Article
Immunology
Mickey V. Patel, Zheng Shen, Marta Rodriguez-Garcia, Edward J. Usherwood, Laura J. Tafe, Charles R. Wira
Summary: Endometrial cancer suppresses host immune function by regulating the cytotoxic capacity of CD8+ T cells. CD103-CD8+ T cells are primarily responsible for killing of allogeneic target cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Mariana S. Parahuleva, Julian Kreutz, Gerhild Euler, Dora Terzieva, Amar Mardini, Ekaterina Uchikova, Nikoleta Parahuleva
Summary: Endometrial cancer (EC) is significantly associated with an increased incidence of atrial fibrillation (AF). Women with EC who are obese and younger are more likely to develop AF. Adiponectin (APN) levels may be associated with new-onset AF, especially when adjusted for BMI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Danielle N. Medgyesi, Britton Trabert, Joshua Sampson, Peter J. Weyer, Anna Prizment, Jared A. Fisher, Laura E. Beane Freeman, Mary H. Ward, Rena R. Jones
Summary: This study investigated the relationship between disinfection byproducts and N-nitroso compounds with endometrial cancer risk. The results showed that high levels of disinfection byproducts were associated with an increased risk of endometrial cancer.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Oncology
Yong Jung Song, Hwi Gon Kim, Hyung Joon Yoon, Kyung Un Choi, Dong Soo Suh, Ki Hyung Kim
Summary: This study aimed to assess the role of preoperative hematologic parameters in differentiating malignant and benign endometrial lesions. The results showed that certain hematologic markers independently predicted the presence of endometrial malignancy, and the combination markers MPV+PDW+NLR had good discriminatory power.
CANCER MANAGEMENT AND RESEARCH
(2023)
Review
Medicine, General & Internal
Emma J. Crosbie, Sarah J. Kitson, Jessica N. McAlpine, Asima Mukhopadhyay, Melanie E. Powell, Naveena Singh
Summary: Endometrial cancer is the most common gynaecological cancer in high income countries, with a global rise in incidence. Obesity is the major underlying cause, posing challenges for diagnosis and treatment. Early presentation with postmenopausal bleeding ensures cure, but advanced cases have poor prognosis. Minimally invasive surgical staging and targeted chemotherapeutic strategies are important advances.
Review
Health Care Sciences & Services
Sean A. Woolen, Ann A. Lazar, Rebecca Smith-Bindman
Summary: This study used systematic review and meta-analysis to evaluate the association between frequent perineal talcum powder use and ovarian cancer. The results suggest that frequent use of talcum powder is associated with an increased risk of ovarian cancer.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Oncology
S. Ghazaleh Dashti, Dallas R. English, Julie A. Simpson, Amalia Karahalios, Margarita Moreno-Betancur, Carine Biessy, Sabina Rinaldi, Pietro Ferrari, Anne Tjonneland, Jytte Halkjaer, Christina C. Dahm, Helene Tilma Vistisen, Florence Menegaux, Vittorio Perduca, Gianluca Severi, Krasimira Aleksandrova, Matthias B. Schulze, Giovanna Masala, Sabina Sieri, Rosario Tumino, Alessandra Macciotta, Salvatore Panico, Anouk E. Hiensch, Anne M. May, J. Ramon Quiros, Antonio Agudo, Maria-Jose Sanchez, Pilar Amiano, Sandra Colorado-Yohar, Eva Ardanaz, Naomi E. Allen, Elisabete Weiderpass, Renee Turzanski Fortner, Sofia Christakoudi, Konstantinos K. Tsilidis, Elio Riboli, Rudolf Kaaks, Marc J. Gunter, Vivian Viallon, Laure Dossus
Summary: Based on a case-control study within the EPIC, the research aimed to quantify the mediating effects of various biomarkers in the link between adiposity and endometrial cancer risk in postmenopausal women. Results showed that reduced adiponectin and increased inflammatory biomarkers, C-peptide, and estrogens mediated approximately 70% of the increased odds of endometrial cancer in women with obesity versus normal weight. These findings could have implications for intervention strategies to reduce endometrial cancer risk in women with obesity.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Obstetrics & Gynecology
Fangfang Ai, Xiaopei Qin, Liane Zhou, Shijun Wang
Summary: This study investigated the factors related to endometrial cancer in postmenopausal women with endometrial thickening, and the value of endometrial thickness in predicting endometrial cancer. The results showed that older age and polypoid mass-like lesions were independent factors associated with endometrial cancer in women with postmenopausal bleeding, while only polypoid mass-like lesions were associated with endometrial cancer in women without postmenopausal bleeding.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Oncology
Cihan Comba, Merve Topaktas, Hilmi Bozkurt, Akif Erbin, Burcu Ozdogan, Omer Demir
Summary: The case presented here is of a 62-year-old woman who underwent total pelvic exenteration for vaginal cancer as a secondary malignancy after radiotherapy for endometrial cancer. The surgery was complicated by the development of an ileo-perineal fistula six months post-operatively.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
Review
Obstetrics & Gynecology
Salvatore Giovanni Vitale, Gaetano Riemma, Sergio Haimovich, Jose Carugno, Luis Alonso Pacheco, Tirso Perez-Medina, John Preston Parry, Peter Torok, Jan Tesarik, Luigi Della Corte, Luigi Cobellis, Attilio Di Spiezio Sardo, Pasquale De Franciscis
Summary: This study aimed to evaluate the risk of endometrial carcinoma and atypical endometrial hyperplasia in asymptomatic postmenopausal women by measuring the endometrial thickness. The analysis of 18 studies showed that the thresholds of 3.0 to 5.9 mm and 10.0 to 13.9 mm for endometrial thickness have higher diagnostic accuracy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Linna Zhang, Ying Guo, Guxia Qian, Tao Su, Hong Xu
Summary: This study suggests that an endometrium thickness (ET) cut-off of >= 8 mm can effectively distinguish atypical hyperplasia (AH) and endometrial carcinoma (EC) in asymptomatic postmenopausal women, reducing the need for invasive endometrial biopsy.
Article
Oncology
Yong-Li Lyu, Li Geng, Fa-Xi Wang, Chun-Liang Yang, Shan-Jie Rong, Hai-Feng Zhou, Fei Sun, Jun-Yi Li
Summary: This study retrospectively analyzed the clinical data of 216 patients with endometrial carcinoma, finding that the clinical manifestations and characteristics differ between premenopausal and postmenopausal women. Surgery is still the main treatment method, but the postoperative prognosis is greatly affected by the pathological state.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Obstetrics & Gynecology
Fangzi Liu, Eva C. W. Cheung, Terence T. Lao
Summary: The study showed that Chinese women with a BMI over 25 kg/m(2) presenting with postmenopausal bleeding have a significantly increased risk of endometrial cancer. Therefore, BMI may serve as an effective indicator to screen for the risk of endometrial cancer in postmenopausal women.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2021)
Article
Obstetrics & Gynecology
Lili Wang, Jiaolin Yang, Huancheng Su, Liuming Shi, Bangtao Chen, Sanyuan Zhang
Summary: The microbiota profiles in postmenopausal endometrial cancer and adjacent non-cancerous endometrium differ significantly, and specific bacteria are clinically relevant. However, further investigation is needed to understand the functional bacteria in the endometrium.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Medical Laboratory Technology
Pei Hui
Summary: Minimal uterine serous carcinoma (MUSC) includes serous endometrial intraepithelial carcinoma and superficial serous carcinoma, and they have a close topographic relationship with endometrial polyp. More than two-thirds of MUSCs involve an endometrial polyp, and over 50% of MUSCs are confined to an endometrial polyp, indicating that most MUSCs arise in an endometrial polyp.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Health Care Sciences & Services
Eric William Hall, Nicole Luisi, Maria Zlotorzynska, Gretchen Wilde, Patrick Sullivan, Travis Sanchez, Heather Bradley, Aaron J. Siegler
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Immunology
Aaron J. Siegler, Eric Hall, Nicole Luisi, Maria Zlotorzynska, Gretchen Wilde, Travis Sanchez, Heather Bradley, Patrick S. Sullivan
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Health Care Sciences & Services
Patrick Sean Sullivan, Cory Woodyatt, Chelsea Koski, Elizabeth Pembleton, Pema McGuinness, Jennifer Taussig, Alexandra Ricca, Nicole Luisi, Eve Mokotoff, Nanette Benbow, Amanda D. Castel, Ann N. Do, Ronald O. Valdiserri, Heather Bradley, Chandni Jaggi, Daniel O'Farrell, Rebecca Filipowicz, Aaron J. Siegler, James Curran, Travis H. Sanchez
JOURNAL OF MEDICAL INTERNET RESEARCH
(2020)
Article
Immunology
Patrick S. Sullivan, Justin Knox, Jeb Jones, Jennifer Taussig, Mariah Valentine Graves, Greg Millett, Nicole Luisi, Eric Hall, Travis H. Sanchez, Carlos Del Rio, Colleen Kelley, Eli S. Rosenberg, Jodie L. Guest
Summary: In Atlanta, Black MSM living with HIV are less likely to achieve viral suppression compared to white MSM. Factors such as ART coverage, housing stability, higher income, and marijuana use help explain and reduce the racial disparity in viral suppression.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2021)
Article
Immunology
Patrick Sean Sullivan, Aaron J. Siegler, Kayoko Shioda, Eric W. Hall, Heather Bradley, Travis Sanchez, Nicole Luisi, Mariah Valentine-Graves, Kristin N. Nelson, Mansour Fahimi, Amanda Kamali, Charles Sailey, Benjamin A. Lopman
Summary: One in 8 US adults had been infected with severe acute respiratory syndrome coronavirus 2 by late October 2020; however, few had been accounted for in public health reporting.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Health Care Sciences & Services
Jodie L. Guest, Elizabeth Adam, Iaah L. Lucas, Cristian J. Chandler, Rebecca Filipowicz, Nicole Luisi, Laura Gravens, Kingsley Leung, Tanaka Chavanduka, Erin E. Bonar, Jose A. Bauermeister, Rob Stephenson, Patrick S. Sullivan
Summary: This study discusses electronic and manual authentication strategies used to monitor and prevent fraudulent enrollment in the iReach randomized controlled trial. By flagging suspicious enrollments and verifying age, IP addresses, email addresses, etc., the strategies successfully identified and prevented potential fraud and ineligible entries.
JMIR MHEALTH AND UHEALTH
(2021)
Article
Immunology
Katherine Lamba, Heather Bradley, Kayoko Shioda, Patrick S. Sullivan, Nicole Luisi, Eric W. Hall, Megha L. Mehrotra, Esther Lim, Seema Jain, Amanda Kamali, Travis Sanchez, Benjamin A. Lopman, Mansour Fahimi, Aaron J. Siegler
Summary: A population-based serosurvey in California estimated a weighted seroprevalence of 4.6% for SARS-CoV-2 during August-December 2020, with a cumulative incidence of 8.7% as of November 2, 2020. The infection fatality ratio was estimated at 0.8% and only 31% of infections were reported to the public health department. Disparities in infection risk were observed among Hispanic/Latinx individuals, those without health insurance, and individuals working outside the home.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Allison T. Chamberlain, Kathleen E. Toomey, Heather Bradley, Eric W. Hall, Mansour Fahimi, Benjamin A. Lopman, Nicole Luisi, Travis Sanchez, Cherie Drenzek, Kayoko Shioda, Aaron J. Siegler, Patrick Sean Sullivan
Summary: Using data from a probability survey of households in Georgia, United States, it was estimated that 1.3 million adults aged 18 and above had been infected with SARS-CoV-2 by November 16, 2020. One in four infections were reported and the infection fatality ratio was 0.78%. The study found that reported COVID-19 cases underestimated the true number of infections and data on asymptomatic infections are needed. The cumulative incidence of SARS-CoV-2 infections adjusted for antibody waning was estimated to be 16.1%, with higher seropositivity rates observed among non-Hispanic black and Hispanic adults compared to non-Hispanic white adults.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Letter
Medicine, General & Internal
Aaron J. Siegler, Nicole Luisi, Eric W. Hall, Heather Bradley, Travis Sanchez, Benjamin A. Lopman, Patrick S. Sullivan
Article
Public, Environmental & Occupational Health
Lisa Gamrad-Streubel, Lisa-Marie Haase, Katharina K. Rudolph, Katrin Ruhle, Annette M. Bachand, Lori Crawford, Kenneth A. Mundt, Juergen Buenger, Dirk Pallapies, Dirk Taeger, Swaantje Casjens, Anja Molkenthin, Savo Neumann, Joerg Giesen, Volker Neumann, Thomas Bruening, Thomas Birk
Summary: The German authorities reassessed the occupational exposure limits for nitrogen oxides and diesel exhaust. A clinical cross-sectional study among salt and potash underground workers exposed to these substances at relatively high levels found no evidence of acute effects on workers' health.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2022)
Article
Infectious Diseases
Kristin N. Nelson, Aaron J. Siegler, Patrick S. Sullivan, Heather Bradley, Eric Hall, Nicole Luisi, Palmer Hipp-Ramsey, Travis Sanchez, Kayoko Shioda, Benjamin A. Lopman
Summary: The COVID-19 pandemic has led to abrupt and dramatic changes in social contact patterns. Our study surveyed different demographic groups in the U.S and found that social contact patterns varied by race, occupation, and antibody test results.
Letter
Medicine, General & Internal
E. Hanna Schurr, Nicole Luisi, Travis Sanchez, Benjamin A. Lopman, Heather Bradley, Patrick S. Sullivan, Aaron J. Siegler
Review
Environmental Sciences
Lori Crawford, Scott A. Halperin, Michael W. Dzierlenga, Becky Skidmore, Matthew W. Linakis, Shinichi Nakagawa, Matthew P. Longnecker
Summary: This systematic review aimed to determine the magnitude of the association between per- and polyfluoroalkyl substances (PFAS) serum concentration and antibody response to vaccines. The results showed that all PFAS tended to have an inverse association with antibody concentrations, but the specific associations were inconsistent. Rating: 8 out of 10.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Substance Abuse
Heather Bradley, Chelsea Austin, Sean T. Allen, Alice Asher, Tyler S. Bartholomew, Amy Board, Annick Borquez, Kate Buchacz, Anastasia Carter, Hannah L. F. Cooper, Judith Feinberg, Nathan Furukawa, Becky Genberg, Pamina M. Gorbach, Holly Hagan, Emalie Huriaux, Hermione Hurley, Nicole Luisi, Natasha K. Martin, Eli S. Rosenberg, Steffanie A. Strathdee, Don C. Des Jarlais
Summary: This article introduces an expert stakeholder generated multi-level framework for monitoring changes in PWID health outcomes potentially attributable to COVID-19. The framework elucidates proximal and distal contributors to infectious disease and overdose outcomes.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Health Policy & Services
Simone Wien, Jodie L. Guest, Nicole Luisi, Jennifer Taussig, Michael R. Kramer, Rob Stephenson, Greg Millett, Carlos del Rio, Patrick S. Sullivan
Summary: There are disparities in HIV outcomes and transportation access among Black gay, bisexual, and other sexual minority men who have sex with men (GBMSM). This study examines the relationship between transportation dependence and undetectable viral load among Black and White GBMSM in Atlanta. It was found that more Black GBMSM had detectable viral load and depended on public transportation compared to White GBMSM. Independent transportation was associated with undetectable viral load for White GBMSM but not Black GBMSM, possibly due to additional barriers to HIV care for Black GBMSM.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2023)