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)