Article
Cell & Tissue Engineering
Xiaoru Xu, Shuang Song, Xiangdong Liu, Yuchao Zhou, Shaojie Shi, Guoqiang Zhao, Xingxing Wang, Xutao Chen, Wenshuang Zhao, Sijia Zhang, Wei Ma, Yingliang Song
Summary: Cell sheet technology utilizing adipose-derived stromal cells (ASCs) shows promise in promoting angiogenesis and may have valuable clinical applications.
STEM CELLS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Xi Chen, Xiao Wang, Zedu Cui, Qian Luo, Zihua Jiang, Yuke Huang, Jingyi Jiang, Jin Qiu, Yan Li, Keming Yu, Jing Zhuang
Summary: Activation of microglia is crucial in neovascular retinal diseases and understanding its mechanisms can provide potential therapeutic strategies. Through single-cell RNA sequencing, this study reveals that M1 microglia-derived exosomes enhance activation and proangiogenic ability of resting microglia. The communication is mediated by miRNA miR-155-5p, which promotes microglial activation and initiates inflammatory cascade.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Sanghyuk Choi, Jinyeong Yu, Wootak Kim, Ki-Sook Park
Summary: In this study, N-cadherin was identified as a key molecule in mediating the migration of BM-MSCs towards breast tumors. The expression of N-cadherin increased on the intercellular borders of BM-MSCs through TGF-beta canonical signaling, leading to their collective migration in response to breast tumor cells via N-cadherin-dependent cell-cell adhesion. This introduces a novel and promising strategy for controlling and re-engineering the breast tumor microenvironment.
Article
Multidisciplinary Sciences
Junko Okano, Yuki Nakae, Takahiko Nakagawa, Miwako Katagi, Tomoya Terashima, Daisuke Nagakubo, Takashi Nakayama, Osamu Yoshie, Yoshihisa Suzuki, Hideto Kojima
Summary: Exposure to moderate doses of ionizing radiation can cause skin injury, but can also lead to recovery. Bone marrow-derived cells play a crucial role in this recovery process by secreting CCL17, which promotes proliferation of basal cells and accelerates the healing of skin damage caused by IR.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Jinok Noh, Jinyeong Yu, Wootak Kim, Aran Park, Ki-Sook Park
Summary: The tumor microenvironment in prostate cancer plays vital roles in tumor cell metastasis and re-growth. Bone marrow-derived mesenchymal stem cells (BM-MSCs) are crucial in forming this microenvironment. The study found that N-cadherin is a key mediator of BM-MSCs migration towards hormone-insensitive prostate tumor cells.
Article
Oncology
Chika Iwamoto, Kenoki Ohuchida, Tomohiko Shinkawa, Sho Okuda, Yoshiki Otsubo, Takashi Okumura, Akiko Sagara, Kazuhiro Koikawa, Yohei Ando, Koji Shindo, Naoki Ikenaga, Kohei Nakata, Taiki Moriyama, Yoshihiro Miyasaka, Takao Ohtsuka, Masatoshi Eto, Koichi Akashi, Masafumi Nakamura
Summary: This study found that in PDAC, macrophages derived from bone marrow can partially convert into CAF-like cells, acting as a specific subtype that promotes pancreatic cancer growth and invasion. This conversion may represent a novel therapeutic strategy.
Article
Engineering, Biomedical
Siqi He, Tanaya Walimbe, Hongyuan Chen, Kewa Gao, Priyadarsini Kumar, Yifan Wei, Dake Hao, Ruiwu Liu, Diana L. Farmer, Kit S. Lam, Jianda Zhou, Alyssa Panitch, Aijun Wang
Summary: In this study, a multi-functional pro-angiogenic molecule was designed and synthesized to enhance the treatment of diabetic ischemic wounds. The modified extracellular matrix scaffolds significantly promoted cell attachment, growth, and survival, leading to improved wound healing and neovascularization in an ischemic environment.
BIOACTIVE MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Shiyang Wang, Yue Shi
Summary: Exosomes are small vesicles secreted by living cells, carrying proteins, lipids, RNA, and other important substances for cell-to-cell communication. This review focuses on the effects of immune cell-derived exosomes on tumor cells, immune cells, and other stromal cells in the tumor microenvironment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Cell Biology
Jiachao Xiong, Hong Qiang, Ting Li, Jiayi Zhao, Ziyu Wang, Fei Li, Jianwen Xu
Summary: The study demonstrates that human adipose-derived stem cells can promote the vascularization of seawater-treated wounds by differentiating into vascular endothelial cells and promoting their proliferation and migration. Bioinformatics analysis identified genes that may regulate wound healing mechanisms such as extracellular matrix remodeling, programmed cell death, inflammation, and vascularization.
Article
Oncology
Kai Cheng, Fengru Tang, Xuanlin Liu, Junsong Wei, Huining You, Qinglu Du, Yanlan Lin, Weiyi Feng
Summary: This study found that specific low-dose metronomic chemotherapy may promote tumor angiogenesis and growth by increasing the mobilization of proangiogenic bone marrow-derived cells. This suggests potential therapeutic risks from inappropriate LDM chemotherapy dosage and highlights the urgency of optimizing LDM chemotherapy regimens.
ANTICANCER RESEARCH
(2023)
Review
Nanoscience & Nanotechnology
Qi Li, Suna Cai, Mengjiao Li, Kab Ibrahim Salma, Xiaojie Zhou, Feiyu Han, Jinzhao Chen, Ting Huyan
Summary: The article discusses the effects of tumor-derived extracellular vesicles on immune cells and summarizes their research progress in tumor immunotherapy and diagnosis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Engineering, Biomedical
Meng Luo, Yidan Wang, Chenxi Xie, Bo Lei
Summary: This study reports a bioactive hydrogel derived from multiple metal coordination that exhibits anti-inflammatory, proangiogenic, and hemostatic properties for wound repair. The hydrogel demonstrates good physical properties and biocompatibility, and effectively promotes wound healing in animal models. This research suggests that multiple metal-organic coordination is an effective strategy for constructing multifunctional bioactive hydrogels.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Fawzy Akad, Veronica Mocanu, Sorin Nicolae Peiu, Viorel Scripcariu, Bogdan Filip, Daniel Timofte, Florin Zugun-Eloae, Magdalena Cuciureanu, Monica Hancianu, Teodor Oboroceanu, Laura Condur, Radu Florin Popa
Summary: Individualized gastric cancer treatment uses targeted therapies based on the latest research. Extracellular vesicle microRNAs are biomarkers for GC prognosis. H. pylori infection influences therapeutic response and drivers of malignant changes in gastritis. Transplanted MSCs have been successfully used for gastric ulcer healing and studying their effects on tumor neovascularization and potential antiangiogenic therapies. MSCs derived from various sources have pro- and antiangiogenic effects that complement their role in immune regulation and tissue regeneration and provide further understanding of the biology of GC and resistance to antiangiogenic drugs.
Review
Oncology
Kathryn Cole, Kristina Pravoverov, James E. Talmadge
Summary: Metastasis, the spread of primary tumor cells to distant organs, is the main cause of cancer mortality, and understanding its timing and mechanisms is crucial. Tumor cells may enter a dormant state during metastasis before forming occult lesions, regulated by immune responses and interactions. Myeloid-derived suppressor cells play a major role in tumor progression, potentially promoting escape from dormancy and the development of occult metastases.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Yoon Kyung Jeon, Young Yang, Myeong-Sok Lee, Jong-Seok Lim
Summary: This study investigated the role of MITF in immunosuppressive myeloid cells, including MDSCs. The results showed that MITF plays an important regulatory role in tumor development through its impact on the differentiation and function of MDSCs. This finding provides a basis for the development of novel therapeutic targets for modulating MDSC activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)