Editorial Material
Chemistry, Physical
Jeffrey A. Eastman
Summary: The observation of large remnant polarization in epitaxial yttrium-doped hafnium oxide thin films suggests that robust ferroelectric behavior can be achieved without small-grained or ultrathin microstructures.
Article
Endocrinology & Metabolism
Yu Kodani, Miho Kawata, Hidetaka Suga, Takatoshi Kasai, Chikafumi Ozone, Mayu Sakakibara, Atsushi Kuwahara, Shiori Taga, Hiroshi Arima, Toshiki Kameyama, Kanako Saito, Akira Nakashima, Hiroshi Nagasaki
Summary: Human stem cell-derived organoids are a valuable tool for studying cellular function and specific cell types in native organs. In this study, researchers successfully enriched human anterior pituitary cells using surface marker profiling. These enriched cells could be used for further research in stem cell biology and regenerative medicine.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Francesco Magaletti, Mirko Gallo, Carlo Massimo Casciola
Summary: Predicting cavitation in water has been a challenging task, but recent progress has improved our predictive capability. Using a self-contained model and a rare event technique, accurate reproduction of cavitation data for water over a wide range of temperatures has been achieved.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Seong-Wook Park, Sei-Yong Jun, Ji-Sun Kim, Yong-Sung Kim
Summary: By engineering a higher affinity EpCAM-targeting cyclic peptide, the peptide-fused antibody showed enhanced cellular internalization and tumor accumulation, leading to more efficient antitumor effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yagmur Yildizhan, Kaat Driessens, Hong Shen Kevin Tsao, Robin Boiy, Debby Thomas, Nick Geukens, An Hendrix, Jeroen Lammertyn, Dragana Spasic
Summary: EVs have great potential as biomarkers for cancer diagnostics. There is a need for sensitive and standardized EV detection methods. We have developed a bioassay using a FO-SPR biosensor, which shows remarkable sensitivity and specificity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Taylor C. Brown, Narendra Sankpal, William E. Gillanders
Summary: Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein that plays a crucial role in epithelial tissue homeostasis and is a target of molecular therapies for tumor biology. Its expression is frequently high in epithelial cancers and silenced in mesenchymal cancers. EpCAM's functional impact on tumor biology is multifunctional and depends on the predominant oncogenic signaling pathways in different cancer types. Its regulation during epithelial-to-mesenchymal transition (EMT) involves downregulation by extracellular signal-regulated kinases (ERK) and EMT transcription factors, as well as regulated intramembrane proteolysis (RIP).
Article
Chemistry, Physical
Dimo Kashchiev
Summary: The present study provides a general approximate expression for the work required to form a nucleus and derives explicit formulas for the lowest-order approximations. The results obtained are applicable to various nucleation phenomena.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Editorial Material
Hematology
Tatjana Stankovic, Marwan Kwok
Summary: The study demonstrates the clinical benefit of ibrutinib for relapsed hairy cell leukemia in a phase 2 clinical trial.
Article
Multidisciplinary Sciences
Fatma E. Omar, Taylor P. Brown, William A. Gillanders, Timothy M. Fleming, Michael V. Smith, Ross Bremner, Narendra Sankpal
Summary: Next generation sequencing has identified novel therapeutic targets in human cancer mutations. Activating Ras oncogene mutations play a central role in oncogenesis, promoting the transformation of normal cells into tumor cells. This study investigated the role of altered localization of epithelial cell adhesion molecule (EpCAM) in Ras-expressing cells, revealing that EpCAM mutations can cooperate with H-Ras and promote epithelial-to-mesenchymal transition (EMT).
Review
Oncology
Yiyang Liu, Yufei Wang, Sheng Sun, Zeyu Chen, Shuai Xiang, Zeyang Ding, Zhao Huang, Bixiang Zhang
Summary: This article investigates the role of EpCAM in cancer and its communication with other signaling pathways. It introduces the impact on the biology of cancers and the latest clinical applications of EpCAM, aiming to shed light on its translational prospects.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Engineering, Aerospace
Martin Weiss, Tal Shima
Summary: A generic guidance design framework is proposed based on minimizing guidance effort and applying performance constraints during flight, effectively addressing guidance issues related to multiple target scenarios.
JOURNAL OF GUIDANCE CONTROL AND DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Reyhaneh Roshan, Shamsi Naderi, Mahdi Behdani, Reza Ahangari Cohan, Fatemeh Kazemi-Lomedasht
Summary: In this study, an anti-EpCAM immunotoxin was developed and shown to have anti-proliferative and apoptotic activity in MCF-7 cells, as well as the ability to significantly reduce tumor size in vivo, indicating its potential as a novel therapeutic for cancer therapy.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Rocio Munoz-Hernandez, Sheila Gato, Antonio Gil-Gomez, Rocio Aller, Angela Rojas, Laura Moran, Javier Gallego, Elena Blazquez-Lopez, Rocio Gallego-Duran, Rocio Montero-Vallejo, Vanessa Garcia-Fernandez, Douglas Maya-Miles, Maria del C. Rico, Francisco J. Cubero, Javier Vaquero, Javier Ampuero, Rafael Banares, Manuel Romero-Gomez
Summary: This study evaluated the circulating AV+ EpCAM+ CD133+ EVs as a potential biomarker for the transition from simple steatosis to steatohepatitis. The results showed that these EVs increased during disease progression in both mouse models and clinical validation. Therefore, EpCAM+ CD133+ EVs hold promise as a non-invasive biomarker for evaluating and managing NAFLD patients.
LIVER INTERNATIONAL
(2023)
Article
Biotechnology & Applied Microbiology
Tina Vida Plavec, Ana Mitrovic, Milica Perisic Nanut, Borut Strukelj, Janko Kos, Ales Berlec
Summary: The development of targeted treatment for colorectal cancer is crucial for avoiding side effects. In this study, safe multifunctional cancer cell-targeting bacteria Lactococcus lactis were engineered to target cancer-associated receptors like EpCAM and HER2. Through in vitro experiments on human cell lines, it was demonstrated that the engineered bacteria could successfully target cells with overexpressed tumor antigens, showing promise for future biopharmaceutical delivery in the treatment of colorectal cancer.
MICROBIAL BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alice Ossoli, Federica Cetti, Monica Gomaraschi
Summary: Epidemiological studies consistently show a positive association between exposure to air pollutants, especially PM2.5, and the incidence of cardiovascular disease. Air pollution is now considered a modifiable risk factor for cardiovascular outcomes such as mortality, acute coronary syndrome, stroke, heart failure, and arrhythmias. Long-term exposure to air pollution contributes to the progression of atherosclerosis by promoting dyslipidemia, hypertension, and other metabolic disorders through systemic inflammation and oxidative stress. Studies have also indicated that air pollution can impair HDL function, including its cholesterol efflux capacity, antioxidant and anti-inflammatory potential, and ability to promote nitric oxide release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
