Article
Environmental Sciences
Yang Yue, Huadong Zhang, Ping Deng, Miduo Tan, Chengzhi Chen, Bo Tang, Jingdian Li, Fengqiong Chen, Qi Zhao, Ling Li, Rongrong Hao, Hui Wang, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Zhengping Yu, Zhou Zhou, Huifeng Pi
Summary: Cadmium (Cd) exposure has been reported to be linked to breast cancer (BC) development. In this study, a transgenic mouse model (MMTV-Erbb2) was used to investigate the effects of Cd exposure on BC tumorigenesis. The results showed that Cd exposure accelerated tumor growth and increased Ki67 density in MMTV-Erbb2 mice. Furthermore, Cd exposure disturbed gut microbiota homeostasis, altering Glutamine (Gln) metabolism and promoting mammary tumorigenesis. This study provides new insights into Cd exposure-mediated carcinogenesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Shau-Hsuan Li, Limei Qian, Yen-Hao Chen, Hung- Lu, Hsin-Ting Tsai, Haiwen Lyu, Runxiang Yang, Chang-Han Chen
Summary: MYO1B expression is increased in ESCC and correlated with tumor stage, TNM stage, and poor outcomes. Depletion of MYO1B impairs oncogenesis and enhances chemosensitivity in ESCC. SNAI2 is a downstream effector of MYO1B, and suppression of MYO1B downregulates SNAI2 expression and inhibits the SNAI2/cyclin D1 pathway.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yan Xiong, Yue Zhong, Hyerin Yim, Xiaobao Yang, Kwang-Su Park, Ling Xie, Poulikos I. Poulikakos, Xiaoran Han, Yue Xiong, Xian Chen, Jing Liu, Jian Jin
Summary: Proteolysis Targeting Chimeras (PROTACs) are effective for degrading disease-causing proteins. A novel approach called bridged PROTAC has been developed to target undruggable proteins by bringing the protein complex close to an E3 ubiquitin ligase using a small molecule binder of the target protein's binding partner. This approach has led to the discovery of MS28, the first-in-class degrader of cyclin D1, and it shows superior degradation efficiency and proliferation inhibition compared to CDK4/6 inhibitors and degraders. The bridged PROTAC strategy could serve as a generalizable platform for targeting undruggable proteins.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Satoshi Miyashita, Tomoo Owa, Yusuke Seto, Mariko Yamashita, Shogo Aida, Masaki Sone, Kentaro Ichijo, Tomoki Nishioka, Kozo Kaibuchi, Yoshiya Kawaguchi, Shinichiro Taya, Mikio Hoshino
Summary: The study reveals that cyclin D1 (CCND1) directly regulates both proliferative and immature states of cerebellar granule cell progenitors (GCPs) by controlling the phosphorylation state of ATOH1 protein and cell cycle progression. Additionally, PROX1 downregulates Ccnd1 expression by histone deacetylation in GCPs, leading to cell cycle exit and differentiation. WNT signaling upregulates PROX1 expression in GCPs, suggesting a cooperative signaling cascade involving WNT-PROX1-CCND1-ATOH1 in controlling the states of GCPs.
Article
Cell Biology
Xuejing Ren, Hang Zhao, Lin Shi, Zhengran Li, Ruiyan Kong, Rui Ma, Lemei Jia, Shan Lu, Jian-Hua Wang, Meng-Qiu Dong, Yingchun Wang, Zhouhua Li
Summary: Stem cell proliferation is regulated by phosphorylation, and the interdependence of phosphorylation sites affects the function of Yun in intestinal stem cell proliferation.
CELL PROLIFERATION
(2022)
Article
Oncology
Lin Yan, Sneha Sundaram, Bret M. Rust, Matthew J. Picklo, Michael R. Bukowski
Summary: The study revealed that adipose-derived MCP-1 plays a role in the development of male breast cancer. Mice with a deficiency in adipose Mcp-1 had lower tumor incidence and weight, impacting pathways of amino acid and carbohydrate metabolism. Further investigation into the potential role of adipose-derived MCP-1 in cancer metabolism and tumorigenesis is warranted.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Peipei Ding, Yanqing Xu, Luying Li, Xinyue Lv, Ling Li, Jianfeng Chen, Danlei Zhou, Xiaochao Wang, Qi Wang, Wei Zhang, Tian Liao, Qing-Hai Ji, Qun-Ying Lei, Weiguo Hu
Summary: This study uncovers the activation of C5 complement within tumor cells, which affects colorectal tumorigenesis by regulating the stability of beta-catenin. The findings provide a potential target for tumor prevention and treatment.
Article
Multidisciplinary Sciences
Ga-Hyun Lim, Ju-Hyun An, Su-Min Park, Ga-Hee Youn, Ye-In Oh, Kyoung-Won Seo, Hwa-Young Youn
Summary: Tumor-associated macrophages play a significant role in the tumor microenvironment, affecting tumor development and resistance to anti-cancer drugs through cytokine and growth factor production. In this study, a hybrid spheroid model of canine mammary gland tumor cells and macrophages was established, which reflects the hypoxic tumor microenvironment and demonstrates that macrophages can induce anti-cancer drug resistance in canine tumor cells.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Yu Liu, Sen Li, Ruoping Chen, Juxiang Chen, Bo Xiao, Yicheng Lu, Jiangang Liu
Summary: This study found that BTBD10 is downregulated in human glioma tissue and its expression negatively correlates with the pathological grade of the tumor. BTBD10 overexpression inhibits cell proliferation, induces G0/G1 arrest, and promotes cell apoptosis.
OPEN LIFE SCIENCES
(2022)
Article
Oncology
Miguel A. Ortega, Leonel Pekarek, Oscar Fraile-Martinez, Cielo Garcia-Montero, Miguel A. Saez, Angel Asunsolo, Miguel A. Alvarez-Mon, Jorge Monserrat, Lidia Ruiz-Llorente, Natalio Garcia-Honduvilla, Agustin Albillos, Julia Bujan, Melchor Alvarez-Mon, Luis G. Guijarro
Summary: Pancreatic cancer is expected to become the second leading cause of cancer-related deaths by 2030. The pathophysiology and treatment options for pancreatic adenocarcinoma, the most common type of pancreatic cancer, remain major challenges in oncology. Despite efforts to improve clinical outcomes, early diagnosis is difficult and many patients are diagnosed at advanced stages. Numerous diagnostic tests, treatments, and approaches have been developed to prolong the survival of patients with pancreatic cancer. Advances in understanding the molecular basis of pancreatic cancer have identified potential therapeutic targets, but further research is needed to fully understand the underlying mechanisms. This study examines the expression of markers such as EGFR, Cyclin D1, and CDK4 to identify prognostic factors for patients with pancreatic adenocarcinoma and highlights the clinical importance of ErbB2 in patient survival rates.
Article
Biochemistry & Molecular Biology
Ha-Na Lee, Yeon-Seo Choi, Seong Hoon Kim, Xiancai Zhong, Wonki Kim, Joon Sung Park, Soma Saeidi, Byung Woo Han, Nayoung Kim, Hye Seung Lee, Yoon Jin Choi, Jeong-Heum Baek, Hye-Kyung Na, Young-Joon Surh
Summary: The research reveals a decreased level of RvD1 in blood from colorectal cancer patients and mice with inflammation-induced colon cancer, and demonstrates that RvD1 can protect against colorectal carcinogenesis by suppressing IL-6-mediated chromosomal instability. Additionally, RvD1 inhibits the STAT3 signaling pathway by blocking the IL-6 receptor, suggesting a potential novel function of RvD1 as an IL-6R antagonist that may contribute to inhibiting tumorigenesis.
Article
Veterinary Sciences
Gholamreza Mesbah, Fatemeh Namazi, Fatemeh T. Shamsabadi, Zahra Maleki, Mehrab Nasirikenari, Majid Shahbazi
Summary: The inhibitory effect of G1 cyclins was evaluated in nude mice, and it was found that the treatment led to a significant reduction in tumor weight and volume. Additionally, histopathological analysis showed more apoptotic cells in the treated mice compared to the control group.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Immunology
Vincent Fregona, Manon Bayet, Mathieu Bouttier, Laetitia Largeaud, Camille Hamelle, Laura A. Jamrog, Nais Prade, Stephanie Lagarde, Sylvie Hebrard, Isabelle Luquet, Veronique Mansat-De Mas, Marie Nolla, Marlene Pasquet, Christine Didier, Ahmed Amine Khamlichi, Cyril Broccardo, Eric Delabesse, Stephane J. C. Mancini, Bastien Gerby
Summary: The PAX5::ELN oncogenic model disrupts differentiation of preleukemic cells and leads to the emergence of rare and quiescent pre-LSCs that reactivate an immature molecular program similar to chemo-resistant cells in B-ALL.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Fang Wang, Jurgen van Baal, Lu Ma, Xuejun Gao, Jan Dijkstra, Dengpan Bu
Summary: This study investigated the role of MRCK alpha in milk protein and fat production in dairy cows and found a positive correlation between MRCK alpha expression and beta-casein levels in the mammary gland. Silencing MRCK alpha in bovine mammary epithelial cells led to a decrease in basal beta-casein and cell growth, while overexpression had the opposite effect. These findings suggest that MRCK alpha plays an important role in mammary tissue development.
Article
Medicine, Research & Experimental
Alhomidi Almotiri, Hamed Alzahrani, Juan Bautista Menendez-Gonzalez, Ali Abdelfattah, Badi Alotaibi, Lubaid Saleh, Adelle Greene, Mia Georgiou, Alex Gibbs, Amani Alsayari, Sarab Taha, Leigh-anne Thomas, Dhruv Shah, Sarah Edkins, Peter Giles, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, Ashleigh S. Boyd, Florian A. Siebzehnrubl, Neil P. Rodrigues
Summary: The study suggests that loss of Zeb1 in adult stem cells leads to significant defects in stem cell renewal and differentiation, which are associated with leukemia signaling. Therefore, Zeb1 plays a crucial role as a transcriptional regulator in hematopoiesis, coordinating HSC self-renewal and differentiation to suppress the potential development of AML.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Molly M. Morgan, Lisa M. Arendt, Elaine T. Alarid, David J. Beebe, Brian P. Johnson
Article
Biochemical Research Methods
Yang Zhang, Fatma Kucuk Baloglu, Lauren E. Hillers Ziemer, Zhiyi Liu, Boyang Lyu, Lisa M. Arendt, Irene Georgakoudi
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Oncology
Lauren E. Hillers-Ziemer, Rachel Q. McMahon, Margaret Hietpas, Gretchen Paderta, Jennelle LeBeau, Jessica McCready, Lisa M. Arendt
Article
Biochemistry & Molecular Biology
Tamara Chamberlin, Victoria Thompson, Lauren E. Hillers-Ziemer, Brenna N. Walton, Lisa M. Arendt
Article
Oncology
Lauren E. Hillers-Ziemer, Lisa M. Arendt
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2020)
Article
Oncology
Genevra Kuziel, Victoria Thompson, Joseph V. D'Amato, Lisa M. Arendt
Article
Oncology
Tamara Chamberlin, Megan Clack, Caylee Silvers, Genevra Kuziel, Victoria Thompson, Haley Johnson, Lisa M. Arendt
Article
Endocrinology & Metabolism
Adrienne A. Cheng, Wenli Li, Teresa M. Walker, Caylee Silvers, Lisa M. Arendt, Laura L. Hernandez
Summary: The study investigated the impact of diet and genotype on lactation, finding that obesity and genotype can affect milk composition and immune system at different stages, illustrating the complexities in understanding the intersection of these parameters.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Oncology
Lauren E. Hillers-Ziemer, Abbey E. Williams, Amanda Janquart, Caitlin Grogan, Victoria Thompson, Adriana Sanchez, Lisa M. Arendt
Summary: Obesity promotes rapid growth and metastases of mammary tumors in mice by increasing recruitment of myeloid lineage cells and deposition of collagen fibers within the lungs. Lung stromal cells isolated from obese mice show higher expression of extracellular matrix proteins and inflammatory cytokines, facilitating metastatic growth prior to tumor formation. Understanding these mechanisms may provide new therapeutic options for obese breast cancer patients.
Article
Environmental Sciences
Conner L. Kennedy, Audrey Spiegelhoff, Kathy Wang, Thomas Lavery, Alexandra Nunez, Robbie Manuel, Lauren Hillers-Ziemer, Lisa M. Arendt, Kimberly P. Keil Stietz
Summary: Research suggests that developmental exposure to PCBs may lead to changes in immune cells in the bladder of mice, particularly an increase in macrophages in female bladders. Additionally, decreased collagen density and increased cell division were observed in the bladder, indicating potential inflammatory events.
Article
Orthopedics
Shannon K. Walsh, Rikin Soni, Lisa M. Arendt, Melissa C. Skala, Corinne R. Henak
Summary: The study revealed age-dependent metabolic activity in cartilage, with metabolic dysfunction impacting gene expression related to tissue maintenance. Glycolysis, oxidative phosphorylation activity, and optical redox ratio were positively correlated with severity of cartilage damage.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Oncology
Lauren E. Hillers-Ziemer, Genevra Kuziel, Abbey E. Williams, Brittney N. Moore, Lisa M. Arendt
Summary: Obese women with breast cancer have poorer prognosis and increased metastasis rates. Obesity also affects the response of breast cancer to endocrine and chemotherapeutic treatments. Changes in the breast tumor microenvironment caused by obesity promote rapid tumor growth and resistance to therapies.
CANCER AND METASTASIS REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Genevra Kuziel, Brittney N. Moore, Grace P. Haugstad, Lisa M. Arendt
Summary: Obesity increases the risk of breast cancer, and this is partly due to chronic inflammation and fibrosis in the mammary gland. In this study, the researchers used a high-fat diet model and genetically modified mice to investigate the role of immune cells in obesity-induced fibrosis. They found that obesity increased the recruitment of a specific population of cells, called fibrocytes, which contributed to the formation of myofibroblasts and fibrosis in the mammary gland. Transplanting myeloid progenitor cells, which give rise to fibrocytes, into obese mice further increased myofibroblast formation. These findings suggest that obesity enhances the recruitment of fibrocytes and promotes fibrosis in the mammary gland.
Review
Oncology
Genevra Kuziel, Brittney N. Moore, Lisa M. Arendt
Summary: Obesity is associated with worsened breast cancer prognosis due to tumor desmoplasia and fibrotic changes in adipose tissue. Adipose tissue fibrosis is a consequence of obesity arising from altered secretion of extracellular matrix and chronic inflammation mediated by macrophages. The long-term effects of weight loss on adipose tissue fibrosis and inflammation within breast tissue are still unclear, but increased fibrosis may promote tumor development and aggressiveness.
Article
Oncology
Michael Doyle, Noor Kwami, Jaitri Joshi, Lisa M. Arendt, Jessica Mccready
Summary: Breast cancer diagnosed during pregnancy and lactation (pregnancy-associated breast cancer, PABC) is more aggressive and has a decreased survival rate compared to breast cancers diagnosed at other stages in life. Previous research indicates that developmental changes to the fat cells in the mammary gland in lactation increase blood vessel growth within tumors. This study aimed to determine if other cells within the tumor contribute to PABC aggressiveness. The findings indicate that tumor cells transplanted with fat cells isolated during lactation increase inflammatory cells called macrophages and promote tumor cell growth in the mammary glands of mice.
